Q9G6J1 (COX1_OCTVU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 1
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide I

Gene names

Name:

COI

Encoded on

Mitochondrion

Organism

Octopus vulgaris (Common octopus)

Taxonomic identifier

6645 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Cephalopoda › Coleoidea › Neocoleoidea › Octopodiformes › Octopoda › Incirrata › Octopodidae › Octopus

Protein attributes

Sequence length	209 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Pathway	Energy metabolism; oxidative phosphorylation.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the heme-copper respiratory oxidase family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Heme Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	aerobic respiration Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW oxidative phosphorylation Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›209	›209	Cytochrome c oxidase subunit 1		PRO_0000183368
Regions
	Transmembrane	‹1 – 21	›21	Helical; Name=1; Potential
	Topological domain	22 – 33	12	Mitochondrial intermembrane Potential
	Transmembrane	34 – 54	21	Helical; Name=2; Potential
	Topological domain	55 – 79	25	Mitochondrial matrix Potential
	Transmembrane	80 – 100	21	Helical; Name=3; Potential
	Topological domain	101 – 122	22	Mitochondrial intermembrane Potential
	Transmembrane	123 – 143	21	Helical; Name=4; Potential
	Topological domain	144 – 160	17	Mitochondrial matrix Potential
	Transmembrane	161 – 181	21	Helical; Name=5; Potential
	Topological domain	182 – 209	28	Mitochondrial intermembrane Potential
Sites
	Metal binding	39	1	Iron (heme A axial ligand) Probable
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	209	1

Sequences

	Sequence		Length	Mass (Da)
	Q9G6J1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: C3BF7A25DD5C53CF	FASTA	209	22,607
	10 20 30 40 50 60 GIWSGLLGTS LSLMIRTELG QPGSLLNDDQ LYNVIVTAHA FVMIFFLVMP VMIGGFGNWL 70 80 90 100 110 120 VPLMLGAPDM AFPRMNNMSF WLLPPSLTLL LSSAAVESGA GTGWTVYPPL SSNLAHMGPS 130 140 150 160 170 180 VDLAIFSLHL AGISSILGAI NFITTIINMR WEGMLMERLP LFVWSVFITA ILLLLSLPVL 190 200 AGAITMLLTD RNFNTTFFDP SGGGDPILY

References

[1]	"Octopus vulgaris mRNA for cytochrome c oxidase subunit I." Minakata H., Iwakoshi E., Takuwa K. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB052253 mRNA. Translation: BAB18938.1.
3D structure databases
ProteinModelPortal	Q9G6J1.
SMR	Q9G6J1. Positions 1-209.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00705.
Family and domain databases
Gene3D	1.20.210.10. 1 hit.
InterPro	IPR000883. Cyt_c_Oxase_su1. IPR023616. Cyt_c_Oxase_su1_dom. [Graphical view]
PANTHER	PTHR10422. PTHR10422. 1 hit.
Pfam	PF00115. COX1. 1 hit. [Graphical view]
PRINTS	PR01165. CYCOXIDASEI.
SUPFAM	SSF81442. COX1. 1 hit.
PROSITE	PS50855. COX1. 1 hit. PS00077. COX1_CUB. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX1_OCTVU

Accession

Primary (citable) accession number: Q9G6J1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	March 1, 2001
Last modified:	March 6, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)