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Q9G2X2 (COX2_MYXGL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:MT-CO2
Synonyms:COII, COXII, MTCO2
Encoded onMitochondrion
OrganismMyxine glutinosa (Atlantic hagfish)
Taxonomic identifier7769 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataHyperotretiMyxiniformesMyxinidaeMyxininaeMyxine

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 229229Cytochrome c oxidase subunit 2
PRO_0000183637

Regions

Topological domain1 – 2626Mitochondrial intermembrane Potential
Transmembrane27 – 4822Helical; Probable
Topological domain49 – 6214Mitochondrial matrix Potential
Transmembrane63 – 8220Helical; Probable
Topological domain83 – 229147Mitochondrial intermembrane Potential

Sites

Metal binding1621Copper A Probable
Metal binding1971Copper A Probable
Metal binding2011Copper A Probable
Metal binding2051Copper A Probable

Experimental info

Sequence conflict411V → I in CAA75482. Ref.1
Sequence conflict1311N → K in CAA75482. Ref.1
Sequence conflict2111A → T in CAA75482. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9G2X2 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 676578489BA05F92

FASTA22926,070
        10         20         30         40         50         60 
MANHLQFNFQ DATSPLMQEL VKFHDHSLTI LFFISALILY VLMMTSLSKL TNKNILDSQE 

        70         80         90        100        110        120 
IEMVWTVIPA FILIMLALPS IQILYLMDEI ASPDITIKTV GHQWYWTYEF SDLSKESEIE 

       130        140        150        160        170        180 
SYMLPTADLQ NGDFRLLEVD NRISVPMDSK IRMLITSEDV LHAWTLPSMG IKVDAVPGRL 

       190        200        210        220 
NQVTFSSSLP GLFFGQCSEI CGANHSFMPI AMEVIPLKTF ESWIIKLSL 

« Hide

References

[1]"The mitochondrial DNA molecule of the hagfish (Myxine glutinosa) and vertebrate phylogeny."
Rasmussen A.S., Janke A., Arnason U.
J. Mol. Evol. 46:382-388(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete mitochondrial genome of the hagfish Myxine glutinosa: unique features of the control region."
Delarbre C., Rasmussen A.S., Arnason U., Gachelin G.
J. Mol. Evol. 53:634-641(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y15183 Genomic DNA. Translation: CAA75482.2.
AJ404477 Genomic DNA. Translation: CAC20652.1.
RefSeqNP_073276.1. NC_002639.1.

3D structure databases

ProteinModelPortalQ9G2X2.
SMRQ9G2X2. Positions 1-227.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID802340.

Organism-specific databases

CTD4513.

Phylogenomic databases

HOVERGENHBG012727.
ProtClustDBMTH00168.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_MYXGL
AccessionPrimary (citable) accession number: Q9G2X2
Secondary accession number(s): O63914
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families