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Protein

Calmodulin-binding transcription activator 1

Gene

CMTA1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates transcriptional activity in response to calcium signals. Binds to the consensus sequence 5'-[ACG]CGCG[GTC]-3'. Activates the expression of the V-PPase proton pump in pollen.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi18 – 144127CG-1PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Stress response, Transcription, Transcription regulation

Keywords - Ligandi

Calcium, Calmodulin-binding, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-binding transcription activator 1
Alternative name(s):
Ethylene-induced calmodulin-binding protein b
Short name:
EICBP.b
Signal-responsive protein 2
Gene namesi
Name:CMTA1
Synonyms:SR2
Ordered Locus Names:At5g09410
ORF Names:T5E8.210
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G09410.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10071007Calmodulin-binding transcription activator 1PRO_0000114486Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei942 – 9421PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiQ9FY74.

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves, pollen and siliques.2 Publications

Inductioni

By temperature, UVB, salt, wounding, ethylene and methyl jasmonate.1 Publication

Gene expression databases

ExpressionAtlasiQ9FY74. baseline and differential.
GenevisibleiQ9FY74. AT.

Interactioni

Subunit structurei

Binds to calmodulin.

Protein-protein interaction databases

BioGridi16078. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9FY74.
SMRiQ9FY74. Positions 413-501, 586-737.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati612 – 64130ANK 1Add
BLAST
Repeati645 – 67430ANK 2Add
BLAST
Domaini821 – 85030IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini844 – 87330IQ 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni233 – 398166Transcription activationAdd
BLAST
Regioni863 – 89735Calmodulin-bindingAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili915 – 94329Sequence analysisAdd
BLAST

Domaini

The two IQ domains are probably not interacting with calcium/calmodulin.

Sequence similaritiesi

Belongs to the CAMTA family.Curated
Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 CG-1 DNA-binding domain.PROSITE-ProRule annotation
Contains 2 IQ domains.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

HOGENOMiHOG000240102.
InParanoidiQ9FY74.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005559. CG-1_dom.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000048. IQ_motif_EF-hand-BS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF03859. CG-1. 1 hit.
PF00612. IQ. 2 hits.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 1 hit.
SM01076. CG-1. 1 hit.
SM00015. IQ. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS51437. CG_1. 1 hit.
PS50096. IQ. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9FY74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVDRRSFGSI TPPLQLDMEQ LLSEAQHRWL RPTEICEILQ NYHKFHIASE
60 70 80 90 100
SPTRPASGSL FLFDRKVLRY FRKDGHNWRK KKDGKTIREA HEKLKVGSID
110 120 130 140 150
VLHCYYAHGE ANENFQRRCY WMLEQHLMHI VFVHYLEVKG NRTSIGMKEN
160 170 180 190 200
NSNSVNGTAS VNIDSTASPT STLSSLCEDA DTGDSQQASS VLRPSPEPQT
210 220 230 240 250
GNRYGWTPAP GMRNVSQVHG NRVRESDSQR LVDVRALDTV GNSLTRFHDQ
260 270 280 290 300
PYCNNLLTQM QPSNTDSMLV EENSEKGGRL KAEHIRNPLQ TQFNWQDDTD
310 320 330 340 350
LALFEQSAQD NFETFSSLLG SENLQPFGIS YQAPPSNMDS EYMPVMKILR
360 370 380 390 400
RSEDSLKKVD SFSKWAIKEL GEMEDLQMQS SRGDIAWTTV ECETAAAGIS
410 420 430 440 450
LSPSLSEDQR FTIVDFWPKS AKTDAEVEVM VIGTFLLSPQ EVTKYNWSCM
460 470 480 490 500
FGEVEVPAEI LVDGVLCCHA PPHTAGHVPF YVTCSNRFAC SEVREFDFLS
510 520 530 540 550
GSTQKINATD VYGTYTNEAS LQLRFEKMLA HRDFVHEHHI FEDVGDKRRQ
560 570 580 590 600
ISKIMLLKEE KEYLLPGTYQ RDSTKQEPKG QLFRELFEEE LYIWLIHKVT
610 620 630 640 650
EEGKGPNILD EDGQGILHFV AALGYDWAIK PVLAAGVNIN FRDANGWSAL
660 670 680 690 700
HWAAFSGREE TVAVLVSLGA DAGALTDPSP ELPLGKTAAD LAYANGHRGI
710 720 730 740 750
SGFLAESSLT SYLEKLTVDS KENSPANSCG EKAVQTVSER TAAPMTYGDV
760 770 780 790 800
PEKLSLKDSL TAVRNATQAA DRLHQVFRMQ SFQRKQLCDI GDDEKIDISD
810 820 830 840 850
QLAVSFAASK TKNPGQGDVS LSCAATHIQK KYRGWKKRKE FLLIRQRIVK
860 870 880 890 900
IQAHVRGHQV RKQYRTVIWS VGLLEKIILR WRRKGNGLRG FKRNAVAKTV
910 920 930 940 950
EPEPPVSAIC PRIPQEDEYD YLKEGRKQTE ERLQKALTRV KSMVQYPEAR
960 970 980 990 1000
DQYRRLLTVV EGFRENEASS SASINNKEEE AVNCEEDDFI DIESLLNDDT

LMMSISP
Length:1,007
Mass (Da):113,853
Last modified:July 27, 2011 - v2
Checksum:i73FAB1EC5F746E06
GO
Isoform 2 (identifier: Q9FY74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-201: Missing.

Show »
Length:989
Mass (Da):111,987
Checksum:i8A00027635BFAC9D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 1371E → Q in CAC05467 (PubMed:11130714).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei184 – 20118Missing in isoform 2. 1 PublicationVSP_040640Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391712 Genomic DNA. Translation: CAC05467.1.
CP002688 Genomic DNA. Translation: AED91388.1.
CP002688 Genomic DNA. Translation: AED91389.1.
AK228740 mRNA. Translation: BAF00640.1.
RefSeqiNP_001119195.1. NM_001125723.1. [Q9FY74-1]
NP_196503.3. NM_120978.4. [Q9FY74-2]
UniGeneiAt.26762.

Genome annotation databases

EnsemblPlantsiAT5G09410.2; AT5G09410.2; AT5G09410. [Q9FY74-1]
GeneIDi830800.
KEGGiath:AT5G09410.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391712 Genomic DNA. Translation: CAC05467.1.
CP002688 Genomic DNA. Translation: AED91388.1.
CP002688 Genomic DNA. Translation: AED91389.1.
AK228740 mRNA. Translation: BAF00640.1.
RefSeqiNP_001119195.1. NM_001125723.1. [Q9FY74-1]
NP_196503.3. NM_120978.4. [Q9FY74-2]
UniGeneiAt.26762.

3D structure databases

ProteinModelPortaliQ9FY74.
SMRiQ9FY74. Positions 413-501, 586-737.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi16078. 1 interaction.

PTM databases

iPTMnetiQ9FY74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G09410.2; AT5G09410.2; AT5G09410. [Q9FY74-1]
GeneIDi830800.
KEGGiath:AT5G09410.

Organism-specific databases

TAIRiAT5G09410.

Phylogenomic databases

HOGENOMiHOG000240102.
InParanoidiQ9FY74.

Miscellaneous databases

PROiQ9FY74.

Gene expression databases

ExpressionAtlasiQ9FY74. baseline and differential.
GenevisibleiQ9FY74. AT.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005559. CG-1_dom.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000048. IQ_motif_EF-hand-BS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF03859. CG-1. 1 hit.
PF00612. IQ. 2 hits.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 1 hit.
SM01076. CG-1. 1 hit.
SM00015. IQ. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS51437. CG_1. 1 hit.
PS50096. IQ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCMTA1_ARATH
AccessioniPrimary (citable) accession number: Q9FY74
Secondary accession number(s): F4KCL6, Q0WQF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.