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Protein

UDP-glucose 6-dehydrogenase 1

Gene

UGD1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the biosynthesis of UDP-glucuronic acid (UDP-GlcA), providing nucleotide sugars for cell-wall polymers.1 Publication

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Enzyme regulationi

Inhibited by UDP-xylose.1 Publication

Pathwayi: UDP-alpha-D-glucuronate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose.
Proteins known to be involved in this subpathway in this organism are:
  1. UDP-glucose 6-dehydrogenase 2 (UGD2), UDP-glucose 6-dehydrogenase 1 (UGD1), UDP-glucose 6-dehydrogenase 4 (UGD4), UDP-glucose 6-dehydrogenase 3 (UGD3)
This subpathway is part of the pathway UDP-alpha-D-glucuronate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose, the pathway UDP-alpha-D-glucuronate biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33NADBy similarity1
Binding sitei38NADBy similarity1
Binding sitei161NADBy similarity1
Active sitei272NucleophileBy similarity1
Binding sitei342NADBy similarity1
Binding sitei448SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 13NADBy similarity6
Nucleotide bindingi86 – 90NADBy similarity5
Nucleotide bindingi127 – 128NADBy similarity2
Nucleotide bindingi272 – 275NADBy similarity4

GO - Molecular functioni

  • NAD binding Source: InterPro
  • UDP-glucose 6-dehydrogenase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciARA:AT1G26570-MONOMER.
ReactomeiR-ATH-173599. Formation of the active cofactor, UDP-glucuronate.
UniPathwayiUPA00038; UER00491.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase 1 (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase 1
Short name:
UDP-GlcDH 1
Short name:
UDPGDH 1
Alternative name(s):
At-UGD1
Gene namesi
Name:UGD1
Synonyms:UGD4
Ordered Locus Names:At1g26570
ORF Names:T1K7.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G26570.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004222651 – 481UDP-glucose 6-dehydrogenase 1Add BLAST481

Proteomic databases

PaxDbiQ9FZE1.
PRIDEiQ9FZE1.

Expressioni

Developmental stagei

Restricted expression to the primary shoot in young seedlings. Later detected in hypocotyl, leaves and flowers.1 Publication

Inductioni

Specifically induced by H.schachtii (cyst nematodes) in nematode-induced syncytia.1 Publication

Gene expression databases

GenevisibleiQ9FZE1. AT.

Interactioni

Protein-protein interaction databases

BioGridi24433. 3 interactors.
IntActiQ9FZE1. 2 interactors.
STRINGi3702.AT1G26570.1.

Structurei

3D structure databases

ProteinModelPortaliQ9FZE1.
SMRiQ9FZE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni157 – 161Substrate bindingBy similarity5
Regioni216 – 223Substrate bindingBy similarity8
Regioni256 – 269Substrate bindingBy similarityAdd BLAST14
Regioni334 – 335Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2666. Eukaryota.
COG1004. LUCA.
HOGENOMiHOG000153773.
InParanoidiQ9FZE1.
KOiK00012.
OMAiIRTAEHI.
OrthoDBiEOG093607HD.
PhylomeDBiQ9FZE1.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9FZE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKICCIGAG YVGGPTMAVM ALKCPEIEVV VVDISEPRIN AWNSDRLPIY
60 70 80 90 100
EPGLEDVVKQ CRGKNLFFST DVEKHVFESD IVFVSVNTPT KTQGLGAGKA
110 120 130 140 150
ADLTYWESAA RMIADVSKSS KIVVEKSTVP VRTAEAIEKI LTHNSKGIEF
160 170 180 190 200
QILSNPEFLA EGTAIKDLYN PDRVLIGGRD TAAGQKAIKA LRDVYAHWVP
210 220 230 240 250
VEQIICTNLW SAELSKLAAN AFLAQRISSV NAMSALCEAT GADVTQVAHA
260 270 280 290 300
VGTDTRIGPK FLNASVGFGG SCFQKDILNL IYICECNGLP EAANYWKQVV
310 320 330 340 350
KVNDYQKIRF ANRVVSSMFN TVSGKKIAIL GFAFKKDTGD TRETPAIDVC
360 370 380 390 400
NRLVADKAKL SIYDPQVLEE QIRRDLSMAR FDWDHPVPLQ QIKAEGISEQ
410 420 430 440 450
VNVVSDAYEA TKDAHGLCVL TEWDEFKSLD FKKIFDNMQK PAFVFDGRNV
460 470 480
VDAVKLREIG FIVYSIGKPL DSWLKDMPAV A
Length:481
Mass (Da):52,972
Last modified:March 1, 2001 - v1
Checksum:iB36F0F7AE3676BC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114A → P in AAM61009 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013427 Genomic DNA. Translation: AAF98561.1.
CP002684 Genomic DNA. Translation: AEE30705.1.
AY070758 mRNA. Translation: AAL50096.1.
AY143922 mRNA. Translation: AAN28861.1.
AY084436 mRNA. Translation: AAM61009.1.
PIRiG86392.
RefSeqiNP_173979.1. NM_102419.4.
UniGeneiAt.27956.

Genome annotation databases

EnsemblPlantsiAT1G26570.1; AT1G26570.1; AT1G26570.
GeneIDi839197.
GrameneiAT1G26570.1; AT1G26570.1; AT1G26570.
KEGGiath:AT1G26570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013427 Genomic DNA. Translation: AAF98561.1.
CP002684 Genomic DNA. Translation: AEE30705.1.
AY070758 mRNA. Translation: AAL50096.1.
AY143922 mRNA. Translation: AAN28861.1.
AY084436 mRNA. Translation: AAM61009.1.
PIRiG86392.
RefSeqiNP_173979.1. NM_102419.4.
UniGeneiAt.27956.

3D structure databases

ProteinModelPortaliQ9FZE1.
SMRiQ9FZE1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi24433. 3 interactors.
IntActiQ9FZE1. 2 interactors.
STRINGi3702.AT1G26570.1.

Proteomic databases

PaxDbiQ9FZE1.
PRIDEiQ9FZE1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G26570.1; AT1G26570.1; AT1G26570.
GeneIDi839197.
GrameneiAT1G26570.1; AT1G26570.1; AT1G26570.
KEGGiath:AT1G26570.

Organism-specific databases

TAIRiAT1G26570.

Phylogenomic databases

eggNOGiKOG2666. Eukaryota.
COG1004. LUCA.
HOGENOMiHOG000153773.
InParanoidiQ9FZE1.
KOiK00012.
OMAiIRTAEHI.
OrthoDBiEOG093607HD.
PhylomeDBiQ9FZE1.

Enzyme and pathway databases

UniPathwayiUPA00038; UER00491.
BioCyciARA:AT1G26570-MONOMER.
ReactomeiR-ATH-173599. Formation of the active cofactor, UDP-glucuronate.

Miscellaneous databases

PROiQ9FZE1.

Gene expression databases

GenevisibleiQ9FZE1. AT.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUGDH1_ARATH
AccessioniPrimary (citable) accession number: Q9FZE1
Secondary accession number(s): Q8LG68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

Was originally assigned as UGD4.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.