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Protein

Calmodulin-binding transcription activator 1

Gene

CAMTA1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription activator that binds calmodulin in a calcium-dependent manner in vitro (PubMed:11925432). Binds to the DNA consensus sequence 5'-[ACG]CGCG[GTC]-3' (By similarity). Regulates transcriptional activity in response to calcium signals (Probable). Involved in freezing tolerance (PubMed:19270186). Involved in freezing tolerance in association with CAMTA2 and CAMTA3. Contributes together with CAMTA2 and CAMTA3 to the positive regulation of the cold-induced expression of DREB1A/CBF3, DREB1B/CBF1 and DREB1C/CBF2 (PubMed:23581962). Involved in drought stress responses by regulating several drought-responsive genes (PubMed:23547968). Involved in auxin signaling and responses to abiotic stresses (PubMed:20383645). Activates the expression of the V-PPase proton pump AVP1 in pollen (PubMed:14581622).By similarity1 Publication6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi18 – 144CG-1PROSITE-ProRule annotationAdd BLAST127

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • response to auxin Source: UniProtKB
  • response to freezing Source: UniProtKB
  • response to water deprivation Source: UniProtKB

Keywordsi

Molecular functionActivator, Calmodulin-binding, DNA-binding
Biological processStress response, Transcription, Transcription regulation
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-binding transcription activator 11 Publication
Short name:
AtCAMTA11 Publication
Alternative name(s):
Ethylene-induced calmodulin-binding protein b1 Publication
Short name:
EICBP.b1 Publication
Signal-responsive protein 21 Publication
Short name:
AtSR21 Publication
Gene namesi
Name:CAMTA11 Publication
Synonyms:CMTA1Curated, SR21 Publication
Ordered Locus Names:At5g09410Imported
ORF Names:T5E8.210Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G09410.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth conditions, but mutant seedling are hyper-responsive to auxin in hypocotyl growth inhibition (PubMed:20383645). No visible phenotype under normal growth conditions, but mutant seedling exhibit reduced drought tolerance (PubMed:23547968). No visible phenotype under normal growth conditions, but the double mutants camta1 and camta3 are impaired in freezing tolerance (PubMed:19270186). No visible phenotype under normal growth conditions, but the double mutants camt1 and camt3 exhibit semi-dwarf phenotypes (PubMed:19270186, PubMed:23581962).4 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001144861 – 1007Calmodulin-binding transcription activator 1Add BLAST1007

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei942PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiQ9FY74.

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves, pollen and siliques.2 Publications

Developmental stagei

During leaf developlement, expressed in young leaf primordia, hydathodes of young leaf tips, hydathodes of the lobes in maturating leaves and lamina within the minor veins in adult leaves. During flower development, expressed in developing stamens, germinating pollen grains, ovules and developing seeds.1 Publication

Inductioni

Induced by UVB, wounding, ethylene and methyl jasmonate (PubMed:12218065). Induced by salt stress and heat shock (PubMed:12218065, PubMed:20383645). Induced by aluminum (PubMed:25627216).3 Publications

Gene expression databases

ExpressionAtlasiQ9FY74. baseline and differential.
GenevisibleiQ9FY74. AT.

Interactioni

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi16078. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ9FY74.
SMRiQ9FY74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati612 – 641ANK 1Add BLAST30
Repeati645 – 674ANK 2Add BLAST30
Domaini821 – 850IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini844 – 873IQ 2PROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni233 – 398Transcription activation1 PublicationAdd BLAST166
Regioni869 – 891Calmodulin-binding1 PublicationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili915 – 943Sequence analysisAdd BLAST29

Domaini

The two IQ domains are probably not interacting with calcium/calmodulin.

Sequence similaritiesi

Belongs to the CAMTA family.Curated

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

HOGENOMiHOG000240102.
InParanoidiQ9FY74.
KOiK21596.

