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Q9FYH1

- HAC2_ARATH

UniProt

Q9FYH1 - HAC2_ARATH

Protein

Histone acetyltransferase HAC2

Gene

HAC2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (31 May 2011)
      Previous versions | rss
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    Functioni

    Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation By similarity. No acetyltransferase activity found in vitro.By similarity1 Publication

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri688 – 76578PHD-typeAdd
    BLAST
    Zinc fingeri1093 – 114048ZZ-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1219 – 126648ZZ-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1274 – 135986TAZ-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. transcription cofactor activity Source: InterPro
    2. transferase activity, transferring acyl groups Source: UniProtKB-KW
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. chromatin modification Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciARA:AT1G67220-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase HAC2 (EC:2.3.1.48)
    Gene namesi
    Name:HAC2
    Synonyms:PCAT1
    Ordered Locus Names:At1g67220
    ORF Names:F1N21.4
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G67220.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13671367Histone acetyltransferase HAC2PRO_0000269741Add
    BLAST

    Proteomic databases

    PaxDbiQ9FYH1.
    PRIDEiQ9FYH1.

    Expressioni

    Tissue specificityi

    Rosette leaves, stems and flowers.1 Publication

    Developmental stagei

    Expressed in young seedlings.1 Publication

    Gene expression databases

    GenevestigatoriQ9FYH1.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT1G67220.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FYH1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati188 – 200131Add
    BLAST
    Repeati223 – 235132Add
    BLAST
    Repeati251 – 263133Add
    BLAST
    Repeati286 – 298134Add
    BLAST
    Repeati314 – 326135Add
    BLAST
    Repeati349 – 361136Add
    BLAST
    Repeati377 – 389137Add
    BLAST
    Repeati418 – 430138Add
    BLAST
    Repeati432 – 444139Add
    BLAST
    Repeati459 – 4711310Add
    BLAST
    Repeati473 – 4851311Add
    BLAST
    Repeati500 – 5121312Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni188 – 51232512 X 13 AA approximate repeatsAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi111 – 15343Ser-richAdd
    BLAST
    Compositional biasi640 – 6434Poly-Glu
    Compositional biasi1187 – 121529His-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PHD-type zinc finger.Curated
    Contains 1 TAZ-type zinc finger.PROSITE-ProRule annotation
    Contains 2 ZZ-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri688 – 76578PHD-typeAdd
    BLAST
    Zinc fingeri1093 – 114048ZZ-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1219 – 126648ZZ-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1274 – 135986TAZ-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG300787.
    HOGENOMiHOG000176849.
    InParanoidiQ9FYH1.
    KOiK04498.
    OMAiIVEPMKC.

    Family and domain databases

    Gene3Di1.20.1020.10. 1 hit.
    3.30.40.10. 1 hit.
    InterProiIPR013178. Histone_H3-K56_AcTrfase_RTT109.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR000197. Znf_TAZ.
    IPR000433. Znf_ZZ.
    [Graphical view]
    PfamiPF08214. KAT11. 1 hit.
    PF00628. PHD. 1 hit.
    PF02135. zf-TAZ. 1 hit.
    PF00569. ZZ. 1 hit.
    [Graphical view]
    SMARTiSM00249. PHD. 1 hit.
    SM00551. ZnF_TAZ. 1 hit.
    SM00291. ZnF_ZZ. 2 hits.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 1 hit.
    SSF57933. SSF57933. 1 hit.
    PROSITEiPS01359. ZF_PHD_1. 1 hit.
    PS50134. ZF_TAZ. 1 hit.
    PS01357. ZF_ZZ_1. 1 hit.
    PS50135. ZF_ZZ_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9FYH1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPPRKRTRD LMPKFLNTES FDEFNQRLNN LPAESNVTSD EDAQFLESRK     50
    CQSKRWRKEE PLKLNLRSPW NVLCSPESIS SAKFIVEKTC LIPVPSFEEA 100
    ATNARRCLNT SSIPGSSGSA SETNSGSDIT KQDFKNDSPS DSKKVQGSST 150
    SKSAKPKVIK VYSFVDLVTT TKKGNIQTEE SSLNHEKKLG TVVDIVEPMK 200
    CDERSKEVQG SSTSKSAKPK VIKVYSFADV VTTTKKGNIQ TEESSLNHEK 250
    KLGTVVDIIE PMKCDERSKE VQGSSTSKSA KLKVIKVYSF ADVVTTTKKG 300
    NIQTEESSLN HEKKLGTVVD IVEPMKCDER SKEVQGSSTS KSEKPKVIKV 350
    YSFADVVTTT KKGNIQTEES SLNHEKKLGT VVDIVEPMKC DEGTKCEVTT 400
    TNKGKIHTEE RSLNHEKKLG TVVDIVEPMK CDEGSKCEVT TTNKGNTQTE 450
    ERSLNHEKKL GIGVDIVEPM KCDEGTKCEV TTTNKGKIQT EERSLNYEKK 500
    LGIGVDIVEP MKCDEENKCE VNADTFDVVI VEPMKCNKVT KCEVNVDTTG 550
    VNIVEPMKCN EVTKCEVNVD TIGVDIVEPM KCNEESKCEV NADTMSLQKR 600
    SKRAVSLVER FTEEEIKLHI MSLKKPSTQS AVEGMCDLKE EEESCQLCDD 650
    GTLLFPPQPL YCLLCSRRID DRSFYYTPGE EELSNAQHQI CSPCHSRCKT 700
    KFPLCGVFID KHKMLKRSNF DNADTEEWVQ CESCEKWQHQ ICGLYNKLKD 750
    EDKTAEYICP TCLLEECQSI NNMALVDYTD SGAKDLPETV LSYFLEQRLF 800
    KRLKEERYQT AKATGKSIND VPEPEGLTLR VVFSADRTLT VNKQFASLLH 850
    KENFPSEFPY RSKVILLFQK VHGVDICIFA LFVQEFGSEC SQPNQRSTYI 900
    FYLDSVKYFK PERVTFAGEA LRTFVYHEVL IGYLEYCKLR GFTTSYIWAC 950
    PPKIGQDYIM YSHPKTQQTP DTKKLRKWYV SMLQKAAEQR VVMNVTNLYD 1000
    RFFDSTEEYM TAARLPYFEG SFWSNRAEIM IQDIEREGNN ELQKKVKLLS 1050
    RRKVKTMSYK TTGDVDVDDV KNILLMEKLE KEVFPNKKDL MVVELNYSCT 1100
    RCSKAVLSGL RWFCEKCKNL HLCESCYDAG QELPGEHIYK RMDKEKHQLS 1150
    KVQVNGVLFS TTEDNDIIQE NDMFESRQAF LAFSQKHNYN FHTLRHAKHS 1200
    SMMILHHLHT SNKHHCSQNS SSLTCTACKK DVSTTIYFPC LLCPDYRACT 1250
    GCYTKNRTLR HLHIFPTLPS ANRAPSRTVM VLEILNAISH ALLCQHKTTK 1300
    SCSYPKCHEV KALFTHNVQC KIRKKGTRCN TCYKLWQTIR IHVYHCQDLN 1350
    CPVPQCRDRK EVLIRKV 1367
    Length:1,367
    Mass (Da):155,772
    Last modified:May 31, 2011 - v2
    Checksum:i140EF2D47193F0FB
    GO

