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Q9G6J1

- COX1_OCTVU

UniProt

Q9G6J1 - COX1_OCTVU

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Protein

Cytochrome c oxidase subunit 1

Gene
COI
Organism
Octopus vulgaris (Common octopus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi39 – 391Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiOctopus vulgaris (Common octopus)
Taxonomic identifieri6645 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaOctopodiformesOctopodaIncirrataOctopodidaeOctopus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei‹1 – 21›21Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini22 – 3312Mitochondrial intermembrane Reviewed predictionAdd
BLAST
Transmembranei34 – 5421Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini55 – 7925Mitochondrial matrix Reviewed predictionAdd
BLAST
Transmembranei80 – 10021Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini101 – 12222Mitochondrial intermembrane Reviewed predictionAdd
BLAST
Transmembranei123 – 14321Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini144 – 16017Mitochondrial matrix Reviewed predictionAdd
BLAST
Transmembranei161 – 18121Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini182 – 20928Mitochondrial intermembrane Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›209›209Cytochrome c oxidase subunit 1PRO_0000183368Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9G6J1.
SMRiQ9G6J1. Positions 1-209.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9G6J1-1 [UniParc]FASTAAdd to Basket

« Hide

GIWSGLLGTS LSLMIRTELG QPGSLLNDDQ LYNVIVTAHA FVMIFFLVMP    50
VMIGGFGNWL VPLMLGAPDM AFPRMNNMSF WLLPPSLTLL LSSAAVESGA 100
GTGWTVYPPL SSNLAHMGPS VDLAIFSLHL AGISSILGAI NFITTIINMR 150
WEGMLMERLP LFVWSVFITA ILLLLSLPVL AGAITMLLTD RNFNTTFFDP 200
SGGGDPILY 209
Length:209
Mass (Da):22,607
Last modified:March 1, 2001 - v1
Checksum:iC3BF7A25DD5C53CF
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei209 – 2091

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB052253 mRNA. Translation: BAB18938.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB052253 mRNA. Translation: BAB18938.1 .

3D structure databases

ProteinModelPortali Q9G6J1.
SMRi Q9G6J1. Positions 1-209.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Octopus vulgaris mRNA for cytochrome c oxidase subunit I."
    Minakata H., Iwakoshi E., Takuwa K.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCOX1_OCTVU
AccessioniPrimary (citable) accession number: Q9G6J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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