Histone acetyltransferase HAC2 - Arabidopsis thaliana (Mouse-ear cress)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Histone acetyltransferase HAC2
EC=2.3.1.48

Gene names

Name:	HAC2
Synonyms:	PCAT1
Ordered Locus Names:	At1g67220
ORF Names:	F1N21.4

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	1367 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation By similarity. No acetyltransferase activity found in vitro. Ref.3
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Subcellular location	Nucleus Probable.
Tissue specificity	Rosette leaves, stems and flowers. Ref.3
Developmental stage	Expressed in young seedlings. Ref.3
Sequence similarities	Contains 1 PHD-type zinc finger. Contains 1 TAZ-type zinc finger. Contains 2 ZZ-type zinc fingers.
Sequence caution	The sequence AAG00238.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Activator Acyltransferase Chromatin regulator Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	transcription cofactor activity Inferred from electronic annotation. Source: InterPro transferase activity, transferring acyl groups Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1367

1367

Histone acetyltransferase HAC2

PRO_0000269741

Regions

Repeat

188 – 200

13

1

Repeat

223 – 235

13

2

Repeat

251 – 263

13

3

Repeat

286 – 298

13

4

Repeat

314 – 326

13

5

Repeat

349 – 361

13

6

Repeat

377 – 389

13

7

Repeat

418 – 430

13

8

Repeat

432 – 444

13

9

Repeat

459 – 471

13

10

Repeat

473 – 485

13

11

Repeat

500 – 512

13

12

Zinc finger

688 – 765

78

PHD-type

Zinc finger

1093 – 1140

48

ZZ-type 1

Zinc finger

1219 – 1266

48

ZZ-type 2

Zinc finger

1274 – 1359

86

TAZ-type

Region

188 – 512

325

12 X 13 AA approximate repeats

Compositional bias

111 – 153

43

Ser-rich

Compositional bias

640 – 643

4

Poly-Glu

Compositional bias

1187 – 1215

29

His-rich

Sequences

Sequence

Length

Mass (Da)

Tools

Q9FYH1 [UniParc].

Last modified May 31, 2011. Version 2.
Checksum: 140EF2D47193F0FB
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FASTA

1,367

155,772

        10         20         30         40         50         60 
MAPPRKRTRD LMPKFLNTES FDEFNQRLNN LPAESNVTSD EDAQFLESRK CQSKRWRKEE 

        70         80         90        100        110        120 
PLKLNLRSPW NVLCSPESIS SAKFIVEKTC LIPVPSFEEA ATNARRCLNT SSIPGSSGSA 

       130        140        150        160        170        180 
SETNSGSDIT KQDFKNDSPS DSKKVQGSST SKSAKPKVIK VYSFVDLVTT TKKGNIQTEE 

       190        200        210        220        230        240 
SSLNHEKKLG TVVDIVEPMK CDERSKEVQG SSTSKSAKPK VIKVYSFADV VTTTKKGNIQ 

       250        260        270        280        290        300 
TEESSLNHEK KLGTVVDIIE PMKCDERSKE VQGSSTSKSA KLKVIKVYSF ADVVTTTKKG 

       310        320        330        340        350        360 
NIQTEESSLN HEKKLGTVVD IVEPMKCDER SKEVQGSSTS KSEKPKVIKV YSFADVVTTT 

       370        380        390        400        410        420 
KKGNIQTEES SLNHEKKLGT VVDIVEPMKC DEGTKCEVTT TNKGKIHTEE RSLNHEKKLG 

       430        440        450        460        470        480 
TVVDIVEPMK CDEGSKCEVT TTNKGNTQTE ERSLNHEKKL GIGVDIVEPM KCDEGTKCEV 

       490        500        510        520        530        540 
TTTNKGKIQT EERSLNYEKK LGIGVDIVEP MKCDEENKCE VNADTFDVVI VEPMKCNKVT 

       550        560        570        580        590        600 
KCEVNVDTTG VNIVEPMKCN EVTKCEVNVD TIGVDIVEPM KCNEESKCEV NADTMSLQKR 

       610        620        630        640        650        660 
SKRAVSLVER FTEEEIKLHI MSLKKPSTQS AVEGMCDLKE EEESCQLCDD GTLLFPPQPL 

       670        680        690        700        710        720 
YCLLCSRRID DRSFYYTPGE EELSNAQHQI CSPCHSRCKT KFPLCGVFID KHKMLKRSNF 

