Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9GIY3 (2B1E_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HLA class II histocompatibility antigen, DRB1-14 beta chain
Alternative name(s):
MHC class II antigen DRB1*14
Short name=DR-14
Short name=DR14
Gene names
Name:HLA-DRB1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

Subunit structure

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.

Subcellular location

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. Ref.62

Post-translational modification

Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II Probable. Ref.62

Polymorphism

The following alleles of DRB1-14 are known: DRB1*14:01, DRB1*14:02, DRB1*14:03, DRB1*14:04, DRB1*14:05, DRB1*14:06, DRB1*14:07, DRB1*14:08, DRB1*14:09, DRB1*14:10, DRB1*14:11, DRB1*14:12, DRB1*14:13, DRB1*14:14, DRB1*14:15, DRB1*14:16, DRB1*14:17, DRB1*14:18, DRB1*14:19, DRB1*14:20, DRB1*14:21, DRB1*14:22, DRB1*14:23, DRB1*14:24, DRB1*14:25, DRB1*14:26, DRB1*14:27, DRB1*14:28, DRB1*14:29, DRB1*14:30, DRB1*14:31, DRB1*14:32, DRB1*14:33, DRB1*14:34, DRB1*14:35, DRB1*14:36, DRB1*14:37, DRB1*14:38, DRB1*14:39, DRB1*14:40, DRB1*14:41, DRB1*14:42, DRB1*14:43, DRB1*14:44, DRB1*14:45, DRB1*14:46, DRB1*14:47, DRB1*14:48, DRB1*14:49, DRB1*14:50, DRB1*14:51, DRB1*14:52, DRB1*14:53, DRB1*14:54, DRB1*14:55, DRB1*14:56, DRB1*14:57, DRB1*14:58, DRB1*14:59, DRB1*14:60, DRB1*14:61, DRB1*14:62, DRB1*14:63, DRB1*14:64, DRB1*14:65, DRB1*14:67, DRB1*14:68, DRB1*14:69, DRB1*14:70, DRB1*14:71, DRB1*14:72, DRB1*14:73, DRB1*14:74, DRB1*14:75, DRB1*14:76, DRB1*14:77, DRB1*14:78, DRB1*14:79, DRB1*14:80, DRB1*14:81, DRB1*14:82, DRB1*14:83, DRB1*14:84 and DRB1*14:85. The sequence shown is that of DRB1*14:01.

Sequence similarities

Belongs to the MHC class II family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Sequence caution

The sequence CAB45249.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 266237HLA class II histocompatibility antigen, DRB1-14 beta chain
PRO_5000066676

Regions

Transmembrane228 – 24821Helical; Potential
Domain126 – 21489Ig-like C1-type

Amino acid modifications

Glycosylation481N-linked (GlcNAc...) Potential
Disulfide bond146 ↔ 202 By similarity
Cross-link254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Natural variations

