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Protein

HLA class II histocompatibility antigen, DRB1-14 beta chain

Gene

HLA-DRB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

BioCyciZFISH:G66-33273-MONOMER.
ReactomeiR-HSA-202424. Downstream TCR signaling.
R-HSA-202427. Phosphorylation of CD3 and TCR zeta chains.
R-HSA-202430. Translocation of ZAP-70 to Immunological synapse.
R-HSA-202433. Generation of second messenger molecules.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-389948. PD-1 signaling.
R-HSA-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DRB1-14 beta chain
Alternative name(s):
MHC class II antigen DRB1*14
Short name:
DR-14
Short name:
DR14
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4948. HLA-DRB1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

Pathology & Biotechi

Organism-specific databases

MalaCardsiHLA-DRB1.

Polymorphism and mutation databases

DMDMi74761361.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500006667630 – 266HLA class II histocompatibility antigen, DRB1-14 beta chainAdd BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi146 ↔ 202PROSITE-ProRule annotation
Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PeptideAtlasiQ9GIY3.
PRIDEiQ9GIY3.

Expressioni

Gene expression databases

BgeeiENSG00000196126.
ExpressionAtlasiQ9GIY3. baseline and differential.
GenevisibleiQ9GIY3. HS.

Organism-specific databases

HPAiCAB015400.
CAB034021.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.

Protein-protein interaction databases

IntActiQ9GIY3. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ9GIY3.
SMRiQ9GIY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 214Ig-like C1-typeAdd BLAST89

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012730.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GIY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCLRLPGGS CMAVLTVTLM VLSSPLALAG DTRPRFLEYS TSECHFFNGT
60 70 80 90 100
ERVRFLDRYF HNQEEFVRFD SDVGEYRAVT ELGRPAAEHW NSQKDLLERR
110 120 130 140 150
RAEVDTYCRH NYGVVESFTV QRRVHPKVTV YPSKTQPLQH YNLLVCSVSG
160 170 180 190 200
FYPGSIEVRW FRNGQEEKTG VVSTGLIHNG DWTFQTLVML ETVPRSGEVY
210 220 230 240 250
TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF
260
RNQKGHSGLQ PRGFLS
Length:266
Mass (Da):30,139
Last modified:March 1, 2001 - v1
Checksum:iFA4BE90DFAB4FA55
GO

Sequence cautioni

The sequence CAB45249 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124V → G in BAH23562 (Ref. 10) Curated1

