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Protein

Hexokinase-like 1 protein

Gene

At1g47840

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi104 – 109ATPSequence analysis6

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • fructokinase activity Source: TAIR
  • glucokinase activity Source: TAIR
  • glucose binding Source: InterPro
  • hexokinase activity Source: TAIR
  • mannokinase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G47840-MONOMER.
BRENDAi2.7.1.1. 399.
ReactomeiR-ATH-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-ATH-6798695. Neutrophil degranulation.
R-ATH-70171. Glycolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-like 1 protein (EC:2.7.1.1)
Gene namesi
Ordered Locus Names:At1g47840
ORF Names:T2E6.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G47840.
TAIRilocus:2202410. AT1G47840.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002596331 – 493Hexokinase-like 1 proteinAdd BLAST493

Proteomic databases

PaxDbiQ9FZG4.
PRIDEiQ9FZG4.

Expressioni

Gene expression databases

ExpressionAtlasiQ9FZG4. baseline and differential.
GenevisibleiQ9FZG4. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G47840.1.

Structurei

3D structure databases

ProteinModelPortaliQ9FZG4.
SMRiQ9FZG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 488HexokinasePROSITE-ProRule annotationAdd BLAST451

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni93 – 232Hexokinase small subdomainPROSITE-ProRule annotationAdd BLAST140
Regioni175 – 201Glucose-bindingSequence analysisAdd BLAST27
Regioni233 – 477Hexokinase large subdomainPROSITE-ProRule annotationAdd BLAST245

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
HOGENOMiHOG000162670.
InParanoidiQ9FZG4.
KOiK00844.
OMAiMIPTFVT.
OrthoDBiEOG093608SG.
PhylomeDBiQ9FZG4.

Family and domain databases

InterProiView protein in InterPro
IPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiView protein in Pfam
PF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
PROSITEiView protein in PROSITE
PS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9FZG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLMFSSPVV TPALGSFTFS SRPRSNYIVM SAVRSNSAST CPILTKFQKD
60 70 80 90 100
CATPTPYLRN VANAIADDMR DGLAVEGGGD LEMILTFVDA LPSGNEEGLF
110 120 130 140 150
YALDLGGTNF RVRSVQLGGK KERVLATESE QISISQKLMI GTSEELFGFI
160 170 180 190 200
ASKLANFVAK EKPGRFLLEE GRKRELGFTF SFPVKQTSID SGTLSKWTKG
210 220 230 240 250
FKVSGMEGKN VVACLNEAME AHGLDMRVSA LVNDGVGTLA GARYWDEDVM
260 270 280 290 300
VGVILGTGTN ACYVEQKHAI PKLRSKSSSG TTIINTEWGG FSKILPQTIF
310 320 330 340 350
DLEMDETSLN PGEHLYEKMI SGMYLGEIVR RVLLHMCETS DLFGHFAPAK
360 370 380 390 400
LSTPLALRTE HLCKMQEDNT DDLRDVGSIL YDFLDVEANM NARRRVVEVC
410 420 430 440 450
DTVVKRGGRL AGAGIVAILE KIEKDTKRMG SGKRTVVAMD GALYEKYPQY
460 470 480 490
RQYMQDALVE LLGHKLASHV AIKHTKDVSG LGAALLAATN SIY
Length:493
Mass (Da):53,880
Last modified:October 31, 2006 - v2
Checksum:i485C0BA6FBCDECF9
GO

Sequence cautioni

The sequence AAF99786 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012463 Genomic DNA. Translation: AAF99786.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE32221.1.
BT030472 mRNA. Translation: ABP88126.1.
RefSeqiNP_175220.2. NM_103682.4.
UniGeneiAt.38526.

Genome annotation databases

EnsemblPlantsiAT1G47840.1; AT1G47840.1; AT1G47840.
GeneIDi841200.
GrameneiAT1G47840.1; AT1G47840.1; AT1G47840.
KEGGiath:AT1G47840.

Similar proteinsi

Entry informationi

Entry nameiHXKL1_ARATH
AccessioniPrimary (citable) accession number: Q9FZG4
Secondary accession number(s): A4VCN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: October 25, 2017
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families