Q9FYH1 (HAC2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone acetyltransferase HAC2
EC=2.3.1.48

Gene names

Name:	HAC2
Synonyms:	PCAT1
Ordered Locus Names:	At1g67220
ORF Names:	F1N21.4

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	1367 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation By similarity. No acetyltransferase activity found in vitro. Ref.3
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Subcellular location	Nucleus Probable.
Tissue specificity	Rosette leaves, stems and flowers. Ref.3
Developmental stage	Expressed in young seedlings. Ref.3
Sequence similarities	Contains 1 PHD-type zinc finger. Contains 1 TAZ-type zinc finger. Contains 2 ZZ-type zinc fingers.
Sequence caution	The sequence AAG00238.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Activator Acyltransferase Chromatin regulator Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC transcription cofactor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1367	1367	Histone acetyltransferase HAC2		PRO_0000269741
Regions
	Repeat	188 – 200	13	1
	Repeat	223 – 235	13	2
	Repeat	251 – 263	13	3
	Repeat	286 – 298	13	4
	Repeat	314 – 326	13	5
	Repeat	349 – 361	13	6
	Repeat	377 – 389	13	7
	Repeat	418 – 430	13	8
	Repeat	432 – 444	13	9
	Repeat	459 – 471	13	10
	Repeat	473 – 485	13	11
	Repeat	500 – 512	13	12
	Zinc finger	688 – 765	78	PHD-type
	Zinc finger	1093 – 1140	48	ZZ-type 1
	Zinc finger	1219 – 1266	48	ZZ-type 2
	Zinc finger	1274 – 1359	86	TAZ-type
	Region	188 – 512	325	12 X 13 AA approximate repeats
	Compositional bias	111 – 153	43	Ser-rich
	Compositional bias	640 – 643	4	Poly-Glu
	Compositional bias	1187 – 1215	29	His-rich

Sequences

	Sequence		Length	Mass (Da)
	Q9FYH1 [UniParc]. Last modified May 31, 2011. Version 2. Checksum: 140EF2D47193F0FB	FASTA	1,367	155,772
	10 20 30 40 50 60 MAPPRKRTRD LMPKFLNTES FDEFNQRLNN LPAESNVTSD EDAQFLESRK CQSKRWRKEE 70 80 90 100 110 120 PLKLNLRSPW NVLCSPESIS SAKFIVEKTC LIPVPSFEEA ATNARRCLNT SSIPGSSGSA 130 140 150 160 170 180 SETNSGSDIT KQDFKNDSPS DSKKVQGSST SKSAKPKVIK VYSFVDLVTT TKKGNIQTEE 190 200 210 220 230 240 SSLNHEKKLG TVVDIVEPMK CDERSKEVQG SSTSKSAKPK VIKVYSFADV VTTTKKGNIQ 250 260 270 280 290 300 TEESSLNHEK KLGTVVDIIE PMKCDERSKE VQGSSTSKSA KLKVIKVYSF ADVVTTTKKG 310 320 330 340 350 360 NIQTEESSLN HEKKLGTVVD IVEPMKCDER SKEVQGSSTS KSEKPKVIKV YSFADVVTTT 370 380 390 400 410 420 KKGNIQTEES SLNHEKKLGT VVDIVEPMKC DEGTKCEVTT TNKGKIHTEE RSLNHEKKLG 430 440 450 460 470 480 TVVDIVEPMK CDEGSKCEVT TTNKGNTQTE ERSLNHEKKL GIGVDIVEPM KCDEGTKCEV 490 500 510 520 530 540 TTTNKGKIQT EERSLNYEKK LGIGVDIVEP MKCDEENKCE VNADTFDVVI VEPMKCNKVT 550 560 570 580 590 600 KCEVNVDTTG VNIVEPMKCN EVTKCEVNVD TIGVDIVEPM KCNEESKCEV NADTMSLQKR 610 620 630 640 650 660 SKRAVSLVER FTEEEIKLHI MSLKKPSTQS AVEGMCDLKE EEESCQLCDD GTLLFPPQPL 670 680 690 700 710 720 YCLLCSRRID DRSFYYTPGE EELSNAQHQI CSPCHSRCKT KFPLCGVFID KHKMLKRSNF 730 740 750 760 770 780 DNADTEEWVQ CESCEKWQHQ ICGLYNKLKD EDKTAEYICP TCLLEECQSI NNMALVDYTD 790 800 810 820 830 840 SGAKDLPETV LSYFLEQRLF KRLKEERYQT AKATGKSIND VPEPEGLTLR VVFSADRTLT 850 860 870 880 890 900 VNKQFASLLH KENFPSEFPY RSKVILLFQK VHGVDICIFA LFVQEFGSEC SQPNQRSTYI 910 920 930 940 950 960 FYLDSVKYFK PERVTFAGEA LRTFVYHEVL IGYLEYCKLR GFTTSYIWAC PPKIGQDYIM 970 980 990 1000 1010 1020 YSHPKTQQTP DTKKLRKWYV SMLQKAAEQR VVMNVTNLYD RFFDSTEEYM TAARLPYFEG 1030 1040 1050 1060 1070 1080 SFWSNRAEIM IQDIEREGNN ELQKKVKLLS RRKVKTMSYK TTGDVDVDDV KNILLMEKLE 1090 1100 1110 1120 1130 1140 KEVFPNKKDL MVVELNYSCT RCSKAVLSGL RWFCEKCKNL HLCESCYDAG QELPGEHIYK 1150 1160 1170 1180 1190 1200 RMDKEKHQLS KVQVNGVLFS TTEDNDIIQE NDMFESRQAF LAFSQKHNYN FHTLRHAKHS 1210 1220 1230 1240 1250 1260 SMMILHHLHT SNKHHCSQNS SSLTCTACKK DVSTTIYFPC LLCPDYRACT GCYTKNRTLR 1270 1280 1290 1300 1310 1320 HLHIFPTLPS ANRAPSRTVM VLEILNAISH ALLCQHKTTK SCSYPKCHEV KALFTHNVQC 1330 1340 1350 1360 KIRKKGTRCN TCYKLWQTIR IHVYHCQDLN CPVPQCRDRK EVLIRKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins." Bordoli L., Netsch M., Luethi U., Lutz W., Eckner R. Nucleic Acids Res. 29:589-597(2001) [PubMed: 11160878] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1357, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, FUNCTION.
[4]	"Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes." Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A. Nucleic Acids Res. 30:5036-5055(2002) [PubMed: 12466527] [Abstract] Cited for: NOMENCLATURE.
+	Additional computationally mapped references.

