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Protein

Peptidoglycan recognition protein 1

Gene

PGLYRP1

Organism
Camelus dromedarius (Dromedary) (Arabian camel)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. Is microbicidal for Gram-positive and Gram-negative bacteria and yeast. May function in intracellular killing of bacteria (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial
Biological processImmunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan recognition protein 1
Alternative name(s):
Peptidoglycan recognition protein short
Short name:
PGRP-S
Gene namesi
Name:PGLYRP1
Synonyms:PGLYRP, PGRP
OrganismiCamelus dromedarius (Dromedary) (Arabian camel)
Taxonomic identifieri9838 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaTylopodaCamelidaeCamelus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000002390022 – 193Peptidoglycan recognition protein 1Add BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 1521 Publication
Disulfide bondi44 ↔ 891 Publication
Disulfide bondi65 ↔ 711 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9GK12.

Interactioni

Subunit structurei

Homotetramer.1 Publication

Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni34 – 38Combined sources5
Beta strandi50 – 59Combined sources10
Helixi68 – 84Combined sources17
Beta strandi94 – 97Combined sources4
Beta strandi103 – 107Combined sources5
Beta strandi109 – 111Combined sources3
Beta strandi114 – 116Combined sources3
Helixi117 – 120Combined sources4
Helixi121 – 123Combined sources3
Beta strandi124 – 131Combined sources8
Beta strandi134 – 136Combined sources3
Helixi140 – 155Combined sources16
Beta strandi158 – 167Combined sources10
Helixi168 – 171Combined sources4
Beta strandi172 – 174Combined sources3
Helixi179 – 185Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R2KX-ray3.25A/B/C/D23-193[»]
2R90X-ray2.80A/B/C/D23-193[»]
2Z9NX-ray3.20A/B/C/D23-193[»]
3C2XX-ray1.83A/B/C/D23-193[»]
3CG9X-ray2.90A/B/C/D23-193[»]
3CORX-ray3.10A/B/C/D23-193[»]
3CXAX-ray3.40A/B/C/D23-193[»]
3NG4X-ray1.73A/B/C/D23-193[»]
3NNOX-ray2.90A/B/C/D23-193[»]
3NW3X-ray2.50A/B/C/D23-193[»]
3O4KX-ray2.11A/B/C/D23-193[»]
3OGXX-ray2.80A/B/C/D23-193[»]
3QJ1X-ray3.20A/B/C/D23-193[»]
3QS0X-ray2.50A/B/C/D23-193[»]
3QV4X-ray2.70A/B/C/D23-193[»]
3RT4X-ray1.70A/B/C/D23-193[»]
3T2VX-ray2.51A/B/C/D23-193[»]
3T39X-ray2.70A/B/C/D23-193[»]
3TRUX-ray3.20A/B/C/D23-193[»]
3UILX-ray2.20A/B/C/D23-193[»]
3UMLX-ray2.15A/B/C/D23-193[»]
3UMQX-ray2.20A/B/C/D23-193[»]
3USXX-ray2.28A/B/C/D23-193[»]
4FNNX-ray2.24A/B/C/D23-193[»]
4GF9X-ray2.80A/B/C/D23-193[»]
4OPPX-ray2.30A/B/C/D23-193[»]
4ORVX-ray2.50A/B/C/D23-193[»]
4OUGX-ray2.46A/B/C/D23-193[»]
4Q8SX-ray2.09A/B/C/D23-193[»]
4Q9EX-ray2.31A/B/C/D23-193[»]
5DWFX-ray1.83A/B/C/D28-193[»]
5E0AX-ray2.60A/B/C/D23-193[»]
5E0BX-ray2.60A/B/C/D23-193[»]
ProteinModelPortaliQ9GK12.
SMRiQ9GK12.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9GK12.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG007406.
OrthoDBiEOG09020DBJ.