Polymorphismi

The following alleles of DRB1-14 are known: DRB1*14:01, DRB1*14:02, DRB1*14:03, DRB1*14:04, DRB1*14:05, DRB1*14:06, DRB1*14:07, DRB1*14:08, DRB1*14:09, DRB1*14:10, DRB1*14:11, DRB1*14:12, DRB1*14:13, DRB1*14:14, DRB1*14:15, DRB1*14:16, DRB1*14:17, DRB1*14:18, DRB1*14:19, DRB1*14:20, DRB1*14:21, DRB1*14:22, DRB1*14:23, DRB1*14:24, DRB1*14:25, DRB1*14:26, DRB1*14:27, DRB1*14:28, DRB1*14:29, DRB1*14:30, DRB1*14:31, DRB1*14:32, DRB1*14:33, DRB1*14:34, DRB1*14:35, DRB1*14:36, DRB1*14:37, DRB1*14:38, DRB1*14:39, DRB1*14:40, DRB1*14:41, DRB1*14:42, DRB1*14:43, DRB1*14:44, DRB1*14:45, DRB1*14:46, DRB1*14:47, DRB1*14:48, DRB1*14:49, DRB1*14:50, DRB1*14:51, DRB1*14:52, DRB1*14:53, DRB1*14:54, DRB1*14:55, DRB1*14:56, DRB1*14:57, DRB1*14:58, DRB1*14:59, DRB1*14:60, DRB1*14:61, DRB1*14:62, DRB1*14:63, DRB1*14:64, DRB1*14:65, DRB1*14:67, DRB1*14:68, DRB1*14:69, DRB1*14:70, DRB1*14:71, DRB1*14:72, DRB1*14:73, DRB1*14:74, DRB1*14:75, DRB1*14:76, DRB1*14:77, DRB1*14:78, DRB1*14:79, DRB1*14:80, DRB1*14:81, DRB1*14:82, DRB1*14:83, DRB1*14:84 and DRB1*14:85. The sequence shown is that of DRB1*14:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06290739Y → L in allele DRB1*14:46; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06290639Y → Q in allele DRB1*14:10 and allele DRB1*14:57; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06291040S → P in allele DRB1*14:39. 1
Natural variantiVAR_06290840S → R in allele DRB1*14:46. 1
Natural variantiVAR_06290940S → V in allele DRB1*14:10 and allele DRB1*14:57; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06291141T → K in allele DRB1*14:10, allele DRB1*14:46 and allele DRB1*14:57. 1
Natural variantiVAR_06291342S → G in allele DRB1*14:04, allele DRB1*14:11, allele DRB1*14:15, allele DRB1*14:28, allele DRB1*14:31, allele DRB1*14:50, allele DRB1*14:52, allele DRB1*14:61, allele DRB1*14:68, allele DRB1*14:71, allele DRB1*14:73, allele DRB1*14:76 and allele DRB1*14:79. 1
Natural variantiVAR_06291242S → H in allele DRB1*14:10 and allele DRB1*14:57; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06291545H → Q in allele DRB1*14:05, allele DRB1*14:37, allele DRB1*14:43, allele DRB1*14:44, allele DRB1*14:45, allele DRB1*14:56 and allele DRB1*14:84. 1
Natural variantiVAR_06291445H → Y in allele DRB1*14:04, allele DRB1*14:11, allele DRB1*14:15, allele DRB1*14:28, allele DRB1*14:31, allele DRB1*14:50, allele DRB1*14:52, allele DRB1*14:68, allele DRB1*14:71, allele DRB1*14:73, allele DRB1*14:76 and allele DRB1*14:79. 1
Natural variantiVAR_06291654R → Q in allele DRB1*14:26. 1
Natural variantiVAR_06291755F → Y in allele DRB1*14:82. 1
Natural variantiVAR_06291856L → M in allele DRB1*14:83. 1
Natural variantiVAR_06291957D → E in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:06, allele DRB1*14:12, allele DRB1*14:13, allele DRB1*14:18, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:24, allele DRB1*14:27, allele DRB1*14:29, allele DRB1*14:40, allele DRB1*14:41, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:49, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:63, allele DRB1*14:67, allele DRB1*14:77, allele DRB1*14:78, allele DRB1*14:81, allele DRB1*14:83 and allele DRB1*14:85. 1
