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Q9FY79

- LAC14_ARATH

UniProt

Q9FY79 - LAC14_ARATH

Protein

Laccase-14

Gene

LAC14

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.By similarity

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi91 – 911Copper 1; type 2By similarity
    Metal bindingi93 – 931Copper 2; type 3By similarity
    Metal bindingi136 – 1361Copper 2; type 3By similarity
    Metal bindingi138 – 1381Copper 3; type 3By similarity
    Metal bindingi470 – 4701Copper 4; type 1By similarity
    Metal bindingi473 – 4731Copper 1; type 2By similarity
    Metal bindingi475 – 4751Copper 3; type 3By similarity
    Metal bindingi532 – 5321Copper 3; type 3By similarity
    Metal bindingi533 – 5331Copper 4; type 1By similarity
    Metal bindingi534 – 5341Copper 2; type 3By similarity
    Metal bindingi538 – 5381Copper 4; type 1By similarity
    Metal bindingi543 – 5431Copper 4; type 1By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT5G09360-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-14 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 14
    Diphenol oxidase 14
    Urishiol oxidase 14
    Gene namesi
    Name:LAC14
    Ordered Locus Names:At5g09360
    ORF Names:T5E8.160
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G09360.

    Subcellular locationi

    GO - Cellular componenti

    1. apoplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Apoplast, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 569536Laccase-14PRO_0000283642Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi336 – 3361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi374 – 3741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi395 – 3951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi430 – 4301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi452 – 4521N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9FY79.
    PRIDEiQ9FY79.

    Expressioni

    Tissue specificityi

    Expressed at low levels in flowers and siliques.1 Publication

    Gene expression databases

    GenevestigatoriQ9FY79.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FY79.
    SMRiQ9FY79. Positions 33-548.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 157117Plastocyanin-like 1Add
    BLAST
    Domaini167 – 320154Plastocyanin-like 2Add
    BLAST
    Domaini420 – 553134Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG2132.
    HOGENOMiHOG000241916.
    InParanoidiQ9FY79.
    OMAiKENIMHI.
    PhylomeDBiQ9FY79.

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 3 hits.
    TIGRFAMsiTIGR03389. laccase. 1 hit.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9FY79-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFKLNIPNT IIKTLQTIVF FLFVLLAFQI AEAEIHHHTF KIKSKAYTRL    50
    CNTNKILTVN GEFPGPTLKA YRGDKLIVNV INNANYNITL HWHGARQIRN 100
    PWSDGPEYVT QCPIRPGESY VYRIDLKVEE GTIWWHAHSQ WARATVHGAF 150
    IVYPKRGSSY PFPKPHREIP LILGEWWKKE NIMHIPGKAN KTGGEPAISD 200
    SYTINGQPGY LYPCSKPETF KITVVRGRRY LLRIINAVMD EELFFAIANH 250
    TLTVVAKDGF YLKHFKSDYL MITPGQSMDV LLHANQRPNH YFVAARAYSS 300
    AFGAGFDKTT TTAILQYKGD TLNRIKPILP YLPPYNRTEA STRFTNQFRS 350
    QRPVNVPVKI NTRLLYAISV NLMNCSDDRP CTGPFGKRFS SSINNISFVN 400
    PSVDILRAYY RHIGGVFQED FPRNPPTKFN YTGENLPFPT RFGTKVVVLD 450
    YNSSVELILQ GTTVWASNIH PIHLHGYNFY VVGSGFGNFD RRKDPLRYNL 500
    VDPPEETTVG VPRNGWTAVR FVANNPGVWL LHCHIERHAT WGMNTVFIVK 550
    DGPTKSSRMV KPPPDLPSC 569
    Length:569
    Mass (Da):64,878
    Last modified:March 1, 2001 - v1
    Checksum:iFE8E2C1F8A329188
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti463 – 4697TVWASNI → NVLASDN in ABE66147. (PubMed:17147637)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL391712 Genomic DNA. Translation: CAC05462.1.
    CP002688 Genomic DNA. Translation: AED91381.1.
    DQ446936 mRNA. Translation: ABE66147.1.
    RefSeqiNP_196498.1. NM_120972.1.
    UniGeneiAt.54782.

    Genome annotation databases

    EnsemblPlantsiAT5G09360.1; AT5G09360.1; AT5G09360.
    GeneIDi830795.
    KEGGiath:AT5G09360.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL391712 Genomic DNA. Translation: CAC05462.1 .
    CP002688 Genomic DNA. Translation: AED91381.1 .
    DQ446936 mRNA. Translation: ABE66147.1 .
    RefSeqi NP_196498.1. NM_120972.1.
    UniGenei At.54782.

    3D structure databases

    ProteinModelPortali Q9FY79.
    SMRi Q9FY79. Positions 33-548.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9FY79.
    PRIDEi Q9FY79.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G09360.1 ; AT5G09360.1 ; AT5G09360 .
    GeneIDi 830795.
    KEGGi ath:AT5G09360.

    Organism-specific databases

    TAIRi AT5G09360.

    Phylogenomic databases

    eggNOGi COG2132.
    HOGENOMi HOG000241916.
    InParanoidi Q9FY79.
    OMAi KENIMHI.
    PhylomeDBi Q9FY79.

    Enzyme and pathway databases

    BioCyci ARA:AT5G09360-MONOMER.

    Gene expression databases

    Genevestigatori Q9FY79.

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 3 hits.
    TIGRFAMsi TIGR03389. laccase. 1 hit.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
      Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
      , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
      Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations."
      Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.
      Plant Biotechnol. J. 4:317-324(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
      Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
      J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiLAC14_ARATH
    AccessioniPrimary (citable) accession number: Q9FY79
    Secondary accession number(s): Q1PDY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3