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Protein
Submitted name:

MHC class II transactivator type I

Gene

Ciita

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • cellular response to electrical stimulus Source: RGD
  • cellular response to exogenous dsRNA Source: RGD
  • cellular response to interferon-gamma Source: RGD
  • inflammatory response Source: RGD
  • negative regulation of transcription from RNA polymerase II promoter Source: RGD
  • positive regulation of MHC class II biosynthetic process Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
Complete GO annotation...

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class II transactivator type IImported
Gene namesi
Name:CiitaImported
Synonyms:C2taImported, CIITAImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi619813. Ciita.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: RGD
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ9GJE0.
PRIDEiQ9GJE0.

Expressioni

Gene expression databases

GenevisibleiQ9GJE0. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003572.

Structurei

3D structure databases

ProteinModelPortaliQ9GJE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini440 – 586147NACHTInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains NACHT domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
HOGENOMiHOG000107439.
HOVERGENiHBG000174.
PhylomeDBiQ9GJE0.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR008095. MHC_II_transact.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
PRINTSiPR01719. MHCIIACTVATR.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GJE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHFQAILAQ VQTLLSSQQP RQVRALLDGL LEEELLSREY HCALLHEPDG
60 70 80 90 100
EALARKISLT LLEKGDLDLA FVSWVCNRLQ VPEVERGPNC RDHGGHTLCA
110 120 130 140 150
TMELGSPEGS YLELLNSDAD PLHLYHLYDQ MDLAGEEEIE LNSETDMDTI
160 170 180 190 200
NCDQFSKLLQ DMEMDEETRE AYANIAELDQ YVFQDTQLEG LSKDLFIQHI
210 220 230 240 250
GPEEGFGENV EGPAESGEKP QKRRFPEEHA MDSKHRKLVP PSRTSLNYLD
260 270 280 290 300
LPAGHIQIFT TLPQGLWQIS GVGTGLSSVL VYHGEMPQVN QLLSSSSPTV
310 320 330 340 350
PSLPESPDRP GSTSPFAPST ADLPGMPEPA LTSRVNETED TTPPSPCQED
360 370 380 390 400
PEPSIKLPKW PESVERFQHS LQDKYQALPG SPSGPLVAME LVRARLERGS
410 420 430 440 450
NKSQERELAT PDWTERQLAH GGLAEVLRVV GDSRRSRETQ VVAVLGKAGQ
460 470 480 490 500
GKSHWARTVS HIWAQGQLPQ YDFVFYVPCQ CLDRPGDTYH LRDLLCPPNL
510 520 530 540 550
QPLAMNDEVI DHIVRQPDRV LLILDAFEEL EAQDSLLHGP CGPLSPEPCS
560 570 580 590 600
LRGLLAGLFQ RKLLRGCTLL LTARPRGRLA QSLSKADAIF EVPSFSTKQA
610 620 630 640 650
QIYMRHYFEN SGTAGSHDKA LGLLEGQPFL LTHSHSPVLC SAVCQLSKAL
660 670 680 690 700
LDQGAGAQLP CTLTGLYVGL LGPAAQNSPP GALVELAKLA WELGRRHQST
710 720 730 740 750
LQETQFPSVE VKTWAVAQGL MQQTTEAQLA FSSFLLQCFL GAVWLAQCNE
760 770 780 790 800
MKDKELPQYL ALTPRKKRPY DNWLEGVPRF LAGLVFQPRA HCLGALVEPA
810 820 830 840 850
MAAVADRKRK VLTRYLKRLK LGTLRAGRLL ELLHCAHETQ EPGIWKHVSH
860 870 880 890 900
QLPGHLSFLG TRLTAPDVYV LGRALETASQ DFSLDLRQTG IEPSRLGDLV
910 920 930 940 950
GLSCVTSFRA SLSDTMALWE SLQHQGETQL LQAAEEKFTI EPFKAKSPKD
960 970 980 990 1000
VEDLDSLVQT QRLRNPSADA AKDLPAIRDL KKLEFALGPV LGPQAFPTLA
1010 1020 1030 1040 1050
KILPAFSSLQ HLDLDSLSEN KIGDKGVSKL SATFPQLKAL ETLNLSQNSI
1060 1070 1080 1090 1100
TDVGACKLAE ALPALAKSLL RLSLYNNCIC DEGAKSLARV LPDMVSLRVM
1110 1120 1130 1140 1150
DVQFNKFTAV GAQQLTSSLQ KCPQVETLAM WTPTIPFGVQ EHLQQLDARI

SLR
Length:1,153
Mass (Da):127,301
Last modified:March 1, 2001 - v1
Checksum:i3F5609DA973BDE4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251305 mRNA. Translation: AAG02181.1.
UniGeneiRn.16740.

Genome annotation databases

UCSCiRGD:619813. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251305 mRNA. Translation: AAG02181.1.
UniGeneiRn.16740.

3D structure databases

ProteinModelPortaliQ9GJE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003572.

Proteomic databases

PaxDbiQ9GJE0.
PRIDEiQ9GJE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:619813. rat.

Organism-specific databases

RGDi619813. Ciita.

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
HOGENOMiHOG000107439.
HOVERGENiHBG000174.
PhylomeDBiQ9GJE0.

Gene expression databases

GenevisibleiQ9GJE0. RN.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR008095. MHC_II_transact.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
PRINTSiPR01719. MHCIIACTVATR.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9GJE0_RAT
AccessioniPrimary (citable) accession number: Q9GJE0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.