Natural variant391Y → L in allele DRB1*14:46; requires 2 nucleotide substitutions.
VAR_062907
Natural variant391Y → Q in allele DRB1*14:10 and allele DRB1*14:57; requires 2 nucleotide substitutions.
VAR_062906
Natural variant401S → P in allele DRB1*14:39.
VAR_062910
Natural variant401S → R in allele DRB1*14:46.
VAR_062908
Natural variant401S → V in allele DRB1*14:10 and allele DRB1*14:57; requires 2 nucleotide substitutions.
VAR_062909
Natural variant411T → K in allele DRB1*14:10, allele DRB1*14:46 and allele DRB1*14:57.
VAR_062911
Natural variant421S → G in allele DRB1*14:04, allele DRB1*14:11, allele DRB1*14:15, allele DRB1*14:28, allele DRB1*14:31, allele DRB1*14:50, allele DRB1*14:52, allele DRB1*14:61, allele DRB1*14:68, allele DRB1*14:71, allele DRB1*14:73, allele DRB1*14:76 and allele DRB1*14:79.
VAR_062913
Natural variant421S → H in allele DRB1*14:10 and allele DRB1*14:57; requires 2 nucleotide substitutions.
VAR_062912
Natural variant451H → Q in allele DRB1*14:05, allele DRB1*14:37, allele DRB1*14:43, allele DRB1*14:44, allele DRB1*14:45, allele DRB1*14:56 and allele DRB1*14:84.
VAR_062915
Natural variant451H → Y in allele DRB1*14:04, allele DRB1*14:11, allele DRB1*14:15, allele DRB1*14:28, allele DRB1*14:31, allele DRB1*14:50, allele DRB1*14:52, allele DRB1*14:68, allele DRB1*14:71, allele DRB1*14:73, allele DRB1*14:76 and allele DRB1*14:79.
VAR_062914
Natural variant541R → Q in allele DRB1*14:26.
VAR_062916
Natural variant551F → Y in allele DRB1*14:82.
VAR_062917
Natural variant561L → M in allele DRB1*14:83.
VAR_062918
Natural variant571D → E in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:06, allele DRB1*14:12, allele DRB1*14:13, allele DRB1*14:18, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:24, allele DRB1*14:27, allele DRB1*14:29, allele DRB1*14:40, allele DRB1*14:41, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:49, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:63, allele DRB1*14:67, allele DRB1*14:77, allele DRB1*14:78, allele DRB1*14:81, allele DRB1*14:83 and allele DRB1*14:85.
VAR_062919
Natural variant591Y → H in allele DRB1*14:70.
VAR_062920
Natural variant611H → Y in allele DRB1*14:25, allele DRB1*14:42, allele DRB1*14:53, allele DRB1*14:58 and allele DRB1*14:69.
VAR_062921
Natural variant661F → N in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:06, allele DRB1*14:09, allele DRB1*14:12, allele DRB1*14:13, allele DRB1*14:17, allele DRB1*14:18, allele DRB1*14:19, allele DRB1*14:21, allele DRB1*14:24, allele DRB1*14:27, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:59, allele DRB1*14:63, allele DRB1*14:64, allele DRB1*14:67, allele DRB1*14:78, allele DRB1*14:80, allele DRB1*14:81, allele DRB1*14:83 and allele DRB1*14:85; requires 2 nucleotide substitutions.
VAR_062923
Natural variant661F → Y in allele DRB1*14:25, allele DRB1*14:42, allele DRB1*14:53, allele DRB1*14:58 and allele DRB1*14:69.
VAR_062922
Natural variant671V → L in allele DRB1*14:41 and allele DRB1*14:77.
VAR_062924
Natural variant741G → R in allele DRB1*14:36 and allele DRB1*14:60.
VAR_062925
Natural variant761Y → F in allele DRB1*14:17, allele DRB1*14:21, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:35, allele DRB1*14:42, allele DRB1*14:53, allele DRB1*14:64, allele DRB1*14:65 and allele DRB1*14:72.
VAR_062926
Natural variant801T → R in allele DRB1*14:59.
VAR_062927
Natural variant861A → D in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:05, allele DRB1*14:06, allele DRB1*14:08, allele DRB1*14:09, allele DRB1*14:11, allele DRB1*14:12, allele DRB1*14:14, allele DRB1*14:15, allele DRB1*14:17, allele DRB1*14:18, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:21, allele DRB1*14:23, allele DRB1*14:24, allele DRB1*14:27, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:34, allele DRB1*14:36, allele DRB1*14:37, allele DRB1*14:40, allele DRB1*14:41, allele DRB1*14:42, allele DRB1*14:43, allele DRB1*14:44, allele DRB1*14:45, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:56, allele DRB1*14:59, allele DRB1*14:64, allele DRB1*14:67, allele DRB1*14:72, allele DRB1*14:77, allele DRB1*14:80, allele DRB1*14:81, allele DRB1*14:83 and allele DRB1*14:84.
VAR_062928
Natural variant861A → S in allele DRB1*14:13, allele DRB1*14:63, allele DRB1*14:65, allele DRB1*14:78 and allele DRB1*14:85.
VAR_062929
Natural variant861A → T in allele DRB1*14:62.
VAR_062930
Natural variant861A → V in allele DRB1*14:48.
VAR_062931
Natural variant871A → E in allele DRB1*14:11.
VAR_062932
Natural variant891H → S in allele DRB1*14:48 and allele DRB1*14:64; requires 2 nucleotide substitutions.
VAR_062934
Natural variant891H → Y in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:05, allele DRB1*14:06, allele DRB1*14:09, allele DRB1*14:11, allele DRB1*14:12, allele DRB1*14:13, allele DRB1*14:14, allele DRB1*14:15, allele DRB1*14:17, allele DRB1*14:18, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:21, allele DRB1*14:23, allele DRB1*14:24, allele DRB1*14:27, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:36, allele DRB1*14:37, allele DRB1*14:40, allele DRB1*14:41, allele DRB1*14:42, allele DRB1*14:43, allele DRB1*14:44, allele DRB1*14:45, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:56, allele DRB1*14:57, allele DRB1*14:59, allele DRB1*14:63, allele DRB1*14:65, allele DRB1*14:67, allele DRB1*14:76, allele DRB1*14:77, allele DRB1*14:78, allele DRB1*14:80, allele DRB1*14:81, allele DRB1*14:83, allele DRB1*14:84 and allele DRB1*14:85.
VAR_062933
Natural variant961L → F in allele DRB1*14:15, allele DRB1*14:22, allele DRB1*14:25, allele DRB1*14:27, allele DRB1*14:53 and allele DRB1*14:73.
VAR_062935
Natural variant961L → I in allele DRB1*14:16, allele DRB1*14:24, allele DRB1*14:37, allele DRB1*14:45, allele DRB1*14:57, allele DRB1*14:63, allele DRB1*14:67 and allele DRB1*14:78.
VAR_062936
Natural variant991R → D in allele DRB1*14:03, allele DRB1*14:12, allele DRB1*14:15, allele DRB1*14:16, allele DRB1*14:22, allele DRB1*14:25, allele DRB1*14:27, allele DRB1*14:40, allele DRB1*14:53, allele DRB1*14:57, allele DRB1*14:63, allele DRB1*14:67, allele DRB1*14:69, allele DRB1*14:73, allele DRB1*14:74, allele DRB1*14:77, allele DRB1*14:78, allele DRB1*14:84 and allele DRB1*14:85; requires 2 nucleotide substitutions.
VAR_062938
Natural variant991R → Q in allele DRB1*14:02, allele DRB1*14:06, allele DRB1*14:09, allele DRB1*14:13, allele DRB1*14:17, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:21, allele DRB1*14:24, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:37, allele DRB1*14:41, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:49, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:76, allele DRB1*14:79, allele DRB1*14:80 and allele DRB1*14:83.
VAR_062937
Natural variant1001R → A in allele DRB1*14:24 and allele DRB1*14:37; requires 2 nucleotide substitutions.
VAR_062941
Natural variant1001R → E in allele DRB1*14:16 and allele DRB1*14:57; requires 2 nucleotide substitutions.
VAR_062940
Natural variant1001R → K in allele DRB1*14:19, allele DRB1*14:21, allele DRB1*14:76 and allele DRB1*14:79.
VAR_062939
Natural variant1021A → G in allele DRB1*14:76 and allele DRB1*14:79.
VAR_062943
Natural variant1021A → S in allele DRB1*14:56.
VAR_062942
Natural variant1031E → A in allele DRB1*14:02, allele DRB1*14:06, allele DRB1*14:09, allele DRB1*14:13, allele DRB1*14:16, allele DRB1*14:17, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:21, allele DRB1*14:22, allele DRB1*14:24, allele DRB1*14:25, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:31, allele DRB1*14:32, allele DRB1*14:34, allele DRB1*14:37, allele DRB1*14:41, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:49, allele DRB1*14:52, allele DRB1*14:53, allele DRB1*14:57, allele DRB1*14:65, allele DRB1*14:69, allele DRB1*14:74, allele DRB1*14:80, allele DRB1*14:81 and allele DRB1*14:83.
VAR_062944
Natural variant1031E → L in allele DRB1*14:03, allele DRB1*14:12, allele DRB1*14:15, allele DRB1*14:27, allele DRB1*14:40, allele DRB1*14:55, allele DRB1*14:63, allele DRB1*14:67, allele DRB1*14:77, allele DRB1*14:78, allele DRB1*14:84 and allele DRB1*14:85; requires 2 nucleotide substitutions.
VAR_062945
Natural variant1031E → R in allele DRB1*14:76 and allele DRB1*14:79; requires 2 nucleotide substitutions.
VAR_062946
Natural variant1061T → A in allele DRB1*14:43.
VAR_062948
Natural variant1061T → N in allele DRB1*14:38, allele DRB1*14:47, allele DRB1*14:50, allele DRB1*14:76 and allele DRB1*14:79.
VAR_062947
Natural variant1101H → Y in allele DRB1*14:75.
VAR_062949
Natural variant1141V → A in allele DRB1*14:28 and allele DRB1*14:29.
VAR_062950
Natural variant1151V → G in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:07, allele DRB1*14:09, allele DRB1*14:13, allele DRB1*14:14, allele DRB1*14:19, allele DRB1*14:22, allele DRB1*14:24, allele DRB1*14:25, allele DRB1*14:27, allele DRB1*14:30, allele DRB1*14:36, allele DRB1*14:40, allele DRB1*14:41, allele DRB1*14:42, allele DRB1*14:44, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:49, allele DRB1*14:51, allele DRB1*14:53, allele DRB1*14:63, allele DRB1*14:67, allele DRB1*14:68, allele DRB1*14:69, allele DRB1*14:77 and allele DRB1*14:85.
VAR_062951
Natural variant1151V → M in allele DRB1*14:71.
VAR_062952
Natural variant1411Y → H in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:04, allele DRB1*14:05, allele DRB1*14:06, allele DRB1*14:07, allele DRB1*14:10, allele DRB1*14:11, allele DRB1*14:13, allele DRB1*14:14, allele DRB1*14:21, allele DRB1*14:46, allele DRB1*14:54, allele DRB1*14:57 and allele DRB1*14:82.
VAR_062953

