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Protein

Laccase-14

Gene

LAC14

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi91Copper 1; type 2By similarity1
Metal bindingi93Copper 2; type 3By similarity1
Metal bindingi136Copper 2; type 3By similarity1
Metal bindingi138Copper 3; type 3By similarity1
Metal bindingi470Copper 4; type 1By similarity1
Metal bindingi473Copper 1; type 2By similarity1
Metal bindingi475Copper 3; type 3By similarity1
Metal bindingi532Copper 3; type 3By similarity1
Metal bindingi533Copper 4; type 1By similarity1
Metal bindingi534Copper 2; type 3By similarity1
Metal bindingi538Copper 4; type 1By similarity1
Metal bindingi543Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLignin degradation
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G09360-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-14 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 14
Diphenol oxidase 14
Urishiol oxidase 14
Gene namesi
Name:LAC14
Ordered Locus Names:At5g09360
ORF Names:T5E8.160
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi

Organism-specific databases

AraportiAT5G09360
TAIRilocus:2184802 AT5G09360

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000028364234 – 569Laccase-14Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi249N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi336N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi374N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi395N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi430N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi452N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9FY79
PRIDEiQ9FY79

Expressioni

Tissue specificityi

Expressed at low levels in flowers and siliques.1 Publication

Gene expression databases

ExpressionAtlasiQ9FY79 differential
GenevisibleiQ9FY79 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G09360.1

Structurei

3D structure databases

ProteinModelPortaliQ9FY79
SMRiQ9FY79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 157Plastocyanin-like 1Add BLAST117
Domaini167 – 320Plastocyanin-like 2Add BLAST154
Domaini420 – 553Plastocyanin-like 3Add BLAST134

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263 Eukaryota
COG2132 LUCA
HOGENOMiHOG000241916
InParanoidiQ9FY79
KOiK05909
OMAiNKTGGEP
OrthoDBiEOG093606A1
PhylomeDBiQ9FY79

Family and domain databases

CDDicd13849 CuRO_1_LCC_plant, 1 hit
cd13875 CuRO_2_LCC_plant, 1 hit
cd13897 CuRO_3_LCC_plant, 1 hit
Gene3Di2.60.40.420, 3 hits
InterProiView protein in InterPro
IPR001117 Cu-oxidase
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR002355 Cu_oxidase_Cu_BS
IPR008972 Cupredoxin
IPR034288 CuRO_1_LCC
IPR034285 CuRO_2_LCC
IPR034289 CuRO_3_LCC
IPR017761 Laccase
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07731 Cu-oxidase_2, 1 hit
PF07732 Cu-oxidase_3, 1 hit
SUPFAMiSSF49503 SSF49503, 3 hits
TIGRFAMsiTIGR03389 laccase, 1 hit
PROSITEiView protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 1 hit
PS00080 MULTICOPPER_OXIDASE2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FY79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFKLNIPNT IIKTLQTIVF FLFVLLAFQI AEAEIHHHTF KIKSKAYTRL
60 70 80 90 100
CNTNKILTVN GEFPGPTLKA YRGDKLIVNV INNANYNITL HWHGARQIRN
110 120 130 140 150
PWSDGPEYVT QCPIRPGESY VYRIDLKVEE GTIWWHAHSQ WARATVHGAF
160 170 180 190 200
IVYPKRGSSY PFPKPHREIP LILGEWWKKE NIMHIPGKAN KTGGEPAISD
210 220 230 240 250
SYTINGQPGY LYPCSKPETF KITVVRGRRY LLRIINAVMD EELFFAIANH
260 270 280 290 300
TLTVVAKDGF YLKHFKSDYL MITPGQSMDV LLHANQRPNH YFVAARAYSS
310 320 330 340 350
AFGAGFDKTT TTAILQYKGD TLNRIKPILP YLPPYNRTEA STRFTNQFRS
360 370 380 390 400
QRPVNVPVKI NTRLLYAISV NLMNCSDDRP CTGPFGKRFS SSINNISFVN
410 420 430 440 450
PSVDILRAYY RHIGGVFQED FPRNPPTKFN YTGENLPFPT RFGTKVVVLD
460 470 480 490 500
YNSSVELILQ GTTVWASNIH PIHLHGYNFY VVGSGFGNFD RRKDPLRYNL
510 520 530 540 550
VDPPEETTVG VPRNGWTAVR FVANNPGVWL LHCHIERHAT WGMNTVFIVK
560
DGPTKSSRMV KPPPDLPSC
Length:569
Mass (Da):64,878
Last modified:March 1, 2001 - v1
Checksum:iFE8E2C1F8A329188
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti463 – 469TVWASNI → NVLASDN in ABE66147 (PubMed:17147637).Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391712 Genomic DNA Translation: CAC05462.1
CP002688 Genomic DNA Translation: AED91381.1
DQ446936 mRNA Translation: ABE66147.1
RefSeqiNP_196498.1, NM_120972.1
UniGeneiAt.54782

Genome annotation databases

EnsemblPlantsiAT5G09360.1; AT5G09360.1; AT5G09360
GeneIDi830795
GrameneiAT5G09360.1; AT5G09360.1; AT5G09360
KEGGiath:AT5G09360

Similar proteinsi

Entry informationi

Entry nameiLAC14_ARATH
AccessioniPrimary (citable) accession number: Q9FY79
Secondary accession number(s): Q1PDY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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