Q9FXE4 (P2C14_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable protein phosphatase 2C 14
Short name=AtPP2C14
EC=3.1.3.16

Alternative name(s):
Protein phosphatase AP2C4

Gene names

Ordered Locus Names:	At1g67820
ORF Names:	F12A21.5

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 2 magnesium or manganese ions per subunit By similarity.
Sequence similarities	Belongs to the PP2C family. Contains 1 PP2C-like domain.
Sequence caution	The sequence AAG28911.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BX813565 differs from that shown. Reason: Sequencing errors.

Ontologies

Keywords
Ligand	Magnesium Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein dephosphorylation Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 445	445	Probable protein phosphatase 2C 14		PRO_0000367945
Regions
	Domain	119 – 330	212	PP2C-like
Sites
	Metal binding	156	1	Manganese 1 By similarity
	Metal binding	156	1	Manganese 2 By similarity
	Metal binding	157	1	Manganese 1; via carbonyl oxygen By similarity
	Metal binding	318	1	Manganese 2 By similarity
	Metal binding	431	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9FXE4 [UniParc]. Last modified April 14, 2009. Version 2. Checksum: C0E01A328F2F4CFF	FASTA	445	49,353
	10 20 30 40 50 60 MTNKLRSEET ITSLSSFMAS TLSIASPSPC SIPLSVTKVS PLKRKRPTHL NIPDLNPQQP 70 80 90 100 110 120 ISTDYFRFRE GDAKVSPLKR KRPAHLNIPD LNPQQPIRTD YFSFTDFAHQ NGTVSFGGNG 130 140 150 160 170 180 FGVVSRNGKK KFMEDTHRIV PCLVGNSKKS FFGVYDGHGG AKAAEFVAEN LHKYVVEMME 190 200 210 220 230 240 NCKGKEEKVE AFKAAFLRTD RDFLEKGVVS GACCVTAVIQ DQEMIVSNLG DCRAVLCRAG 250 260 270 280 290 300 VAEALTDDHK PGRDDEKERI ESQGGYVDNH QGAWRVQGIL AVSRSIGDAH LKKWVVAEPE 310 320 330 340 350 360 TRVLELEQDM EFLVLASDGL WDVVSNQEAV YTVLHVLAQR KTPKESEEEN LVQGFVNMSP 370 380 390 400 410 420 SSKLRRASLV KSPRCAKSQS YYYNSENESP SLNREIGSSP SKSPITPWKS LWAKAACKEL 430 440 ANLAAKRGSM DDITVVIIDL NHYKG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation." Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M. Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis." Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y. BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC008113 Genomic DNA. Translation: AAG28911.1. Sequence problems. CP002684 Genomic DNA. Translation: AEE34702.1. BX813565 mRNA. No translation available.
IPI	IPI00522546.
PIR	H96700.
RefSeq	NP_176948.2. NM_105450.3.
UniGene	At.23529. At.35596.
3D structure databases
HSSP	HSSP built from PDB template 1A6Q based on UniProtKB P35813.
ProteinModelPortal	Q9FXE4.
SMR	Q9FXE4. Positions 121-440.
ModBase	Search...
Protein-protein interaction databases
STRING	3702.AT1G67820.1-P.
Proteomic databases
PaxDb	Q9FXE4.
PRIDE	Q9FXE4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G67820.1; AT1G67820.1; AT1G67820.
GeneID	843108.
KEGG	ath:AT1G67820.
Organism-specific databases
TAIR	At1g67820.
Phylogenomic databases
eggNOG	COG0631.
HOGENOM	HOG000090868.
InParanoid	Q9FXE4.
OMA	KKFMEDT.
PhylomeDB	Q9FXE4.
ProtClustDB	CLSN2680783.
Gene expression databases
ArrayExpress	Q9FXE4.
Genevestigator	Q9FXE4.
Family and domain databases
Gene3D	3.60.40.10. 2 hits.
InterPro	IPR001932. PP2C-like. IPR000222. PP2C_Mn2_Asp60_BS. IPR015655. Protein_Pase_2C. [Graphical view]
PANTHER	PTHR13832. PTHR13832. 1 hit.
Pfam	PF00481. PP2C. 1 hit. [Graphical view]
SMART	SM00331. PP2C_SIG. 1 hit. SM00332. PP2Cc. 1 hit. [Graphical view]
SUPFAM	SSF81606. PP2C-related. 1 hit.
PROSITE	PS01032. PP2C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P2C14_ARATH

Accession

Primary (citable) accession number: Q9FXE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 14, 2009
Last modified:	May 1, 2013
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program