    Sequence cautioni

    The sequence AAG00238.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC002130 Genomic DNA. Translation: AAG00238.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE34614.1.
    PIRiB96696.
    RefSeqiNP_564891.4. NM_105391.4.
    UniGeneiAt.52418.

    Genome annotation databases

    EnsemblPlantsiAT1G67220.1; AT1G67220.1; AT1G67220.
    GeneIDi843042.
    KEGGiath:AT1G67220.

    Cross-referencesi

    Web resourcesi

    PlantsUBQ

    A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC002130 Genomic DNA. Translation: AAG00238.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE34614.1 .
    PIRi B96696.
    RefSeqi NP_564891.4. NM_105391.4.
    UniGenei At.52418.

    3D structure databases

    ProteinModelPortali Q9FYH1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT1G67220.1-P.

    Proteomic databases

    PaxDbi Q9FYH1.
    PRIDEi Q9FYH1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G67220.1 ; AT1G67220.1 ; AT1G67220 .
    GeneIDi 843042.
    KEGGi ath:AT1G67220.

    Organism-specific databases

    TAIRi AT1G67220.

    Phylogenomic databases

    eggNOGi NOG300787.
    HOGENOMi HOG000176849.
    InParanoidi Q9FYH1.
    KOi K04498.
    OMAi IVEPMKC.

    Enzyme and pathway databases

    BioCyci ARA:AT1G67220-MONOMER.

    Gene expression databases

    Genevestigatori Q9FYH1.

    Family and domain databases

    Gene3Di 1.20.1020.10. 1 hit.
    3.30.40.10. 1 hit.
    InterProi IPR013178. Histone_H3-K56_AcTrfase_RTT109.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR000197. Znf_TAZ.
    IPR000433. Znf_ZZ.
    [Graphical view ]
    Pfami PF08214. KAT11. 1 hit.
    PF00628. PHD. 1 hit.
    PF02135. zf-TAZ. 1 hit.
    PF00569. ZZ. 1 hit.
    [Graphical view ]
    SMARTi SM00249. PHD. 1 hit.
    SM00551. ZnF_TAZ. 1 hit.
    SM00291. ZnF_ZZ. 2 hits.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 1 hit.
    SSF57933. SSF57933. 1 hit.
    PROSITEi PS01359. ZF_PHD_1. 1 hit.
    PS50134. ZF_TAZ. 1 hit.
    PS01357. ZF_ZZ_1. 1 hit.
    PS50135. ZF_ZZ_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins."
      Bordoli L., Netsch M., Luethi U., Lutz W., Eckner R.
      Nucleic Acids Res. 29:589-597(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1357, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, FUNCTION.
    4. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
      Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
      Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiHAC2_ARATH
    AccessioniPrimary (citable) accession number: Q9FYH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3