Experimental info

Sequence conflict1241V → G in BAH23562. Ref.10

Sequences

Sequence LengthMass (Da)Tools
Q9GIY3 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: FA4BE90DFAB4FA55

FASTA26630,139
        10         20         30         40         50         60 
MVCLRLPGGS CMAVLTVTLM VLSSPLALAG DTRPRFLEYS TSECHFFNGT ERVRFLDRYF 

        70         80         90        100        110        120 
HNQEEFVRFD SDVGEYRAVT ELGRPAAEHW NSQKDLLERR RAEVDTYCRH NYGVVESFTV 

       130        140        150        160        170        180 
QRRVHPKVTV YPSKTQPLQH YNLLVCSVSG FYPGSIEVRW FRNGQEEKTG VVSTGLIHNG 

       190        200        210        220        230        240 
DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL 

       250        260 
FLGAGLFIYF RNQKGHSGLQ PRGFLS 

« Hide

References

[1]"Complete cDNA coding sequence of the HLA-DRB1*1405 allele."
Kohsaka H., Nasu K., Matsushita S., Miyasaka N.
DNA Seq. 13:359-361(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*14:05).
[2]"Complete cDNA sequences of the HLA-DRB1*14011, *1402, *1403 and *1404 alleles."
Corell A., Cox S.T., Soteriou B., Ramon D., Madrigal J.A., Marsh S.G.E.
Tissue Antigens 59:66-69(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES DRB1*14:01 AND DRB1*14:04), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-264 (ALLELES DRB1*14:02 AND DRB1*14:03).
[3]"Ancient haplotypes of the HLA Class II region."
Raymond C.K., Kas A., Paddock M., Qiu R., Zhou Y., Subramanian S., Chang J., Palmieri A., Haugen E., Kaul R., Olson M.V.
Genome Res. 15:1250-1257(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DRB1*14:05).
[4]"Group-specific amplification of cDNA from DRB1 genes. Complete coding sequences of partially defined alleles and identification of the new alleles DRB1*040602, DRB1*111102, DRB1*080103, and DRB1*0113."
Balas A., Vilches C., Rodriguez M.A., Fernandez B., Martinez M.P., de Pablo R., Garcia-Sanchez F., Vicario J.L.
Hum. Immunol. 67:1008-1016(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*14:11), NUCLEOTIDE SEQUENCE [MRNA] OF 1-265 (ALLELE DRB1*14:46).
[5]"Characterization of HLA-B*5516, -B*1313, -B*9512, and -DRB1*1457 alleles identified in a southwest Chinese population."
Chen Q., Zou H., Xu X.H., Luo M., Wang J., Zuo Y.Q., Chen Y.H., Chen X.H., Chen X.L., Yao Z.Q., Song N., Zeng J., Mi X.Y., Sun S.X., Wang J.X., Zhao T.M.
Tissue Antigens 68:339-343(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-217 (ALLELE DRB1*14:57).
[6]"New allele name of some HLA-DRB1*1401: HLA-DRB1*1454."
Yang K.L., Chen M.J., Lee S.K., Lin C.C., Tsai M.J., Chiu H.M., Jiang S., Chao Y.C., Chen S.P., Lin S., Shyr M.H., Lin P.Y.
Int. J. Immunogenet. 36:119-120(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-208 (ALLELE DRB1*14:54).
[7]"A novel HLA-DR allele, DRB1*1419."
Loeffler D., Woelpl A., Kern P., Eiermann T.H.
Tissue Antigens 46:343-344(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-123 (ALLELE DRB1*14:19).
[8]"A novel HLA-DRB1*14 allele identified by sequence-based typing."
Ogrzewalla K., Tillmann G., Scheibelhut N., Lauber J., Enczmann J.
Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-217 (ALLELE DRB1*14:82).
[9]"The nature of diversity of HLA-DRB1 exon 3."
Horn P.A., Albis-Camps M., Verboom M., Bunce M., Yousaf K., Williams S., Blasczyk R.
Tissue Antigens 70:335-337(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-216 (ALLELES DRB1*14:06; DRB1*14:07; DRB1*14:10; DRB1*14:13; DRB1*14:14 AND DRB1*14:21).
Tissue: Peripheral blood.
[10]"HLA-DR new allele related with DRB1*1403."
Maruya E., Matsushita M., Saji H., Ounuma T., Futagami T., Kojima H., Tujino T., Hayashi K., Kusunoki Y., Yoshida T., Maekawajiri S.
Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-124 (ALLELE DRB1*14:85).
[11]"Sequencing of a new HLA-DR14 allele (DRB1(*)1422)."
Adami N., Aubert V., Jeannet M., Tiercy J.M.
Immunogenetics 43:248-249(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:22).
[12]"Nomenclature for factors of the HLA system, 1998."
Bodmer J., Marsh S., Albert E., Bodmer W.
Tissue Antigens 53:407-446(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:36).
[13]"Polymorphism of human HLA-DRB1 antigens generated by genetic exchange between DR2 (DRB1*15011) and DR6 (DRB1*1405) alleles: a novel DRB1 allele (DRB1*1437) identified in a Paiwan tribe member of Taiwan."
Wu S., Shiao Y.M., Lai C.Y., Lai S.M., Chen S.P., Sidebottom D.A., Hildebrand W.H., Tilanus M.G.J., Chou F.C., Tsai M.F.
Tissue Antigens 57:384-387(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:37).
Tissue: Blood.
[14]"DRB1*14 diversity and DRB3 associations in four major population groups in the United States."
Gans C.P., Tang T.F., Slack R., Ng J., Hartzman R.J., Hurley C.K.
Tissue Antigens 59:364-369(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:41), NUCLEOTIDE SEQUENCE [MRNA] OF 35-123 (ALLELE DRB1*14:42).
