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Protein

Urokinase plasminogen activator surface receptor

Gene

PLAUR

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Urokinase plasminogen activator surface receptor
Short name:
U-PAR
Short name:
uPAR
Alternative name(s):
CD_antigen: CD87
Gene namesi
Name:PLAUR
Synonyms:UPAR
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

  • Cell membrane By similarity
  • Cell projectioninvadopodium membrane By similarity
  • Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

  • Note: Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000003609223 – ?305Urokinase plasminogen activator surface receptorAdd BLAST283
PropeptideiPRO_0000036093?306 – 335Removed in mature formSequence analysisAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 46By similarity
Disulfide bondi28 ↔ 34By similarity
Disulfide bondi39 ↔ 67By similarity
Glycosylationi74N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi93 ↔ 98By similarity
Disulfide bondi117 ↔ 144By similarity
Disulfide bondi120 ↔ 127By similarity
Disulfide bondi137 ↔ 169By similarity
Disulfide bondi175 ↔ 192By similarity
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi193 ↔ 198By similarity
Glycosylationi194N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi216 ↔ 244By similarity
Disulfide bondi219 ↔ 227By similarity
Glycosylationi222N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi237 ↔ 263By similarity
Glycosylationi255N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi269 ↔ 287By similarity
Glycosylationi284N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi288 ↔ 293By similarity
Lipidationi305GPI-anchor amidated glycineSequence analysis1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei105 – 106Cleavage; by U-PABy similarity2
Sitei111 – 112Cleavage; by U-PABy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Interactioni

Subunit structurei

Monomer (Probable). Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with MRC2. Interacts with SORL1. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane.By similarityCurated

Structurei

3D structure databases

ProteinModelPortaliQ9GK78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 114UPAR/Ly6 1Add BLAST92
Domaini115 – 213UPAR/Ly6 2Add BLAST99
Domaini214 – 305UPAR/Ly6 3Add BLAST92

Sequence similaritiesi

Contains 3 UPAR/Ly6 domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG000245.
KOiK03985.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
IPR033084. U-PAR.
[Graphical view]
PANTHERiPTHR10624:SF6. PTHR10624:SF6. 1 hit.
PfamiPF00021. UPAR_LY6. 2 hits.
[Graphical view]
SMARTiSM00134. LU. 3 hits.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GK78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHPLLLPLL LLLHTCVPAS WGLRCMQCKS NGDCRVEECA LGQDLCRTTI
60 70 80 90 100
VRMWEEGEEL ELVEKSCTHS EKTNRTMSYR TGLKITSLTE VVCGLDLCNQ
110 120 130 140 150
GNSGRAVTFS RSRYLECISC GSSDMSCERG RHQSLQCRSP EEQCLDVVTH
160 170 180 190 200
WIQEGEEGRP KDDRHLRGCG YLPSCPGSSG FHNNDTFHFL KCCNTTKCNE
210 220 230 240 250
GPILELENLP QNGHQCYSCK GNSTHGCSSE ETFLIDCRGP MNQCLVATGT
260 270 280 290 300
YEPKNQSYMV RGCVTASMCQ RAHLGDAFSM HHINVSCCTE SGCNHPDLDI
310 320 330
QYRKGAAPQP GPAHLSLTIT LLMTARLWGG TLLWT
Length:335
Mass (Da):37,135
Last modified:March 1, 2001 - v1
Checksum:iE82254F8F73AF803
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302073 mRNA. Translation: AAG40761.1.
RefSeqiNP_001274620.1. NM_001287691.1.
UniGeneiMfa.5762.

Genome annotation databases

GeneIDi102139334.
KEGGimcf:102139334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302073 mRNA. Translation: AAG40761.1.
RefSeqiNP_001274620.1. NM_001287691.1.
UniGeneiMfa.5762.

3D structure databases

ProteinModelPortaliQ9GK78.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102139334.
KEGGimcf:102139334.

Organism-specific databases

CTDi5329.

Phylogenomic databases

HOVERGENiHBG000245.
KOiK03985.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
IPR033084. U-PAR.
[Graphical view]
PANTHERiPTHR10624:SF6. PTHR10624:SF6. 1 hit.
PfamiPF00021. UPAR_LY6. 2 hits.
[Graphical view]
SMARTiSM00134. LU. 3 hits.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUPAR_MACFA
AccessioniPrimary (citable) accession number: Q9GK78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2001
Last modified: October 5, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.