Q9FZ42 (GRDH1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose and ribitol dehydrogenase homolog 1
EC=1.1.1.-

Gene names

Ordered Locus Names:	At1g54870
ORF Names:	F14C21_16, T24C10.1

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act as a short alcohol-polyol-sugar dehydrogenase possibly related to carbohydrate metabolism and the acquisition of desiccation tolerance. May also be involved in signal transduction By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Coding sequence diversity	Alternative initiation
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	chloroplast Inferred from direct assay PubMed 21169366. Source: TAIR
Molecular_function	alcohol dehydrogenase (NADP+) activity Inferred from direct assay PubMed 21169366. Source: TAIR nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]

Isoform 1 (identifier: Q9FZ42-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9FZ42-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNVLCRVFTSSRVLSSNVTFSFSQIPNNTKKPLLEKRRLSPRVCLRAM

Note: Derived from EST data. No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Glucose and ribitol dehydrogenase homolog 1		PRO_0000239257
Regions
	Nucleotide binding	41 – 65	25	NAD or NADP By similarity
Sites
	Active site	192	1	Proton acceptor By similarity
	Binding site	179	1	Substrate By similarity
Natural variations
	Alternative sequence	1	1	M → MNVLCRVFTSSRVLSSNVTF SFSQIPNNTKKPLLEKRRLS PRVCLRAM in isoform 2.		VSP_041301
Experimental info
	Sequence conflict	37 – 38	2	Missing in AAG51119. Ref.1
	Sequence conflict	193	1	T → A in CAA81564. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 0359C488117CE518	FASTA	288	31,387
	10 20 30 40 50 60 MASEKQKQHA QPGKEHVMES SPQFSSSDYQ PSNKLRGKVA LITGGDSGIG RAVGYCFASE 70 80 90 100 110 120 GATVAFTYVK GQEEKDAQET LQMLKEVKTS DSKEPIAIPT DLGFDENCKR VVDEVVNAFG 130 140 150 160 170 180 RIDVLINNAA EQYESSTIEE IDEPRLERVF RTNIFSYFFL TRHALKHMKE GSSIINTTSV 190 200 210 220 230 240 NAYKGNASLL DYTATKGAIV AFTRGLALQL AEKGIRVNGV APGPIWTPLI PASFNEEKIK 250 260 270 280 NFGSEVPMKR AGQPIEVAPS YVFLACNHCS SYFTGQVLHP NGGAVVNA
	Isoform 2 [UniParc]. Checksum: 62971FF8C7AAC7AF	FASTA	335	36,765
	10 20 30 40 50 60 MNVLCRVFTS SRVLSSNVTF SFSQIPNNTK KPLLEKRRLS PRVCLRAMAS EKQKQHAQPG 70 80 90 100 110 120 KEHVMESSPQ FSSSDYQPSN KLRGKVALIT GGDSGIGRAV GYCFASEGAT VAFTYVKGQE 130 140 150 160 170 180 EKDAQETLQM LKEVKTSDSK EPIAIPTDLG FDENCKRVVD EVVNAFGRID VLINNAAEQY 190 200 210 220 230 240 ESSTIEEIDE PRLERVFRTN IFSYFFLTRH ALKHMKEGSS IINTTSVNAY KGNASLLDYT 250 260 270 280 290 300 ATKGAIVAFT RGLALQLAEK GIRVNGVAPG PIWTPLIPAS FNEEKIKNFG SEVPMKRAGQ 310 320 330 PIEVAPSYVF LACNHCSSYF TGQVLHPNGG AVVNA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: cv. Columbia.
[4]	"Further progress towards a catalogue of all Arabidopsis genes: analysis of a set of 5000 non-redundant ESTs." Cooke R., Raynal M., Laudie M., Grellet F., Delseny M., Morris P.-C., Guerrier D., Giraudat J., Quigley F., Clabault G., Li Y.-F., Mache R., Krivitzky M., Gy I.J.-J., Kreis M., Lecharny A., Parmentier Y., Marbach J. , Fleck J., Clement B., Philipps G., Herve C., Bardet C., Tremousaygue D., Lescure B., Lacomme C., Roby D., Jourjon M.-F., Chabrier P., Charpenteau J.-L., Desprez T., Amselem J., Chiapello H., Hoefte H. Plant J. 9:101-124(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 170-288 (ISOFORMS 1/2). Strain: cv. Columbia. Tissue: Dry seed.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC064840 Genomic DNA. Translation: AAG00870.1. AC069144 Genomic DNA. Translation: AAG51119.1. CP002684 Genomic DNA. Translation: AEE33158.1. AF372931 mRNA. Translation: AAK50071.1. AY124852 mRNA. Translation: AAM70561.1. Z27012 mRNA. Translation: CAA81564.1.
IPI	IPI00530438. IPI01018443.
PIR	C96590.
RefSeq	NP_564670.2. NM_104360.3.
UniGene	At.16081. At.70639.
3D structure databases
ProteinModelPortal	Q9FZ42.
SMR	Q9FZ42. Positions 6-288.
ModBase	Search...
Protein-protein interaction databases
STRING	3702.AT1G54870.1-P.
Proteomic databases
PaxDb	Q9FZ42.
PRIDE	Q9FZ42.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	841926.
KEGG	ath:AT1G54870.
Organism-specific databases
TAIR	At1g54870.
Phylogenomic databases
eggNOG	COG1028.
InParanoid	Q9FZ42.
OMA	AYKGNAS.
PhylomeDB	Q9FZ42.
Enzyme and pathway databases
BioCyc	ARA:AT1G54870-MONOMER. MetaCyc:AT1G54870-MONOMER.
Gene expression databases
ArrayExpress	Q9FZ42.
Genevestigator	Q9FZ42.
GermOnline	AT1G54870. Arabidopsis thaliana.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GRDH1_ARATH

Accession

Primary (citable) accession number: Q9FZ42
Secondary accession number(s): Q42157, Q42225, Q9C7L3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program