Natural variantiVAR_06292059Y → H in allele DRB1*14:70. 1
Natural variantiVAR_06292161H → Y in allele DRB1*14:25, allele DRB1*14:42, allele DRB1*14:53, allele DRB1*14:58 and allele DRB1*14:69. 1
Natural variantiVAR_06292366F → N in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:06, allele DRB1*14:09, allele DRB1*14:12, allele DRB1*14:13, allele DRB1*14:17, allele DRB1*14:18, allele DRB1*14:19, allele DRB1*14:21, allele DRB1*14:24, allele DRB1*14:27, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:59, allele DRB1*14:63, allele DRB1*14:64, allele DRB1*14:67, allele DRB1*14:78, allele DRB1*14:80, allele DRB1*14:81, allele DRB1*14:83 and allele DRB1*14:85; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06292266F → Y in allele DRB1*14:25, allele DRB1*14:42, allele DRB1*14:53, allele DRB1*14:58 and allele DRB1*14:69. 1
Natural variantiVAR_06292467V → L in allele DRB1*14:41 and allele DRB1*14:77. 1
Natural variantiVAR_06292574G → R in allele DRB1*14:36 and allele DRB1*14:60. 1
Natural variantiVAR_06292676Y → F in allele DRB1*14:17, allele DRB1*14:21, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:35, allele DRB1*14:42, allele DRB1*14:53, allele DRB1*14:64, allele DRB1*14:65 and allele DRB1*14:72. 1
Natural variantiVAR_06292780T → R in allele DRB1*14:59. 1
Natural variantiVAR_06292886A → D in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:05, allele DRB1*14:06, allele DRB1*14:08, allele DRB1*14:09, allele DRB1*14:11, allele DRB1*14:12, allele DRB1*14:14, allele DRB1*14:15, allele DRB1*14:17, allele DRB1*14:18, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:21, allele DRB1*14:23, allele DRB1*14:24, allele DRB1*14:27, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:34, allele DRB1*14:36, allele DRB1*14:37, allele DRB1*14:40, allele DRB1*14:41, allele DRB1*14:42, allele DRB1*14:43, allele DRB1*14:44, allele DRB1*14:45, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:56, allele DRB1*14:59, allele DRB1*14:64, allele DRB1*14:67, allele DRB1*14:72, allele DRB1*14:77, allele DRB1*14:80, allele DRB1*14:81, allele DRB1*14:83 and allele DRB1*14:84. 1
Natural variantiVAR_06292986A → S in allele DRB1*14:13, allele DRB1*14:63, allele DRB1*14:65, allele DRB1*14:78 and allele DRB1*14:85. 1
Natural variantiVAR_06293086A → T in allele DRB1*14:62. 1
Natural variantiVAR_06293186A → V in allele DRB1*14:48. 1
Natural variantiVAR_06293287A → E in allele DRB1*14:11. 1