       730        740        750        760        770        780 
DNADTEEWVQ CESCEKWQHQ ICGLYNKLKD EDKTAEYICP TCLLEECQSI NNMALVDYTD 

       790        800        810        820        830        840 
SGAKDLPETV LSYFLEQRLF KRLKEERYQT AKATGKSIND VPEPEGLTLR VVFSADRTLT 

       850        860        870        880        890        900 
VNKQFASLLH KENFPSEFPY RSKVILLFQK VHGVDICIFA LFVQEFGSEC SQPNQRSTYI 

       910        920        930        940        950        960 
FYLDSVKYFK PERVTFAGEA LRTFVYHEVL IGYLEYCKLR GFTTSYIWAC PPKIGQDYIM 

       970        980        990       1000       1010       1020 
YSHPKTQQTP DTKKLRKWYV SMLQKAAEQR VVMNVTNLYD RFFDSTEEYM TAARLPYFEG 

      1030       1040       1050       1060       1070       1080 
SFWSNRAEIM IQDIEREGNN ELQKKVKLLS RRKVKTMSYK TTGDVDVDDV KNILLMEKLE 

      1090       1100       1110       1120       1130       1140 
KEVFPNKKDL MVVELNYSCT RCSKAVLSGL RWFCEKCKNL HLCESCYDAG QELPGEHIYK 

      1150       1160       1170       1180       1190       1200 
RMDKEKHQLS KVQVNGVLFS TTEDNDIIQE NDMFESRQAF LAFSQKHNYN FHTLRHAKHS 

      1210       1220       1230       1240       1250       1260 
SMMILHHLHT SNKHHCSQNS SSLTCTACKK DVSTTIYFPC LLCPDYRACT GCYTKNRTLR 

      1270       1280       1290       1300       1310       1320 
HLHIFPTLPS ANRAPSRTVM VLEILNAISH ALLCQHKTTK SCSYPKCHEV KALFTHNVQC 

      1330       1340       1350       1360 
KIRKKGTRCN TCYKLWQTIR IHVYHCQDLN CPVPQCRDRK EVLIRKV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. Davis R.W. Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins." Bordoli L., Netsch M., Luethi U., Lutz W., Eckner R. Nucleic Acids Res. 29:589-597(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1357, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, FUNCTION.
[4]	"Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes." Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A. Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE.
+	Additional computationally mapped references.

Web resources

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC002130 Genomic DNA. Translation: AAG00238.1. Sequence problems. CP002684 Genomic DNA. Translation: AEE34614.1.
IPI	IPI00526244.
PIR	B96696.
RefSeq	NP_564891.4. NM_105391.4.
UniGene	At.52418.
3D structure databases
HSSP	HSSP built from PDB template 1F81 based on UniProtKB P45481.
ProteinModelPortal	Q9FYH1.
SMR	Q9FYH1. Positions 783-1036, 1276-1363.
ModBase	Search...
Protein-protein interaction databases
STRING	3702.AT1G67220.1-P.
Proteomic databases
PaxDb	Q9FYH1.
PRIDE	Q9FYH1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G67220.1; AT1G67220.1; AT1G67220.
GeneID	843042.
KEGG	ath:AT1G67220.
Organism-specific databases
TAIR	At1g67220.
Phylogenomic databases
eggNOG	NOG300787.
HOGENOM	HOG000176849.
InParanoid	Q9FYH1.
KO	K04498.
OMA	IVEPMKC.
Gene expression databases
Genevestigator	Q9FYH1.
Family and domain databases
Gene3D	1.20.1020.10. 1 hit. 3.30.40.10. 1 hit.
InterPro	IPR013178. Histone_H3-K56_AcTrfase_RTT109. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. IPR013083. Znf_RING/FYVE/PHD. IPR000197. Znf_TAZ. IPR000433. Znf_ZZ. [Graphical view]
Pfam	PF08214. KAT11. 1 hit. PF00628. PHD. 1 hit. PF02135. zf-TAZ. 1 hit. PF00569. ZZ. 1 hit. [Graphical view]
SMART	SM00249. PHD. 1 hit. SM00551. ZnF_TAZ. 1 hit. SM00291. ZnF_ZZ. 2 hits. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 1 hit. SSF57933. TAZ_finger. 1 hit.
PROSITE	PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. False negative. PS50134. ZF_TAZ. 1 hit. PS01357. ZF_ZZ_1. 1 hit. PS50135. ZF_ZZ_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HAC2_ARATH

Accession

Primary (citable) accession number: Q9FYH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	May 31, 2011
Last modified:	May 1, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents