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Q9FYH1

- HAC2_ARATH

UniProt

Q9FYH1 - HAC2_ARATH

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Protein
Histone acetyltransferase HAC2
Gene
HAC2, PCAT1, At1g67220, F1N21.4
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation By similarity. No acetyltransferase activity found in vitro.1 Publication

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri688 – 76578PHD-type
Add
BLAST
Zinc fingeri1093 – 114048ZZ-type 1
Add
BLAST
Zinc fingeri1219 – 126648ZZ-type 2
Add
BLAST
Zinc fingeri1274 – 135986TAZ-type
Add
BLAST

GO - Molecular functioni

  1. transcription cofactor activity Source: InterPro
  2. transferase activity, transferring acyl groups Source: UniProtKB-KW
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. chromatin modification Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G67220-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase HAC2 (EC:2.3.1.48)
Gene namesi
Name:HAC2
Synonyms:PCAT1
Ordered Locus Names:At1g67220
ORF Names:F1N21.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G67220.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13671367Histone acetyltransferase HAC2
PRO_0000269741Add
BLAST

Proteomic databases

PaxDbiQ9FYH1.
PRIDEiQ9FYH1.

Expressioni

Tissue specificityi

Rosette leaves, stems and flowers.1 Publication

Developmental stagei

Expressed in young seedlings.1 Publication

Gene expression databases

GenevestigatoriQ9FYH1.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G67220.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9FYH1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati188 – 200131
Add
BLAST
Repeati223 – 235132
Add
BLAST
Repeati251 – 263133
Add
BLAST
Repeati286 – 298134
Add
BLAST
Repeati314 – 326135
Add
BLAST
Repeati349 – 361136
Add
BLAST
Repeati377 – 389137
Add
BLAST
Repeati418 – 430138
Add
BLAST
Repeati432 – 444139
Add
BLAST
Repeati459 – 4711310
Add
BLAST
Repeati473 – 4851311
Add
BLAST
Repeati500 – 5121312
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni188 – 51232512 X 13 AA approximate repeats
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi111 – 15343Ser-rich
Add
BLAST
Compositional biasi640 – 6434Poly-Glu
Compositional biasi1187 – 121529His-rich
Add
BLAST

Sequence similaritiesi

Contains 2 ZZ-type zinc fingers.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG300787.
HOGENOMiHOG000176849.
InParanoidiQ9FYH1.
KOiK04498.
OMAiIVEPMKC.

Family and domain databases

Gene3Di1.20.1020.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF08214. KAT11. 1 hit.
PF00628. PHD. 1 hit.
PF02135. zf-TAZ. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 1 hit.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FYH1-1 [UniParc]FASTAAdd to Basket

« Hide

MAPPRKRTRD LMPKFLNTES FDEFNQRLNN LPAESNVTSD EDAQFLESRK     50
CQSKRWRKEE PLKLNLRSPW NVLCSPESIS SAKFIVEKTC LIPVPSFEEA 100
ATNARRCLNT SSIPGSSGSA SETNSGSDIT KQDFKNDSPS DSKKVQGSST 150
SKSAKPKVIK VYSFVDLVTT TKKGNIQTEE SSLNHEKKLG TVVDIVEPMK 200
CDERSKEVQG SSTSKSAKPK VIKVYSFADV VTTTKKGNIQ TEESSLNHEK 250
KLGTVVDIIE PMKCDERSKE VQGSSTSKSA KLKVIKVYSF ADVVTTTKKG 300
NIQTEESSLN HEKKLGTVVD IVEPMKCDER SKEVQGSSTS KSEKPKVIKV 350
YSFADVVTTT KKGNIQTEES SLNHEKKLGT VVDIVEPMKC DEGTKCEVTT 400
TNKGKIHTEE RSLNHEKKLG TVVDIVEPMK CDEGSKCEVT TTNKGNTQTE 450
ERSLNHEKKL GIGVDIVEPM KCDEGTKCEV TTTNKGKIQT EERSLNYEKK 500
LGIGVDIVEP MKCDEENKCE VNADTFDVVI VEPMKCNKVT KCEVNVDTTG 550
VNIVEPMKCN EVTKCEVNVD TIGVDIVEPM KCNEESKCEV NADTMSLQKR 600
SKRAVSLVER FTEEEIKLHI MSLKKPSTQS AVEGMCDLKE EEESCQLCDD 650
GTLLFPPQPL YCLLCSRRID DRSFYYTPGE EELSNAQHQI CSPCHSRCKT 700
KFPLCGVFID KHKMLKRSNF DNADTEEWVQ CESCEKWQHQ ICGLYNKLKD 750
EDKTAEYICP TCLLEECQSI NNMALVDYTD SGAKDLPETV LSYFLEQRLF 800
KRLKEERYQT AKATGKSIND VPEPEGLTLR VVFSADRTLT VNKQFASLLH 850
KENFPSEFPY RSKVILLFQK VHGVDICIFA LFVQEFGSEC SQPNQRSTYI 900
FYLDSVKYFK PERVTFAGEA LRTFVYHEVL IGYLEYCKLR GFTTSYIWAC 950
PPKIGQDYIM YSHPKTQQTP DTKKLRKWYV SMLQKAAEQR VVMNVTNLYD 1000
RFFDSTEEYM TAARLPYFEG SFWSNRAEIM IQDIEREGNN ELQKKVKLLS 1050
RRKVKTMSYK TTGDVDVDDV KNILLMEKLE KEVFPNKKDL MVVELNYSCT 1100
RCSKAVLSGL RWFCEKCKNL HLCESCYDAG QELPGEHIYK RMDKEKHQLS 1150
KVQVNGVLFS TTEDNDIIQE NDMFESRQAF LAFSQKHNYN FHTLRHAKHS 1200
SMMILHHLHT SNKHHCSQNS SSLTCTACKK DVSTTIYFPC LLCPDYRACT 1250
GCYTKNRTLR HLHIFPTLPS ANRAPSRTVM VLEILNAISH ALLCQHKTTK 1300
SCSYPKCHEV KALFTHNVQC KIRKKGTRCN TCYKLWQTIR IHVYHCQDLN 1350
CPVPQCRDRK EVLIRKV 1367
Length:1,367
Mass (Da):155,772
Last modified:May 31, 2011 - v2
Checksum:i140EF2D47193F0FB
GO

Sequence cautioni

The sequence AAG00238.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC002130 Genomic DNA. Translation: AAG00238.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE34614.1.
PIRiB96696.
RefSeqiNP_564891.4. NM_105391.4.
UniGeneiAt.52418.

Genome annotation databases

EnsemblPlantsiAT1G67220.1; AT1G67220.1; AT1G67220.
GeneIDi843042.
KEGGiath:AT1G67220.

Cross-referencesi

Web resourcesi

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC002130 Genomic DNA. Translation: AAG00238.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE34614.1 .
PIRi B96696.
RefSeqi NP_564891.4. NM_105391.4.
UniGenei At.52418.

3D structure databases

ProteinModelPortali Q9FYH1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT1G67220.1-P.

Proteomic databases

PaxDbi Q9FYH1.
PRIDEi Q9FYH1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G67220.1 ; AT1G67220.1 ; AT1G67220 .
GeneIDi 843042.
KEGGi ath:AT1G67220.

Organism-specific databases

TAIRi AT1G67220.

Phylogenomic databases

eggNOGi NOG300787.
HOGENOMi HOG000176849.
InParanoidi Q9FYH1.
KOi K04498.
OMAi IVEPMKC.

Enzyme and pathway databases

BioCyci ARA:AT1G67220-MONOMER.

Gene expression databases

Genevestigatori Q9FYH1.

Family and domain databases

Gene3Di 1.20.1020.10. 1 hit.
3.30.40.10. 1 hit.
InterProi IPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view ]
Pfami PF08214. KAT11. 1 hit.
PF00628. PHD. 1 hit.
PF02135. zf-TAZ. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 1 hit.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 1 hit.
PROSITEi PS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins."
    Bordoli L., Netsch M., Luethi U., Lutz W., Eckner R.
    Nucleic Acids Res. 29:589-597(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1357, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, FUNCTION.
  4. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
    Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
    Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiHAC2_ARATH
AccessioniPrimary (citable) accession number: Q9FYH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 31, 2011
Last modified: February 19, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3