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Q9FZ49 (ALG9_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

EC=2.4.1.259
Alternative name(s):
Alpha-1,2-mannosyltransferase ALG9
Asparagine-linked glycosylation protein 9
Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
EC=2.4.1.261
Gene names
Name:ALG9
Ordered Locus Names:At1g16900
ORF Names:F6I1.10, F17F16.20
OrganismArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonscore eudicotyledonsrosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for N-linked oligosaccharide assembly. Adds the seventh and the ninth mannose residues in an alpha-1,2 linkage onto the dolichol-PP-oligosaccharide precursors dolichol-PP-Man6GlcNAc2 and dolichol-PP-Man8GlcNAc2. Ref.4

Catalytic activity

Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. Ref.4

Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Probable.

Miscellaneous

In the absence of ALG9 activity, the N-glycans transferred to proteins are aberrant, indicating that the oligosaccharyltransferase (OST) complex is substrat tolerant.

Sequence similarities

Belongs to the glycosyltransferase 22 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
PRO_0000412587

Regions

Transmembrane129 – 14921Helical; Potential
Transmembrane160 – 18021Helical; Potential
Transmembrane208 – 22821Helical; Potential
Transmembrane237 – 25721Helical; Potential
Transmembrane297 – 31721Helical; Potential
Transmembrane324 – 34421Helical; Potential
Transmembrane349 – 36921Helical; Potential
Transmembrane381 – 40121Helical; Potential
Compositional bias14 – 218Poly-Ser
Compositional bias257 – 2604Poly-Tyr

Amino acid modifications

Glycosylation4731N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9FZ49 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: CE6885EA115D0997

FASTA57065,083
        10         20         30         40         50         60 
MDLTTTRQRR PLISDSSSSS STKSYSKTDK PGRSNGGDAE DGGLRWFLPF IALCYLRYMS 

        70         80         90        100        110        120 
ATSNIIHDCD EVFNYWEPLH YILYKSGFQT WEYSSNFALR SYLYILFHEL AGRPASWWFG 

       130        140        150        160        170        180 
DDKVRVFYAV RLFLGLVSAV SDTVLVVALS RKYGKRIATY AVAMLCLTSG CFFASTSFLP 

       190        200        210        220        230        240 
SSFSMYAISL SSGLLLFEKY AMAVAVSVVG VILGWPFSIL AFLPVVIYSL VKRFKQAFIA 

       250        260        270        280        290        300 
GAVTTIFLLG VSLLVDYYYY KRWTSSVLNL LIYNVLGGGE SHLYGTEGAL FYIRNGFNNF 

       310        320        330        340        350        360 
NFCFILAMLF VAIYPVIRRK YDRALLVVIS PMYIWLAFMS LQPHKEERFL YPIYPLICVS 

       370        380        390        400        410        420 
ASAVIENIPE LFREKYSSRE SLLVTITKYM RPVILGCILC ASHSRTFALI NGYSAPLEVY 

       430        440        450        460        470        480 
KLLEHHDDAG PGSVLCVGSE WHRYPSSFFV PHYISEVRWI DDGFRGLLPF PFNNTLGGTS 

       490        500        510        520        530        540 
ASPPYFNNKN QASEEQYLKN IETCTFLIEL QLSRPYQYRG SDLSTWEAIA VLPYLDRELS 

       550        560        570 
PAKYRSFFIP HMWQEKNVFG KYVALRRVPK 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed: 11130712] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed: 14593172] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Mutations of an alpha1,6 mannosyltransferase inhibit endoplasmic reticulum-associated degradation of defective brassinosteroid receptors in Arabidopsis."
Hong Z., Jin H., Fitchette A.C., Xia Y., Monk A.M., Faye L., Li J.
Plant Cell 21:3792-3802(2009) [PubMed: 20023196] [Abstract]
Cited for: FUNCTION, CATALYTIC ACTIVITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC051629 Genomic DNA. Translation: AAF99843.1.
CP002684 Genomic DNA. Translation: AEE29518.1.
AY140061 mRNA. Translation: AAM98202.1.
BT010395 mRNA. Translation: AAQ56838.1.
IPIIPI00528313.
PIRD86304.
RefSeqNP_173134.2. NM_101551.3.
UniGeneAt.41864.

3D structure databases

ProteinModelPortalQ9FZ49.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9FZ49. 1 interaction.
STRINGQ9FZ49.

Protein family/group databases

CAZyGT22. Glycosyltransferase Family 22.

Proteomic databases

PRIDEQ9FZ49.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G16900.1; AT1G16900.1; AT1G16900.
GeneID838261.
GenomeReviewsGene locus AT1G16900 in contig CT485782_GR.
KEGGath:AT1G16900.

Organism-specific databases

TAIRAt1g16900.

Phylogenomic databases

eggNOGKOG2515.
GeneTreeEPGT00050000009884.
HOGENOMHBG736291.
InParanoidQ9FZ49.
PhylomeDBQ9FZ49.
ProtClustDBCLSN2691194.

Gene expression databases

ArrayExpressQ9FZ49.
GenevestigatorQ9FZ49.

Family and domain databases

InterProIPR005599. GPI_mannosylTrfase.
[Graphical view]
KOK03846.
PANTHERPTHR22760. Alg9_trans. 1 hit.
PfamPF03901. Glyco_transf_22. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALG9_ARATH
AccessionPrimary (citable) accession number: Q9FZ49
Entry history
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: March 1, 2001
Last modified: January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families