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Protein

UDP-glucose 6-dehydrogenase 1

Gene

UGD1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the biosynthesis of UDP-glucuronic acid (UDP-GlcA), providing nucleotide sugars for cell-wall polymers.1 Publication

Caution

Was originally assigned as UGD4.1 Publication

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Enzyme regulationi

Inhibited by UDP-xylose.1 Publication

Pathwayi: UDP-alpha-D-glucuronate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose.
Proteins known to be involved in this subpathway in this organism are:
  1. UDP-glucose 6-dehydrogenase 2 (UGD2), UDP-glucose 6-dehydrogenase 1 (UGD1), UDP-glucose 6-dehydrogenase 4 (UGD4), UDP-glucose 6-dehydrogenase 3 (UGD3)
This subpathway is part of the pathway UDP-alpha-D-glucuronate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose, the pathway UDP-alpha-D-glucuronate biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33NADBy similarity1
Binding sitei38NADBy similarity1
Binding sitei161NADBy similarity1
Active sitei272NucleophileBy similarity1
Binding sitei342NADBy similarity1
Binding sitei448SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 13NADBy similarity6
Nucleotide bindingi86 – 90NADBy similarity5
Nucleotide bindingi127 – 128NADBy similarity2
Nucleotide bindingi272 – 275NADBy similarity4

GO - Molecular functioni

  • NAD binding Source: InterPro
  • UDP-glucose 6-dehydrogenase activity Source: UniProtKB

GO - Biological processi

  • glycosaminoglycan biosynthetic process Source: GO_Central
  • UDP-glucuronate biosynthetic process Source: UniProtKB

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciARA:AT1G26570-MONOMER
ReactomeiR-ATH-173599 Formation of the active cofactor, UDP-glucuronate
UniPathwayiUPA00038; UER00491

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase 1 (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase 1
Short name:
UDP-GlcDH 1
Short name:
UDPGDH 1
Alternative name(s):
At-UGD1
Gene namesi
Name:UGD1
Synonyms:UGD4
Ordered Locus Names:At1g26570
ORF Names:T1K7.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G26570
TAIRilocus:2197945 AT1G26570

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004222651 – 481UDP-glucose 6-dehydrogenase 1Add BLAST481

Proteomic databases

PaxDbiQ9FZE1
PRIDEiQ9FZE1

Expressioni

Developmental stagei

Restricted expression to the primary shoot in young seedlings. Later detected in hypocotyl, leaves and flowers.1 Publication

Inductioni

Specifically induced by H.schachtii (cyst nematodes) in nematode-induced syncytia.1 Publication

Gene expression databases

ExpressionAtlasiQ9FZE1 baseline and differential
GenevisibleiQ9FZE1 AT

Interactioni

Protein-protein interaction databases

BioGridi24433, 3 interactors
IntActiQ9FZE1, 2 interactors
STRINGi3702.AT1G26570.1

Structurei

3D structure databases

ProteinModelPortaliQ9FZE1
SMRiQ9FZE1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni157 – 161Substrate bindingBy similarity5
Regioni216 – 223Substrate bindingBy similarity8
Regioni256 – 269Substrate bindingBy similarityAdd BLAST14
Regioni334 – 335Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2666 Eukaryota
COG1004 LUCA
HOGENOMiHOG000153773
InParanoidiQ9FZE1
KOiK00012
OMAiTPRINAW
OrthoDBiEOG093607HD
PhylomeDBiQ9FZE1

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028356 UDPglc_DH_euk
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500133 UDPglc_DH_euk, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FZE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKICCIGAG YVGGPTMAVM ALKCPEIEVV VVDISEPRIN AWNSDRLPIY
60 70 80 90 100
EPGLEDVVKQ CRGKNLFFST DVEKHVFESD IVFVSVNTPT KTQGLGAGKA
110 120 130 140 150
ADLTYWESAA RMIADVSKSS KIVVEKSTVP VRTAEAIEKI LTHNSKGIEF
160 170 180 190 200
QILSNPEFLA EGTAIKDLYN PDRVLIGGRD TAAGQKAIKA LRDVYAHWVP
210 220 230 240 250
VEQIICTNLW SAELSKLAAN AFLAQRISSV NAMSALCEAT GADVTQVAHA
260 270 280 290 300
VGTDTRIGPK FLNASVGFGG SCFQKDILNL IYICECNGLP EAANYWKQVV
310 320 330 340 350
KVNDYQKIRF ANRVVSSMFN TVSGKKIAIL GFAFKKDTGD TRETPAIDVC
360 370 380 390 400
NRLVADKAKL SIYDPQVLEE QIRRDLSMAR FDWDHPVPLQ QIKAEGISEQ
410 420 430 440 450
VNVVSDAYEA TKDAHGLCVL TEWDEFKSLD FKKIFDNMQK PAFVFDGRNV
460 470 480
VDAVKLREIG FIVYSIGKPL DSWLKDMPAV A
Length:481
Mass (Da):52,972
Last modified:March 1, 2001 - v1
Checksum:iB36F0F7AE3676BC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114A → P in AAM61009 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013427 Genomic DNA Translation: AAF98561.1
CP002684 Genomic DNA Translation: AEE30705.1
AY070758 mRNA Translation: AAL50096.1
AY143922 mRNA Translation: AAN28861.1
AY084436 mRNA Translation: AAM61009.1
PIRiG86392
RefSeqiNP_173979.1, NM_102419.4
UniGeneiAt.27956

Genome annotation databases

EnsemblPlantsiAT1G26570.1; AT1G26570.1; AT1G26570
GeneIDi839197
GrameneiAT1G26570.1; AT1G26570.1; AT1G26570
KEGGiath:AT1G26570

Similar proteinsi

Entry informationi

Entry nameiUGDH1_ARATH
AccessioniPrimary (citable) accession number: Q9FZE1
Secondary accession number(s): Q8LG68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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