Natural variantiVAR_06293489H → S in allele DRB1*14:48 and allele DRB1*14:64; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06293389H → Y in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:05, allele DRB1*14:06, allele DRB1*14:09, allele DRB1*14:11, allele DRB1*14:12, allele DRB1*14:13, allele DRB1*14:14, allele DRB1*14:15, allele DRB1*14:17, allele DRB1*14:18, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:21, allele DRB1*14:23, allele DRB1*14:24, allele DRB1*14:27, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:36, allele DRB1*14:37, allele DRB1*14:40, allele DRB1*14:41, allele DRB1*14:42, allele DRB1*14:43, allele DRB1*14:44, allele DRB1*14:45, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:56, allele DRB1*14:57, allele DRB1*14:59, allele DRB1*14:63, allele DRB1*14:65, allele DRB1*14:67, allele DRB1*14:76, allele DRB1*14:77, allele DRB1*14:78, allele DRB1*14:80, allele DRB1*14:81, allele DRB1*14:83, allele DRB1*14:84 and allele DRB1*14:85. 1
Natural variantiVAR_06293596L → F in allele DRB1*14:15, allele DRB1*14:22, allele DRB1*14:25, allele DRB1*14:27, allele DRB1*14:53 and allele DRB1*14:73. 1
Natural variantiVAR_06293696L → I in allele DRB1*14:16, allele DRB1*14:24, allele DRB1*14:37, allele DRB1*14:45, allele DRB1*14:57, allele DRB1*14:63, allele DRB1*14:67 and allele DRB1*14:78. 1
Natural variantiVAR_06293899R → D in allele DRB1*14:03, allele DRB1*14:12, allele DRB1*14:15, allele DRB1*14:16, allele DRB1*14:22, allele DRB1*14:25, allele DRB1*14:27, allele DRB1*14:40, allele DRB1*14:53, allele DRB1*14:57, allele DRB1*14:63, allele DRB1*14:67, allele DRB1*14:69, allele DRB1*14:73, allele DRB1*14:74, allele DRB1*14:77, allele DRB1*14:78, allele DRB1*14:84 and allele DRB1*14:85; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06293799R → Q in allele DRB1*14:02, allele DRB1*14:06, allele DRB1*14:09, allele DRB1*14:13, allele DRB1*14:17, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:21, allele DRB1*14:24, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:37, allele DRB1*14:41, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:49, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:76, allele DRB1*14:79, allele DRB1*14:80 and allele DRB1*14:83. 1
Natural variantiVAR_062941100R → A in allele DRB1*14:24 and allele DRB1*14:37; requires 2 nucleotide substitutions. 1
Natural variantiVAR_062940100R → E in allele DRB1*14:16 and allele DRB1*14:57; requires 2 nucleotide substitutions. 1
Natural variantiVAR_062939100R → K in allele DRB1*14:19, allele DRB1*14:21, allele DRB1*14:76 and allele DRB1*14:79. 1
Natural variantiVAR_062943102A → G in allele DRB1*14:76 and allele DRB1*14:79. 1
Natural variantiVAR_062942102A → S in allele DRB1*14:56. 1
Natural variantiVAR_062944103E → A in allele DRB1*14:02, allele DRB1*14:06, allele DRB1*14:09, allele DRB1*14:13, allele DRB1*14:16, allele DRB1*14:17, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:21, allele DRB1*14:22, allele DRB1*14:24, allele DRB1*14:25, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:31, allele DRB1*14:32, allele DRB1*14:34, allele DRB1*14:37, allele DRB1*14:41, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:49, allele DRB1*14:52, allele DRB1*14:53, allele DRB1*14:57, allele DRB1*14:65, allele DRB1*14:69, allele DRB1*14:74, allele DRB1*14:80, allele DRB1*14:81 and allele DRB1*14:83. 1
