Reviewed, UniProtKB/Swiss-Prot Q9FXM5 (G6PI_ARAGE)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase, cytosolic
      Short name=GPI
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase
      Short name=PGI
    Phosphohexose isomerase
      Short name=PHI

Gene names

Name:

PGIC

Organism

Arabis gemmifera

Taxonomic identifier

63677 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	560 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the GPI family.
Sequence caution	The sequence BAB17655.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 560	560	Glucose-6-phosphate isomerase, cytosolic		PRO_0000180549
Sites
	Active site	361	1	Proton donor By similarity
	Active site	392	1	By similarity
	Active site	517	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9FXM5-1 [UniParc]. Last modified November 2, 2001. Version 2. Checksum: 3EB74AA686A2172C	FASTA	560	61,754
	10 20 30 40 50 60 MASSTALFCD TEAWKDLKGH VEDIKKTHLR DLMSDANRCQ SMMMEFDGLL LDYSRQRAPV 70 80 90 100 110 120 ETMDKLLNLA KAAQLTEKIS RMFNGEHINS TENRSVLHVA LRAPKDAVIK ADGKNVVPEV 130 140 150 160 170 180 WNVLDKIKEF SEKIRSGSWV GATGKPLKDV IAIGIGGSFL GPLFVHTALQ TDPEALESAK 190 200 210 220 230 240 GRQLRFLANI DPVDVARNIK GLNPETTLVV VVSKTFTTAE TMLNARTLRE WITAALGASA 250 260 270 280 290 300 VAKHMVAVST NLALVEKFGI DPNNAFAFWD WVGGRYSVCS AVGVLPLSLQ YGFSVVEKFL 310 320 330 340 350 360 KGASSIDQHF QSTPFEKNIP VLLGLLSVWN VSFLGYPARA ILPYSQALEK FAPHIQQVSM 370 380 390 400 410 420 ESNGKGVSID GLPLPFETGE VDFGEPGTNG QHSFYQLIHQ GRVIPCDFIG IVKSQQPVYL 430 440 450 460 470 480 KGEVVSNHDE LMSNFFAQPD ALAYGKTPEQ LQKENVSENL IPHKTFSGNR PSLSLLLPEL 490 500 510 520 530 540 TAYNVGQLLA IYEHRVAVQG FVWGINSFDQ WGVELGKVLA TQVRKQLHSS RTQGTALEGF 550 560 NYSTTTLLKR YLETSSEPQM

References

[1]	"DNA polymorphism at the cytosolic phosphoglucose isomerase (PgiC) locus of the wild plant Arabidopsis thaliana." Kawabe A., Yamane K., Miyashita N.T. Genetics 156:1339-1347(2000) [PubMed: 11063706] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: cv. Ashibi 56.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB044968 Genomic DNA. Translation: BAB17655.1. Sequence problems.
3D structure databases
HSSP	HSSP built from PDB template 1HM5 based on UniProtKB Q9N1E2.
ModBase	Search...
Family and domain databases
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_ARAGE

Accession

Primary (citable) accession number: Q9FXM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	November 2, 2001
Last modified:	October 13, 2009
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)