Q9GIY3 (2B1E_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HLA class II histocompatibility antigen, DRB1-14 beta chain

Alternative name(s):
MHC class II antigen DRB1*14
Short name=DR-14
Short name=DR14

Gene names

Name:

HLA-DRB1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
Subunit structure	Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.
Subcellular location	Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus › trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. Ref.62
Post-translational modification	Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II Probable. Ref.62
Polymorphism	The following alleles of DRB1-14 are known: DRB1*14:01, DRB1*14:02, DRB1*14:03, DRB1*14:04, DRB1*14:05, DRB1*14:06, DRB1*14:07, DRB1*14:08, DRB1*14:09, DRB1*14:10, DRB1*14:11, DRB1*14:12, DRB1*14:13, DRB1*14:14, DRB1*14:15, DRB1*14:16, DRB1*14:17, DRB1*14:18, DRB1*14:19, DRB1*14:20, DRB1*14:21, DRB1*14:22, DRB1*14:23, DRB1*14:24, DRB1*14:25, DRB1*14:26, DRB1*14:27, DRB1*14:28, DRB1*14:29, DRB1*14:30, DRB1*14:31, DRB1*14:32, DRB1*14:33, DRB1*14:34, DRB1*14:35, DRB1*14:36, DRB1*14:37, DRB1*14:38, DRB1*14:39, DRB1*14:40, DRB1*14:41, DRB1*14:42, DRB1*14:43, DRB1*14:44, DRB1*14:45, DRB1*14:46, DRB1*14:47, DRB1*14:48, DRB1*14:49, DRB1*14:50, DRB1*14:51, DRB1*14:52, DRB1*14:53, DRB1*14:54, DRB1*14:55, DRB1*14:56, DRB1*14:57, DRB1*14:58, DRB1*14:59, DRB1*14:60, DRB1*14:61, DRB1*14:62, DRB1*14:63, DRB1*14:64, DRB1*14:65, DRB1*14:67, DRB1*14:68, DRB1*14:69, DRB1*14:70, DRB1*14:71, DRB1*14:72, DRB1*14:73, DRB1*14:74, DRB1*14:75, DRB1*14:76, DRB1*14:77, DRB1*14:78, DRB1*14:79, DRB1*14:80, DRB1*14:81, DRB1*14:82, DRB1*14:83, DRB1*14:84 and DRB1*14:85. The sequence shown is that of DRB1*14:01.
Sequence similarities	Belongs to the MHC class II family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Sequence caution	The sequence CAB45249.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Immunity
Cellular component	Cell membrane Endoplasmic reticulum Endosome Golgi apparatus Lysosome MHC II Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Isopeptide bond Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell costimulation Traceable author statement. Source: Reactome T cell receptor signaling pathway Traceable author statement. Source: Reactome antigen processing and presentation of exogenous peptide antigen via MHC class II Traceable author statement. Source: Reactome interferon-gamma-mediated signaling pathway Traceable author statement. Source: Reactome
Cellular_component	ER to Golgi transport vesicle membrane Traceable author statement. Source: Reactome Golgi membrane Traceable author statement. Source: Reactome MHC class II protein complex Inferred from electronic annotation. Source: UniProtKB-KW clathrin-coated endocytic vesicle membrane Traceable author statement. Source: Reactome integral to lumenal side of endoplasmic reticulum membrane Traceable author statement. Source: Reactome late endosome membrane Inferred from direct assay Ref.62. Source: UniProtKB lysosomal membrane Inferred from direct assay Ref.62. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome trans-Golgi network membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 266	237	HLA class II histocompatibility antigen, DRB1-14 beta chain		PRO_5000066676
Regions
	Transmembrane	228 – 248	21	Helical; Potential
	Domain	126 – 214	89	Ig-like C1-type
Amino acid modifications
	Glycosylation	48	1	N-linked (GlcNAc...) Potential
	Disulfide bond	146 ↔ 202		By similarity
	Cross-link	254		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Natural variations
	Natural variant	39	1	Y → L in allele DRB1*14:46; requires 2 nucleotide substitutions.		VAR_062907
	Natural variant	39	1	Y → Q in allele DRB1*14:10 and allele DRB1*14:57; requires 2 nucleotide substitutions.		VAR_062906
	Natural variant	40	1	S → P in allele DRB1*14:39.		VAR_062910
	Natural variant	40	1	S → R in allele DRB1*14:46.		VAR_062908
	Natural variant	40	1	S → V in allele DRB1*14:10 and allele DRB1*14:57; requires 2 nucleotide substitutions.		VAR_062909
	Natural variant	41	1	T → K in allele DRB1*14:10, allele DRB1*14:46 and allele DRB1*14:57.		VAR_062911
	Natural variant	42	1	S → G in allele DRB1*14:04, allele DRB1*14:11, allele DRB1*14:15, allele DRB1*14:28, allele DRB1*14:31, allele DRB1*14:50, allele DRB1*14:52, allele DRB1*14:61, allele DRB1*14:68, allele DRB1*14:71, allele DRB1*14:73, allele DRB1*14:76 and allele DRB1*14:79.		VAR_062913
	Natural variant	42	1	S → H in allele DRB1*14:10 and allele DRB1*14:57; requires 2 nucleotide substitutions.		VAR_062912
	Natural variant	45	1	H → Q in allele DRB1*14:05, allele DRB1*14:37, allele DRB1*14:43, allele DRB1*14:44, allele DRB1*14:45, allele DRB1*14:56 and allele DRB1*14:84.		VAR_062915
	Natural variant	45	1	H → Y in allele DRB1*14:04, allele DRB1*14:11, allele DRB1*14:15, allele DRB1*14:28, allele DRB1*14:31, allele DRB1*14:50, allele DRB1*14:52, allele DRB1*14:68, allele DRB1*14:71, allele DRB1*14:73, allele DRB1*14:76 and allele DRB1*14:79.		VAR_062914
	Natural variant	54	1	R → Q in allele DRB1*14:26.		VAR_062916
	Natural variant	55	1	F → Y in allele DRB1*14:82.		VAR_062917
	Natural variant	56	1	L → M in allele DRB1*14:83.		VAR_062918
	Natural variant	57	1	D → E in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:06, allele DRB1*14:12, allele DRB1*14:13, allele DRB1*14:18, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:24, allele DRB1*14:27, allele DRB1*14:29, allele DRB1*14:40, allele DRB1*14:41, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:49, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:63, allele DRB1*14:67, allele DRB1*14:77, allele DRB1*14:78, allele DRB1*14:81, allele DRB1*14:83 and allele DRB1*14:85.		VAR_062919
	Natural variant	59	1	Y → H in allele DRB1*14:70.		VAR_062920
	Natural variant	61	1	H → Y in allele DRB1*14:25, allele DRB1*14:42, allele DRB1*14:53, allele DRB1*14:58 and allele DRB1*14:69.		VAR_062921
	Natural variant	66	1	F → N in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:06, allele DRB1*14:09, allele DRB1*14:12, allele DRB1*14:13, allele DRB1*14:17, allele DRB1*14:18, allele DRB1*14:19, allele DRB1*14:21, allele DRB1*14:24, allele DRB1*14:27, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:59, allele DRB1*14:63, allele DRB1*14:64, allele DRB1*14:67, allele DRB1*14:78, allele DRB1*14:80, allele DRB1*14:81, allele DRB1*14:83 and allele DRB1*14:85; requires 2 nucleotide substitutions.		VAR_062923
	Natural variant	66	1	F → Y in allele DRB1*14:25, allele DRB1*14:42, allele DRB1*14:53, allele DRB1*14:58 and allele DRB1*14:69.		VAR_062922
	Natural variant	67	1	V → L in allele DRB1*14:41 and allele DRB1*14:77.		VAR_062924
	Natural variant	74	1	G → R in allele DRB1*14:36 and allele DRB1*14:60.		VAR_062925
	Natural variant	76	1	Y → F in allele DRB1*14:17, allele DRB1*14:21, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:35, allele DRB1*14:42, allele DRB1*14:53, allele DRB1*14:64, allele DRB1*14:65 and allele DRB1*14:72.		VAR_062926
	Natural variant	80	1	T → R in allele DRB1*14:59.		VAR_062927
	Natural variant	86	1	A → D in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:05, allele DRB1*14:06, allele DRB1*14:08, allele DRB1*14:09, allele DRB1*14:11, allele DRB1*14:12, allele DRB1*14:14, allele DRB1*14:15, allele DRB1*14:17, allele DRB1*14:18, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:21, allele DRB1*14:23, allele DRB1*14:24, allele DRB1*14:27, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:34, allele DRB1*14:36, allele DRB1*14:37, allele DRB1*14:40, allele DRB1*14:41, allele DRB1*14:42, allele DRB1*14:43, allele DRB1*14:44, allele DRB1*14:45, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:56, allele DRB1*14:59, allele DRB1*14:64, allele DRB1*14:67, allele DRB1*14:72, allele DRB1*14:77, allele DRB1*14:80, allele DRB1*14:81, allele DRB1*14:83 and allele DRB1*14:84.		VAR_062928
	Natural variant	86	1	A → S in allele DRB1*14:13, allele DRB1*14:63, allele DRB1*14:65, allele DRB1*14:78 and allele DRB1*14:85.		VAR_062929
	Natural variant	86	1	A → T in allele DRB1*14:62.		VAR_062930
	Natural variant	86	1	A → V in allele DRB1*14:48.		VAR_062931
	Natural variant	87	1	A → E in allele DRB1*14:11.		VAR_062932
	Natural variant	89	1	H → S in allele DRB1*14:48 and allele DRB1*14:64; requires 2 nucleotide substitutions.		VAR_062934
	Natural variant	89	1	H → Y in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:05, allele DRB1*14:06, allele DRB1*14:09, allele DRB1*14:11, allele DRB1*14:12, allele DRB1*14:13, allele DRB1*14:14, allele DRB1*14:15, allele DRB1*14:17, allele DRB1*14:18, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:21, allele DRB1*14:23, allele DRB1*14:24, allele DRB1*14:27, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:36, allele DRB1*14:37, allele DRB1*14:40, allele DRB1*14:41, allele DRB1*14:42, allele DRB1*14:43, allele DRB1*14:44, allele DRB1*14:45, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:56, allele DRB1*14:57, allele DRB1*14:59, allele DRB1*14:63, allele DRB1*14:65, allele DRB1*14:67, allele DRB1*14:76, allele DRB1*14:77, allele DRB1*14:78, allele DRB1*14:80, allele DRB1*14:81, allele DRB1*14:83, allele DRB1*14:84 and allele DRB1*14:85.		VAR_062933
	Natural variant	96	1	L → F in allele DRB1*14:15, allele DRB1*14:22, allele DRB1*14:25, allele DRB1*14:27, allele DRB1*14:53 and allele DRB1*14:73.		VAR_062935
