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Protein

Peptidoglycan recognition protein 1

Gene

PGLYRP1

Organism
Camelus dromedarius (Dromedary) (Arabian camel)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. Is microbicidal for Gram-positive and Gram-negative bacteria and yeast. May function in intracellular killing of bacteria (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan recognition protein 1
Alternative name(s):
Peptidoglycan recognition protein short
Short name:
PGRP-S
Gene namesi
Name:PGLYRP1
Synonyms:PGLYRP, PGRP
OrganismiCamelus dromedarius (Dromedary) (Arabian camel)
Taxonomic identifieri9838 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaTylopodaCamelidaeCamelus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 193172Peptidoglycan recognition protein 1PRO_0000023900Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 1521 Publication
Disulfide bondi44 ↔ 891 Publication
Disulfide bondi65 ↔ 711 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9GK12.

Interactioni

Subunit structurei

Homotetramer.1 Publication

Structurei

Secondary structure

1
193
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni34 – 385Combined sources
Beta strandi50 – 5910Combined sources
Helixi68 – 8417Combined sources
Beta strandi94 – 974Combined sources
Beta strandi103 – 1075Combined sources
Beta strandi109 – 1113Combined sources
Beta strandi114 – 1163Combined sources
Helixi117 – 1204Combined sources
Helixi121 – 1233Combined sources
Beta strandi124 – 1318Combined sources
Beta strandi134 – 1363Combined sources
Helixi140 – 15516Combined sources
Beta strandi158 – 16710Combined sources
Helixi168 – 1714Combined sources
Beta strandi172 – 1743Combined sources
Helixi179 – 1857Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2R2KX-ray3.25A/B/C/D23-193[»]
2R90X-ray2.80A/B/C/D23-193[»]
2Z9NX-ray3.20A/B/C/D23-193[»]
3C2XX-ray1.83A/B/C/D23-193[»]
3CG9X-ray2.90A/B/C/D23-193[»]
3CORX-ray3.10A/B/C/D23-193[»]
3CXAX-ray3.40A/B/C/D23-193[»]
3NG4X-ray1.73A/B/C/D23-193[»]
3NNOX-ray2.90A/B/C/D23-193[»]
3NW3X-ray2.50A/B/C/D23-193[»]
3O4KX-ray2.11A/B/C/D23-193[»]
3OGXX-ray2.80A/B/C/D23-193[»]
3QJ1X-ray3.20A/B/C/D23-193[»]
3QS0X-ray2.50A/B/C/D23-193[»]
3QV4X-ray2.70A/B/C/D23-193[»]
3RT4X-ray1.70A/B/C/D23-193[»]
3T2VX-ray2.51A/B/C/D23-193[»]
3T39X-ray2.70A/B/C/D23-193[»]
3TRUX-ray3.20A/B/C/D23-193[»]
3UILX-ray2.20A/B/C/D23-193[»]
3UMLX-ray2.15A/B/C/D23-193[»]
3UMQX-ray2.20A/B/C/D23-193[»]
3USXX-ray2.28A/B/C/D23-193[»]
4FNNX-ray2.24A/B/C/D23-193[»]
4GF9X-ray2.80A/B/C/D23-193[»]
4OPPX-ray2.30A/B/C/D23-193[»]
4ORVX-ray2.50A/B/C/D23-193[»]
4OUGX-ray2.46A/B/C/D23-193[»]
4Q8SX-ray2.09A/B/C/D23-193[»]
4Q9EX-ray2.31A/B/C/D23-193[»]
5DWFX-ray1.83A/B/C/D28-193[»]
5E0AX-ray2.60A/B/C/D23-193[»]
5E0BX-ray2.60A/B/C/D23-193[»]
ProteinModelPortaliQ9GK12.
SMRiQ9GK12. Positions 23-193.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9GK12.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG007406.
OrthoDBiEOG091G0O6Z.

Family and domain databases

CDDicd06583. PGRP. 1 hit.
Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GK12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRHCVLLVW ALLALLSLGA AREDPPACGS IVPRREWRAL ASECRERLTR
60 70 80 90 100
PVRYVVVSHT AGSHCDTPAS CAQQAQNVQS YHVRNLGWCD VGYNFLIGED
110 120 130 140 150
GLVYEGRGWN IKGAHAGPTW NPISIGISFM GNYMNRVPPP RALRAAQNLL
160 170 180 190
ACGVALGALR SNYEVKGHRD VQPTLSPGDR LYEIIQTWSH YRA
Length:193
Mass (Da):21,377
Last modified:March 1, 2001 - v1
Checksum:iB6A1BD818030A7CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131676 mRNA. Translation: CAC19553.1.
AJ409286 Genomic DNA. Translation: CAC84130.1.
RefSeqiXP_010996001.1. XM_010997699.1.

Genome annotation databases

GeneIDi105104021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131676 mRNA. Translation: CAC19553.1.
AJ409286 Genomic DNA. Translation: CAC84130.1.
RefSeqiXP_010996001.1. XM_010997699.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2R2KX-ray3.25A/B/C/D23-193[»]
2R90X-ray2.80A/B/C/D23-193[»]
2Z9NX-ray3.20A/B/C/D23-193[»]
3C2XX-ray1.83A/B/C/D23-193[»]
3CG9X-ray2.90A/B/C/D23-193[»]
3CORX-ray3.10A/B/C/D23-193[»]
3CXAX-ray3.40A/B/C/D23-193[»]
3NG4X-ray1.73A/B/C/D23-193[»]
3NNOX-ray2.90A/B/C/D23-193[»]
3NW3X-ray2.50A/B/C/D23-193[»]
3O4KX-ray2.11A/B/C/D23-193[»]
3OGXX-ray2.80A/B/C/D23-193[»]
3QJ1X-ray3.20A/B/C/D23-193[»]
3QS0X-ray2.50A/B/C/D23-193[»]
3QV4X-ray2.70A/B/C/D23-193[»]
3RT4X-ray1.70A/B/C/D23-193[»]
3T2VX-ray2.51A/B/C/D23-193[»]
3T39X-ray2.70A/B/C/D23-193[»]
3TRUX-ray3.20A/B/C/D23-193[»]
3UILX-ray2.20A/B/C/D23-193[»]
3UMLX-ray2.15A/B/C/D23-193[»]
3UMQX-ray2.20A/B/C/D23-193[»]
3USXX-ray2.28A/B/C/D23-193[»]
4FNNX-ray2.24A/B/C/D23-193[»]
4GF9X-ray2.80A/B/C/D23-193[»]
4OPPX-ray2.30A/B/C/D23-193[»]
4ORVX-ray2.50A/B/C/D23-193[»]
4OUGX-ray2.46A/B/C/D23-193[»]
4Q8SX-ray2.09A/B/C/D23-193[»]
4Q9EX-ray2.31A/B/C/D23-193[»]
5DWFX-ray1.83A/B/C/D28-193[»]
5E0AX-ray2.60A/B/C/D23-193[»]
5E0BX-ray2.60A/B/C/D23-193[»]
ProteinModelPortaliQ9GK12.
SMRiQ9GK12. Positions 23-193.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9GK12.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi105104021.

Organism-specific databases

CTDi8993.

Phylogenomic databases

HOVERGENiHBG007406.
OrthoDBiEOG091G0O6Z.

Miscellaneous databases

EvolutionaryTraceiQ9GK12.

Family and domain databases

CDDicd06583. PGRP. 1 hit.
Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPGRP1_CAMDR
AccessioniPrimary (citable) accession number: Q9GK12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.