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Protein

Urokinase plasminogen activator surface receptor

Gene

PLAUR

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Urokinase plasminogen activator surface receptor
Short name:
U-PAR
Short name:
uPAR
Alternative name(s):
CD_antigen: CD87
Gene namesi
Name:PLAUR
Synonyms:UPAR
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000003609223 – ?305Urokinase plasminogen activator surface receptorAdd BLAST283
PropeptideiPRO_0000036093?306 – 335Removed in mature formSequence analysisAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 46By similarity
Disulfide bondi28 ↔ 34By similarity
Disulfide bondi39 ↔ 67By similarity
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi93 ↔ 98By similarity
Disulfide bondi117 ↔ 144By similarity
Disulfide bondi120 ↔ 127By similarity
Disulfide bondi137 ↔ 169By similarity
Disulfide bondi175 ↔ 192By similarity
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi193 ↔ 198By similarity
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi216 ↔ 244By similarity
Disulfide bondi219 ↔ 227By similarity
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi237 ↔ 263By similarity
Glycosylationi255N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi269 ↔ 287By similarity
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi288 ↔ 293By similarity
Lipidationi305GPI-anchor amidated glycineSequence analysis1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei105 – 106Cleavage; by U-PABy similarity2
Sitei111 – 112Cleavage; by U-PABy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiQ9GK78

Interactioni

Subunit structurei

Monomer (Probable). Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with MRC2. Interacts with SORL1. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane.By similarityCurated

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9GK78
SMRiQ9GK78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 114UPAR/Ly6 1Add BLAST92
Domaini115 – 213UPAR/Ly6 2Add BLAST99
Domaini214 – 305UPAR/Ly6 3Add BLAST92

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00510000049144
HOVERGENiHBG000245
KOiK03985

Family and domain databases

InterProiView protein in InterPro
IPR018363 CD59_antigen_CS
IPR016054 LY6_UPA_recep-like
IPR033084 U-PAR
PANTHERiPTHR10624:SF6 PTHR10624:SF6, 1 hit
PfamiView protein in Pfam
PF00021 UPAR_LY6, 2 hits
SMARTiView protein in SMART
SM00134 LU, 3 hits
PROSITEiView protein in PROSITE
PS00983 LY6_UPAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GK78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHPLLLPLL LLLHTCVPAS WGLRCMQCKS NGDCRVEECA LGQDLCRTTI
60 70 80 90 100
VRMWEEGEEL ELVEKSCTHS EKTNRTMSYR TGLKITSLTE VVCGLDLCNQ
110 120 130 140 150
GNSGRAVTFS RSRYLECISC GSSDMSCERG RHQSLQCRSP EEQCLDVVTH
160 170 180 190 200
WIQEGEEGRP KDDRHLRGCG YLPSCPGSSG FHNNDTFHFL KCCNTTKCNE
210 220 230 240 250
GPILELENLP QNGHQCYSCK GNSTHGCSSE ETFLIDCRGP MNQCLVATGT
260 270 280 290 300
YEPKNQSYMV RGCVTASMCQ RAHLGDAFSM HHINVSCCTE SGCNHPDLDI
310 320 330
QYRKGAAPQP GPAHLSLTIT LLMTARLWGG TLLWT
Length:335
Mass (Da):37,135
Last modified:March 1, 2001 - v1
Checksum:iE82254F8F73AF803
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302073 mRNA Translation: AAG40761.1
RefSeqiNP_001274620.1, NM_001287691.1
UniGeneiMfa.5762

Genome annotation databases

EnsembliENSMFAT00000033440; ENSMFAP00000025292; ENSMFAG00000044138
GeneIDi102139334
KEGGimcf:102139334

Similar proteinsi

Entry informationi

Entry nameiUPAR_MACFA
AccessioniPrimary (citable) accession number: Q9GK78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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