Family and domain databases

CDDicd06583. PGRP. 1 hit.
Gene3Di3.40.80.10. 1 hit.
InterProiView protein in InterPro
IPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiView protein in Pfam
PF01510. Amidase_2. 1 hit.
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiView protein in SMART
SM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GK12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRHCVLLVW ALLALLSLGA AREDPPACGS IVPRREWRAL ASECRERLTR
60 70 80 90 100
PVRYVVVSHT AGSHCDTPAS CAQQAQNVQS YHVRNLGWCD VGYNFLIGED
110 120 130 140 150
GLVYEGRGWN IKGAHAGPTW NPISIGISFM GNYMNRVPPP RALRAAQNLL
160 170 180 190
ACGVALGALR SNYEVKGHRD VQPTLSPGDR LYEIIQTWSH YRA
Length:193
Mass (Da):21,377
Last modified:March 1, 2001 - v1
Checksum:iB6A1BD818030A7CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131676 mRNA. Translation: CAC19553.1.
AJ409286 Genomic DNA. Translation: CAC84130.1.
RefSeqiXP_010996001.1. XM_010997699.1.

Genome annotation databases

GeneIDi105104021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131676 mRNA. Translation: CAC19553.1.
AJ409286 Genomic DNA. Translation: CAC84130.1.
RefSeqiXP_010996001.1. XM_010997699.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R2KX-ray3.25A/B/C/D23-193[»]
2R90X-ray2.80A/B/C/D23-193[»]
2Z9NX-ray3.20A/B/C/D23-193[»]
3C2XX-ray1.83A/B/C/D23-193[»]
3CG9X-ray2.90A/B/C/D23-193[»]
3CORX-ray3.10A/B/C/D23-193[»]
3CXAX-ray3.40A/B/C/D23-193[»]
3NG4X-ray1.73A/B/C/D23-193[»]
3NNOX-ray2.90A/B/C/D23-193[»]
3NW3X-ray2.50A/B/C/D23-193[»]
3O4KX-ray2.11A/B/C/D23-193[»]
3OGXX-ray2.80A/B/C/D23-193[»]
3QJ1X-ray3.20A/B/C/D23-193[»]
3QS0X-ray2.50A/B/C/D23-193[»]
3QV4X-ray2.70A/B/C/D23-193[»]
3RT4X-ray1.70A/B/C/D23-193[»]
3T2VX-ray2.51A/B/C/D23-193[»]
3T39X-ray2.70A/B/C/D23-193[»]
3TRUX-ray3.20A/B/C/D23-193[»]
3UILX-ray2.20A/B/C/D23-193[»]
3UMLX-ray2.15A/B/C/D23-193[»]
3UMQX-ray2.20A/B/C/D23-193[»]
3USXX-ray2.28A/B/C/D23-193[»]
4FNNX-ray2.24A/B/C/D23-193[»]
4GF9X-ray2.80A/B/C/D23-193[»]
4OPPX-ray2.30A/B/C/D23-193[»]
4ORVX-ray2.50A/B/C/D23-193[»]
4OUGX-ray2.46A/B/C/D23-193[»]
4Q8SX-ray2.09A/B/C/D23-193[»]
4Q9EX-ray2.31A/B/C/D23-193[»]
5DWFX-ray1.83A/B/C/D28-193[»]
5E0AX-ray2.60A/B/C/D23-193[»]
5E0BX-ray2.60A/B/C/D23-193[»]
ProteinModelPortaliQ9GK12.
SMRiQ9GK12.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9GK12.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi105104021.

Organism-specific databases

CTDi8993.

Phylogenomic databases

HOVERGENiHBG007406.
OrthoDBiEOG09020DBJ.

Miscellaneous databases

EvolutionaryTraceiQ9GK12.

Family and domain databases

CDDicd06583. PGRP. 1 hit.
Gene3Di3.40.80.10. 1 hit.
InterProiView protein in InterPro
IPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiView protein in Pfam
PF01510. Amidase_2. 1 hit.
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiView protein in SMART
SM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
SUPFAMiSSF55846. SSF55846. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPGRP1_CAMDR
AccessioniPrimary (citable) accession number: Q9GK12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2001
Last modified: February 15, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.