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Protein

Laccase-14

Gene

LAC14

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi91Copper 1; type 2By similarity1
Metal bindingi93Copper 2; type 3By similarity1
Metal bindingi136Copper 2; type 3By similarity1
Metal bindingi138Copper 3; type 3By similarity1
Metal bindingi470Copper 4; type 1By similarity1
Metal bindingi473Copper 1; type 2By similarity1
Metal bindingi475Copper 3; type 3By similarity1
Metal bindingi532Copper 3; type 3By similarity1
Metal bindingi533Copper 4; type 1By similarity1
Metal bindingi534Copper 2; type 3By similarity1
Metal bindingi538Copper 4; type 1By similarity1
Metal bindingi543Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G09360-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-14 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 14
Diphenol oxidase 14
Urishiol oxidase 14
Gene namesi
Name:LAC14
Ordered Locus Names:At5g09360
ORF Names:T5E8.160
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G09360.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000028364234 – 569Laccase-14Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...)Sequence analysis1
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1
Glycosylationi249N-linked (GlcNAc...)Sequence analysis1
Glycosylationi336N-linked (GlcNAc...)Sequence analysis1
Glycosylationi374N-linked (GlcNAc...)Sequence analysis1
Glycosylationi395N-linked (GlcNAc...)Sequence analysis1
Glycosylationi430N-linked (GlcNAc...)Sequence analysis1
Glycosylationi452N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9FY79.
PRIDEiQ9FY79.

Expressioni

Tissue specificityi

Expressed at low levels in flowers and siliques.1 Publication

Gene expression databases

GenevisibleiQ9FY79. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G09360.1.

Structurei

3D structure databases

ProteinModelPortaliQ9FY79.
SMRiQ9FY79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 157Plastocyanin-like 1Add BLAST117
Domaini167 – 320Plastocyanin-like 2Add BLAST154
Domaini420 – 553Plastocyanin-like 3Add BLAST134

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ9FY79.
KOiK05909.
OMAiHREIPLI.
OrthoDBiEOG093606A1.
PhylomeDBiQ9FY79.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FY79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFKLNIPNT IIKTLQTIVF FLFVLLAFQI AEAEIHHHTF KIKSKAYTRL
60 70 80 90 100
CNTNKILTVN GEFPGPTLKA YRGDKLIVNV INNANYNITL HWHGARQIRN
110 120 130 140 150
PWSDGPEYVT QCPIRPGESY VYRIDLKVEE GTIWWHAHSQ WARATVHGAF
160 170 180 190 200
IVYPKRGSSY PFPKPHREIP LILGEWWKKE NIMHIPGKAN KTGGEPAISD
210 220 230 240 250
SYTINGQPGY LYPCSKPETF KITVVRGRRY LLRIINAVMD EELFFAIANH
260 270 280 290 300
TLTVVAKDGF YLKHFKSDYL MITPGQSMDV LLHANQRPNH YFVAARAYSS
310 320 330 340 350
AFGAGFDKTT TTAILQYKGD TLNRIKPILP YLPPYNRTEA STRFTNQFRS
360 370 380 390 400
QRPVNVPVKI NTRLLYAISV NLMNCSDDRP CTGPFGKRFS SSINNISFVN
410 420 430 440 450
PSVDILRAYY RHIGGVFQED FPRNPPTKFN YTGENLPFPT RFGTKVVVLD
460 470 480 490 500
YNSSVELILQ GTTVWASNIH PIHLHGYNFY VVGSGFGNFD RRKDPLRYNL
510 520 530 540 550
VDPPEETTVG VPRNGWTAVR FVANNPGVWL LHCHIERHAT WGMNTVFIVK
560
DGPTKSSRMV KPPPDLPSC
Length:569
Mass (Da):64,878
Last modified:March 1, 2001 - v1
Checksum:iFE8E2C1F8A329188
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti463 – 469TVWASNI → NVLASDN in ABE66147 (PubMed:17147637).Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391712 Genomic DNA. Translation: CAC05462.1.
CP002688 Genomic DNA. Translation: AED91381.1.
DQ446936 mRNA. Translation: ABE66147.1.
RefSeqiNP_196498.1. NM_120972.1.
UniGeneiAt.54782.

Genome annotation databases

EnsemblPlantsiAT5G09360.1; AT5G09360.1; AT5G09360.
GeneIDi830795.
GrameneiAT5G09360.1; AT5G09360.1; AT5G09360.
KEGGiath:AT5G09360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391712 Genomic DNA. Translation: CAC05462.1.
CP002688 Genomic DNA. Translation: AED91381.1.
DQ446936 mRNA. Translation: ABE66147.1.
RefSeqiNP_196498.1. NM_120972.1.
UniGeneiAt.54782.

3D structure databases

ProteinModelPortaliQ9FY79.
SMRiQ9FY79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G09360.1.

Proteomic databases

PaxDbiQ9FY79.
PRIDEiQ9FY79.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G09360.1; AT5G09360.1; AT5G09360.
GeneIDi830795.
GrameneiAT5G09360.1; AT5G09360.1; AT5G09360.
KEGGiath:AT5G09360.

Organism-specific databases

TAIRiAT5G09360.

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ9FY79.
KOiK05909.
OMAiHREIPLI.
OrthoDBiEOG093606A1.
PhylomeDBiQ9FY79.

Enzyme and pathway databases

BioCyciARA:AT5G09360-MONOMER.

Miscellaneous databases

PROiQ9FY79.

Gene expression databases

GenevisibleiQ9FY79. AT.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAC14_ARATH
AccessioniPrimary (citable) accession number: Q9FY79
Secondary accession number(s): Q1PDY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.