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Protein

Glucose-6-phosphate isomerase, cytosolic

Gene

PGIC

Organism
Arabidopsis lyrata subsp. petraea (Northern rock-cress) (Cardaminopsis petraea)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (PgiC), Glucose-6-phosphate isomerase, cytosolic (PGIC), Glucose-6-phosphate isomerase (PgiC)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei361Proton donorBy similarity1
Active sitei392By similarity1
Active sitei517By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase, cytosolic (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:PGIC
OrganismiArabidopsis lyrata subsp. petraea (Northern rock-cress) (Cardaminopsis petraea)
Taxonomic identifieri59691 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001805512 – 560Glucose-6-phosphate isomerase, cytosolicAdd BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ9FXM4

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9FXM4
SMRiQ9FXM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FXM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSTALISD TEAWKDLKGH VEDIKKTHLR DLMTDANRCQ SMMMEFDGLL
60 70 80 90 100
LDYSRQRAPV ETMDKLLNLA KAAQLTEKIS RMFNGEHINS TENRSVLHVA
110 120 130 140 150
LRAPKDAVIK ADGKNVVQEV WNVLDKIKEF SEKIRSGSWV GATGKPLKDV
160 170 180 190 200
IAIGIGGSFL GPLFVHTALQ TDPEALESAK GRQLRFLANI DPVDVARNII
210 220 230 240 250
GLNPETTLVV VVSKTFTTAE TMLNARTLRE WITAALGASA VAKHMVAVST
260 270 280 290 300
NLALVEKFGI DPNNAFAFWD WVGGRYSVCS AVGVLPLSLQ YGFSVVEKFL
310 320 330 340 350
KGASSIDQHF QSTPFEKNIP VLLGLLSVWN VSFLGYPARA ILPYSQALEK
360 370 380 390 400
FAPHIQQVSM ESNGKGVSID GLPLPFETGE IDFGEPGTNG QHSFYQLIHQ
410 420 430 440 450
GRVIPCDFIG IVKSQQPVYL KGEVVSNHDE LMSNFFAQPD ALAYGKTPEQ
460 470 480 490 500
LQKENVSENL IPHKTFSGNR PSLSLLLPEL TAYNVGQLLA IYEHRVAVQG
510 520 530 540 550
FVWGINSFDQ WGVELGKVLA TQVRKQLHSS RTQGTALEGF NYSTTTLLKR
560
YLETSSEPQM
Length:560
Mass (Da):61,748
Last modified:March 1, 2001 - v1
Checksum:i7352158EB28CFC48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB044969 Genomic DNA Translation: BAB17656.1

Similar proteinsi

Entry informationi

Entry nameiG6PI_ARALP
AccessioniPrimary (citable) accession number: Q9FXM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

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