Reviewed, UniProtKB/Swiss-Prot Q9GKS6 (AT10D_MACFA)

Names and origin

Protein names

Recommended name:
    Probable phospholipid-transporting ATPase VD
    EC=3.6.3.1
Alternative name(s):
    ATPase class V type 10D

Gene names

Name:	ATP10D
ORF Names:	QnpA-21212

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	653 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + H2O + phospholipid(In) = ADP + phosphate + phospholipid(Out).
Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type IV subfamily.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro phospholipid transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phospholipid-translocating ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 653	›653	Probable phospholipid-transporting ATPase VD		PRO_0000046383
Regions
	Topological domain	‹1 – 375	›375	Cytoplasmic Potential
	Transmembrane	376 – 396	21	Potential
	Topological domain	397 – 407	11	Extracellular Potential
	Transmembrane	408 – 428	21	Potential
	Topological domain	429 – 458	30	Cytoplasmic Potential
	Transmembrane	459 – 480	22	Potential
	Topological domain	481 – 487	7	Extracellular Potential
	Transmembrane	488 – 510	23	Potential
	Topological domain	511 – 516	6	Cytoplasmic Potential
	Transmembrane	517 – 537	21	Potential
	Topological domain	538 – 555	18	Extracellular Potential
	Transmembrane	556 – 580	25	Potential
	Topological domain	581 – 653	73	Cytoplasmic Potential
	Nucleotide binding	259 – 266	8	ATP Potential
Sites
	Metal binding	319	1	Magnesium By similarity
	Metal binding	323	1	Magnesium By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q9GKS6-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: FBE2C478DFB2B92D	FASTA	653	73,060
	10 20 30 40 50 60 MACNLCYEAE SPDEAALVYA ARAYQCTLQS RTPEQVMVDF AASGPLTFQL LHILPFDSVR 70 80 90 100 110 120 KRMSVVVRHP LSNQVVVYTK GADSVIMELL SVASPDGAGP EKQQMIIREK TQRHLDDYAK 130 140 150 160 170 180 QGLRTLCIAK KVMSDTEYAE WLRNHFLAET SIDNREELLL ESAMRLENKL TLLGATGIED 190 200 210 220 230 240 RLQEGVPESI EALHKAGIKI WMLTGDKQET AVNIAYACML MSTILKELQK KTQALPEQVS 250 260 270 280 290 300 LSVDLHQPPV PQDSGLRAGL IITGKTLEFA LQESLQKQFL ELTSWCQTVV CCRATPLQKS 310 320 330 340 350 360 EVVKLVRSHL QVMTLAIGDG ANDVSMIQVA DIGIGVSGQE GMQAVMASDF AVSQFKHLSK 370 380 390 400 410 420 LLLVHGHWCY TRLSNMILYF FYKNVAYVNL LFWYQFFCGF SGTSMTDYWV LIFFNLLFTS 430 440 450 460 470 480 APPVIYGVLE KDVSAETLMQ LPELYKSGQK SEAYLPHTFW ITLLDAFYQS LVCFFVPYFT 490 500 510 520 530 540 YQGSDIDIFA FGNPLNTAAL FIILLHLIIE SKSLTWIHML VITGSILSYF LFAIVFGAMC 550 560 570 580 590 600 VTCNPPSNPY WIMQEHVLDP VFYLVCILTT CIALLPRFVY RGAGKMNQVT SNYANQSADK 610 620 630 640 650 SGRRPKPGPS TVFAMKSATS CAIEQGNLSL CETALDQGYS ETKAFEMARP CKD

References

[1]

"Isolation of full-length cDNA clones from macaque brain cDNA libraries." Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirata M., Suto Y., Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K., Kususda J. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Parietal cortex.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB052153 mRNA. Translation: BAB19008.1.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q9GKS6.
Enzyme and pathway databases
BRENDA	3.6.3.1. 3438.
Family and domain databases
InterPro	IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR006539. ATPase_P-typ_Plipid-transl. IPR013200. HAD-SF_hydro-like_3. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF08282. Hydrolase_3. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
TIGRFAMs	TIGR01652. ATPase-Plipid. 1 hit. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AT10D_MACFA

Accession

Primary (citable) accession number: Q9GKS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	March 1, 2001
Last modified:	October 13, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)