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Q9FY79

- LAC14_ARATH

UniProt

Q9FY79 - LAC14_ARATH

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Protein
Laccase-14
Gene
LAC14, At5g09360, T5E8.160
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products By similarity.

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi91 – 911Copper 1; type 2 By similarity
Metal bindingi93 – 931Copper 2; type 3 By similarity
Metal bindingi136 – 1361Copper 2; type 3 By similarity
Metal bindingi138 – 1381Copper 3; type 3 By similarity
Metal bindingi470 – 4701Copper 4; type 1 By similarity
Metal bindingi473 – 4731Copper 1; type 2 By similarity
Metal bindingi475 – 4751Copper 3; type 3 By similarity
Metal bindingi532 – 5321Copper 3; type 3 By similarity
Metal bindingi533 – 5331Copper 4; type 1 By similarity
Metal bindingi534 – 5341Copper 2; type 3 By similarity
Metal bindingi538 – 5381Copper 4; type 1 By similarity
Metal bindingi543 – 5431Copper 4; type 1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G09360-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-14 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 14
Diphenol oxidase 14
Urishiol oxidase 14
Gene namesi
Name:LAC14
Ordered Locus Names:At5g09360
ORF Names:T5E8.160
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G09360.

Subcellular locationi

Secretedextracellular spaceapoplast Reviewed prediction

GO - Cellular componenti

  1. apoplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed prediction
Add
BLAST
Chaini34 – 569536Laccase-14
PRO_0000283642Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi87 – 871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi190 – 1901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi249 – 2491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi336 – 3361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi374 – 3741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi395 – 3951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi430 – 4301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi452 – 4521N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9FY79.
PRIDEiQ9FY79.

Expressioni

Tissue specificityi

Expressed at low levels in flowers and siliques.1 Publication

Gene expression databases

GenevestigatoriQ9FY79.

Structurei

3D structure databases

ProteinModelPortaliQ9FY79.
SMRiQ9FY79. Positions 33-548.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 157117Plastocyanin-like 1
Add
BLAST
Domaini167 – 320154Plastocyanin-like 2
Add
BLAST
Domaini420 – 553134Plastocyanin-like 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000241916.
InParanoidiQ9FY79.
OMAiKENIMHI.
PhylomeDBiQ9FY79.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FY79-1 [UniParc]FASTAAdd to Basket

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MEFKLNIPNT IIKTLQTIVF FLFVLLAFQI AEAEIHHHTF KIKSKAYTRL    50
CNTNKILTVN GEFPGPTLKA YRGDKLIVNV INNANYNITL HWHGARQIRN 100
PWSDGPEYVT QCPIRPGESY VYRIDLKVEE GTIWWHAHSQ WARATVHGAF 150
IVYPKRGSSY PFPKPHREIP LILGEWWKKE NIMHIPGKAN KTGGEPAISD 200
SYTINGQPGY LYPCSKPETF KITVVRGRRY LLRIINAVMD EELFFAIANH 250
TLTVVAKDGF YLKHFKSDYL MITPGQSMDV LLHANQRPNH YFVAARAYSS 300
AFGAGFDKTT TTAILQYKGD TLNRIKPILP YLPPYNRTEA STRFTNQFRS 350
QRPVNVPVKI NTRLLYAISV NLMNCSDDRP CTGPFGKRFS SSINNISFVN 400
PSVDILRAYY RHIGGVFQED FPRNPPTKFN YTGENLPFPT RFGTKVVVLD 450
YNSSVELILQ GTTVWASNIH PIHLHGYNFY VVGSGFGNFD RRKDPLRYNL 500
VDPPEETTVG VPRNGWTAVR FVANNPGVWL LHCHIERHAT WGMNTVFIVK 550
DGPTKSSRMV KPPPDLPSC 569
Length:569
Mass (Da):64,878
Last modified:March 1, 2001 - v1
Checksum:iFE8E2C1F8A329188
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti463 – 4697TVWASNI → NVLASDN in ABE66147. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL391712 Genomic DNA. Translation: CAC05462.1.
CP002688 Genomic DNA. Translation: AED91381.1.
DQ446936 mRNA. Translation: ABE66147.1.
RefSeqiNP_196498.1. NM_120972.1.
UniGeneiAt.54782.

Genome annotation databases

EnsemblPlantsiAT5G09360.1; AT5G09360.1; AT5G09360.
GeneIDi830795.
KEGGiath:AT5G09360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL391712 Genomic DNA. Translation: CAC05462.1 .
CP002688 Genomic DNA. Translation: AED91381.1 .
DQ446936 mRNA. Translation: ABE66147.1 .
RefSeqi NP_196498.1. NM_120972.1.
UniGenei At.54782.

3D structure databases

ProteinModelPortali Q9FY79.
SMRi Q9FY79. Positions 33-548.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q9FY79.
PRIDEi Q9FY79.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G09360.1 ; AT5G09360.1 ; AT5G09360 .
GeneIDi 830795.
KEGGi ath:AT5G09360.

Organism-specific databases

TAIRi AT5G09360.

Phylogenomic databases

eggNOGi COG2132.
HOGENOMi HOG000241916.
InParanoidi Q9FY79.
OMAi KENIMHI.
PhylomeDBi Q9FY79.

Enzyme and pathway databases

BioCyci ARA:AT5G09360-MONOMER.

Gene expression databases

Genevestigatori Q9FY79.

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
TIGRFAMsi TIGR03389. laccase. 1 hit.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations."
    Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.
    Plant Biotechnol. J. 4:317-324(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
    Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
    J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiLAC14_ARATH
AccessioniPrimary (citable) accession number: Q9FY79
Secondary accession number(s): Q1PDY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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