	Natural variant	96	1	L → I in allele DRB1*14:16, allele DRB1*14:24, allele DRB1*14:37, allele DRB1*14:45, allele DRB1*14:57, allele DRB1*14:63, allele DRB1*14:67 and allele DRB1*14:78.		VAR_062936
	Natural variant	99	1	R → D in allele DRB1*14:03, allele DRB1*14:12, allele DRB1*14:15, allele DRB1*14:16, allele DRB1*14:22, allele DRB1*14:25, allele DRB1*14:27, allele DRB1*14:40, allele DRB1*14:53, allele DRB1*14:57, allele DRB1*14:63, allele DRB1*14:67, allele DRB1*14:69, allele DRB1*14:73, allele DRB1*14:74, allele DRB1*14:77, allele DRB1*14:78, allele DRB1*14:84 and allele DRB1*14:85; requires 2 nucleotide substitutions.		VAR_062938
	Natural variant	99	1	R → Q in allele DRB1*14:02, allele DRB1*14:06, allele DRB1*14:09, allele DRB1*14:13, allele DRB1*14:17, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:21, allele DRB1*14:24, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:37, allele DRB1*14:41, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:49, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:76, allele DRB1*14:79, allele DRB1*14:80 and allele DRB1*14:83.		VAR_062937
	Natural variant	100	1	R → A in allele DRB1*14:24 and allele DRB1*14:37; requires 2 nucleotide substitutions.		VAR_062941
	Natural variant	100	1	R → E in allele DRB1*14:16 and allele DRB1*14:57; requires 2 nucleotide substitutions.		VAR_062940
	Natural variant	100	1	R → K in allele DRB1*14:19, allele DRB1*14:21, allele DRB1*14:76 and allele DRB1*14:79.		VAR_062939
	Natural variant	102	1	A → G in allele DRB1*14:76 and allele DRB1*14:79.		VAR_062943
	Natural variant	102	1	A → S in allele DRB1*14:56.		VAR_062942
	Natural variant	103	1	E → A in allele DRB1*14:02, allele DRB1*14:06, allele DRB1*14:09, allele DRB1*14:13, allele DRB1*14:16, allele DRB1*14:17, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:21, allele DRB1*14:22, allele DRB1*14:24, allele DRB1*14:25, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:31, allele DRB1*14:32, allele DRB1*14:34, allele DRB1*14:37, allele DRB1*14:41, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:49, allele DRB1*14:52, allele DRB1*14:53, allele DRB1*14:57, allele DRB1*14:65, allele DRB1*14:69, allele DRB1*14:74, allele DRB1*14:80, allele DRB1*14:81 and allele DRB1*14:83.		VAR_062944
	Natural variant	103	1	E → L in allele DRB1*14:03, allele DRB1*14:12, allele DRB1*14:15, allele DRB1*14:27, allele DRB1*14:40, allele DRB1*14:55, allele DRB1*14:63, allele DRB1*14:67, allele DRB1*14:77, allele DRB1*14:78, allele DRB1*14:84 and allele DRB1*14:85; requires 2 nucleotide substitutions.		VAR_062945
	Natural variant	103	1	E → R in allele DRB1*14:76 and allele DRB1*14:79; requires 2 nucleotide substitutions.		VAR_062946
	Natural variant	106	1	T → A in allele DRB1*14:43.		VAR_062948
	Natural variant	106	1	T → N in allele DRB1*14:38, allele DRB1*14:47, allele DRB1*14:50, allele DRB1*14:76 and allele DRB1*14:79.		VAR_062947
	Natural variant	110	1	H → Y in allele DRB1*14:75.		VAR_062949
	Natural variant	114	1	V → A in allele DRB1*14:28 and allele DRB1*14:29.		VAR_062950
	Natural variant	115	1	V → G in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:07, allele DRB1*14:09, allele DRB1*14:13, allele DRB1*14:14, allele DRB1*14:19, allele DRB1*14:22, allele DRB1*14:24, allele DRB1*14:25, allele DRB1*14:27, allele DRB1*14:30, allele DRB1*14:36, allele DRB1*14:40, allele DRB1*14:41, allele DRB1*14:42, allele DRB1*14:44, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:49, allele DRB1*14:51, allele DRB1*14:53, allele DRB1*14:63, allele DRB1*14:67, allele DRB1*14:68, allele DRB1*14:69, allele DRB1*14:77 and allele DRB1*14:85.		VAR_062951
	Natural variant	115	1	V → M in allele DRB1*14:71.		VAR_062952
	Natural variant	141	1	Y → H in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:04, allele DRB1*14:05, allele DRB1*14:06, allele DRB1*14:07, allele DRB1*14:10, allele DRB1*14:11, allele DRB1*14:13, allele DRB1*14:14, allele DRB1*14:21, allele DRB1*14:46, allele DRB1*14:54, allele DRB1*14:57 and allele DRB1*14:82.		VAR_062953
Experimental info
	Sequence conflict	124	1	V → G in BAH23562. Ref.10

Sequences

	Sequence		Length	Mass (Da)
	Q9GIY3 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: FA4BE90DFAB4FA55	FASTA	266	30,139
	10 20 30 40 50 60 MVCLRLPGGS CMAVLTVTLM VLSSPLALAG DTRPRFLEYS TSECHFFNGT ERVRFLDRYF 70 80 90 100 110 120 HNQEEFVRFD SDVGEYRAVT ELGRPAAEHW NSQKDLLERR RAEVDTYCRH NYGVVESFTV 130 140 150 160 170 180 QRRVHPKVTV YPSKTQPLQH YNLLVCSVSG FYPGSIEVRW FRNGQEEKTG VVSTGLIHNG 190 200 210 220 230 240 DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL 250 260 FLGAGLFIYF RNQKGHSGLQ PRGFLS

References

[1]	"Complete cDNA coding sequence of the HLA-DRB1*1405 allele." Kohsaka H., Nasu K., Matsushita S., Miyasaka N. DNA Seq. 13:359-361(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*14:05).