Web resources

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC002130 Genomic DNA. Translation: AAG00238.1. Sequence problems. CP002684 Genomic DNA. Translation: AEE34614.1.
IPI	IPI00526244.
PIR	B96696.
RefSeq	NP_564891.4. NM_105391.4.
UniGene	At.52418.
3D structure databases
HSSP	HSSP built from PDB template 1F81 based on UniProtKB P45481.
ProteinModelPortal	Q9FYH1.
SMR	Q9FYH1. Positions 781-1211, 1217-1270, 1272-1366.
ModBase	Search...
Proteomic databases
PRIDE	Q9FYH1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G67220.1; AT1G67220.1; AT1G67220.
GeneID	843042.
GenomeReviews	Gene locus AT1G67220 in contig CT485782_GR.
KEGG	ath:AT1G67220.
NMPDR	fig|3702.1.peg.6157.
Organism-specific databases
TAIR	At1g67220.
Phylogenomic databases
eggNOG	KOG1778.
GeneTree	EPGT00050000000620.
InParanoid	Q9FYH1.
OMA	IVEPMKC.
Gene expression databases
Genevestigator	Q9FYH1.
Family and domain databases
InterPro	IPR013178. Histone_H3-K56_AcTrfase_RTT109. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. IPR013083. Znf_RING/FYVE/PHD. IPR000197. Znf_TAZ. IPR000433. Znf_ZZ. [Graphical view]
Gene3D	G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit. G3DSA:1.20.1020.10. Znf_TAZ. 1 hit.
KO	K04498.
Pfam	PF08214. KAT11. 1 hit. PF00628. PHD. 1 hit. PF02135. zf-TAZ. 1 hit. PF00569. ZZ. 1 hit. [Graphical view]
SMART	SM00249. PHD. 1 hit. SM00551. ZnF_TAZ. 1 hit. SM00291. ZnF_ZZ. 2 hits. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 1 hit. SSF57933. TAZ_finger. 1 hit.
PROSITE	PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. False negative. PS50134. ZF_TAZ. 1 hit. PS01357. ZF_ZZ_1. 1 hit. PS50135. ZF_ZZ_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HAC2_ARATH

Accession

Primary (citable) accession number: Q9FYH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	May 31, 2011
Last modified:	January 25, 2012
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program