Natural variantiVAR_062945103E → L in allele DRB1*14:03, allele DRB1*14:12, allele DRB1*14:15, allele DRB1*14:27, allele DRB1*14:40, allele DRB1*14:55, allele DRB1*14:63, allele DRB1*14:67, allele DRB1*14:77, allele DRB1*14:78, allele DRB1*14:84 and allele DRB1*14:85; requires 2 nucleotide substitutions. 1
Natural variantiVAR_062946103E → R in allele DRB1*14:76 and allele DRB1*14:79; requires 2 nucleotide substitutions. 1
Natural variantiVAR_062948106T → A in allele DRB1*14:43. 1
Natural variantiVAR_062947106T → N in allele DRB1*14:38, allele DRB1*14:47, allele DRB1*14:50, allele DRB1*14:76 and allele DRB1*14:79. 1
Natural variantiVAR_062949110H → Y in allele DRB1*14:75. 1
Natural variantiVAR_062950114V → A in allele DRB1*14:28 and allele DRB1*14:29. 1
Natural variantiVAR_062951115V → G in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:07, allele DRB1*14:09, allele DRB1*14:13, allele DRB1*14:14, allele DRB1*14:19, allele DRB1*14:22, allele DRB1*14:24, allele DRB1*14:25, allele DRB1*14:27, allele DRB1*14:30, allele DRB1*14:36, allele DRB1*14:40, allele DRB1*14:41, allele DRB1*14:42, allele DRB1*14:44, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:49, allele DRB1*14:51, allele DRB1*14:53, allele DRB1*14:63, allele DRB1*14:67, allele DRB1*14:68, allele DRB1*14:69, allele DRB1*14:77 and allele DRB1*14:85. 1
Natural variantiVAR_062952115V → M in allele DRB1*14:71. 1
Natural variantiVAR_062953141Y → H in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:04, allele DRB1*14:05, allele DRB1*14:06, allele DRB1*14:07, allele DRB1*14:10, allele DRB1*14:11, allele DRB1*14:13, allele DRB1*14:14, allele DRB1*14:21, allele DRB1*14:46, allele DRB1*14:54, allele DRB1*14:57 and allele DRB1*14:82. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062112 mRNA. Translation: BAB84521.2.
AJ297582 mRNA. Translation: CAC08822.1.
AJ297583 mRNA. Translation: CAC08823.1.
AJ297584 mRNA. Translation: CAC08824.1.
AJ297585 mRNA. Translation: CAC08825.1.
AY663408 Genomic DNA. Translation: AAU88014.1.
AY935719 mRNA. Translation: AAX33315.1.
AY961071 mRNA. Translation: AAX63459.2.
DQ235685 Genomic DNA. Translation: ABB52004.1.
DQ390459 Genomic DNA. Translation: ABD60300.1.
DQ390460 Genomic DNA. Translation: ABD60301.1.
FJ379259 Genomic DNA. Translation: ACJ06537.1.
Z38072 Genomic DNA. Translation: CAA86217.1.
FM196525 Genomic DNA. Translation: CAQ86516.1.
AM109998 Genomic DNA. Translation: CAJ33605.1.
AM109999 Genomic DNA. Translation: CAJ33606.1.
AM110000 Genomic DNA. Translation: CAJ33607.1.
AM110001 Genomic DNA. Translation: CAJ33608.1.
AM110002 Genomic DNA. Translation: CAJ33609.1.
AM110003 Genomic DNA. Translation: CAJ33610.1.
AB485773 Genomic DNA. Translation: BAH23562.1.
Z50730 Genomic DNA. No translation available.
AJ242985 Genomic DNA. Translation: CAB45249.1. Sequence problems.
AJ251985 Genomic DNA. Translation: CAC19086.1.
AY050186 Genomic DNA. Translation: AAL23547.1.
AY054375 mRNA. Translation: AAL15169.1.
AF400066 Genomic DNA. Translation: AAK85431.1.
AY267905 Genomic DNA. Translation: AAP32696.1.
AY267906 Genomic DNA. Translation: AAP32697.1.
AJ969417 Genomic DNA. Translation: CAI94542.1.
AY912075 Genomic DNA. Translation: AAY17288.1.
DQ333353 Genomic DNA. Translation: ABC59115.1.
AM259285 Genomic DNA. Translation: CAJ90660.1.
EF199810 Genomic DNA. Translation: ABM90423.1.
AM774161 Genomic DNA. Translation: CAO81738.1.
EF495154 Genomic DNA. Translation: ABP38039.1.
AM922324 Genomic DNA. Translation: CAP58300.1.
DQ494324 Genomic DNA. Translation: ABF50050.1.
EU588391 Genomic DNA. Translation: ACB97664.1.
D86502 Genomic DNA. Translation: BAA13097.1.
D86504 Genomic DNA. Translation: BAA13099.1.
D88310 Genomic DNA. Translation: BAA13587.1.
AJ010982 Genomic DNA. Translation: CAA09450.1.
AF172071 Genomic DNA. Translation: AAD51970.1.
AJ543433 Genomic DNA. Translation: CAD65908.1.
AY277390 Genomic DNA. Translation: AAP34694.1.
AJ581744 Genomic DNA. Translation: CAE46451.1.
AJ812566 Genomic DNA. Translation: CAH23708.1.
AY770520 Genomic DNA. Translation: AAV37191.1.
DQ021915 Genomic DNA. Translation: AAY85747.1.
AM084908 Genomic DNA. Translation: CAJ29895.1.
DQ327711 Genomic DNA. Translation: ABC59293.1.
DQ358688 Genomic DNA. Translation: ABC84557.1.
AM233907 Genomic DNA. Translation: CAJ80873.1.
DQ643390 Genomic DNA. Translation: ABG25965.1.
U95115 Genomic DNA. Translation: AAB58397.2.
AM933133 Genomic DNA. Translation: CAP69806.1.
EU545181 Genomic DNA. Translation: ACB30275.1.
AB049830 Genomic DNA. Translation: BAB16682.1.
AB049831 Genomic DNA. Translation: BAB16683.1.
AB049832 Genomic DNA. Translation: BAB16684.1.
AB087875 Genomic DNA. Translation: BAC02938.1.
AB087876 Genomic DNA. Translation: BAC02939.1.
AB436778 Genomic DNA. Translation: BAG32234.1.
EF078986 Genomic DNA. Translation: ABK56696.1.
EF536016 Genomic DNA. Translation: ABQ08747.1.
EU029787 Genomic DNA. Translation: ABU86846.1.
EU029788 Genomic DNA. Translation: ABU86847.1.
EU029792 Genomic DNA. Translation: ABU86851.1.
EU029793 Genomic DNA. Translation: ABU86852.1.
EU029798 Genomic DNA. Translation: ABU86857.1.
EU643616 Genomic DNA. Translation: ACD01094.1.
EU812536 Genomic DNA. Translation: ACE88696.1.
EU924810 Genomic DNA. Translation: ACH57405.1.
DQ060439 Genomic DNA. Translation: AAY59541.1.
DQ060441 Genomic DNA. Translation: AAY59543.1.
DQ782331 Genomic DNA. Translation: ABG91054.1.
FM179681 Genomic DNA. Translation: CAQ77159.1.
FJ594768 Genomic DNA. Translation: ACM47962.1.
AF177215 Genomic DNA. Translation: AAD53910.1.
X99839 Genomic DNA. Translation: CAA68150.1.
AJ289123 Genomic DNA. Translation: CAC19015.1.
AY174092 Genomic DNA. Translation: AAO20089.1.
AY174181 Genomic DNA. Translation: AAO17053.1.
M77673 Genomic DNA. Translation: AAA73131.1.
AF028010 Genomic DNA. Translation: AAB94612.1.
AF112879 Genomic DNA. Translation: AAD29584.1.
X86974 Genomic DNA. No translation available.
U41489 Genomic DNA. Translation: AAA86242.1.
AJ508388 Genomic DNA. Translation: CAD48196.1.
PIRiB33287.
C33287.
C60748.
F60748.
PH0157.
PH0158.
S03440.
UniGeneiHs.485130.
Hs.534322.
Hs.696211.
Hs.716081.
Hs.723344.
Hs.736560.

Genome annotation databases

EnsembliENST00000328980; ENSP00000331343; ENSG00000206306.
ENST00000360004; ENSP00000353099; ENSG00000196126.
ENST00000399450; ENSP00000382378; ENSG00000206240.
ENST00000412634; ENSP00000408795; ENSG00000228080.
ENST00000415796; ENSP00000412168; ENSG00000206306.
ENST00000419393; ENSP00000403458; ENSG00000228080.
ENST00000428566; ENSP00000392280; ENSG00000206240.
UCSCiuc063uqx.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062112 mRNA. Translation: BAB84521.2.
AJ297582 mRNA. Translation: CAC08822.1.
AJ297583 mRNA. Translation: CAC08823.1.
AJ297584 mRNA. Translation: CAC08824.1.
AJ297585 mRNA. Translation: CAC08825.1.
AY663408 Genomic DNA. Translation: AAU88014.1.
AY935719 mRNA. Translation: AAX33315.1.
AY961071 mRNA. Translation: AAX63459.2.
DQ235685 Genomic DNA. Translation: ABB52004.1.
DQ390459 Genomic DNA. Translation: ABD60300.1.
DQ390460 Genomic DNA. Translation: ABD60301.1.
FJ379259 Genomic DNA. Translation: ACJ06537.1.
Z38072 Genomic DNA. Translation: CAA86217.1.
FM196525 Genomic DNA. Translation: CAQ86516.1.
AM109998 Genomic DNA. Translation: CAJ33605.1.
AM109999 Genomic DNA. Translation: CAJ33606.1.
AM110000 Genomic DNA. Translation: CAJ33607.1.
AM110001 Genomic DNA. Translation: CAJ33608.1.
AM110002 Genomic DNA. Translation: CAJ33609.1.
AM110003 Genomic DNA. Translation: CAJ33610.1.
AB485773 Genomic DNA. Translation: BAH23562.1.
Z50730 Genomic DNA. No translation available.
AJ242985 Genomic DNA. Translation: CAB45249.1. Sequence problems.
AJ251985 Genomic DNA. Translation: CAC19086.1.
AY050186 Genomic DNA. Translation: AAL23547.1.
AY054375 mRNA. Translation: AAL15169.1.
AF400066 Genomic DNA. Translation: AAK85431.1.
AY267905 Genomic DNA. Translation: AAP32696.1.
AY267906 Genomic DNA. Translation: AAP32697.1.
AJ969417 Genomic DNA. Translation: CAI94542.1.
AY912075 Genomic DNA. Translation: AAY17288.1.
DQ333353 Genomic DNA. Translation: ABC59115.1.
AM259285 Genomic DNA. Translation: CAJ90660.1.
EF199810 Genomic DNA. Translation: ABM90423.1.
AM774161 Genomic DNA. Translation: CAO81738.1.
EF495154 Genomic DNA. Translation: ABP38039.1.
AM922324 Genomic DNA. Translation: CAP58300.1.
DQ494324 Genomic DNA. Translation: ABF50050.1.
EU588391 Genomic DNA. Translation: ACB97664.1.
D86502 Genomic DNA. Translation: BAA13097.1.
D86504 Genomic DNA. Translation: BAA13099.1.
D88310 Genomic DNA. Translation: BAA13587.1.
AJ010982 Genomic DNA. Translation: CAA09450.1.
AF172071 Genomic DNA. Translation: AAD51970.1.
AJ543433 Genomic DNA. Translation: CAD65908.1.
AY277390 Genomic DNA. Translation: AAP34694.1.
AJ581744 Genomic DNA. Translation: CAE46451.1.
AJ812566 Genomic DNA. Translation: CAH23708.1.
AY770520 Genomic DNA. Translation: AAV37191.1.
DQ021915 Genomic DNA. Translation: AAY85747.1.
AM084908 Genomic DNA. Translation: CAJ29895.1.
DQ327711 Genomic DNA. Translation: ABC59293.1.
DQ358688 Genomic DNA. Translation: ABC84557.1.
AM233907 Genomic DNA. Translation: CAJ80873.1.
DQ643390 Genomic DNA. Translation: ABG25965.1.
U95115 Genomic DNA. Translation: AAB58397.2.
AM933133 Genomic DNA. Translation: CAP69806.1.
EU545181 Genomic DNA. Translation: ACB30275.1.
AB049830 Genomic DNA. Translation: BAB16682.1.
AB049831 Genomic DNA. Translation: BAB16683.1.
AB049832 Genomic DNA. Translation: BAB16684.1.
AB087875 Genomic DNA. Translation: BAC02938.1.
AB087876 Genomic DNA. Translation: BAC02939.1.
AB436778 Genomic DNA. Translation: BAG32234.1.
EF078986 Genomic DNA. Translation: ABK56696.1.
EF536016 Genomic DNA. Translation: ABQ08747.1.
EU029787 Genomic DNA. Translation: ABU86846.1.
EU029788 Genomic DNA. Translation: ABU86847.1.
EU029792 Genomic DNA. Translation: ABU86851.1.
EU029793 Genomic DNA. Translation: ABU86852.1.
EU029798 Genomic DNA. Translation: ABU86857.1.
EU643616 Genomic DNA. Translation: ACD01094.1.
EU812536 Genomic DNA. Translation: ACE88696.1.
EU924810 Genomic DNA. Translation: ACH57405.1.
DQ060439 Genomic DNA. Translation: AAY59541.1.
DQ060441 Genomic DNA. Translation: AAY59543.1.
DQ782331 Genomic DNA. Translation: ABG91054.1.
FM179681 Genomic DNA. Translation: CAQ77159.1.
FJ594768 Genomic DNA. Translation: ACM47962.1.
AF177215 Genomic DNA. Translation: AAD53910.1.
X99839 Genomic DNA. Translation: CAA68150.1.
AJ289123 Genomic DNA. Translation: CAC19015.1.
AY174092 Genomic DNA. Translation: AAO20089.1.
AY174181 Genomic DNA. Translation: AAO17053.1.
M77673 Genomic DNA. Translation: AAA73131.1.
AF028010 Genomic DNA. Translation: AAB94612.1.
AF112879 Genomic DNA. Translation: AAD29584.1.
X86974 Genomic DNA. No translation available.
U41489 Genomic DNA. Translation: AAA86242.1.
AJ508388 Genomic DNA. Translation: CAD48196.1.
PIRiB33287.
C33287.
C60748.
F60748.
PH0157.
PH0158.
S03440.
UniGeneiHs.485130.
Hs.534322.
Hs.696211.
Hs.716081.
Hs.723344.
Hs.736560.

