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Q9G6J1 (COX1_OCTVU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COI
Encoded onMitochondrion
OrganismOctopus vulgaris (Common octopus)
Taxonomic identifier6645 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaOctopodiformesOctopodaIncirrataOctopodidaeOctopus

Protein attributes

Sequence length209 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›209›209Cytochrome c oxidase subunit 1
PRO_0000183368

Regions

Transmembrane‹1 – 21›21Helical; Name=1; Potential
Topological domain22 – 3312Mitochondrial intermembrane Potential
Transmembrane34 – 5421Helical; Name=2; Potential
Topological domain55 – 7925Mitochondrial matrix Potential
Transmembrane80 – 10021Helical; Name=3; Potential
Topological domain101 – 12222Mitochondrial intermembrane Potential
Transmembrane123 – 14321Helical; Name=4; Potential
Topological domain144 – 16017Mitochondrial matrix Potential
Transmembrane161 – 18121Helical; Name=5; Potential
Topological domain182 – 20928Mitochondrial intermembrane Potential

Sites

Metal binding391Iron (heme A axial ligand) Probable

Experimental info

Non-terminal residue11
Non-terminal residue2091

Sequences

Sequence LengthMass (Da)Tools
Q9G6J1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: C3BF7A25DD5C53CF

FASTA20922,607
        10         20         30         40         50         60 
GIWSGLLGTS LSLMIRTELG QPGSLLNDDQ LYNVIVTAHA FVMIFFLVMP VMIGGFGNWL 

        70         80         90        100        110        120 
VPLMLGAPDM AFPRMNNMSF WLLPPSLTLL LSSAAVESGA GTGWTVYPPL SSNLAHMGPS 

       130        140        150        160        170        180 
VDLAIFSLHL AGISSILGAI NFITTIINMR WEGMLMERLP LFVWSVFITA ILLLLSLPVL 

       190        200 
AGAITMLLTD RNFNTTFFDP SGGGDPILY 

« Hide

References

[1]"Octopus vulgaris mRNA for cytochrome c oxidase subunit I."
Minakata H., Iwakoshi E., Takuwa K.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB052253 mRNA. Translation: BAB18938.1.

3D structure databases

ProteinModelPortalQ9G6J1.
SMRQ9G6J1. Positions 1-209.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_OCTVU
AccessionPrimary (citable) accession number: Q9G6J1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways