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Q9GIY3

- 2B1E_HUMAN

UniProt

Q9GIY3 - 2B1E_HUMAN

Protein

HLA class II histocompatibility antigen, DRB1-14 beta chain

Gene

HLA-DRB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
    2. cytokine-mediated signaling pathway Source: Reactome
    3. interferon-gamma-mediated signaling pathway Source: Reactome
    4. T cell costimulation Source: Reactome
    5. T cell receptor signaling pathway Source: Reactome

    Keywords - Biological processi

    Immunity

    Enzyme and pathway databases

    ReactomeiREACT_121399. MHC class II antigen presentation.
    REACT_12555. Downstream TCR signaling.
    REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
    REACT_12596. Translocation of ZAP-70 to Immunological synapse.
    REACT_12623. Generation of second messenger molecules.
    REACT_19324. PD-1 signaling.
    REACT_25078. Interferon gamma signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HLA class II histocompatibility antigen, DRB1-14 beta chain
    Alternative name(s):
    MHC class II antigen DRB1*14
    Short name:
    DR-14
    Short name:
    DR14
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4948. HLA-DRB1.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endoplasmic reticulum membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Golgi apparatustrans-Golgi network membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Lysosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Late endosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication
    Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

    GO - Cellular componenti

    1. clathrin-coated endocytic vesicle membrane Source: Reactome
    2. endocytic vesicle membrane Source: Reactome
    3. ER to Golgi transport vesicle membrane Source: Reactome
    4. Golgi membrane Source: Reactome
    5. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
    6. late endosome membrane Source: UniProtKB
    7. lysosomal membrane Source: UniProtKB
    8. MHC class II protein complex Source: UniProtKB-KW
    9. plasma membrane Source: Reactome
    10. trans-Golgi network membrane Source: Reactome
    11. transport vesicle membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 266237HLA class II histocompatibility antigen, DRB1-14 beta chainPRO_5000066676Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi146 ↔ 202PROSITE-ProRule annotation
    Cross-linki254 – 254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Post-translational modificationi

    Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

    Proteomic databases

    PRIDEiQ9GIY3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9GIY3.
    BgeeiQ9GIY3.

    Organism-specific databases

    HPAiCAB015400.
    CAB034021.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.

    Protein-protein interaction databases

    IntActiQ9GIY3. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GIY3.
    SMRiQ9GIY3. Positions 34-220.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei228 – 24821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini126 – 21489Ig-like C1-typeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MHC class II family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG012730.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00969. MHC_II_beta. 1 hit.
    [Graphical view]
    ProDomiPD000328. MHC_II_b_N. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00407. IGc1. 1 hit.
    SM00921. MHC_II_beta. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9GIY3-1 [UniParc]FASTAAdd to Basket

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    MVCLRLPGGS CMAVLTVTLM VLSSPLALAG DTRPRFLEYS TSECHFFNGT    50
    ERVRFLDRYF HNQEEFVRFD SDVGEYRAVT ELGRPAAEHW NSQKDLLERR 100
    RAEVDTYCRH NYGVVESFTV QRRVHPKVTV YPSKTQPLQH YNLLVCSVSG 150
    FYPGSIEVRW FRNGQEEKTG VVSTGLIHNG DWTFQTLVML ETVPRSGEVY 200
    TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF 250
    RNQKGHSGLQ PRGFLS 266
    Length:266
    Mass (Da):30,139
    Last modified:March 1, 2001 - v1
    Checksum:iFA4BE90DFAB4FA55
    GO

    Sequence cautioni

    The sequence CAB45249.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti124 – 1241V → G in BAH23562. 1 PublicationCurated