3D structure databases

ProteinModelPortaliQ9GIY3.
SMRiQ9GIY3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9GIY3. 1 interactor.

Polymorphism and mutation databases

DMDMi74761361.

Proteomic databases

PeptideAtlasiQ9GIY3.
PRIDEiQ9GIY3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328980; ENSP00000331343; ENSG00000206306.
ENST00000360004; ENSP00000353099; ENSG00000196126.
ENST00000399450; ENSP00000382378; ENSG00000206240.
ENST00000412634; ENSP00000408795; ENSG00000228080.
ENST00000415796; ENSP00000412168; ENSG00000206306.
ENST00000419393; ENSP00000403458; ENSG00000228080.
ENST00000428566; ENSP00000392280; ENSG00000206240.
UCSCiuc063uqx.1. human.

Organism-specific databases

GeneCardsiHLA-DRB1.
HGNCiHGNC:4948. HLA-DRB1.
HPAiCAB015400.
CAB034021.
MalaCardsiHLA-DRB1.
MIMi142857. gene.
neXtProtiNX_Q9GIY3.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG012730.

Enzyme and pathway databases

BioCyciZFISH:G66-33273-MONOMER.
ReactomeiR-HSA-202424. Downstream TCR signaling.
R-HSA-202427. Phosphorylation of CD3 and TCR zeta chains.
R-HSA-202430. Translocation of ZAP-70 to Immunological synapse.
R-HSA-202433. Generation of second messenger molecules.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-389948. PD-1 signaling.
R-HSA-877300. Interferon gamma signaling.

Miscellaneous databases

ChiTaRSiHLA-DRB1. human.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196126.
ExpressionAtlasiQ9GIY3. baseline and differential.
GenevisibleiQ9GIY3. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei2B1E_HUMAN
AccessioniPrimary (citable) accession number: Q9GIY3
Secondary accession number(s): A0N0W1
, A2TGX3, A4ZY86, A5H000, A5HKN8, A7DZP9, A7X5B1, A7X5B7, A7X5E0, A7X5E6, A7X5H8, A9JPG0, B1GWE7, B2CR03, B2LVF9, B2NJ29, B2ZCY1, B3VTP8, B5B8U0, B5B9V5, B5LZ25, B6VEL9, B9VRA4, B9X248, O02876, O46793, O77969, O78210, Q0PQ39, Q155F7, Q1AP33, Q1JRP3, Q27PR6, Q27PR7, Q29734, Q29770, Q29772, Q29800, Q2A120, Q2HZE5, Q2LE76, Q2MJA6, Q2VQU1, Q307W5, Q31636, Q3LA87, Q3LA88, Q3LA89, Q3LA90, Q3LA91, Q3LA92, Q3T919, Q4PRC3, Q4PRC5, Q4VZY7, Q56FP1, Q5BM92, Q5U9W6, Q683P7, Q70GL2, Q7YNY9, Q7YQA5, Q860D8, Q860D9, Q860S0, Q861H5, Q861H7, Q8MH59, Q8MH60, Q8WLU3, Q95348, Q95HK1, Q95HL0, Q95IG2, Q9GIL5, Q9GIL6, Q9GIY0, Q9GIY1, Q9GIY2, Q9GJ56, Q9GJ57, Q9GJ58, Q9TPB6, Q9TPW1, Q9XRY4, Q9Y4H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.