Q9FZG4 (HXKL1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hexokinase-like 1 protein
EC=2.7.1.1

Gene names

Ordered Locus Names:	At1g47840
ORF Names:	T2E6.5

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + D-hexose = ADP + D-hexose 6-phosphate.
Sequence similarities	Belongs to the hexokinase family.
Sequence caution	The sequence AAF99786.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	chloroplast Inferred from direct assay PubMed 18481082. Source: TAIR
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW fructokinase activity Inferred from direct assay PubMed 18481082. Source: TAIR glucokinase activity Inferred from direct assay PubMed 18481082. Source: TAIR
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Hexokinase-like 1 protein		PRO_0000259633
Regions
	Nucleotide binding	104 – 109	6	ATP Potential
	Region	175 – 201	27	Glucose-binding Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9FZG4 [UniParc]. Last modified October 31, 2006. Version 2. Checksum: 485C0BA6FBCDECF9	FASTA	493	53,880
	10 20 30 40 50 60 MSLMFSSPVV TPALGSFTFS SRPRSNYIVM SAVRSNSAST CPILTKFQKD CATPTPYLRN 70 80 90 100 110 120 VANAIADDMR DGLAVEGGGD LEMILTFVDA LPSGNEEGLF YALDLGGTNF RVRSVQLGGK 130 140 150 160 170 180 KERVLATESE QISISQKLMI GTSEELFGFI ASKLANFVAK EKPGRFLLEE GRKRELGFTF 190 200 210 220 230 240 SFPVKQTSID SGTLSKWTKG FKVSGMEGKN VVACLNEAME AHGLDMRVSA LVNDGVGTLA 250 260 270 280 290 300 GARYWDEDVM VGVILGTGTN ACYVEQKHAI PKLRSKSSSG TTIINTEWGG FSKILPQTIF 310 320 330 340 350 360 DLEMDETSLN PGEHLYEKMI SGMYLGEIVR RVLLHMCETS DLFGHFAPAK LSTPLALRTE 370 380 390 400 410 420 HLCKMQEDNT DDLRDVGSIL YDFLDVEANM NARRRVVEVC DTVVKRGGRL AGAGIVAILE 430 440 450 460 470 480 KIEKDTKRMG SGKRTVVAMD GALYEKYPQY RQYMQDALVE LLGHKLASHV AIKHTKDVSG 490 LGAALLAATN SIY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Arabidopsis ORF clones." Bautista-Mercan V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C., Ecker J.R. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC012463 Genomic DNA. Translation: AAF99786.1. Sequence problems. CP002684 Genomic DNA. Translation: AEE32221.1. BT030472 mRNA. Translation: ABP88126.1.
IPI	IPI00548050.
RefSeq	NP_175220.2. NM_103682.3.
UniGene	At.38526.
3D structure databases
ProteinModelPortal	Q9FZG4.
SMR	Q9FZG4. Positions 30-488.
ModBase	Search...
Proteomic databases
PaxDb	Q9FZG4.
PRIDE	Q9FZG4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G47840.1; AT1G47840.1; AT1G47840.
GeneID	841200.
KEGG	ath:AT1G47840.
Organism-specific databases
TAIR	At1g47840.
Phylogenomic databases
eggNOG	COG5026.
HOGENOM	HOG000162670.
InParanoid	Q9FZG4.
KO	K00844.
OMA	MDSQICA.
PhylomeDB	Q9FZG4.
ProtClustDB	PLN02914.
Gene expression databases
Genevestigator	Q9FZG4.
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR022673. Hexokinase_C. IPR019807. Hexokinase_CS. IPR022672. Hexokinase_N. [Graphical view]
PANTHER	PTHR19443. PTHR19443. 1 hit.
Pfam	PF00349. Hexokinase_1. 1 hit. PF03727. Hexokinase_2. 1 hit. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
PROSITE	PS00378. HEXOKINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXKL1_ARATH

Accession

Primary (citable) accession number: Q9FZG4
Secondary accession number(s): A4VCN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 31, 2006
Last modified:	May 29, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program