Q9G2X2 (COX2_MYXGL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:	MT-CO2
Synonyms:	COII, COXII, MTCO2

Encoded on

Mitochondrion

Organism

Myxine glutinosa (Atlantic hagfish)

Taxonomic identifier

7769 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Hyperotreti › Myxiniformes › Myxinidae › Myxininae › Myxine

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	Cytochrome c oxidase subunit 2		PRO_0000183637
Regions
	Topological domain	1 – 26	26	Mitochondrial intermembrane Potential
	Transmembrane	27 – 48	22	Helical; Probable
	Topological domain	49 – 62	14	Mitochondrial matrix Potential
	Transmembrane	63 – 82	20	Helical; Probable
	Topological domain	83 – 229	147	Mitochondrial intermembrane Potential
Sites
	Metal binding	162	1	Copper A Probable
	Metal binding	197	1	Copper A Probable
	Metal binding	201	1	Copper A Probable
	Metal binding	205	1	Copper A Probable
Experimental info
	Sequence conflict	41	1	V → I in CAA75482. Ref.1
	Sequence conflict	131	1	N → K in CAA75482. Ref.1
	Sequence conflict	211	1	A → T in CAA75482. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9G2X2 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 676578489BA05F92	FASTA	229	26,070
	10 20 30 40 50 60 MANHLQFNFQ DATSPLMQEL VKFHDHSLTI LFFISALILY VLMMTSLSKL TNKNILDSQE 70 80 90 100 110 120 IEMVWTVIPA FILIMLALPS IQILYLMDEI ASPDITIKTV GHQWYWTYEF SDLSKESEIE 130 140 150 160 170 180 SYMLPTADLQ NGDFRLLEVD NRISVPMDSK IRMLITSEDV LHAWTLPSMG IKVDAVPGRL 190 200 210 220 NQVTFSSSLP GLFFGQCSEI CGANHSFMPI AMEVIPLKTF ESWIIKLSL

References

[1]	"The mitochondrial DNA molecule of the hagfish (Myxine glutinosa) and vertebrate phylogeny." Rasmussen A.S., Janke A., Arnason U. J. Mol. Evol. 46:382-388(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The complete mitochondrial genome of the hagfish Myxine glutinosa: unique features of the control region." Delarbre C., Rasmussen A.S., Arnason U., Gachelin G. J. Mol. Evol. 53:634-641(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y15183 Genomic DNA. Translation: CAA75482.2. AJ404477 Genomic DNA. Translation: CAC20652.1.
RefSeq	NP_073276.1. NC_002639.1.
3D structure databases
ProteinModelPortal	Q9G2X2.
SMR	Q9G2X2. Positions 1-227.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	802340.
Organism-specific databases
CTD	4513.
Phylogenomic databases
HOVERGEN	HBG012727.
ProtClustDB	MTH00168.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR014222. Cyt_c_oxidase_su2. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
TIGRFAMs	TIGR02866. CoxB. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_MYXGL

Accession

Primary (citable) accession number: Q9G2X2
Secondary accession number(s): O63914

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program