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Q9FY79

- LAC14_ARATH

UniProt

Q9FY79 - LAC14_ARATH

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Protein

Laccase-14

Gene

LAC14

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi91 – 911Copper 1; type 2By similarity
Metal bindingi93 – 931Copper 2; type 3By similarity
Metal bindingi136 – 1361Copper 2; type 3By similarity
Metal bindingi138 – 1381Copper 3; type 3By similarity
Metal bindingi470 – 4701Copper 4; type 1By similarity
Metal bindingi473 – 4731Copper 1; type 2By similarity
Metal bindingi475 – 4751Copper 3; type 3By similarity
Metal bindingi532 – 5321Copper 3; type 3By similarity
Metal bindingi533 – 5331Copper 4; type 1By similarity
Metal bindingi534 – 5341Copper 2; type 3By similarity
Metal bindingi538 – 5381Copper 4; type 1By similarity
Metal bindingi543 – 5431Copper 4; type 1By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G09360-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-14 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 14
Diphenol oxidase 14
Urishiol oxidase 14
Gene namesi
Name:LAC14
Ordered Locus Names:At5g09360
ORF Names:T5E8.160
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G09360.

Subcellular locationi

GO - Cellular componenti

  1. apoplast Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 569536Laccase-14PRO_0000283642Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi336 – 3361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi374 – 3741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi395 – 3951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi430 – 4301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi452 – 4521N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9FY79.
PRIDEiQ9FY79.

Expressioni

Tissue specificityi

Expressed at low levels in flowers and siliques.1 Publication

Gene expression databases

GenevestigatoriQ9FY79.

Structurei

3D structure databases

ProteinModelPortaliQ9FY79.
SMRiQ9FY79. Positions 25-548.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 157117Plastocyanin-like 1Add
BLAST
Domaini167 – 320154Plastocyanin-like 2Add
BLAST
Domaini420 – 553134Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000241916.
InParanoidiQ9FY79.
OMAiKENIMHI.
PhylomeDBiQ9FY79.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FY79-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFKLNIPNT IIKTLQTIVF FLFVLLAFQI AEAEIHHHTF KIKSKAYTRL
60 70 80 90 100
CNTNKILTVN GEFPGPTLKA YRGDKLIVNV INNANYNITL HWHGARQIRN
110 120 130 140 150
PWSDGPEYVT QCPIRPGESY VYRIDLKVEE GTIWWHAHSQ WARATVHGAF
160 170 180 190 200
IVYPKRGSSY PFPKPHREIP LILGEWWKKE NIMHIPGKAN KTGGEPAISD
210 220 230 240 250
SYTINGQPGY LYPCSKPETF KITVVRGRRY LLRIINAVMD EELFFAIANH
260 270 280 290 300
TLTVVAKDGF YLKHFKSDYL MITPGQSMDV LLHANQRPNH YFVAARAYSS
310 320 330 340 350
AFGAGFDKTT TTAILQYKGD TLNRIKPILP YLPPYNRTEA STRFTNQFRS
360 370 380 390 400
QRPVNVPVKI NTRLLYAISV NLMNCSDDRP CTGPFGKRFS SSINNISFVN
410 420 430 440 450
PSVDILRAYY RHIGGVFQED FPRNPPTKFN YTGENLPFPT RFGTKVVVLD
460 470 480 490 500
YNSSVELILQ GTTVWASNIH PIHLHGYNFY VVGSGFGNFD RRKDPLRYNL
510 520 530 540 550
VDPPEETTVG VPRNGWTAVR FVANNPGVWL LHCHIERHAT WGMNTVFIVK
560
DGPTKSSRMV KPPPDLPSC
Length:569
Mass (Da):64,878
Last modified:March 1, 2001 - v1
Checksum:iFE8E2C1F8A329188
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti463 – 4697TVWASNI → NVLASDN in ABE66147. (PubMed:17147637)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL391712 Genomic DNA. Translation: CAC05462.1.
CP002688 Genomic DNA. Translation: AED91381.1.
DQ446936 mRNA. Translation: ABE66147.1.
RefSeqiNP_196498.1. NM_120972.1.
UniGeneiAt.54782.

Genome annotation databases

EnsemblPlantsiAT5G09360.1; AT5G09360.1; AT5G09360.
GeneIDi830795.
KEGGiath:AT5G09360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL391712 Genomic DNA. Translation: CAC05462.1 .
CP002688 Genomic DNA. Translation: AED91381.1 .
DQ446936 mRNA. Translation: ABE66147.1 .
RefSeqi NP_196498.1. NM_120972.1.
UniGenei At.54782.

3D structure databases

ProteinModelPortali Q9FY79.
SMRi Q9FY79. Positions 25-548.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q9FY79.
PRIDEi Q9FY79.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G09360.1 ; AT5G09360.1 ; AT5G09360 .
GeneIDi 830795.
KEGGi ath:AT5G09360.

Organism-specific databases

TAIRi AT5G09360.

Phylogenomic databases

eggNOGi COG2132.
HOGENOMi HOG000241916.
InParanoidi Q9FY79.
OMAi KENIMHI.
PhylomeDBi Q9FY79.

Enzyme and pathway databases

BioCyci ARA:AT5G09360-MONOMER.

Gene expression databases

Genevestigatori Q9FY79.

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
TIGRFAMsi TIGR03389. laccase. 1 hit.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations."
    Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.
    Plant Biotechnol. J. 4:317-324(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
    Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
    J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiLAC14_ARATH
AccessioniPrimary (citable) accession number: Q9FY79
Secondary accession number(s): Q1PDY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3