[15]"Two novel HLA-DRB1 alleles identified using a sequence-based typing: HLA-DRB1*1443 and HLA-DRB1*1351*."
Chu C.C., Lee H.L., Hsieh N.K., Trejaut J., Lin M.
Tissue Antigens 64:308-310(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:43).
[16]"Ten novel HLA-DRB1 alleles and one novel DRB3 allele."
Lazaro A.M., Steiner N.K., Moraes M.E., Moraes J.R., Ng J., Hartzman R.J., Hurley C.K.
Tissue Antigens 66:327-329(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB1*14:47 AND DRB1*14:48).
[17]"Exon 2 sequence analysis of a novel HLA-DRB1 allele, DRB1*1450."
Tijssen H.J., Zeeuw van der S.C., Joosten I.
Tissue Antigens 66:332-333(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:50).
Tissue: Peripheral blood.
[18]"Characterization of a novel DRB1*14 allele (DRB1*1449) in the Han-Chinese population."
Miao K.R., Xue M., Zhou X.Y., Xu R., Fei X.M., Pan Q.Q., Zhang J.W., Zhao X., Fan S., Kukuruga D., Xu A.L., Wang C.Y.
Int. J. Immunogenet. 33:33-35(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:49).
[19]"Identification of a novel HLA-DRB1*14 allele, DRB1*1456, in the cord blood of a Korean baby."
Baek J.Y., Yun H.S., Hur S.S., Kwon O.J., Kwack K.
Tissue Antigens 68:97-98(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:56).
[20]"Exon 2 sequence analysis of a novel HLA-DRB1 allele, DRB1*1460."
Tijssen H.J., van den Dungen-Toet J.H.G., van Houwelingen K.P., Allebes W.A., Joosten I.
Tissue Antigens 68:346-347(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:60).
Tissue: Peripheral blood.
[21]"Identification of three novel alleles of HLA-DRB1 and HLA-A in the Brazilian population."
Abdeen H., McErlean C., Moraes M.E., Torres M., Campiotto S., Galvao S., Gouvea C., Middleton D.
Tissue Antigens 69:607-610(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:65).
[22]"DNA typing by microbead arrays and PCR-SSP: apparent false-negative or -positive hybridization or amplification signals disclose new HLA-B and -DRB1 alleles."
Rahal M., Kervaire B., Villard J., Tiercy J.M.
Tissue Antigens 71:238-241(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:74).
[23]"Sequence-based typing reveals the novel HLA-DRB1*1467 allele in a Chinese individual."
Yan L.N., Li S.Y., Dong Z., Dong L., Xie J.H., An S.P., Yuan Y.H.
Tissue Antigens 72:409-410(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:67).
Tissue: Blood.
[24]"Sequence-based typing of a novel HLA-DRB1*14 allele, DRB1*1475, in a Caucasian woman."
Schuett S., Geflitter A., von Baehr V.
Tissue Antigens 72:501-502(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:75).
[25]"Identification of a novel HLA-DRB allele, HLA-DRB1*1461."
Wang Z., Shan X., Zhang Z.
Tissue Antigens 72:603-604(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:61).
[26]"Identification of a new HLA-DRB1*14 variant, HLA-DRB1*1478, in a Korean individual."
Han S.H., Jung S.M., Park S.R., Chung S.Y., Han H.
Tissue Antigens 73:81-83(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:78).
[27]"Sequence of new allele."
Kashiwase K., Tokunaga K., Akaza T., Tadokoro K., Juji T.
Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB1*14:26; DRB1*14:27 AND DRB1*14:29).
[28]"A new HLA-DRB1*14 variant."
Blasczyk R.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:32).
[29]"Novel DRB1*14 and 15 alleles in the Western Australian population."
Whidborne R.S., Sayer D.C., Christiansen F.T.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:34).
[30]"Confirmatory sequence for HLA-DRB1*1417 gene obtained by sequence based typing."
Gervais T.G., Latinne D.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:17).
[31]"Complete exon 2 sequence for HLA-DRB1*1418."
Rizzo M., Steiner N.K., Nichol L., Hurley C.K.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:18).
[32]"An unusual HLA-DR/DQ haplotype carrying a new DR8 variant and the DRB3*0202 allele."
Kervaire B., Villard J., Tiercy J.M.
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:15).
[33]"Novel HLA-DRB1*11 allele."
Velickovic Z.M.
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:23).
Tissue: Blood.
[34]Oh H.B., Byun E.K., Hong S.A., Lee M.N., Kwon O.J.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:12).
[35]"Identification of a novel HLA-DRB1*14 allele."
Lee T.D.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:01).
[36]Dormoy A.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:53).
[37]"Characterization of a new HLA-DRB1*14 allele."
Hirv K., Krauss A., Mytilineos J.
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:55).
Tissue: Leukocyte.
[38]"Identification of a new HLA-DRB1*14 allele by sequence-based typing."
Karvunidis T., Jindra P., Fischer G., Koza V.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:58).
[39]"A new DRB1*14 allele close to the DRB1*1418 allele is different for 3 substitutions at nucleotide positions 84, 152 and 174 leading to the change of 2 amino acids at positions 28 and 51."
Dormoy A., Weschler B., Leinsenbach R.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:59).
[40]"Identification a novel HLA-DRB1*14 new allele."
Ye S., Liu M., Qi J.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:63).
[41]Greville W.D., Dunckley H.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:30).
[42]"Identification of a novel DRB1 allele."
Tavoularis S., Rebeiro E., Sayer D.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:76).
Tissue: Blood.
[43]"A new allele of HLA-DRB1*14 detected with SBT."
Yan L.N., An S.P., Li S.Y., Xie J.H., Dong L., Dong Z., Yuan Y.H.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:77).
Tissue: Blood.
[44]"HLA-DRB1*1401V1M, HLA-DRB1*1401V2, HLA-DRB1*1403V2, HLA-DRB1*1405V1, HLA-DRB1*1405V2, HLA-DRB1*1406V1."
Juji T., Shimizu M., Kashiwase K., Nakajima F., Tadokoro K., Tanaka H.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB1*14:38; DRB1*14:39; DRB1*14:40; DRB1*14:44; DRB1*14:45 AND DRB1*14:80).
[45]"Novel class II allele."
Lazaro A.M., Cao K., Xiao Y., Lebeck L., Hurley C.K.
Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB1*14:51; DRB1*14:52; DRB1*14:62; DRB1*14:64; DRB1*14:68; DRB1*14:69; DRB1*14:70; DRB1*14:71; DRB1*14:72; DRB1*14:73; DRB1*14:79; DRB1*14:81 AND DRB1*14:83).
[46]"The HLA-DRB1*14New allele has 3 nucleotide changes from the DRB1*1402 allele at positions 286, 298 and 299 of exon 2 where: C286->A286 (codon 72 (CTC->ATC)) resulting in a change of amino acid: Leu->Ile A298->G298 + G299->C299 (codon 76 (AGG->GCG)) resulting in a change of amino acid: Arg->Ala."
Dormoy A., Weschler B.
Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:24).
[47]"A new DR14-related DRB1 allele, identified by sequence-based typing."
Lee T.-D., Chien W.-C.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:84).
Tissue: Peripheral blood.
[48]"PCR-RFLP typing detects new HLA-DRB1 alleles: DRB1*13022, DRB1*1336 and DRB1*1435."
Trejaut J., Kennedy A., Hobart D., Le T., Greville W.D., Ng G., Taverniti A., Dunckley H.
Eur. J. Immunogenet. 28:441-447(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-122 (ALLELE DRB1*14:35).
[49]"Identification of new DRB1*01 (DRB1*01022), DRB1*14 (DRB1*1428) and DRB3* (DRB3*0206) alleles."
Hashemi-Tavoularis S., Couture C., Buyse I.M.
Tissue Antigens 50:89-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DRB1*14:28).
Tissue: Blood.
[50]"Identification of three novel alleles: DRB3*0110, DRB1*1140, and DRB1*140102."
Tavoularis S., Couture C., Ribeiro-Barros E.
Tissue Antigens 63:496-500(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DRB1*14:01).
Tissue: Peripheral blood.
[51]"Confirmatory sequence of HLA class II DRB1*1409 and DRB1*1425."
Vayntrub T., Lo B.
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-123 (ALLELES DRB1*14:09 AND DRB1*14:25).
[52]"HLA class II diversity in Australian aborigines: unusual HLA-DRB1 alleles."
Gao X., Veale A., Serjeantson S.W.
Immunogenetics 36:333-337(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-122 (ALLELE DRB1*14:08).
Tissue: Blood.
[53]"New HLA class II alleles in the Indonesian population."
Panigoro R., Greville W.D., Kennedy A., Trejaut J., Dunckley H.
Tissue Antigens 54:521-523(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-119 (ALLELE DRB1*14:31).
[54]"New HLA class II (DRB1) alleles detected by sequencing-based typing."
Greville W.D., van Eijck A., Dunckley H.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-122 (ALLELE DRB1*14:33).
[55]"Six newly identified HLA-DRB alleles: DRB1*1121, *1419, *1420, *1421, DRB3*0203 and DRB5*0103."
Verduyn W., Anholts J.D., Versluis L.F., Parlevliet J., Drabbels J., De Meester J., Tilanus M.G., Doxiadis I.I., Giphart M.J., Schreuder G.M.
Tissue Antigens 48:80-86(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-116 (ALLELE DRB1*14:20).
[56]Hurley C.K.
Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 42-131 (ALLELE DRB1*14:24).
Tissue: B-cell.
[57]"Confirmatory typing for exon 2 of HLA-DRB1*1416 gene, obtained by sequence-based typing."
Gervais T.G., Latinne D.
Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 43-120 (ALLELE DRB1*14:16).
[58]"Invariant chain structure and MHC class II function."
Cresswell P.
Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[59]"Presentation of antigens by MHC class II molecules: getting the most out of them."
Villadangos J.A.
Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[60]"Autophagy in MHC class II presentation: sampling from within."
Menendez-Benito V., Neefjes J.
Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[61]"MHC class II molecules on the move for successful antigen presentation."
Rocha N., Neefjes J.
EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[62]"MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation."
