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Q9FYH1

- HAC2_ARATH

UniProt

Q9FYH1 - HAC2_ARATH

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Protein

Histone acetyltransferase HAC2

Gene

HAC2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). No acetyltransferase activity found in vitro.By similarity1 Publication

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei978 – 9781Acetyl-CoABy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri688 – 76578PHD-typeAdd
BLAST
Zinc fingeri1093 – 114048ZZ-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1219 – 126648ZZ-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1274 – 135986TAZ-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. transcription cofactor activity Source: InterPro
  2. transferase activity, transferring acyl groups Source: UniProtKB-KW
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. chromatin modification Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G67220-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase HAC2 (EC:2.3.1.48By similarity)
Gene namesi
Name:HAC2
Synonyms:PCAT1
Ordered Locus Names:At1g67220
ORF Names:F1N21.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G67220.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13671367Histone acetyltransferase HAC2PRO_0000269741Add
BLAST

Proteomic databases

PaxDbiQ9FYH1.
PRIDEiQ9FYH1.

Expressioni

Tissue specificityi

Rosette leaves, stems and flowers.1 Publication

Developmental stagei

Expressed in young seedlings.1 Publication

Gene expression databases

GenevestigatoriQ9FYH1.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G67220.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9FYH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati188 – 200131Add
BLAST
Repeati223 – 235132Add
BLAST
Repeati251 – 263133Add
BLAST
Repeati286 – 298134Add
BLAST
Repeati314 – 326135Add
BLAST
Repeati349 – 361136Add
BLAST
Repeati377 – 389137Add
BLAST
Repeati418 – 430138Add
BLAST
Repeati432 – 444139Add
BLAST
Repeati459 – 4711310Add
BLAST
Repeati473 – 4851311Add
BLAST
Repeati500 – 5121312Add
BLAST
Domaini780 – 1213434CBP/p300-type HATPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni188 – 51232512 X 13 AA approximate repeatsAdd
BLAST
Regioni903 – 9053Acetyl-CoA bindingBy similarity
Regioni922 – 9232Acetyl-CoA bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi111 – 15343Ser-richAdd
BLAST
Compositional biasi640 – 6434Poly-Glu
Compositional biasi1187 – 121529His-richAdd
BLAST

Sequence similaritiesi

Contains 1 CBP/p300-type HAT (histone acetyltransferase) domain.PROSITE-ProRule annotation
Contains 1 PHD-type zinc finger.Curated
Contains 1 TAZ-type zinc finger.PROSITE-ProRule annotation
Contains 2 ZZ-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri688 – 76578PHD-typeAdd
BLAST
Zinc fingeri1093 – 114048ZZ-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1219 – 126648ZZ-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1274 – 135986TAZ-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG300787.
HOGENOMiHOG000176849.
InParanoidiQ9FYH1.
KOiK04498.
OMAiIVEPMKC.

Family and domain databases

Gene3Di1.20.1020.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF08214. KAT11. 1 hit.
PF00628. PHD. 1 hit.
PF02135. zf-TAZ. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 1 hit.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 1 hit.
PROSITEiPS51727. CBP_P300_HAT. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FYH1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPPRKRTRD LMPKFLNTES FDEFNQRLNN LPAESNVTSD EDAQFLESRK
60 70 80 90 100
CQSKRWRKEE PLKLNLRSPW NVLCSPESIS SAKFIVEKTC LIPVPSFEEA
110 120 130 140 150
ATNARRCLNT SSIPGSSGSA SETNSGSDIT KQDFKNDSPS DSKKVQGSST
160 170 180 190 200
SKSAKPKVIK VYSFVDLVTT TKKGNIQTEE SSLNHEKKLG TVVDIVEPMK
210 220 230 240 250
CDERSKEVQG SSTSKSAKPK VIKVYSFADV VTTTKKGNIQ TEESSLNHEK
260 270 280 290 300
KLGTVVDIIE PMKCDERSKE VQGSSTSKSA KLKVIKVYSF ADVVTTTKKG
310 320 330 340 350
NIQTEESSLN HEKKLGTVVD IVEPMKCDER SKEVQGSSTS KSEKPKVIKV
360 370 380 390 400
YSFADVVTTT KKGNIQTEES SLNHEKKLGT VVDIVEPMKC DEGTKCEVTT
410 420 430 440 450
TNKGKIHTEE RSLNHEKKLG TVVDIVEPMK CDEGSKCEVT TTNKGNTQTE
460 470 480 490 500
ERSLNHEKKL GIGVDIVEPM KCDEGTKCEV TTTNKGKIQT EERSLNYEKK
510 520 530 540 550
LGIGVDIVEP MKCDEENKCE VNADTFDVVI VEPMKCNKVT KCEVNVDTTG
560 570 580 590 600
VNIVEPMKCN EVTKCEVNVD TIGVDIVEPM KCNEESKCEV NADTMSLQKR
610 620 630 640 650
SKRAVSLVER FTEEEIKLHI MSLKKPSTQS AVEGMCDLKE EEESCQLCDD
660 670 680 690 700
GTLLFPPQPL YCLLCSRRID DRSFYYTPGE EELSNAQHQI CSPCHSRCKT
710 720 730 740 750
KFPLCGVFID KHKMLKRSNF DNADTEEWVQ CESCEKWQHQ ICGLYNKLKD
760 770 780 790 800
EDKTAEYICP TCLLEECQSI NNMALVDYTD SGAKDLPETV LSYFLEQRLF
810 820 830 840 850
KRLKEERYQT AKATGKSIND VPEPEGLTLR VVFSADRTLT VNKQFASLLH
860 870 880 890 900
KENFPSEFPY RSKVILLFQK VHGVDICIFA LFVQEFGSEC SQPNQRSTYI
910 920 930 940 950
FYLDSVKYFK PERVTFAGEA LRTFVYHEVL IGYLEYCKLR GFTTSYIWAC
960 970 980 990 1000
PPKIGQDYIM YSHPKTQQTP DTKKLRKWYV SMLQKAAEQR VVMNVTNLYD
1010 1020 1030 1040 1050
RFFDSTEEYM TAARLPYFEG SFWSNRAEIM IQDIEREGNN ELQKKVKLLS
1060 1070 1080 1090 1100
RRKVKTMSYK TTGDVDVDDV KNILLMEKLE KEVFPNKKDL MVVELNYSCT
1110 1120 1130 1140 1150
RCSKAVLSGL RWFCEKCKNL HLCESCYDAG QELPGEHIYK RMDKEKHQLS
1160 1170 1180 1190 1200
KVQVNGVLFS TTEDNDIIQE NDMFESRQAF LAFSQKHNYN FHTLRHAKHS
1210 1220 1230 1240 1250
SMMILHHLHT SNKHHCSQNS SSLTCTACKK DVSTTIYFPC LLCPDYRACT
1260 1270 1280 1290 1300
GCYTKNRTLR HLHIFPTLPS ANRAPSRTVM VLEILNAISH ALLCQHKTTK
1310 1320 1330 1340 1350
SCSYPKCHEV KALFTHNVQC KIRKKGTRCN TCYKLWQTIR IHVYHCQDLN
1360
CPVPQCRDRK EVLIRKV
Length:1,367
Mass (Da):155,772
Last modified:May 31, 2011 - v2
Checksum:i140EF2D47193F0FB
GO

Sequence cautioni

The sequence AAG00238.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC002130 Genomic DNA. Translation: AAG00238.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE34614.1.
PIRiB96696.
RefSeqiNP_564891.4. NM_105391.4.
UniGeneiAt.52418.

Genome annotation databases

EnsemblPlantsiAT1G67220.1; AT1G67220.1; AT1G67220.
GeneIDi843042.
KEGGiath:AT1G67220.

Cross-referencesi

Web resourcesi

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC002130 Genomic DNA. Translation: AAG00238.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE34614.1 .
PIRi B96696.
RefSeqi NP_564891.4. NM_105391.4.
UniGenei At.52418.

3D structure databases

ProteinModelPortali Q9FYH1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT1G67220.1-P.

Proteomic databases

PaxDbi Q9FYH1.
PRIDEi Q9FYH1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G67220.1 ; AT1G67220.1 ; AT1G67220 .
GeneIDi 843042.
KEGGi ath:AT1G67220.

Organism-specific databases

TAIRi AT1G67220.

Phylogenomic databases

eggNOGi NOG300787.
HOGENOMi HOG000176849.
InParanoidi Q9FYH1.
KOi K04498.
OMAi IVEPMKC.

Enzyme and pathway databases

BioCyci ARA:AT1G67220-MONOMER.

Gene expression databases

Genevestigatori Q9FYH1.

Family and domain databases

Gene3Di 1.20.1020.10. 1 hit.
3.30.40.10. 1 hit.
InterProi IPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view ]
Pfami PF08214. KAT11. 1 hit.
PF00628. PHD. 1 hit.
PF02135. zf-TAZ. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 1 hit.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 1 hit.
PROSITEi PS51727. CBP_P300_HAT. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins."
    Bordoli L., Netsch M., Luethi U., Lutz W., Eckner R.
    Nucleic Acids Res. 29:589-597(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1357, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, FUNCTION.
  4. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
    Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
    Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiHAC2_ARATH
AccessioniPrimary (citable) accession number: Q9FYH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 31, 2011
Last modified: October 29, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3