ID   TPS2_ARATH              Reviewed;         822 AA.
AC   Q9FZ57; F4I627;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   24-JAN-2024, entry version 112.
DE   RecName: Full=Probable alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2;
DE            EC=2.4.1.15;
DE   AltName: Full=Trehalose-6-phosphate synthase 2;
DE            Short=AtTPS2;
GN   Name=TPS2; OrderedLocusNames=At1g16980; ORFNames=F6I1.1;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11701378; DOI=10.1016/s1360-1385(01)02125-2;
RA   Leyman B., Van Dijck P., Thevelein J.M.;
RT   "An unexpected plethora of trehalose biosynthesis genes in Arabidopsis
RT   thaliana.";
RL   Trends Plant Sci. 6:510-513(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-
CC         trehalose 6-phosphate + H(+) + UDP; Xref=Rhea:RHEA:18889,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:58429,
CC         ChEBI:CHEBI:58885, ChEBI:CHEBI:61548; EC=2.4.1.15;
CC   -!- SIMILARITY: In the N-terminal section; belongs to the
CC       glycosyltransferase 20 family. {ECO:0000305}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the trehalose
CC       phosphatase family. {ECO:0000305}.
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DR   EMBL; AC051629; AAF99834.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE29528.2; -; Genomic_DNA.
DR   PIR; E86305; E86305.
DR   RefSeq; NP_173142.2; NM_101559.2.
DR   AlphaFoldDB; Q9FZ57; -.
DR   SMR; Q9FZ57; -.
DR   STRING; 3702.Q9FZ57; -.
DR   CAZy; GT20; Glycosyltransferase Family 20.
DR   PaxDb; 3702-AT1G16980-1; -.
DR   ProteomicsDB; 228332; -.
DR   EnsemblPlants; AT1G16980.1; AT1G16980.1; AT1G16980.
DR   GeneID; 838269; -.
DR   Gramene; AT1G16980.1; AT1G16980.1; AT1G16980.
DR   KEGG; ath:AT1G16980; -.
DR   Araport; AT1G16980; -.
DR   TAIR; AT1G16980; TPS2.
DR   eggNOG; KOG1050; Eukaryota.
DR   HOGENOM; CLU_002351_0_1_1; -.
DR   InParanoid; Q9FZ57; -.
DR   OrthoDB; 1023at2759; -.
DR   PhylomeDB; Q9FZ57; -.
DR   PRO; PR:Q9FZ57; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9FZ57; baseline and differential.
DR   GO; GO:0003825; F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity; IBA:GO_Central.
DR   GO; GO:0005992; P:trehalose biosynthetic process; IBA:GO_Central.
DR   GO; GO:0070413; P:trehalose metabolism in response to stress; IBA:GO_Central.
DR   CDD; cd03788; GT20_TPS; 1.
DR   CDD; cd01627; HAD_TPP; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR001830; Glyco_trans_20.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR012766; Trehalose_OtsA.
DR   InterPro; IPR003337; Trehalose_PPase.
DR   NCBIfam; TIGR02400; trehalose_OtsA; 1.
DR   PANTHER; PTHR10788:SF90; ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE [UDP-FORMING] 2-RELATED; 1.
DR   PANTHER; PTHR10788; TREHALOSE-6-PHOSPHATE SYNTHASE; 1.
DR   Pfam; PF00982; Glyco_transf_20; 1.
DR   Pfam; PF02358; Trehalose_PPase; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR   Genevisible; Q9FZ57; AT.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..822
FT                   /note="Probable alpha,alpha-trehalose-phosphate synthase
FT                   [UDP-forming] 2"
FT                   /id="PRO_0000324823"
FT   REGION          12..479
FT                   /note="Glycosyltransferase"
SQ   SEQUENCE   822 AA;  93005 MW;  6270EB4998DBD7D5 CRC64;
     MMDYDDARGE RPRLLVVANR LPVSAKRTGE NSWSLEMSPG GLVSGLLGIT SQFDTKWVGW
     PGVDVHDEIE KNALTESLAE MKCIPVFLNG VFDQYYNGYC NGILWPILHH MGLPQEDQHD
     TNQTFETQYD AYKKANRMFL DVIIDNYEEG DIVWCHDYHL MFLPQYLKEY NNKIKVGWFL
     HSPFPSSEVY KTLPSRSELL RAILAADLLG FHTYDFARHF LSTCTRILGV EGTHEGVVYQ
     GRVTRVAVFP IGIDPDRFIR TCKLPEVTQQ MNELQEKFAG KKVILGVDRL DMIKGIPQKY
     LAFEKFLEEN PYWRDKVVLV QIAVPTRNDV PEYRKLKSQV HGLVGRINGR FGSVSSLPIH
     HLDCSVDFNY LCAIYAIADV MLVTSLRDGM NLVSYEFVAC QEAKKGVLVL SEFAGAGQSL
     GVGALIVNPW DVTEVSSAIK EALNMPAEER ETRHRSNFQY VCTHSAEKWG LDFMSELNGI
     IPESEMQMRK IPLQLPEQDV IQQYSQSNNR LIILGFFGTL AEPMNSGTKE MDLKLNPELK
     GTLKALCNDP KTTVVVLSRS GKNILNKNFG ESNIWLAAEN GMFEKQTTGE WVTNMPQNVN
     LDWVDGVKNV FKYFTDRTPR SYFEASETSL VWNYEYADVE FGRAQARDLL QYLWAGPISN
     ASVDVVRGNH SVEVHAIGET KGAAIGRILG EIVHRKSMTT PIDFVFCSGY FLEKDEDIYT
     FFESKILSSK SPNGLDLKKE NYFSAAIGQA RTKARYVIDS AHGVVDLLHK LAVVADTTMT
     DSFSDSEIYE PRDANANENS KRWINSVRRR KVEIGDTGQI GM
//