De Gassart A., Camosseto V., Thibodeau J., Ceppi M., Catalan N., Pierre P., Gatti E.
Proc. Natl. Acad. Sci. U.S.A. 105:3491-3496(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION BY MARCH1, SUBCELLULAR LOCATION.
[63]"MHC class II transport at a glance."
Berger A.C., Roche P.A.
J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[64]"CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."
Beswick E.J., Reyes V.E.
World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB062112 mRNA. Translation: BAB84521.2.
AJ297582 mRNA. Translation: CAC08822.1.
AJ297583 mRNA. Translation: CAC08823.1.
AJ297584 mRNA. Translation: CAC08824.1.
AJ297585 mRNA. Translation: CAC08825.1.
AY663408 Genomic DNA. Translation: AAU88014.1.
AY935719 mRNA. Translation: AAX33315.1.
AY961071 mRNA. Translation: AAX63459.2.
DQ235685 Genomic DNA. Translation: ABB52004.1.
DQ390459 Genomic DNA. Translation: ABD60300.1.
DQ390460 Genomic DNA. Translation: ABD60301.1.
FJ379259 Genomic DNA. Translation: ACJ06537.1.
Z38072 Genomic DNA. Translation: CAA86217.1.
FM196525 Genomic DNA. Translation: CAQ86516.1.
AM109998 Genomic DNA. Translation: CAJ33605.1.
AM109999 Genomic DNA. Translation: CAJ33606.1.
AM110000 Genomic DNA. Translation: CAJ33607.1.
AM110001 Genomic DNA. Translation: CAJ33608.1.
AM110002 Genomic DNA. Translation: CAJ33609.1.
AM110003 Genomic DNA. Translation: CAJ33610.1.
AB485773 Genomic DNA. Translation: BAH23562.1.
Z50730 Genomic DNA. No translation available.
AJ242985 Genomic DNA. Translation: CAB45249.1. Sequence problems.
AJ251985 Genomic DNA. Translation: CAC19086.1.
AY050186 Genomic DNA. Translation: AAL23547.1.
AY054375 mRNA. Translation: AAL15169.1.
AF400066 Genomic DNA. Translation: AAK85431.1.
AY267905 Genomic DNA. Translation: AAP32696.1.
AY267906 Genomic DNA. Translation: AAP32697.1.
AJ969417 Genomic DNA. Translation: CAI94542.1.
AY912075 Genomic DNA. Translation: AAY17288.1.
DQ333353 Genomic DNA. Translation: ABC59115.1.
AM259285 Genomic DNA. Translation: CAJ90660.1.
EF199810 Genomic DNA. Translation: ABM90423.1.
AM774161 Genomic DNA. Translation: CAO81738.1.
EF495154 Genomic DNA. Translation: ABP38039.1.
AM922324 Genomic DNA. Translation: CAP58300.1.
DQ494324 Genomic DNA. Translation: ABF50050.1.
EU588391 Genomic DNA. Translation: ACB97664.1.
D86502 Genomic DNA. Translation: BAA13097.1.
D86504 Genomic DNA. Translation: BAA13099.1.
D88310 Genomic DNA. Translation: BAA13587.1.
AJ010982 Genomic DNA. Translation: CAA09450.1.
AF172071 Genomic DNA. Translation: AAD51970.1.
AJ543433 Genomic DNA. Translation: CAD65908.1.
AY277390 Genomic DNA. Translation: AAP34694.1.
AJ581744 Genomic DNA. Translation: CAE46451.1.
AJ812566 Genomic DNA. Translation: CAH23708.1.
AY770520 Genomic DNA. Translation: AAV37191.1.
DQ021915 Genomic DNA. Translation: AAY85747.1.
AM084908 Genomic DNA. Translation: CAJ29895.1.
DQ327711 Genomic DNA. Translation: ABC59293.1.
DQ358688 Genomic DNA. Translation: ABC84557.1.
AM233907 Genomic DNA. Translation: CAJ80873.1.
DQ643390 Genomic DNA. Translation: ABG25965.1.
U95115 Genomic DNA. Translation: AAB58397.2.
AM933133 Genomic DNA. Translation: CAP69806.1.
EU545181 Genomic DNA. Translation: ACB30275.1.
AB049830 Genomic DNA. Translation: BAB16682.1.
AB049831 Genomic DNA. Translation: BAB16683.1.
AB049832 Genomic DNA. Translation: BAB16684.1.
AB087875 Genomic DNA. Translation: BAC02938.1.
AB087876 Genomic DNA. Translation: BAC02939.1.
AB436778 Genomic DNA. Translation: BAG32234.1.
EF078986 Genomic DNA. Translation: ABK56696.1.
EF536016 Genomic DNA. Translation: ABQ08747.1.
EU029787 Genomic DNA. Translation: ABU86846.1.
EU029788 Genomic DNA. Translation: ABU86847.1.
EU029792 Genomic DNA. Translation: ABU86851.1.
EU029793 Genomic DNA. Translation: ABU86852.1.
EU029798 Genomic DNA. Translation: ABU86857.1.
EU643616 Genomic DNA. Translation: ACD01094.1.
EU812536 Genomic DNA. Translation: ACE88696.1.
EU924810 Genomic DNA. Translation: ACH57405.1.
DQ060439 Genomic DNA. Translation: AAY59541.1.
DQ060441 Genomic DNA. Translation: AAY59543.1.
DQ782331 Genomic DNA. Translation: ABG91054.1.
FM179681 Genomic DNA. Translation: CAQ77159.1.
FJ594768 Genomic DNA. Translation: ACM47962.1.
AF177215 Genomic DNA. Translation: AAD53910.1.
X99839 Genomic DNA. Translation: CAA68150.1.
AJ289123 Genomic DNA. Translation: CAC19015.1.
AY174092 Genomic DNA. Translation: AAO20089.1.
AY174181 Genomic DNA. Translation: AAO17053.1.
M77673 Genomic DNA. Translation: AAA73131.1.
AF028010 Genomic DNA. Translation: AAB94612.1.
AF112879 Genomic DNA. Translation: AAD29584.1.
X86974 Genomic DNA. No translation available.
U41489 Genomic DNA. Translation: AAA86242.1.
AJ508388 Genomic DNA. Translation: CAD48196.1.
PIRB33287.
C33287.
C60748.
F60748.
PH0157.
PH0158.
S03440.
UniGeneHs.485130.
Hs.534322.
Hs.696211.
Hs.716081.
Hs.723344.
Hs.736560.

