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Protein
Submitted name:

MHC class II transactivator type IV

Gene

CIITA

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class II transactivator type IVImported
Gene namesi
Name:CIITAImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

PTM / Processingi

Proteomic databases

PaxDbiQ9GJD8.
PRIDEiQ9GJD8.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003572.

Structurei

3D structure databases

ProteinModelPortaliQ9GJD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini339 – 485147NACHTInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains NACHT domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
HOGENOMiHOG000107439.
HOVERGENiHBG000174.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR008095. MHC_II_transact.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
PRINTSiPR01719. MHCIIACTVATR.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GJD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELGSPEGSY LELLNSDADP LHLYHLYDQM DLAGEEEIEL NSETDMDTIN
60 70 80 90 100
CDQFSKLLQD MEMDEETREA YANIAELDQY VFQDTQLEGL SKDLFIQHIG
110 120 130 140 150
PEEGFGENVE GPAESGEKPQ KRRFPEEHAM DSKHRKLVPP SRTSLNYLDL
160 170 180 190 200
PAGHIQIFTT LPQGLWQISG VGTGLSSVLV YHGEMPQVNQ LLSSSSPTVP
210 220 230 240 250
SLPESPDRPG STSPFAPSTA DLPGMPEPAL TSRVNETEDT TPPSPCQEDP
260 270 280 290 300
EPSIKLPKWP ESVERFQHSL QDKYQALPGS PSGPLVAMEL VRARLERGSN
310 320 330 340 350
KSQERELATP DWTERQLAHG GLAEVLRVVG DSRRSRETQV VAVLGKAGQG
360 370 380 390 400
KSHWARTVSH IWAQGQLPQY DFVFYVPCQC LDRPGDTYHL RDLLCPPNLQ
410 420 430 440 450
PLAMNDEVID HIVRQPDRVL LILDAFEELE AQDSLLHGPC GPLSPEPCSL
460 470 480 490 500
RGLLAGLFQR KLLRGCTLLL TARPRGRLAQ SLSKADAIFE VPSFSTKQAQ
510 520 530 540 550
IYMRHYFENS GTAGSHDKAL GLLEGQPFLL THSHSPVLCS AVCQLSKALL
560 570 580 590 600
DQGAGAQLPC TLTGLYVGLL GPAAQNSPPG ALVELAKLAW ELGRRHQSTL
610 620 630 640 650
QETQFPSVEV KTWAVAQGLM QQTTEAQLAF SSFLLQCFLG AVWLAQCNEM
660 670 680 690 700
KDKELPQYLA LTPRKKRPYD NWLEGVPRFL AGLVFQPRAH CLGALVEPAM
710 720 730 740 750
AAVADRKRKV LTRYLKRLKL GTLRAGRLLE LLHCAHETQE PGIWKHVSHQ
760 770 780 790 800
LPGHLSFLGT RLTAPDVYVL GRALETASQD FSLDLRQTGI EPSRLGDLVG
810 820 830 840 850
LSCVTSFRAS LSDTMALWES LQHQGETQLL QAAEEKFTIE PFKAKSPKDV
860 870 880 890 900
EDLDSLVQTQ RLRNPSADAA KDLPAIRDLK KLEFALGPVL GPQAFPTLAK
910 920 930 940 950
ILPAFSSLQH LDLDSLSENK IGDKGVSKLS ATFPQLKALE TLNLSQNSIT
960 970 980 990 1000
DVGACKLAEA LPALAKSLLR LSLYNNCICD EGAKSLARVL PDMVSLRVMD
1010 1020 1030 1040 1050
VQFNKFTAVG AQQLTSSLQK CPQVETLAMW TPTIPFGVQE HLQQLDARIS

LR
Length:1,052
Mass (Da):115,991
Last modified:March 1, 2001 - v1
Checksum:iCF6CF9EB2B98E6FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251307 mRNA. Translation: AAG02183.1.
UniGeneiRn.16740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251307 mRNA. Translation: AAG02183.1.
UniGeneiRn.16740.

3D structure databases

ProteinModelPortaliQ9GJD8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003572.

Proteomic databases

PaxDbiQ9GJD8.
PRIDEiQ9GJD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
HOGENOMiHOG000107439.
HOVERGENiHBG000174.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR008095. MHC_II_transact.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
PRINTSiPR01719. MHCIIACTVATR.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Class II transactivator (CIITA) suppresses transcription of thyroid-specific genes."
    Mori-Aoki A., Pietrarelli M., Nakazato M., Caturegli P., Kohn L.D., Suzuki K.
    Biochem. Biophys. Res. Commun. 0:0-0(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.

Entry informationi

Entry nameiQ9GJD8_RAT
AccessioniPrimary (citable) accession number: Q9GJD8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.