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Protein

Putative L-type amino acid transporter 1-like protein IMAA

Gene

SLC7A5P2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-30916-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative L-type amino acid transporter 1-like protein IMAA
Alternative name(s):
hLAT1 3-transmembrane protein IMAA
Short name:
hLAT1 3TM IMAA
hLAT1 3-transmembrane protein MMAA
Short name:
hLAT1 3TM MMAA
Gene namesi
Name:SLC7A5P2
Synonyms:IMAA, MMAA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:24951. SLC7A5P2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Transmembranei133 – 157HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi387254.

Polymorphism and mutation databases

DMDMi317373378.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003482501 – 190Putative L-type amino acid transporter 1-like protein IMAAAdd BLAST190

Proteomic databases

MaxQBiQ9GIP4.
PeptideAtlasiQ9GIP4.
PRIDEiQ9GIP4.
TopDownProteomicsiQ9GIP4-3. [Q9GIP4-3]

Expressioni

Tissue specificityi

Expressed in peripheral blood mononuclear cells and lymphoid and myeloid cell lines.1 Publication

Inductioni

Up-regulated by concanavalin-A stimulation.1 Publication

Organism-specific databases

HPAiHPA052673.

Structurei

3D structure databases

ProteinModelPortaliQ9GIP4.
SMRiQ9GIP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000124567.
HOVERGENiHBG061804.
InParanoidiQ9GIP4.
PhylomeDBiQ9GIP4.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9GIP4-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGAGPKRRA LAAPVAEEKE EAREKMMAAK RADGAAPAGE GEGVTLQGNI
60 70 80 90 100
TLLKGVAVIV VAIMSSGIFV TPTGVLKEAG SPGLALVVWA ACGVFSIVGA
110 120 130 140 150
LCYAELGTTI SKSGGDYAYM LDVYGSLPAF LKLWIELLII RPSSQYIVAL
160 170 180 190
VFATYLLKPL FPTCPVPEEA AKLVACHSVQ LIVHQPTQVI
Length:190
Mass (Da):19,840
Last modified:January 11, 2011 - v2
Checksum:i326A92370F947AAF
GO
Isoform 2 (identifier: Q9GIP4-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     180-190: QLIVHQPTQVI → H

Show »
Length:180
Mass (Da):18,720
Checksum:i49BA6327CB08322B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26M → I in BAB20039 (PubMed:12009310).Curated1
Sequence conflicti26M → I in BAB97211 (PubMed:12009310).Curated1
Sequence conflicti65S → G in BAB20039 (PubMed:12009310).Curated1
Sequence conflicti65S → G in BAB97211 (PubMed:12009310).Curated1
Sequence conflicti65S → G in BAB97213 (PubMed:12009310).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040419180 – 190QLIVHQPTQVI → H in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040413 mRNA. Translation: BAB20039.1.
AB055225 mRNA. Translation: BAB97211.1.
AB055227 mRNA. Translation: BAB97213.1.
AC005632 Genomic DNA. No translation available.
UniGeneiHs.448808.
Hs.664952.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040413 mRNA. Translation: BAB20039.1.
AB055225 mRNA. Translation: BAB97211.1.
AB055227 mRNA. Translation: BAB97213.1.
AC005632 Genomic DNA. No translation available.
UniGeneiHs.448808.
Hs.664952.

3D structure databases

ProteinModelPortaliQ9GIP4.
SMRiQ9GIP4.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

DMDMi317373378.

Proteomic databases

MaxQBiQ9GIP4.
PeptideAtlasiQ9GIP4.
PRIDEiQ9GIP4.
TopDownProteomicsiQ9GIP4-3. [Q9GIP4-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi387254.
GeneCardsiSLC7A5P2.
HGNCiHGNC:24951. SLC7A5P2.
HPAiHPA052673.
neXtProtiNX_Q9GIP4.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000124567.
HOVERGENiHBG061804.
InParanoidiQ9GIP4.
PhylomeDBiQ9GIP4.

Enzyme and pathway databases

BioCyciZFISH:G66-30916-MONOMER.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAT1L_HUMAN
AccessioniPrimary (citable) accession number: Q9GIP4
Secondary accession number(s): Q6IPZ0, Q8MH62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: January 11, 2011
Last modified: November 2, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.