[2]	"Complete cDNA sequences of the HLA-DRB1*14011, *1402, *1403 and *1404 alleles." Corell A., Cox S.T., Soteriou B., Ramon D., Madrigal J.A., Marsh S.G.E. Tissue Antigens 59:66-69(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES DRB1*14:01 AND DRB1*14:04), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-264 (ALLELES DRB1*14:02 AND DRB1*14:03).
[3]	"Ancient haplotypes of the HLA Class II region." Raymond C.K., Kas A., Paddock M., Qiu R., Zhou Y., Subramanian S., Chang J., Palmieri A., Haugen E., Kaul R., Olson M.V. Genome Res. 15:1250-1257(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DRB1*14:05).
[4]	"Group-specific amplification of cDNA from DRB1 genes. Complete coding sequences of partially defined alleles and identification of the new alleles DRB1*040602, DRB1*111102, DRB1*080103, and DRB1*0113." Balas A., Vilches C., Rodriguez M.A., Fernandez B., Martinez M.P., de Pablo R., Garcia-Sanchez F., Vicario J.L. Hum. Immunol. 67:1008-1016(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*14:11), NUCLEOTIDE SEQUENCE [MRNA] OF 1-265 (ALLELE DRB1*14:46).
[5]	"Characterization of HLA-B*5516, -B*1313, -B*9512, and -DRB1*1457 alleles identified in a southwest Chinese population." Chen Q., Zou H., Xu X.H., Luo M., Wang J., Zuo Y.Q., Chen Y.H., Chen X.H., Chen X.L., Yao Z.Q., Song N., Zeng J., Mi X.Y., Sun S.X., Wang J.X., Zhao T.M. Tissue Antigens 68:339-343(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-217 (ALLELE DRB1*14:57).
[6]	"New allele name of some HLA-DRB1*1401: HLA-DRB1*1454." Yang K.L., Chen M.J., Lee S.K., Lin C.C., Tsai M.J., Chiu H.M., Jiang S., Chao Y.C., Chen S.P., Lin S., Shyr M.H., Lin P.Y. Int. J. Immunogenet. 36:119-120(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-208 (ALLELE DRB1*14:54).
[7]	"A novel HLA-DR allele, DRB1*1419." Loeffler D., Woelpl A., Kern P., Eiermann T.H. Tissue Antigens 46:343-344(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-123 (ALLELE DRB1*14:19).
[8]	"A novel HLA-DRB1*14 allele identified by sequence-based typing." Ogrzewalla K., Tillmann G., Scheibelhut N., Lauber J., Enczmann J. Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-217 (ALLELE DRB1*14:82).
[9]	"The nature of diversity of HLA-DRB1 exon 3." Horn P.A., Albis-Camps M., Verboom M., Bunce M., Yousaf K., Williams S., Blasczyk R. Tissue Antigens 70:335-337(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-216 (ALLELES DRB1*14:06; DRB1*14:07; DRB1*14:10; DRB1*14:13; DRB1*14:14 AND DRB1*14:21). Tissue: Peripheral blood.
[10]	"HLA-DR new allele related with DRB1*1403." Maruya E., Matsushita M., Saji H., Ounuma T., Futagami T., Kojima H., Tujino T., Hayashi K., Kusunoki Y., Yoshida T., Maekawajiri S. Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-124 (ALLELE DRB1*14:85).
[11]	"Sequencing of a new HLA-DR14 allele (DRB1(*)1422)." Adami N., Aubert V., Jeannet M., Tiercy J.M. Immunogenetics 43:248-249(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:22).
[12]	"Nomenclature for factors of the HLA system, 1998." Bodmer J., Marsh S., Albert E., Bodmer W. Tissue Antigens 53:407-446(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:36).
[13]	"Polymorphism of human HLA-DRB1 antigens generated by genetic exchange between DR2 (DRB1*15011) and DR6 (DRB1*1405) alleles: a novel DRB1 allele (DRB1*1437) identified in a Paiwan tribe member of Taiwan." Wu S., Shiao Y.M., Lai C.Y., Lai S.M., Chen S.P., Sidebottom D.A., Hildebrand W.H., Tilanus M.G.J., Chou F.C., Tsai M.F. Tissue Antigens 57:384-387(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:37). Tissue: Blood.
[14]	"DRB1*14 diversity and DRB3 associations in four major population groups in the United States." Gans C.P., Tang T.F., Slack R., Ng J., Hartzman R.J., Hurley C.K. Tissue Antigens 59:364-369(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:41), NUCLEOTIDE SEQUENCE [MRNA] OF 35-123 (ALLELE DRB1*14:42).
[15]	"Two novel HLA-DRB1 alleles identified using a sequence-based typing: HLA-DRB1*1443 and HLA-DRB1*1351*." Chu C.C., Lee H.L., Hsieh N.K., Trejaut J., Lin M. Tissue Antigens 64:308-310(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:43).
[16]	"Ten novel HLA-DRB1 alleles and one novel DRB3 allele." Lazaro A.M., Steiner N.K., Moraes M.E., Moraes J.R., Ng J., Hartzman R.J., Hurley C.K. Tissue Antigens 66:327-329(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB1*14:47 AND DRB1*14:48).
[17]	"Exon 2 sequence analysis of a novel HLA-DRB1 allele, DRB1*1450." Tijssen H.J., Zeeuw van der S.C., Joosten I. Tissue Antigens 66:332-333(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:50). Tissue: Peripheral blood.
[18]	"Characterization of a novel DRB1*14 allele (DRB1*1449) in the Han-Chinese population." Miao K.R., Xue M., Zhou X.Y., Xu R., Fei X.M., Pan Q.Q., Zhang J.W., Zhao X., Fan S., Kukuruga D., Xu A.L., Wang C.Y. Int. J. Immunogenet. 33:33-35(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:49).
[19]	"Identification of a novel HLA-DRB1*14 allele, DRB1*1456, in the cord blood of a Korean baby." Baek J.Y., Yun H.S., Hur S.S., Kwon O.J., Kwack K. Tissue Antigens 68:97-98(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:56).
[20]	"Exon 2 sequence analysis of a novel HLA-DRB1 allele, DRB1*1460." Tijssen H.J., van den Dungen-Toet J.H.G., van Houwelingen K.P., Allebes W.A., Joosten I. Tissue Antigens 68:346-347(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:60). Tissue: Peripheral blood.
[21]	"Identification of three novel alleles of HLA-DRB1 and HLA-A in the Brazilian population." Abdeen H., McErlean C., Moraes M.E., Torres M., Campiotto S., Galvao S., Gouvea C., Middleton D. Tissue Antigens 69:607-610(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:65).
[22]	"DNA typing by microbead arrays and PCR-SSP: apparent false-negative or -positive hybridization or amplification signals disclose new HLA-B and -DRB1 alleles." Rahal M., Kervaire B., Villard J., Tiercy J.M. Tissue Antigens 71:238-241(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:74).
[23]	"Sequence-based typing reveals the novel HLA-DRB1*1467 allele in a Chinese individual." Yan L.N., Li S.Y., Dong Z., Dong L., Xie J.H., An S.P., Yuan Y.H. Tissue Antigens 72:409-410(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:67). Tissue: Blood.
[24]	"Sequence-based typing of a novel HLA-DRB1*14 allele, DRB1*1475, in a Caucasian woman." Schuett S., Geflitter A., von Baehr V. Tissue Antigens 72:501-502(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:75).
[25]	"Identification of a novel HLA-DRB allele, HLA-DRB1*1461." Wang Z., Shan X., Zhang Z. Tissue Antigens 72:603-604(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:61).
[26]	"Identification of a new HLA-DRB1*14 variant, HLA-DRB1*1478, in a Korean individual." Han S.H., Jung S.M., Park S.R., Chung S.Y., Han H. Tissue Antigens 73:81-83(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:78).
[27]	"Sequence of new allele." Kashiwase K., Tokunaga K., Akaza T., Tadokoro K., Juji T. Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB1*14:26; DRB1*14:27 AND DRB1*14:29).
[28]	"A new HLA-DRB1*14 variant." Blasczyk R. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:32).
[29]	"Novel DRB1*14 and 15 alleles in the Western Australian population." Whidborne R.S., Sayer D.C., Christiansen F.T. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:34).
[30]	"Confirmatory sequence for HLA-DRB1*1417 gene obtained by sequence based typing." Gervais T.G., Latinne D. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:17).
[31]	"Complete exon 2 sequence for HLA-DRB1*1418." Rizzo M., Steiner N.K., Nichol L., Hurley C.K. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:18).
[32]	"An unusual HLA-DR/DQ haplotype carrying a new DR8 variant and the DRB3*0202 allele." Kervaire B., Villard J., Tiercy J.M. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:15).
[33]	"Novel HLA-DRB1*11 allele." Velickovic Z.M. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:23). Tissue: Blood.
[34]	Oh H.B., Byun E.K., Hong S.A., Lee M.N., Kwon O.J. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:12).
[35]	"Identification of a novel HLA-DRB1*14 allele." Lee T.D. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:01).
[36]	Dormoy A. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:53).
[37]	"Characterization of a new HLA-DRB1*14 allele." Hirv K., Krauss A., Mytilineos J. Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:55). Tissue: Leukocyte.
[38]	"Identification of a new HLA-DRB1*14 allele by sequence-based typing." Karvunidis T., Jindra P., Fischer G., Koza V. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:58).
[39]	"A new DRB1*14 allele close to the DRB1*1418 allele is different for 3 substitutions at nucleotide positions 84, 152 and 174 leading to the change of 2 amino acids at positions 28 and 51." Dormoy A., Weschler B., Leinsenbach R. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:59).
[40]	"Identification a novel HLA-DRB1*14 new allele." Ye S., Liu M., Qi J. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:63).
[41]	Greville W.D., Dunckley H. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:30).
[42]	"Identification of a novel DRB1 allele." Tavoularis S., Rebeiro E., Sayer D. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:76). Tissue: Blood.
[43]	"A new allele of HLA-DRB1*14 detected with SBT." Yan L.N., An S.P., Li S.Y., Xie J.H., Dong L., Dong Z., Yuan Y.H. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:77). Tissue: Blood.
[44]	"HLA-DRB1*1401V1M, HLA-DRB1*1401V2, HLA-DRB1*1403V2, HLA-DRB1*1405V1, HLA-DRB1*1405V2, HLA-DRB1*1406V1." Juji T., Shimizu M., Kashiwase K., Nakajima F., Tadokoro K., Tanaka H. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB1*14:38; DRB1*14:39; DRB1*14:40; DRB1*14:44; DRB1*14:45 AND DRB1*14:80).
[45]	"Novel class II allele." Lazaro A.M., Cao K., Xiao Y., Lebeck L., Hurley C.K. Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB1*14:51; DRB1*14:52; DRB1*14:62; DRB1*14:64; DRB1*14:68; DRB1*14:69; DRB1*14:70; DRB1*14:71; DRB1*14:72; DRB1*14:73; DRB1*14:79; DRB1*14:81 AND DRB1*14:83).
[46]	"The HLA-DRB1*14New allele has 3 nucleotide changes from the DRB1*1402 allele at positions 286, 298 and 299 of exon 2 where: C286->A286 (codon 72 (CTC->ATC)) resulting in a change of amino acid: Leu->Ile A298->G298 + G299->C299 (codon 76 (AGG->GCG)) resulting in a change of amino acid: Arg->Ala." Dormoy A., Weschler B. Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:24).
[47]	"A new DR14-related DRB1 allele, identified by sequence-based typing." Lee T.-D., Chien W.-C. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*14:84). Tissue: Peripheral blood.
[48]	"PCR-RFLP typing detects new HLA-DRB1 alleles: DRB1*13022, DRB1*1336 and DRB1*1435." Trejaut J., Kennedy A., Hobart D., Le T., Greville W.D., Ng G., Taverniti A., Dunckley H. Eur. J. Immunogenet. 28:441-447(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-122 (ALLELE DRB1*14:35).
[49]	"Identification of new DRB1*01 (DRB1*01022), DRB1*14 (DRB1*1428) and DRB3* (DRB3*0206) alleles." Hashemi-Tavoularis S., Couture C., Buyse I.M. Tissue Antigens 50:89-93(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DRB1*14:28). Tissue: Blood.
[50]	"Identification of three novel alleles: DRB3*0110, DRB1*1140, and DRB1*140102." Tavoularis S., Couture C., Ribeiro-Barros E. Tissue Antigens 63:496-500(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DRB1*14:01). Tissue: Peripheral blood.
[51]	"Confirmatory sequence of HLA class II DRB1*1409 and DRB1*1425." Vayntrub T., Lo B. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-123 (ALLELES DRB1*14:09 AND DRB1*14:25).
[52]	"HLA class II diversity in Australian aborigines: unusual HLA-DRB1 alleles." Gao X., Veale A., Serjeantson S.W. Immunogenetics 36:333-337(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-122 (ALLELE DRB1*14:08). Tissue: Blood.
[53]	"New HLA class II alleles in the Indonesian population." Panigoro R., Greville W.D., Kennedy A., Trejaut J., Dunckley H. Tissue Antigens 54:521-523(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-119 (ALLELE DRB1*14:31).
[54]	"New HLA class II (DRB1) alleles detected by sequencing-based typing." Greville W.D., van Eijck A., Dunckley H. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-122 (ALLELE DRB1*14:33).
[55]	"Six newly identified HLA-DRB alleles: DRB1*1121, *1419, *1420, *1421, DRB3*0203 and DRB5*0103." Verduyn W., Anholts J.D., Versluis L.F., Parlevliet J., Drabbels J., De Meester J., Tilanus M.G., Doxiadis I.I., Giphart M.J., Schreuder G.M. Tissue Antigens 48:80-86(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-116 (ALLELE DRB1*14:20).
