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Protein

Apolipoprotein E

Gene

APOE

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein E
Short name:
Apo-E
Gene namesi
Name:APOE
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chylomicron, HDL, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 317299Apolipoprotein EPRO_0000001991Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei143 – 1431Methionine sulfoxideBy similarity
Modified residuei147 – 1471PhosphoserineBy similarity
Glycosylationi212 – 2121O-linked (GalNAc...)By similarity

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Glycoprotein, Oxidation, Phosphoprotein

Proteomic databases

PaxDbiQ9GJU3.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000054411.

Structurei

3D structure databases

ProteinModelPortaliQ9GJU3.
SMRiQ9GJU3. Positions 30-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati80 – 101221Add
BLAST
Repeati102 – 123222Add
BLAST
Repeati124 – 145223Add
BLAST
Repeati146 – 167224Add
BLAST
Repeati168 – 189225Add
BLAST
Repeati190 – 211226Add
BLAST
Repeati212 – 233227Add
BLAST
Repeati234 – 255228Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni80 – 2551768 X 22 AA approximate tandem repeatsAdd
BLAST
Regioni158 – 16811LDL receptor bindingBy similarityAdd
BLAST
Regioni162 – 1654Heparin-bindingBy similarity
Regioni229 – 2368Heparin-bindingBy similarity

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IVK0. Eukaryota.
ENOG4111MYC. LUCA.
HOGENOMiHOG000034006.
HOVERGENiHBG010582.
InParanoidiQ9GJU3.
KOiK04524.

Family and domain databases

InterProiIPR000074. ApoA_E.
[Graphical view]
PfamiPF01442. Apolipoprotein. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GJU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLWAALLV TFLAGCQAKV EQVVETEPEP ELHQQAEWQS GQRWELALGH
60 70 80 90 100
FWDYLRWVQT LSEQVQEELL SSQVTQELTA LMDETMKELK AYKSELEEQL
110 120 130 140 150
TPVAEETRAR LSKELQAAQA RLGADMEDVR GRLVQYRGEV QAMLGQSTEE
160 170 180 190 200
LRARLASHLR KLRKRLLRDA DDLQKRLAVY QAGAREGAER GVSAIRERLG
210 220 230 240 250
PLVEQGRVRA ATVGSLAGQP LQERAQAWGE RLRARMEEMG SRTRDRLDEV
260 270 280 290 300
KEQVAEVRAK LEEQAQQIRL QAEAFQARLK SWFEPLVEDM QRQWAGLVEK
310
VQAAMGTSAA PVPSDNH
Length:317
Mass (Da):36,102
Last modified:March 1, 2001 - v1
Checksum:i4470AD7ADE0815F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200499, AF200497, AF200498 Genomic DNA. Translation: AAG28578.1.
AF261280 Genomic DNA. Translation: AAG27090.1.
RefSeqiNP_001009007.1. NM_001009007.1.
UniGeneiPtr.6133.

Genome annotation databases

GeneIDi449586.
KEGGiptr:449586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200499, AF200497, AF200498 Genomic DNA. Translation: AAG28578.1.
AF261280 Genomic DNA. Translation: AAG27090.1.
RefSeqiNP_001009007.1. NM_001009007.1.
UniGeneiPtr.6133.

3D structure databases

ProteinModelPortaliQ9GJU3.
SMRiQ9GJU3. Positions 30-203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000054411.

Proteomic databases

PaxDbiQ9GJU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi449586.
KEGGiptr:449586.

Organism-specific databases

CTDi348.

Phylogenomic databases

eggNOGiENOG410IVK0. Eukaryota.
ENOG4111MYC. LUCA.
HOGENOMiHOG000034006.
HOVERGENiHBG010582.
InParanoidiQ9GJU3.
KOiK04524.

Family and domain databases

InterProiIPR000074. ApoA_E.
[Graphical view]
PfamiPF01442. Apolipoprotein. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPOE_PANTR
AccessioniPrimary (citable) accession number: Q9GJU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.