    Polymorphismi

    The following alleles of DRB1-14 are known: DRB1*14:01, DRB1*14:02, DRB1*14:03, DRB1*14:04, DRB1*14:05, DRB1*14:06, DRB1*14:07, DRB1*14:08, DRB1*14:09, DRB1*14:10, DRB1*14:11, DRB1*14:12, DRB1*14:13, DRB1*14:14, DRB1*14:15, DRB1*14:16, DRB1*14:17, DRB1*14:18, DRB1*14:19, DRB1*14:20, DRB1*14:21, DRB1*14:22, DRB1*14:23, DRB1*14:24, DRB1*14:25, DRB1*14:26, DRB1*14:27, DRB1*14:28, DRB1*14:29, DRB1*14:30, DRB1*14:31, DRB1*14:32, DRB1*14:33, DRB1*14:34, DRB1*14:35, DRB1*14:36, DRB1*14:37, DRB1*14:38, DRB1*14:39, DRB1*14:40, DRB1*14:41, DRB1*14:42, DRB1*14:43, DRB1*14:44, DRB1*14:45, DRB1*14:46, DRB1*14:47, DRB1*14:48, DRB1*14:49, DRB1*14:50, DRB1*14:51, DRB1*14:52, DRB1*14:53, DRB1*14:54, DRB1*14:55, DRB1*14:56, DRB1*14:57, DRB1*14:58, DRB1*14:59, DRB1*14:60, DRB1*14:61, DRB1*14:62, DRB1*14:63, DRB1*14:64, DRB1*14:65, DRB1*14:67, DRB1*14:68, DRB1*14:69, DRB1*14:70, DRB1*14:71, DRB1*14:72, DRB1*14:73, DRB1*14:74, DRB1*14:75, DRB1*14:76, DRB1*14:77, DRB1*14:78, DRB1*14:79, DRB1*14:80, DRB1*14:81, DRB1*14:82, DRB1*14:83, DRB1*14:84 and DRB1*14:85. The sequence shown is that of DRB1*14:01.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti39 – 391Y → L in allele DRB1*14:46; requires 2 nucleotide substitutions.
    VAR_062907
    Natural varianti39 – 391Y → Q in allele DRB1*14:10 and allele DRB1*14:57; requires 2 nucleotide substitutions.
    VAR_062906
    Natural varianti40 – 401S → P in allele DRB1*14:39.
    VAR_062910
    Natural varianti40 – 401S → R in allele DRB1*14:46.
    VAR_062908
    Natural varianti40 – 401S → V in allele DRB1*14:10 and allele DRB1*14:57; requires 2 nucleotide substitutions.
    VAR_062909
    Natural varianti41 – 411T → K in allele DRB1*14:10, allele DRB1*14:46 and allele DRB1*14:57.
    VAR_062911
    Natural varianti42 – 421S → G in allele DRB1*14:04, allele DRB1*14:11, allele DRB1*14:15, allele DRB1*14:28, allele DRB1*14:31, allele DRB1*14:50, allele DRB1*14:52, allele DRB1*14:61, allele DRB1*14:68, allele DRB1*14:71, allele DRB1*14:73, allele DRB1*14:76 and allele DRB1*14:79.
    VAR_062913
    Natural varianti42 – 421S → H in allele DRB1*14:10 and allele DRB1*14:57; requires 2 nucleotide substitutions.
    VAR_062912
    Natural varianti45 – 451H → Q in allele DRB1*14:05, allele DRB1*14:37, allele DRB1*14:43, allele DRB1*14:44, allele DRB1*14:45, allele DRB1*14:56 and allele DRB1*14:84.
    VAR_062915
    Natural varianti45 – 451H → Y in allele DRB1*14:04, allele DRB1*14:11, allele DRB1*14:15, allele DRB1*14:28, allele DRB1*14:31, allele DRB1*14:50, allele DRB1*14:52, allele DRB1*14:68, allele DRB1*14:71, allele DRB1*14:73, allele DRB1*14:76 and allele DRB1*14:79.
    VAR_062914
    Natural varianti54 – 541R → Q in allele DRB1*14:26.
    VAR_062916
    Natural varianti55 – 551F → Y in allele DRB1*14:82.
    VAR_062917
    Natural varianti56 – 561L → M in allele DRB1*14:83.
    VAR_062918
    Natural varianti57 – 571D → E in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:06, allele DRB1*14:12, allele DRB1*14:13, allele DRB1*14:18, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:24, allele DRB1*14:27, allele DRB1*14:29, allele DRB1*14:40, allele DRB1*14:41, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:49, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:63, allele DRB1*14:67, allele DRB1*14:77, allele DRB1*14:78, allele DRB1*14:81, allele DRB1*14:83 and allele DRB1*14:85.
    VAR_062919
    Natural varianti59 – 591Y → H in allele DRB1*14:70.
    VAR_062920
    Natural varianti61 – 611H → Y in allele DRB1*14:25, allele DRB1*14:42, allele DRB1*14:53, allele DRB1*14:58 and allele DRB1*14:69.
    VAR_062921
    Natural varianti66 – 661F → N in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:06, allele DRB1*14:09, allele DRB1*14:12, allele DRB1*14:13, allele DRB1*14:17, allele DRB1*14:18, allele DRB1*14:19, allele DRB1*14:21, allele DRB1*14:24, allele DRB1*14:27, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:59, allele DRB1*14:63, allele DRB1*14:64, allele DRB1*14:67, allele DRB1*14:78, allele DRB1*14:80, allele DRB1*14:81, allele DRB1*14:83 and allele DRB1*14:85; requires 2 nucleotide substitutions.
    VAR_062923
    Natural varianti66 – 661F → Y in allele DRB1*14:25, allele DRB1*14:42, allele DRB1*14:53, allele DRB1*14:58 and allele DRB1*14:69.
    VAR_062922
    Natural varianti67 – 671V → L in allele DRB1*14:41 and allele DRB1*14:77.
    VAR_062924
    Natural varianti74 – 741G → R in allele DRB1*14:36 and allele DRB1*14:60.
    VAR_062925
    Natural varianti76 – 761Y → F in allele DRB1*14:17, allele DRB1*14:21, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:35, allele DRB1*14:42, allele DRB1*14:53, allele DRB1*14:64, allele DRB1*14:65 and allele DRB1*14:72.
    VAR_062926
    Natural varianti80 – 801T → R in allele DRB1*14:59.
    VAR_062927
    Natural varianti86 – 861A → D in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:05, allele DRB1*14:06, allele DRB1*14:08, allele DRB1*14:09, allele DRB1*14:11, allele DRB1*14:12, allele DRB1*14:14, allele DRB1*14:15, allele DRB1*14:17, allele DRB1*14:18, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:21, allele DRB1*14:23, allele DRB1*14:24, allele DRB1*14:27, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:34, allele DRB1*14:36, allele DRB1*14:37, allele DRB1*14:40, allele DRB1*14:41, allele DRB1*14:42, allele DRB1*14:43, allele DRB1*14:44, allele DRB1*14:45, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:56, allele DRB1*14:59, allele DRB1*14:64, allele DRB1*14:67, allele DRB1*14:72, allele DRB1*14:77, allele DRB1*14:80, allele DRB1*14:81, allele DRB1*14:83 and allele DRB1*14:84.
    VAR_062928
