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Protein

Vascular endothelial growth factor A

Gene

VEGFA

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor A
Short name:
VEGF-A
Alternative name(s):
Vascular permeability factor
Short name:
VPF
Gene namesi
Name:VEGFA
Synonyms:VEGF
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 20

Subcellular locationi

  • Secreted By similarity

  • Note: Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 190164Vascular endothelial growth factor APRO_0000023385Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 93By similarity
Disulfide bondi76 – 76InterchainBy similarity
Disulfide bondi82 ↔ 127By similarity
Disulfide bondi85 – 85InterchainBy similarity
Disulfide bondi86 ↔ 129By similarity
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Gene expression databases

ExpressionAtlasiQ9GKR0. baseline.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9GKR0.
SMRiQ9GKR0. Positions 37-134, 136-190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00730000110791.
HOGENOMiHOG000230896.
HOVERGENiHBG000105.
InParanoidiQ9GKR0.
KOiK05448.

Family and domain databases

Gene3Di2.10.160.10. 1 hit.
2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR027928. VEGF_C.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
PF14554. VEGF_C. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
SSF57593. SSF57593. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GKR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGEHKTHEVV KFMDVYQRSY
60 70 80 90 100
CRPIETLVDI FQEYPDEIEY IFKPSCVPLM RCGGCCNDEG LECVPTAEFN
110 120 130 140 150
ITMQIMRIKP HQSQHIGEMS FLQHSKCECR PKKDKARQEN PCGPCSERRK
160 170 180 190
HLFVQDPQTC KCSCKNTDSR CKARQLELNE RTCRCDKPRR
Length:190
Mass (Da):22,312
Last modified:March 1, 2001 - v1
Checksum:i87E9E161439E5F87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053350 mRNA. Translation: BAB20890.1.
RefSeqiNP_001075290.1. NM_001081821.1.
UniGeneiEca.12648.

Genome annotation databases

EnsembliENSECAT00000009850; ENSECAP00000007544; ENSECAG00000009402.
GeneIDi100033839.
KEGGiecb:100033839.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053350 mRNA. Translation: BAB20890.1.
RefSeqiNP_001075290.1. NM_001081821.1.
UniGeneiEca.12648.

3D structure databases

ProteinModelPortaliQ9GKR0.
SMRiQ9GKR0. Positions 37-134, 136-190.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSECAT00000009850; ENSECAP00000007544; ENSECAG00000009402.
GeneIDi100033839.
KEGGiecb:100033839.

Organism-specific databases

CTDi7422.

Phylogenomic databases

GeneTreeiENSGT00730000110791.
HOGENOMiHOG000230896.
HOVERGENiHBG000105.
InParanoidiQ9GKR0.
KOiK05448.

Gene expression databases

ExpressionAtlasiQ9GKR0. baseline.

Family and domain databases

Gene3Di2.10.160.10. 1 hit.
2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR027928. VEGF_C.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
PF14554. VEGF_C. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
SSF57593. SSF57593. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of cDNA and high-level expression of equine vascular endotherial growth factor (VEGF)."
    Miura N., Misumi K., Kawahara K., Nakashima M., Fukumitsu S., Kawabata H., Uto N., Oka T., Maruyama I., Sakamoto H.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiVEGFA_HORSE
AccessioniPrimary (citable) accession number: Q9GKR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.