Family and domain databases

CDDicd00204. ANK. 1 hit.
Gene3Di1.25.40.20. 1 hit.
2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR036770. Ankyrin_rpt-contain_sf.
IPR005559. CG-1_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF12796. Ank_2. 1 hit.
PF03859. CG-1. 1 hit.
PF00612. IQ. 2 hits.
PF01833. TIG. 1 hit.
SMARTiView protein in SMART
SM00248. ANK. 1 hit.
SM01076. CG-1. 1 hit.
SM00015. IQ. 2 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS51437. CG_1. 1 hit.
PS50096. IQ. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9FY74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVDRRSFGSI TPPLQLDMEQ LLSEAQHRWL RPTEICEILQ NYHKFHIASE
60 70 80 90 100
SPTRPASGSL FLFDRKVLRY FRKDGHNWRK KKDGKTIREA HEKLKVGSID
110 120 130 140 150
VLHCYYAHGE ANENFQRRCY WMLEQHLMHI VFVHYLEVKG NRTSIGMKEN
160 170 180 190 200
NSNSVNGTAS VNIDSTASPT STLSSLCEDA DTGDSQQASS VLRPSPEPQT
210 220 230 240 250
GNRYGWTPAP GMRNVSQVHG NRVRESDSQR LVDVRALDTV GNSLTRFHDQ
260 270 280 290 300
PYCNNLLTQM QPSNTDSMLV EENSEKGGRL KAEHIRNPLQ TQFNWQDDTD
310 320 330 340 350
LALFEQSAQD NFETFSSLLG SENLQPFGIS YQAPPSNMDS EYMPVMKILR
360 370 380 390 400
RSEDSLKKVD SFSKWAIKEL GEMEDLQMQS SRGDIAWTTV ECETAAAGIS
410 420 430 440 450
LSPSLSEDQR FTIVDFWPKS AKTDAEVEVM VIGTFLLSPQ EVTKYNWSCM
460 470 480 490 500
FGEVEVPAEI LVDGVLCCHA PPHTAGHVPF YVTCSNRFAC SEVREFDFLS
510 520 530 540 550
GSTQKINATD VYGTYTNEAS LQLRFEKMLA HRDFVHEHHI FEDVGDKRRQ
560 570 580 590 600
ISKIMLLKEE KEYLLPGTYQ RDSTKQEPKG QLFRELFEEE LYIWLIHKVT
610 620 630 640 650
EEGKGPNILD EDGQGILHFV AALGYDWAIK PVLAAGVNIN FRDANGWSAL
660 670 680 690 700
HWAAFSGREE TVAVLVSLGA DAGALTDPSP ELPLGKTAAD LAYANGHRGI
710 720 730 740 750
SGFLAESSLT SYLEKLTVDS KENSPANSCG EKAVQTVSER TAAPMTYGDV
760 770 780 790 800
PEKLSLKDSL TAVRNATQAA DRLHQVFRMQ SFQRKQLCDI GDDEKIDISD
810 820 830 840 850
QLAVSFAASK TKNPGQGDVS LSCAATHIQK KYRGWKKRKE FLLIRQRIVK
860 870 880 890 900
IQAHVRGHQV RKQYRTVIWS VGLLEKIILR WRRKGNGLRG FKRNAVAKTV
910 920 930 940 950
EPEPPVSAIC PRIPQEDEYD YLKEGRKQTE ERLQKALTRV KSMVQYPEAR
960 970 980 990 1000
DQYRRLLTVV EGFRENEASS SASINNKEEE AVNCEEDDFI DIESLLNDDT

LMMSISP
Length:1,007
Mass (Da):113,853
Last modified:July 27, 2011 - v2
Checksum:i73FAB1EC5F746E06
GO
Isoform 2 (identifier: Q9FY74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-201: Missing.

Show »
Length:989
Mass (Da):111,987
Checksum:i8A00027635BFAC9D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137E → Q in CAC05467 (PubMed:11130714).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040640184 – 201Missing in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391712 Genomic DNA. Translation: CAC05467.1.
CP002688 Genomic DNA. Translation: AED91388.1.
CP002688 Genomic DNA. Translation: AED91389.1.
AK228740 mRNA. Translation: BAF00640.1.
RefSeqiNP_001119195.1. NM_001125723.2. [Q9FY74-1]
NP_196503.3. NM_120978.5. [Q9FY74-2]
UniGeneiAt.26762.

Genome annotation databases

EnsemblPlantsiAT5G09410.1; AT5G09410.1; AT5G09410. [Q9FY74-2]
AT5G09410.2; AT5G09410.2; AT5G09410. [Q9FY74-1]
GeneIDi830800.
GrameneiAT5G09410.1; AT5G09410.1; AT5G09410. [Q9FY74-2]
AT5G09410.2; AT5G09410.2; AT5G09410. [Q9FY74-1]
KEGGiath:AT5G09410.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCMTA1_ARATH
AccessioniPrimary (citable) accession number: Q9FY74
Secondary accession number(s): F4KCL6, Q0WQF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 27, 2011
Last modified: January 31, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families