    Natural varianti86 – 861A → S in allele DRB1*14:13, allele DRB1*14:63, allele DRB1*14:65, allele DRB1*14:78 and allele DRB1*14:85.
    VAR_062929
    Natural varianti86 – 861A → T in allele DRB1*14:62.
    VAR_062930
    Natural varianti86 – 861A → V in allele DRB1*14:48.
    VAR_062931
    Natural varianti87 – 871A → E in allele DRB1*14:11.
    VAR_062932
    Natural varianti89 – 891H → S in allele DRB1*14:48 and allele DRB1*14:64; requires 2 nucleotide substitutions.
    VAR_062934
    Natural varianti89 – 891H → Y in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:05, allele DRB1*14:06, allele DRB1*14:09, allele DRB1*14:11, allele DRB1*14:12, allele DRB1*14:13, allele DRB1*14:14, allele DRB1*14:15, allele DRB1*14:17, allele DRB1*14:18, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:21, allele DRB1*14:23, allele DRB1*14:24, allele DRB1*14:27, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:36, allele DRB1*14:37, allele DRB1*14:40, allele DRB1*14:41, allele DRB1*14:42, allele DRB1*14:43, allele DRB1*14:44, allele DRB1*14:45, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:56, allele DRB1*14:57, allele DRB1*14:59, allele DRB1*14:63, allele DRB1*14:65, allele DRB1*14:67, allele DRB1*14:76, allele DRB1*14:77, allele DRB1*14:78, allele DRB1*14:80, allele DRB1*14:81, allele DRB1*14:83, allele DRB1*14:84 and allele DRB1*14:85.
    VAR_062933
    Natural varianti96 – 961L → F in allele DRB1*14:15, allele DRB1*14:22, allele DRB1*14:25, allele DRB1*14:27, allele DRB1*14:53 and allele DRB1*14:73.
    VAR_062935
    Natural varianti96 – 961L → I in allele DRB1*14:16, allele DRB1*14:24, allele DRB1*14:37, allele DRB1*14:45, allele DRB1*14:57, allele DRB1*14:63, allele DRB1*14:67 and allele DRB1*14:78.
    VAR_062936
    Natural varianti99 – 991R → D in allele DRB1*14:03, allele DRB1*14:12, allele DRB1*14:15, allele DRB1*14:16, allele DRB1*14:22, allele DRB1*14:25, allele DRB1*14:27, allele DRB1*14:40, allele DRB1*14:53, allele DRB1*14:57, allele DRB1*14:63, allele DRB1*14:67, allele DRB1*14:69, allele DRB1*14:73, allele DRB1*14:74, allele DRB1*14:77, allele DRB1*14:78, allele DRB1*14:84 and allele DRB1*14:85; requires 2 nucleotide substitutions.
    VAR_062938
    Natural varianti99 – 991R → Q in allele DRB1*14:02, allele DRB1*14:06, allele DRB1*14:09, allele DRB1*14:13, allele DRB1*14:17, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:21, allele DRB1*14:24, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:37, allele DRB1*14:41, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:49, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:76, allele DRB1*14:79, allele DRB1*14:80 and allele DRB1*14:83.
    VAR_062937
    Natural varianti100 – 1001R → A in allele DRB1*14:24 and allele DRB1*14:37; requires 2 nucleotide substitutions.
    VAR_062941
    Natural varianti100 – 1001R → E in allele DRB1*14:16 and allele DRB1*14:57; requires 2 nucleotide substitutions.
    VAR_062940
    Natural varianti100 – 1001R → K in allele DRB1*14:19, allele DRB1*14:21, allele DRB1*14:76 and allele DRB1*14:79.
    VAR_062939
    Natural varianti102 – 1021A → G in allele DRB1*14:76 and allele DRB1*14:79.
    VAR_062943
    Natural varianti102 – 1021A → S in allele DRB1*14:56.
    VAR_062942
    Natural varianti103 – 1031E → A in allele DRB1*14:02, allele DRB1*14:06, allele DRB1*14:09, allele DRB1*14:13, allele DRB1*14:16, allele DRB1*14:17, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:21, allele DRB1*14:22, allele DRB1*14:24, allele DRB1*14:25, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:31, allele DRB1*14:32, allele DRB1*14:34, allele DRB1*14:37, allele DRB1*14:41, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:49, allele DRB1*14:52, allele DRB1*14:53, allele DRB1*14:57, allele DRB1*14:65, allele DRB1*14:69, allele DRB1*14:74, allele DRB1*14:80, allele DRB1*14:81 and allele DRB1*14:83.
    VAR_062944
    Natural varianti103 – 1031E → L in allele DRB1*14:03, allele DRB1*14:12, allele DRB1*14:15, allele DRB1*14:27, allele DRB1*14:40, allele DRB1*14:55, allele DRB1*14:63, allele DRB1*14:67, allele DRB1*14:77, allele DRB1*14:78, allele DRB1*14:84 and allele DRB1*14:85; requires 2 nucleotide substitutions.
    VAR_062945
    Natural varianti103 – 1031E → R in allele DRB1*14:76 and allele DRB1*14:79; requires 2 nucleotide substitutions.
    VAR_062946
    Natural varianti106 – 1061T → A in allele DRB1*14:43.
    VAR_062948
    Natural varianti106 – 1061T → N in allele DRB1*14:38, allele DRB1*14:47, allele DRB1*14:50, allele DRB1*14:76 and allele DRB1*14:79.
    VAR_062947
    Natural varianti110 – 1101H → Y in allele DRB1*14:75.
    VAR_062949
    Natural varianti114 – 1141V → A in allele DRB1*14:28 and allele DRB1*14:29.
    VAR_062950
    Natural varianti115 – 1151V → G in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:07, allele DRB1*14:09, allele DRB1*14:13, allele DRB1*14:14, allele DRB1*14:19, allele DRB1*14:22, allele DRB1*14:24, allele DRB1*14:25, allele DRB1*14:27, allele DRB1*14:30, allele DRB1*14:36, allele DRB1*14:40, allele DRB1*14:41, allele DRB1*14:42, allele DRB1*14:44, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:49, allele DRB1*14:51, allele DRB1*14:53, allele DRB1*14:63, allele DRB1*14:67, allele DRB1*14:68, allele DRB1*14:69, allele DRB1*14:77 and allele DRB1*14:85.
    VAR_062951
    Natural varianti115 – 1151V → M in allele DRB1*14:71.
    VAR_062952
    Natural varianti141 – 1411Y → H in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:04, allele DRB1*14:05, allele DRB1*14:06, allele DRB1*14:07, allele DRB1*14:10, allele DRB1*14:11, allele DRB1*14:13, allele DRB1*14:14, allele DRB1*14:21, allele DRB1*14:46, allele DRB1*14:54, allele DRB1*14:57 and allele DRB1*14:82.
    VAR_062953

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB062112 mRNA. Translation: BAB84521.2.
    AJ297582 mRNA. Translation: CAC08822.1.
    AJ297583 mRNA. Translation: CAC08823.1.
    AJ297584 mRNA. Translation: CAC08824.1.
    AJ297585 mRNA. Translation: CAC08825.1.
    AY663408 Genomic DNA. Translation: AAU88014.1.
    AY935719 mRNA. Translation: AAX33315.1.
    AY961071 mRNA. Translation: AAX63459.2.
    DQ235685 Genomic DNA. Translation: ABB52004.1.
    DQ390459 Genomic DNA. Translation: ABD60300.1.
    DQ390460 Genomic DNA. Translation: ABD60301.1.
    FJ379259 Genomic DNA. Translation: ACJ06537.1.
    Z38072 Genomic DNA. Translation: CAA86217.1.
    FM196525 Genomic DNA. Translation: CAQ86516.1.
    AM109998 Genomic DNA. Translation: CAJ33605.1.
    AM109999 Genomic DNA. Translation: CAJ33606.1.
    AM110000 Genomic DNA. Translation: CAJ33607.1.
    AM110001 Genomic DNA. Translation: CAJ33608.1.
    AM110002 Genomic DNA. Translation: CAJ33609.1.
    AM110003 Genomic DNA. Translation: CAJ33610.1.
    AB485773 Genomic DNA. Translation: BAH23562.1.
    Z50730 Genomic DNA. No translation available.
    AJ242985 Genomic DNA. Translation: CAB45249.1. Sequence problems.
    AJ251985 Genomic DNA. Translation: CAC19086.1.
    AY050186 Genomic DNA. Translation: AAL23547.1.
    AY054375 mRNA. Translation: AAL15169.1.
    AF400066 Genomic DNA. Translation: AAK85431.1.
    AY267905 Genomic DNA. Translation: AAP32696.1.
    AY267906 Genomic DNA. Translation: AAP32697.1.
    AJ969417 Genomic DNA. Translation: CAI94542.1.
    AY912075 Genomic DNA. Translation: AAY17288.1.
    DQ333353 Genomic DNA. Translation: ABC59115.1.
    AM259285 Genomic DNA. Translation: CAJ90660.1.
    EF199810 Genomic DNA. Translation: ABM90423.1.
    AM774161 Genomic DNA. Translation: CAO81738.1.
    EF495154 Genomic DNA. Translation: ABP38039.1.
    AM922324 Genomic DNA. Translation: CAP58300.1.
    DQ494324 Genomic DNA. Translation: ABF50050.1.
    EU588391 Genomic DNA. Translation: ACB97664.1.
    D86502 Genomic DNA. Translation: BAA13097.1.
    D86504 Genomic DNA. Translation: BAA13099.1.
    D88310 Genomic DNA. Translation: BAA13587.1.
    AJ010982 Genomic DNA. Translation: CAA09450.1.
    AF172071 Genomic DNA. Translation: AAD51970.1.
    AJ543433 Genomic DNA. Translation: CAD65908.1.
    AY277390 Genomic DNA. Translation: AAP34694.1.
    AJ581744 Genomic DNA. Translation: CAE46451.1.
    AJ812566 Genomic DNA. Translation: CAH23708.1.
    AY770520 Genomic DNA. Translation: AAV37191.1.
    DQ021915 Genomic DNA. Translation: AAY85747.1.
    AM084908 Genomic DNA. Translation: CAJ29895.1.
    DQ327711 Genomic DNA. Translation: ABC59293.1.
    DQ358688 Genomic DNA. Translation: ABC84557.1.
    AM233907 Genomic DNA. Translation: CAJ80873.1.
    DQ643390 Genomic DNA. Translation: ABG25965.1.
    U95115 Genomic DNA. Translation: AAB58397.2.
    AM933133 Genomic DNA. Translation: CAP69806.1.
    EU545181 Genomic DNA. Translation: ACB30275.1.
    AB049830 Genomic DNA. Translation: BAB16682.1.
    AB049831 Genomic DNA. Translation: BAB16683.1.
    AB049832 Genomic DNA. Translation: BAB16684.1.
    AB087875 Genomic DNA. Translation: BAC02938.1.
    AB087876 Genomic DNA. Translation: BAC02939.1.
    AB436778 Genomic DNA. Translation: BAG32234.1.
    EF078986 Genomic DNA. Translation: ABK56696.1.
    EF536016 Genomic DNA. Translation: ABQ08747.1.
    EU029787 Genomic DNA. Translation: ABU86846.1.
    EU029788 Genomic DNA. Translation: ABU86847.1.
    EU029792 Genomic DNA. Translation: ABU86851.1.
    EU029793 Genomic DNA. Translation: ABU86852.1.
    EU029798 Genomic DNA. Translation: ABU86857.1.
    EU643616 Genomic DNA. Translation: ACD01094.1.
    EU812536 Genomic DNA. Translation: ACE88696.1.
    EU924810 Genomic DNA. Translation: ACH57405.1.
    DQ060439 Genomic DNA. Translation: AAY59541.1.
    DQ060441 Genomic DNA. Translation: AAY59543.1.
    DQ782331 Genomic DNA. Translation: ABG91054.1.
    FM179681 Genomic DNA. Translation: CAQ77159.1.
    FJ594768 Genomic DNA. Translation: ACM47962.1.
    AF177215 Genomic DNA. Translation: AAD53910.1.
    X99839 Genomic DNA. Translation: CAA68150.1.
    AJ289123 Genomic DNA. Translation: CAC19015.1.
    AY174092 Genomic DNA. Translation: AAO20089.1.
    AY174181 Genomic DNA. Translation: AAO17053.1.
    M77673 Genomic DNA. Translation: AAA73131.1.
    AF028010 Genomic DNA. Translation: AAB94612.1.
    AF112879 Genomic DNA. Translation: AAD29584.1.
    X86974 Genomic DNA. No translation available.
    U41489 Genomic DNA. Translation: AAA86242.1.
    AJ508388 Genomic DNA. Translation: CAD48196.1.
    PIRiB33287.
    C33287.
    C60748.
    F60748.
    PH0157.
    PH0158.
    S03440.
    UniGeneiHs.485130.
    Hs.534322.
    Hs.696211.
    Hs.716081.
    Hs.723344.
    Hs.736560.