3D structure databases

ProteinModelPortalQ9GIY3.
SMRQ9GIY3. Positions 34-220.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9GIY3. 1 interaction.

Polymorphism databases

DMDM74761361.

Proteomic databases

PRIDEQ9GIY3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000328980; ENSP00000331343; ENSG00000206306.
ENST00000360004; ENSP00000353099; ENSG00000196126.
ENST00000399450; ENSP00000382378; ENSG00000206240.
ENST00000412634; ENSP00000408795; ENSG00000228080.
ENST00000415796; ENSP00000412168; ENSG00000206306.
ENST00000419393; ENSP00000403458; ENSG00000228080.
ENST00000428566; ENSP00000392280; ENSG00000206240.

Organism-specific databases

GeneCardsGC06M032546.
GC06Mj32477.
GC06Mn32480.
GC06Mo32593.
HGNCHGNC:4948. HLA-DRB1.
HPACAB015400.
CAB034021.
MIM142857. gene.
neXtProtNX_Q9GIY3.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG012730.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressQ9GIY3.
BgeeQ9GIY3.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHLA-DRB1. human.
SOURCESearch...

Entry information

Entry name2B1E_HUMAN
AccessionPrimary (citable) accession number: Q9GIY3
Secondary accession number(s): A0N0W1 expand/collapse secondary AC list , A2TGX3, A4ZY86, A5H000, A5HKN8, A7DZP9, A7X5B1, A7X5B7, A7X5E0, A7X5E6, A7X5H8, A9JPG0, B1GWE7, B2CR03, B2LVF9, B2NJ29, B2ZCY1, B3VTP8, B5B8U0, B5B9V5, B5LZ25, B6VEL9, B9VRA4, B9X248, O02876, O46793, O77969, O78210, Q0PQ39, Q155F7, Q1AP33, Q1JRP3, Q27PR6, Q27PR7, Q29734, Q29770, Q29772, Q29800, Q2A120, Q2HZE5, Q2LE76, Q2MJA6, Q2VQU1, Q307W5, Q31636, Q3LA87, Q3LA88, Q3LA89, Q3LA90, Q3LA91, Q3LA92, Q3T919, Q4PRC3, Q4PRC5, Q4VZY7, Q56FP1, Q5BM92, Q5U9W6, Q683P7, Q70GL2, Q7YNY9, Q7YQA5, Q860D8, Q860D9, Q860S0, Q861H5, Q861H7, Q8MH59, Q8MH60, Q8WLU3, Q95348, Q95HK1, Q95HL0, Q95IG2, Q9GIL5, Q9GIL6, Q9GIY0, Q9GIY1, Q9GIY2, Q9GJ56, Q9GJ57, Q9GJ58, Q9TPB6, Q9TPW1, Q9XRY4, Q9Y4H7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 1, 2001
Last modified: February 19, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM