Q9GK30 (PTHR_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Parathyroid hormone-related protein
Short name=PTH-rP
Short name=PTHrP

Gene names

Name:

PTHLH

Organism

Ovis aries (Sheep)

Taxonomic identifier

9940 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length	121 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath By similarity.
Subunit structure	PTHrP interacts with PTH1R (via N-terminal extracellular domain) By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Secreted By similarity.
Post-translational modification	There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions By similarity.
Sequence similarities	Belongs to the parathyroid hormone family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus Secreted
Domain	Signal
Ligand	Calcium
Molecular function	Hormone
PTM	Cleavage on pair of basic residues
Gene Ontology (GO)
Biological_process	regulation of chondrocyte differentiation Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	peptide hormone receptor binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	‹1 – 14	›14	Potential
	Propeptide	15 – 24	10	By similarity		PRO_0000023238
	Chain	27 – ›121	›95	Parathyroid hormone-related protein		PRO_0000023239
Regions
	Region	47 – 58	12	Important for receptor binding By similarity
	Motif	98 – 119	22	Nuclear localization signal By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	121	1

Sequences

	Sequence		Length	Mass (Da)
	Q9GK30 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: FA9437F5A5E041E1	FASTA	121	13,658
	10 20 30 40 50 60 VGVFLLSYSV PSCGRSVEEL GRRLKRAVSE HQLLHDKGKS IQDLRRRFFL HHLIAEIHTA 70 80 90 100 110 120 EIRATSEVSP NSKPAPNTKN HPVRFGSDDE GKYLTQETNK VETYKEQPLK TPGKKKKGKP G

References

[1]	"Expression of mRNA encoding parathyroid hormone-related peptide (PTH-rP) in ovine ovarian follicles." Hastie P.M., Beck N.F.G. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF327654 mRNA. Translation: AAG48348.1.
UniGene	Oar.801.
3D structure databases
ProteinModelPortal	Q9GK30.
SMR	Q9GK30. Positions 27-60, 93-120.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-254359.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG003236.
Family and domain databases
InterPro	IPR003626. PTH-rel. IPR001415. PTH/PTH-rel. [Graphical view]
PANTHER	PTHR17223. PTHR17223. 1 hit.
Pfam	PF01279. Parathyroid. 1 hit. [Graphical view]
SMART	SM00087. PTH. 1 hit. [Graphical view]
PROSITE	PS00335. PARATHYROID. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTHR_SHEEP

Accession

Primary (citable) accession number: Q9GK30

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	March 1, 2001
Last modified:	January 9, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program