[56]	Hurley C.K. Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 42-131 (ALLELE DRB1*14:24). Tissue: B-cell.
[57]	"Confirmatory typing for exon 2 of HLA-DRB1*1416 gene, obtained by sequence-based typing." Gervais T.G., Latinne D. Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 43-120 (ALLELE DRB1*14:16).
[58]	"Invariant chain structure and MHC class II function." Cresswell P. Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[59]	"Presentation of antigens by MHC class II molecules: getting the most out of them." Villadangos J.A. Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[60]	"Autophagy in MHC class II presentation: sampling from within." Menendez-Benito V., Neefjes J. Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[61]	"MHC class II molecules on the move for successful antigen presentation." Rocha N., Neefjes J. EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[62]	"MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation." De Gassart A., Camosseto V., Thibodeau J., Ceppi M., Catalan N., Pierre P., Gatti E. Proc. Natl. Acad. Sci. U.S.A. 105:3491-3496(2008) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION BY MARCH1, SUBCELLULAR LOCATION.
[63]	"MHC class II transport at a glance." Berger A.C., Roche P.A. J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[64]	"CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract." Beswick E.J., Reyes V.E. World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB062112 mRNA. Translation: BAB84521.2. AJ297582 mRNA. Translation: CAC08822.1. AJ297583 mRNA. Translation: CAC08823.1. AJ297584 mRNA. Translation: CAC08824.1. AJ297585 mRNA. Translation: CAC08825.1. AY663408 Genomic DNA. Translation: AAU88014.1. AY935719 mRNA. Translation: AAX33315.1. AY961071 mRNA. Translation: AAX63459.2. DQ235685 Genomic DNA. Translation: ABB52004.1. DQ390459 Genomic DNA. Translation: ABD60300.1. DQ390460 Genomic DNA. Translation: ABD60301.1. FJ379259 Genomic DNA. Translation: ACJ06537.1. Z38072 Genomic DNA. Translation: CAA86217.1. FM196525 Genomic DNA. Translation: CAQ86516.1. AM109998 Genomic DNA. Translation: CAJ33605.1. AM109999 Genomic DNA. Translation: CAJ33606.1. AM110000 Genomic DNA. Translation: CAJ33607.1. AM110001 Genomic DNA. Translation: CAJ33608.1. AM110002 Genomic DNA. Translation: CAJ33609.1. AM110003 Genomic DNA. Translation: CAJ33610.1. AB485773 Genomic DNA. Translation: BAH23562.1. Z50730 Genomic DNA. No translation available. AJ242985 Genomic DNA. Translation: CAB45249.1. Sequence problems. AJ251985 Genomic DNA. Translation: CAC19086.1. AY050186 Genomic DNA. Translation: AAL23547.1. AY054375 mRNA. Translation: AAL15169.1. AF400066 Genomic DNA. Translation: AAK85431.1. AY267905 Genomic DNA. Translation: AAP32696.1. AY267906 Genomic DNA. Translation: AAP32697.1. AJ969417 Genomic DNA. Translation: CAI94542.1. AY912075 Genomic DNA. Translation: AAY17288.1. DQ333353 Genomic DNA. Translation: ABC59115.1. AM259285 Genomic DNA. Translation: CAJ90660.1. EF199810 Genomic DNA. Translation: ABM90423.1. AM774161 Genomic DNA. Translation: CAO81738.1. EF495154 Genomic DNA. Translation: ABP38039.1. AM922324 Genomic DNA. Translation: CAP58300.1. DQ494324 Genomic DNA. Translation: ABF50050.1. EU588391 Genomic DNA. Translation: ACB97664.1. D86502 Genomic DNA. Translation: BAA13097.1. D86504 Genomic DNA. Translation: BAA13099.1. D88310 Genomic DNA. Translation: BAA13587.1. AJ010982 Genomic DNA. Translation: CAA09450.1. AF172071 Genomic DNA. Translation: AAD51970.1. AJ543433 Genomic DNA. Translation: CAD65908.1. AY277390 Genomic DNA. Translation: AAP34694.1. AJ581744 Genomic DNA. Translation: CAE46451.1. AJ812566 Genomic DNA. Translation: CAH23708.1. AY770520 Genomic DNA. Translation: AAV37191.1. DQ021915 Genomic DNA. Translation: AAY85747.1. AM084908 Genomic DNA. Translation: CAJ29895.1. DQ327711 Genomic DNA. Translation: ABC59293.1. DQ358688 Genomic DNA. Translation: ABC84557.1. AM233907 Genomic DNA. Translation: CAJ80873.1. DQ643390 Genomic DNA. Translation: ABG25965.1. U95115 Genomic DNA. Translation: AAB58397.2. AM933133 Genomic DNA. Translation: CAP69806.1. EU545181 