    Genome annotation databases

    EnsembliENST00000328980; ENSP00000331343; ENSG00000206306.
    ENST00000360004; ENSP00000353099; ENSG00000196126.
    ENST00000399450; ENSP00000382378; ENSG00000206240.
    ENST00000412634; ENSP00000408795; ENSG00000228080.
    ENST00000415796; ENSP00000412168; ENSG00000206306.
    ENST00000419393; ENSP00000403458; ENSG00000228080.
    ENST00000428566; ENSP00000392280; ENSG00000206240.

    Polymorphism databases

    DMDMi74761361.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB062112 mRNA. Translation: BAB84521.2 .
    AJ297582 mRNA. Translation: CAC08822.1 .
    AJ297583 mRNA. Translation: CAC08823.1 .
    AJ297584 mRNA. Translation: CAC08824.1 .
    AJ297585 mRNA. Translation: CAC08825.1 .
    AY663408 Genomic DNA. Translation: AAU88014.1 .
    AY935719 mRNA. Translation: AAX33315.1 .
    AY961071 mRNA. Translation: AAX63459.2 .
    DQ235685 Genomic DNA. Translation: ABB52004.1 .
    DQ390459 Genomic DNA. Translation: ABD60300.1 .
    DQ390460 Genomic DNA. Translation: ABD60301.1 .
    FJ379259 Genomic DNA. Translation: ACJ06537.1 .
    Z38072 Genomic DNA. Translation: CAA86217.1 .
    FM196525 Genomic DNA. Translation: CAQ86516.1 .
    AM109998 Genomic DNA. Translation: CAJ33605.1 .
    AM109999 Genomic DNA. Translation: CAJ33606.1 .
    AM110000 Genomic DNA. Translation: CAJ33607.1 .
    AM110001 Genomic DNA. Translation: CAJ33608.1 .
    AM110002 Genomic DNA. Translation: CAJ33609.1 .
    AM110003 Genomic DNA. Translation: CAJ33610.1 .
    AB485773 Genomic DNA. Translation: BAH23562.1 .
    Z50730 Genomic DNA. No translation available.
    AJ242985 Genomic DNA. Translation: CAB45249.1 . Sequence problems.
    AJ251985 Genomic DNA. Translation: CAC19086.1 .
    AY050186 Genomic DNA. Translation: AAL23547.1 .
    AY054375 mRNA. Translation: AAL15169.1 .
    AF400066 Genomic DNA. Translation: AAK85431.1 .
    AY267905 Genomic DNA. Translation: AAP32696.1 .
    AY267906 Genomic DNA. Translation: AAP32697.1 .
    AJ969417 Genomic DNA. Translation: CAI94542.1 .
    AY912075 Genomic DNA. Translation: AAY17288.1 .
    DQ333353 Genomic DNA. Translation: ABC59115.1 .
    AM259285 Genomic DNA. Translation: CAJ90660.1 .
    EF199810 Genomic DNA. Translation: ABM90423.1 .
    AM774161 Genomic DNA. Translation: CAO81738.1 .
    EF495154 Genomic DNA. Translation: ABP38039.1 .
    AM922324 Genomic DNA. Translation: CAP58300.1 .
    DQ494324 Genomic DNA. Translation: ABF50050.1 .
    EU588391 Genomic DNA. Translation: ACB97664.1 .
    D86502 Genomic DNA. Translation: BAA13097.1 .
    D86504 Genomic DNA. Translation: BAA13099.1 .
    D88310 Genomic DNA. Translation: BAA13587.1 .
    AJ010982 Genomic DNA. Translation: CAA09450.1 .
    AF172071 Genomic DNA. Translation: AAD51970.1 .
    AJ543433 Genomic DNA. Translation: CAD65908.1 .
    AY277390 Genomic DNA. Translation: AAP34694.1 .
    AJ581744 Genomic DNA. Translation: CAE46451.1 .
    AJ812566 Genomic DNA. Translation: CAH23708.1 .
    AY770520 Genomic DNA. Translation: AAV37191.1 .
    DQ021915 Genomic DNA. Translation: AAY85747.1 .
    AM084908 Genomic DNA. Translation: CAJ29895.1 .
    DQ327711 Genomic DNA. Translation: ABC59293.1 .
    DQ358688 Genomic DNA. Translation: ABC84557.1 .
    AM233907 Genomic DNA. Translation: CAJ80873.1 .
    DQ643390 Genomic DNA. Translation: ABG25965.1 .
    U95115 Genomic DNA. Translation: AAB58397.2 .
    AM933133 Genomic DNA. Translation: CAP69806.1 .
    EU545181 Genomic DNA. Translation: ACB30275.1 .
    AB049830 Genomic DNA. Translation: BAB16682.1 .
    AB049831 Genomic DNA. Translation: BAB16683.1 .
    AB049832 Genomic DNA. Translation: BAB16684.1 .
    AB087875 Genomic DNA. Translation: BAC02938.1 .
    AB087876 Genomic DNA. Translation: BAC02939.1 .
    AB436778 Genomic DNA. Translation: BAG32234.1 .
    EF078986 Genomic DNA. Translation: ABK56696.1 .
    EF536016 Genomic DNA. Translation: ABQ08747.1 .
    EU029787 Genomic DNA. Translation: ABU86846.1 .
    EU029788 Genomic DNA. Translation: ABU86847.1 .
    EU029792 Genomic DNA. Translation: ABU86851.1 .
    EU029793 Genomic DNA. Translation: ABU86852.1 .
    EU029798 Genomic DNA. Translation: ABU86857.1 .
    EU643616 Genomic DNA. Translation: ACD01094.1 .
    EU812536 Genomic DNA. Translation: ACE88696.1 .
    EU924810 Genomic DNA. Translation: ACH57405.1 .
    DQ060439 Genomic DNA. Translation: AAY59541.1 .
    DQ060441 Genomic DNA. Translation: AAY59543.1 .
    DQ782331 Genomic DNA. Translation: ABG91054.1 .
    FM179681 Genomic DNA. Translation: CAQ77159.1 .
    FJ594768 Genomic DNA. Translation: ACM47962.1 .
    AF177215 Genomic DNA. Translation: AAD53910.1 .
    X99839 Genomic DNA. Translation: CAA68150.1 .
    AJ289123 Genomic DNA. Translation: CAC19015.1 .
    AY174092 Genomic DNA. Translation: AAO20089.1 .
    AY174181 Genomic DNA. Translation: AAO17053.1 .
    M77673 Genomic DNA. Translation: AAA73131.1 .
    AF028010 Genomic DNA. Translation: AAB94612.1 .
    AF112879 Genomic DNA. Translation: AAD29584.1 .
    X86974 Genomic DNA. No translation available.
    U41489 Genomic DNA. Translation: AAA86242.1 .
    AJ508388 Genomic DNA. Translation: CAD48196.1 .
    PIRi B33287.
    C33287.
    C60748.
    F60748.
    PH0157.
    PH0158.
    S03440.
    UniGenei Hs.485130.
    Hs.534322.
    Hs.696211.
    Hs.716081.
    Hs.723344.
    Hs.736560.

    3D structure databases

    ProteinModelPortali Q9GIY3.
    SMRi Q9GIY3. Positions 34-220.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9GIY3. 1 interaction.

    Polymorphism databases

    DMDMi 74761361.

    Proteomic databases

    PRIDEi Q9GIY3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328980 ; ENSP00000331343 ; ENSG00000206306 .
    ENST00000360004 ; ENSP00000353099 ; ENSG00000196126 .
    ENST00000399450 ; ENSP00000382378 ; ENSG00000206240 .
    ENST00000412634 ; ENSP00000408795 ; ENSG00000228080 .
    ENST00000415796 ; ENSP00000412168 ; ENSG00000206306 .
    ENST00000419393 ; ENSP00000403458 ; ENSG00000228080 .
    ENST00000428566 ; ENSP00000392280 ; ENSG00000206240 .

    Organism-specific databases

    GeneCardsi GC06M032546.
    GC06Mj32477.
    GC06Mn32480.
    GC06Mo32593.
    HGNCi HGNC:4948. HLA-DRB1.
    HPAi CAB015400.
    CAB034021.
    MIMi 142857. gene.
    neXtProti NX_Q9GIY3.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG012730.

    Enzyme and pathway databases

    Reactomei REACT_121399. MHC class II antigen presentation.
    REACT_12555. Downstream TCR signaling.
    REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
    REACT_12596. Translocation of ZAP-70 to Immunological synapse.
    REACT_12623. Generation of second messenger molecules.
    REACT_19324. PD-1 signaling.
    REACT_25078. Interferon gamma signaling.

    Miscellaneous databases

    ChiTaRSi HLA-DRB1. human.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9GIY3.
    Bgeei Q9GIY3.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00969. MHC_II_beta. 1 hit.
    [Graphical view ]
    ProDomi PD000328. MHC_II_b_N. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00407. IGc1. 1 hit.
    SM00921. MHC_II_beta. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete cDNA coding sequence of the HLA-DRB1*1405 allele."
      Kohsaka H., Nasu K., Matsushita S., Miyasaka N.
      DNA Seq. 13:359-361(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*14:05).
    2. "Complete cDNA sequences of the HLA-DRB1*14011, *1402, *1403 and *1404 alleles."
      Corell A., Cox S.T., Soteriou B., Ramon D., Madrigal J.A., Marsh S.G.E.
      Tissue Antigens 59:66-69(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES DRB1*14:01 AND DRB1*14:04), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-264 (ALLELES DRB1*14:02 AND DRB1*14:03).
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DRB1*14:05).
    4. "Group-specific amplification of cDNA from DRB1 genes. Complete coding sequences of partially defined alleles and identification of the new alleles DRB1*040602, DRB1*111102, DRB1*080103, and DRB1*0113."
      Balas A., Vilches C., Rodriguez M.A., Fernandez B., Martinez M.P., de Pablo R., Garcia-Sanchez F., Vicario J.L.
      Hum. Immunol. 67:1008-1016(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*14:11), NUCLEOTIDE SEQUENCE [MRNA] OF 1-265 (ALLELE DRB1*14:46).
    5. "Characterization of HLA-B*5516, -B*1313, -B*9512, and -DRB1*1457 alleles identified in a southwest Chinese population."
      Chen Q., Zou H., Xu X.H., Luo M., Wang J., Zuo Y.Q., Chen Y.H., Chen X.H., Chen X.L., Yao Z.Q., Song N., Zeng J., Mi X.Y., Sun S.X., Wang J.X., Zhao T.M.
      Tissue Antigens 68:339-343(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-217 (ALLELE DRB1*14:57).
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-208 (ALLELE DRB1*14:54).
    7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-123 (ALLELE DRB1*14:19).
    8. "A novel HLA-DRB1*14 allele identified by sequence-based typing."
      Ogrzewalla K., Tillmann G., Scheibelhut N., Lauber J., Enczmann J.
      Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-217 (ALLELE DRB1*14:82).
    9. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-216 (ALLELES DRB1*14:06; DRB1*14:07; DRB1*14:10; DRB1*14:13; DRB1*14:14 AND DRB1*14:21).
      Tissue: Peripheral blood.
    10. "HLA-DR new allele related with DRB1*1403."
      Maruya E., Matsushita M., Saji H., Ounuma T., Futagami T., Kojima H., Tujino T., Hayashi K., Kusunoki Y., Yoshida T., Maekawajiri S.
      Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-124 (ALLELE DRB1*14:85).
    11. "Sequencing of a new HLA-DR14 allele (DRB1(*)1422)."
      Adami N., Aubert V., Jeannet M., Tiercy J.M.
      Immunogenetics 43:248-249(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:22).
    12. "Nomenclature for factors of the HLA system, 1998."
      Bodmer J., Marsh S., Albert E., Bodmer W.
      Tissue Antigens 53:407-446(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:36).
    13. "Polymorphism of human HLA-DRB1 antigens generated by genetic exchange between DR2 (DRB1*15011) and DR6 (DRB1*1405) alleles: a novel DRB1 allele (DRB1*1437) identified in a Paiwan tribe member of Taiwan."
      Wu S., Shiao Y.M., Lai C.Y., Lai S.M., Chen S.P., Sidebottom D.A., Hildebrand W.H., Tilanus M.G.J., Chou F.C., Tsai M.F.
      Tissue Antigens 57:384-387(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:37).
      Tissue: Blood.
    14. "DRB1*14 diversity and DRB3 associations in four major population groups in the United States."
      Gans C.P., Tang T.F., Slack R., Ng J., Hartzman R.J., Hurley C.K.
      Tissue Antigens 59:364-369(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:41), NUCLEOTIDE SEQUENCE [MRNA] OF 35-123 (ALLELE DRB1*14:42).
    15. "Two novel HLA-DRB1 alleles identified using a sequence-based typing: HLA-DRB1*1443 and HLA-DRB1*1351*."
      Chu C.C., Lee H.L., Hsieh N.K., Trejaut J., Lin M.
      Tissue Antigens 64:308-310(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:43).
    16. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB1*14:47 AND DRB1*14:48).
    17. "Exon 2 sequence analysis of a novel HLA-DRB1 allele, DRB1*1450."
      Tijssen H.J., Zeeuw van der S.C., Joosten I.
      Tissue Antigens 66:332-333(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:50).
      Tissue: Peripheral blood.
    18. "Characterization of a novel DRB1*14 allele (DRB1*1449) in the Han-Chinese population."
      Miao K.R., Xue M., Zhou X.Y., Xu R., Fei X.M., Pan Q.Q., Zhang J.W., Zhao X., Fan S., Kukuruga D., Xu A.L., Wang C.Y.
      Int. J. Immunogenet. 33:33-35(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:49).
    19. "Identification of a novel HLA-DRB1*14 allele, DRB1*1456, in the cord blood of a Korean baby."
      Baek J.Y., Yun H.S., Hur S.S., Kwon O.J., Kwack K.
      Tissue Antigens 68:97-98(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:56).
    20. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:60).
      Tissue: Peripheral blood.
    21. "Identification of three novel alleles of HLA-DRB1 and HLA-A in the Brazilian population."
      Abdeen H., McErlean C., Moraes M.E., Torres M., Campiotto S., Galvao S., Gouvea C., Middleton D.
      Tissue Antigens 69:607-610(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:65).
    22. "DNA typing by microbead arrays and PCR-SSP: apparent false-negative or -positive hybridization or amplification signals disclose new HLA-B and -DRB1 alleles."
      Rahal M., Kervaire B., Villard J., Tiercy J.M.
      Tissue Antigens 71:238-241(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:74).
    23. "Sequence-based typing reveals the novel HLA-DRB1*1467 allele in a Chinese individual."
      Yan L.N., Li S.Y., Dong Z., Dong L., Xie J.H., An S.P., Yuan Y.H.
      Tissue Antigens 72:409-410(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:67).
      Tissue: Blood.
    24. "Sequence-based typing of a novel HLA-DRB1*14 allele, DRB1*1475, in a Caucasian woman."
      Schuett S., Geflitter A., von Baehr V.
      Tissue Antigens 72:501-502(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:75).
    25. "Identification of a novel HLA-DRB allele, HLA-DRB1*1461."
      Wang Z., Shan X., Zhang Z.
      Tissue Antigens 72:603-604(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:61).
    26. "Identification of a new HLA-DRB1*14 variant, HLA-DRB1*1478, in a Korean individual."
      Han S.H., Jung S.M., Park S.R., Chung S.Y., Han H.
      Tissue Antigens 73:81-83(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:78).
    27. "Sequence of new allele."
      Kashiwase K., Tokunaga K., Akaza T., Tadokoro K., Juji T.
      Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB1*14:26; DRB1*14:27 AND DRB1*14:29).
    28. "A new HLA-DRB1*14 variant."
      Blasczyk R.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:32).
    29. "Novel DRB1*14 and 15 alleles in the Western Australian population."
      Whidborne R.S., Sayer D.C., Christiansen F.T.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:34).
    30. "Confirmatory sequence for HLA-DRB1*1417 gene obtained by sequence based typing."
      Gervais T.G., Latinne D.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:17).
    31. "Complete exon 2 sequence for HLA-DRB1*1418."
      Rizzo M., Steiner N.K., Nichol L., Hurley C.K.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:18).
    32. "An unusual HLA-DR/DQ haplotype carrying a new DR8 variant and the DRB3*0202 allele."
      Kervaire B., Villard J., Tiercy J.M.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:15).
    33. "Novel HLA-DRB1*11 allele."
      Velickovic Z.M.
      Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:23).
      Tissue: Blood.
    34. Oh H.B., Byun E.K., Hong S.A., Lee M.N., Kwon O.J.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:12).
    35. "Identification of a novel HLA-DRB1*14 allele."
      Lee T.D.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:01).
    36. Dormoy A.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:53).
    37. "Characterization of a new HLA-DRB1*14 allele."
      Hirv K., Krauss A., Mytilineos J.
      Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:55).
      Tissue: Leukocyte.
    38. "Identification of a new HLA-DRB1*14 allele by sequence-based typing."
      Karvunidis T., Jindra P., Fischer G., Koza V.
      Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:58).
    39. "A new DRB1*14 allele close to the DRB1*1418 allele is different for 3 substitutions at nucleotide positions 84, 152 and 174 leading to the change of 2 amino acids at positions 28 and 51."
      Dormoy A., Weschler B., Leinsenbach R.
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:59).
    40. "Identification a novel HLA-DRB1*14 new allele."
      Ye S., Liu M., Qi J.
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:63).
    41. Greville W.D., Dunckley H.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:30).
    42. "Identification of a novel DRB1 allele."
      Tavoularis S., Rebeiro E., Sayer D.
      Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:76).
      Tissue: Blood.
    43. "A new allele of HLA-DRB1*14 detected with SBT."
      Yan L.N., An S.P., Li S.Y., Xie J.H., Dong L., Dong Z., Yuan Y.H.
      Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:77).
      Tissue: Blood.
    44. "HLA-DRB1*1401V1M, HLA-DRB1*1401V2, HLA-DRB1*1403V2, HLA-DRB1*1405V1, HLA-DRB1*1405V2, HLA-DRB1*1406V1."
      Juji T., Shimizu M., Kashiwase K., Nakajima F., Tadokoro K., Tanaka H.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB1*14:38; DRB1*14:39; DRB1*14:40; DRB1*14:44; DRB1*14:45 AND DRB1*14:80).
    45. "Novel class II allele."
      Lazaro A.M., Cao K., Xiao Y., Lebeck L., Hurley C.K.
      Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB1*14:51; DRB1*14:52; DRB1*14:62; DRB1*14:64; DRB1*14:68; DRB1*14:69; DRB1*14:70; DRB1*14:71; DRB1*14:72; DRB1*14:73; DRB1*14:79; DRB1*14:81 AND DRB1*14:83).
    46. "The HLA-DRB1*14New allele has 3 nucleotide changes from the DRB1*1402 allele at positions 286, 298 and 299 of exon 2 where: C286->A286 (codon 72 (CTC->ATC)) resulting in a change of amino acid: Leu->Ile A298->G298 + G299->C299 (codon 76 (AGG->GCG)) resulting in a change of amino acid: Arg->Ala."
      Dormoy A., Weschler B.
      Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:24).
    47. "A new DR14-related DRB1 allele, identified by sequence-based typing."
      Lee T.-D., Chien W.-C.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:84).
      Tissue: Peripheral blood.
    48. "PCR-RFLP typing detects new HLA-DRB1 alleles: DRB1*13022, DRB1*1336 and DRB1*1435."
      Trejaut J., Kennedy A., Hobart D., Le T., Greville W.D., Ng G., Taverniti A., Dunckley H.
      Eur. J. Immunogenet. 28:441-447(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-122 (ALLELE DRB1*14:35).
    49. "Identification of new DRB1*01 (DRB1*01022), DRB1*14 (DRB1*1428) and DRB3* (DRB3*0206) alleles."
      Hashemi-Tavoularis S., Couture C., Buyse I.M.
      Tissue Antigens 50:89-93(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DRB1*14:28).
      Tissue: Blood.
    50. "Identification of three novel alleles: DRB3*0110, DRB1*1140, and DRB1*140102."
      Tavoularis S., Couture C., Ribeiro-Barros E.
      Tissue Antigens 63:496-500(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DRB1*14:01).
      Tissue: Peripheral blood.
    51. "Confirmatory sequence of HLA class II DRB1*1409 and DRB1*1425."
      Vayntrub T., Lo B.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-123 (ALLELES DRB1*14:09 AND DRB1*14:25).
    52. "HLA class II diversity in Australian aborigines: unusual HLA-DRB1 alleles."
      Gao X., Veale A., Serjeantson S.W.
      Immunogenetics 36:333-337(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-122 (ALLELE DRB1*14:08).
      Tissue: Blood.
    53. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-119 (ALLELE DRB1*14:31).
    54. "New HLA class II (DRB1) alleles detected by sequencing-based typing."
      Greville W.D., van Eijck A., Dunckley H.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-122 (ALLELE DRB1*14:33).
    55. "Six newly identified HLA-DRB alleles: DRB1*1121, *1419, *1420, *1421, DRB3*0203 and DRB5*0103."
      Verduyn W., Anholts J.D., Versluis L.F., Parlevliet J., Drabbels J., De Meester J., Tilanus M.G., Doxiadis I.I., Giphart M.J., Schreuder G.M.
      Tissue Antigens 48:80-86(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-116 (ALLELE DRB1*14:20).
    56. Hurley C.K.
      Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 42-131 (ALLELE DRB1*14:24).
      Tissue: B-cell.
    57. "Confirmatory typing for exon 2 of HLA-DRB1*1416 gene, obtained by sequence-based typing."
      Gervais T.G., Latinne D.
      Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 43-120 (ALLELE DRB1*14:16).
    58. "Invariant chain structure and MHC class II function."
      Cresswell P.
      Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    59. "Presentation of antigens by MHC class II molecules: getting the most out of them."
      Villadangos J.A.
      Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    60. "Autophagy in MHC class II presentation: sampling from within."
      Menendez-Benito V., Neefjes J.
      Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    61. "MHC class II molecules on the move for successful antigen presentation."
      Rocha N., Neefjes J.
      EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    62. "MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation."
      De Gassart A., Camosseto V., Thibodeau J., Ceppi M., Catalan N., Pierre P., Gatti E.
      Proc. Natl. Acad. Sci. U.S.A. 105:3491-3496(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION BY MARCH1, SUBCELLULAR LOCATION.
    63. "MHC class II transport at a glance."
      Berger A.C., Roche P.A.
      J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    64. "CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."
      Beswick E.J., Reyes V.E.
      World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry namei2B1E_HUMAN
    AccessioniPrimary (citable) accession number: Q9GIY3
    Secondary accession number(s): A0N0W1
    , A2TGX3, A4ZY86, A5H000, A5HKN8, A7DZP9, A7X5B1, A7X5B7, A7X5E0, A7X5E6, A7X5H8, A9JPG0, B1GWE7, B2CR03, B2LVF9, B2NJ29, B2ZCY1, B3VTP8, B5B8U0, B5B9V5, B5LZ25, B6VEL9, B9VRA4, B9X248, O02876, O46793, O77969, O78210, Q0PQ39, Q155F7, Q1AP33, Q1JRP3, Q27PR6, Q27PR7, Q29734, Q29770, Q29772, Q29800, Q2A120, Q2HZE5, Q2LE76, Q2MJA6, Q2VQU1, Q307W5, Q31636, Q3LA87, Q3LA88, Q3LA89, Q3LA90, Q3LA91, Q3LA92, Q3T919, Q4PRC3, Q4PRC5, Q4VZY7, Q56FP1, Q5BM92, Q5U9W6, Q683P7, Q70GL2, Q7YNY9, Q7YQA5, Q860D8, Q860D9, Q860S0, Q861H5, Q861H7, Q8MH59, Q8MH60, Q8WLU3, Q95348, Q95HK1, Q95HL0, Q95IG2, Q9GIL5, Q9GIL6, Q9GIY0, Q9GIY1, Q9GIY2, Q9GJ56, Q9GJ57, Q9GJ58, Q9TPB6, Q9TPW1, Q9XRY4, Q9Y4H7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 23, 2010
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3