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Q9FYH1 (HAC2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone acetyltransferase HAC2

EC=2.3.1.48
Gene names
Name:HAC2
Synonyms:PCAT1
Ordered Locus Names:At1g67220
ORF Names:F1N21.4
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length1367 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation By similarity. No acetyltransferase activity found in vitro. Ref.3

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subcellular location

Nucleus Probable.

Tissue specificity

Rosette leaves, stems and flowers. Ref.3

Developmental stage

Expressed in young seedlings. Ref.3

Sequence similarities

Contains 1 PHD-type zinc finger.

Contains 1 TAZ-type zinc finger.

Contains 2 ZZ-type zinc fingers.

Sequence caution

The sequence AAG00238.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13671367Histone acetyltransferase HAC2
PRO_0000269741

Regions

Repeat188 – 200131
Repeat223 – 235132
Repeat251 – 263133
Repeat286 – 298134
Repeat314 – 326135
Repeat349 – 361136
Repeat377 – 389137
Repeat418 – 430138
Repeat432 – 444139
Repeat459 – 4711310
Repeat473 – 4851311
Repeat500 – 5121312
Zinc finger688 – 76578PHD-type
Zinc finger1093 – 114048ZZ-type 1
Zinc finger1219 – 126648ZZ-type 2
Zinc finger1274 – 135986TAZ-type
Region188 – 51232512 X 13 AA approximate repeats
Compositional bias111 – 15343Ser-rich
Compositional bias640 – 6434Poly-Glu
Compositional bias1187 – 121529His-rich

Sequences

Sequence LengthMass (Da)Tools
Q9FYH1 [UniParc].

Last modified May 31, 2011. Version 2.
Checksum: 140EF2D47193F0FB

FASTA1,367155,772
        10         20         30         40         50         60 
MAPPRKRTRD LMPKFLNTES FDEFNQRLNN LPAESNVTSD EDAQFLESRK CQSKRWRKEE 

        70         80         90        100        110        120 
PLKLNLRSPW NVLCSPESIS SAKFIVEKTC LIPVPSFEEA ATNARRCLNT SSIPGSSGSA 

       130        140        150        160        170        180 
SETNSGSDIT KQDFKNDSPS DSKKVQGSST SKSAKPKVIK VYSFVDLVTT TKKGNIQTEE 

       190        200        210        220        230        240 
SSLNHEKKLG TVVDIVEPMK CDERSKEVQG SSTSKSAKPK VIKVYSFADV VTTTKKGNIQ 

       250        260        270        280        290        300 
TEESSLNHEK KLGTVVDIIE PMKCDERSKE VQGSSTSKSA KLKVIKVYSF ADVVTTTKKG 

       310        320        330        340        350        360 
NIQTEESSLN HEKKLGTVVD IVEPMKCDER SKEVQGSSTS KSEKPKVIKV YSFADVVTTT 

       370        380        390        400        410        420 
KKGNIQTEES SLNHEKKLGT VVDIVEPMKC DEGTKCEVTT TNKGKIHTEE RSLNHEKKLG 

       430        440        450        460        470        480 
TVVDIVEPMK CDEGSKCEVT TTNKGNTQTE ERSLNHEKKL GIGVDIVEPM KCDEGTKCEV 

       490        500        510        520        530        540 
TTTNKGKIQT EERSLNYEKK LGIGVDIVEP MKCDEENKCE VNADTFDVVI VEPMKCNKVT 

       550        560        570        580        590        600 
KCEVNVDTTG VNIVEPMKCN EVTKCEVNVD TIGVDIVEPM KCNEESKCEV NADTMSLQKR 

       610        620        630        640        650        660 
SKRAVSLVER FTEEEIKLHI MSLKKPSTQS AVEGMCDLKE EEESCQLCDD GTLLFPPQPL 

       670        680        690        700        710        720 
YCLLCSRRID DRSFYYTPGE EELSNAQHQI CSPCHSRCKT KFPLCGVFID KHKMLKRSNF 

       730        740        750        760        770        780 
DNADTEEWVQ CESCEKWQHQ ICGLYNKLKD EDKTAEYICP TCLLEECQSI NNMALVDYTD 

       790        800        810        820        830        840 
SGAKDLPETV LSYFLEQRLF KRLKEERYQT AKATGKSIND VPEPEGLTLR VVFSADRTLT 

       850        860        870        880        890        900 
VNKQFASLLH KENFPSEFPY RSKVILLFQK VHGVDICIFA LFVQEFGSEC SQPNQRSTYI 

       910        920        930        940        950        960 
FYLDSVKYFK PERVTFAGEA LRTFVYHEVL IGYLEYCKLR GFTTSYIWAC PPKIGQDYIM 

       970        980        990       1000       1010       1020 
YSHPKTQQTP DTKKLRKWYV SMLQKAAEQR VVMNVTNLYD RFFDSTEEYM TAARLPYFEG 

      1030       1040       1050       1060       1070       1080 
SFWSNRAEIM IQDIEREGNN ELQKKVKLLS RRKVKTMSYK TTGDVDVDDV KNILLMEKLE 

      1090       1100       1110       1120       1130       1140 
KEVFPNKKDL MVVELNYSCT RCSKAVLSGL RWFCEKCKNL HLCESCYDAG QELPGEHIYK 

      1150       1160       1170       1180       1190       1200 
RMDKEKHQLS KVQVNGVLFS TTEDNDIIQE NDMFESRQAF LAFSQKHNYN FHTLRHAKHS 

      1210       1220       1230       1240       1250       1260 
SMMILHHLHT SNKHHCSQNS SSLTCTACKK DVSTTIYFPC LLCPDYRACT GCYTKNRTLR 

      1270       1280       1290       1300       1310       1320 
HLHIFPTLPS ANRAPSRTVM VLEILNAISH ALLCQHKTTK SCSYPKCHEV KALFTHNVQC 

      1330       1340       1350       1360 
KIRKKGTRCN TCYKLWQTIR IHVYHCQDLN CPVPQCRDRK EVLIRKV 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins."
Bordoli L., Netsch M., Luethi U., Lutz W., Eckner R.
Nucleic Acids Res. 29:589-597(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1357, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, FUNCTION.
[4]"Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE.

Web resources

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC002130 Genomic DNA. Translation: AAG00238.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE34614.1.
PIRB96696.
RefSeqNP_564891.4. NM_105391.4.
UniGeneAt.52418.

3D structure databases

ProteinModelPortalQ9FYH1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3702.AT1G67220.1-P.

Proteomic databases

PaxDbQ9FYH1.
PRIDEQ9FYH1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G67220.1; AT1G67220.1; AT1G67220.
GeneID843042.
KEGGath:AT1G67220.

Organism-specific databases

TAIRAT1G67220.

Phylogenomic databases

eggNOGNOG300787.
HOGENOMHOG000176849.
InParanoidQ9FYH1.
KOK04498.
OMAIVEPMKC.

Enzyme and pathway databases

BioCycARA:AT1G67220-MONOMER.

Gene expression databases

GenevestigatorQ9FYH1.

Family and domain databases

Gene3D1.20.1020.10. 1 hit.
3.30.40.10. 1 hit.
InterProIPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
PfamPF08214. KAT11. 1 hit.
PF00628. PHD. 1 hit.
PF02135. zf-TAZ. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTSM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 1 hit.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view]
SUPFAMSSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 1 hit.
PROSITEPS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHAC2_ARATH
AccessionPrimary (citable) accession number: Q9FYH1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 31, 2011
Last modified: February 19, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names