Genomic DNA. Translation: ACB30275.1. AB049830 Genomic DNA. Translation: BAB16682.1. AB049831 Genomic DNA. Translation: BAB16683.1. AB049832 Genomic DNA. Translation: BAB16684.1. AB087875 Genomic DNA. Translation: BAC02938.1. AB087876 Genomic DNA. Translation: BAC02939.1. AB436778 Genomic DNA. Translation: BAG32234.1. EF078986 Genomic DNA. Translation: ABK56696.1. EF536016 Genomic DNA. Translation: ABQ08747.1. EU029787 Genomic DNA. Translation: ABU86846.1. EU029788 Genomic DNA. Translation: ABU86847.1. EU029792 Genomic DNA. Translation: ABU86851.1. EU029793 Genomic DNA. Translation: ABU86852.1. EU029798 Genomic DNA. Translation: ABU86857.1. EU643616 Genomic DNA. Translation: ACD01094.1. EU812536 Genomic DNA. Translation: ACE88696.1. EU924810 Genomic DNA. Translation: ACH57405.1. DQ060439 Genomic DNA. Translation: AAY59541.1. DQ060441 Genomic DNA. Translation: AAY59543.1. DQ782331 Genomic DNA. Translation: ABG91054.1. FM179681 Genomic DNA. Translation: CAQ77159.1. FJ594768 Genomic DNA. Translation: ACM47962.1. AF177215 Genomic DNA. Translation: AAD53910.1. X99839 Genomic DNA. Translation: CAA68150.1. AJ289123 Genomic DNA. Translation: CAC19015.1. AY174092 Genomic DNA. Translation: AAO20089.1. AY174181 Genomic DNA. Translation: AAO17053.1. M77673 Genomic DNA. Translation: AAA73131.1. AF028010 Genomic DNA. Translation: AAB94612.1. AF112879 Genomic DNA. Translation: AAD29584.1. X86974 Genomic DNA. No translation available. U41489 Genomic DNA. Translation: AAA86242.1. AJ508388 Genomic DNA. Translation: CAD48196.1.
IPI	IPI00956007.
PIR	B33287. C33287. C60748. F60748. PH0157. PH0158. S03440.
UniGene	Hs.485130. Hs.534322. Hs.696211. Hs.716081. Hs.723344. Hs.736560.
3D structure databases
HSSP	HSSP built from PDB template 1D5M based on UniProtKB Q9MY13.
ProteinModelPortal	Q9GIY3.
SMR	Q9GIY3. Positions 34-220.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9GIY3. 1 interaction.
Polymorphism databases
DMDM	74761361.
Proteomic databases
PRIDE	Q9GIY3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328980; ENSP00000331343; ENSG00000206306. ENST00000360004; ENSP00000353099; ENSG00000196126. ENST00000399450; ENSP00000382378; ENSG00000206240. ENST00000412634; ENSP00000408795; ENSG00000228080. ENST00000415796; ENSP00000412168; ENSG00000206306. ENST00000419393; ENSP00000403458; ENSG00000228080. ENST00000428566; ENSP00000392280; ENSG00000206240.
Organism-specific databases
GeneCards	GC06M032546. GC06Mn32480.
HGNC	HGNC:4948. HLA-DRB1.
HPA	CAB015400. CAB034021.
MIM	142857. gene.
neXtProt	NX_Q9GIY3.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG012730.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q9GIY3.
Bgee	Q9GIY3.
Family and domain databases
Gene3D	2.60.40.10. 1 hit. 3.10.320.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011162. MHC_I/II-like_Ag-recog. IPR014745. MHC_II_a/b_N. IPR000353. MHC_II_b_N. [Graphical view]
Pfam	PF07654. C1-set. 1 hit. PF00969. MHC_II_beta. 1 hit. [Graphical view]
ProDom	PD000328. MHC_II_b_N. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00407. IGc1. 1 hit. SM00921. MHC_II_beta. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HLA-DRB1. human.
SOURCE	Search...

Entry information

Entry name

2B1E_HUMAN

Accession

Primary (citable) accession number: Q9GIY3
Secondary accession number(s): A0N0W1 , A2TGX3, A4ZY86, A5H000, A5HKN8, A7DZP9, A7X5B1, A7X5B7, A7X5E0, A7X5E6, A7X5H8, A9JPG0, B1GWE7, B2CR03, B2LVF9, B2NJ29, B2ZCY1, B3VTP8, B5B8U0, B5B9V5, B5LZ25, B6VEL9, B9VRA4, B9X248, O02876, O46793, O77969, O78210, Q0PQ39, Q155F7, Q1AP33, Q1JRP3, Q27PR6, Q27PR7, Q29734, Q29770, Q29772, Q29800, Q2A120, Q2HZE5, Q2LE76, Q2MJA6, Q2VQU1, Q307W5, Q31636, Q3LA87, Q3LA88, Q3LA89, Q3LA90, Q3LA91, Q3LA92, Q3T919, Q4PRC3, Q4PRC5, Q4VZY7, Q56FP1, Q5BM92, Q5U9W6, Q683P7, Q70GL2, Q7YNY9, Q7YQA5, Q860D8, Q860D9, Q860S0, Q861H5, Q861H7, Q8MH59, Q8MH60, Q8WLU3, Q95348, Q95HK1, Q95HL0, Q95IG2, Q9GIL5, Q9GIL6, Q9GIY0, Q9GIY1, Q9GIY2, Q9GJ56, Q9GJ57, Q9GJ58, Q9TPB6, Q9TPW1, Q9XRY4, Q9Y4H7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 23, 2010
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.