Q9FX64 (HOP2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homologous-pairing protein 2 homolog

Alternative name(s):
Protein AHP2
Short name=AtAHP2
Protein ARABIDOPSIS HOMOLOG PAIRING 2
Protein HOP2
Short name=AtHOP2

Gene names

Name:	HOP2
Synonyms:	AHP2
Ordered Locus Names:	At1g13330
ORF Names:	T6J4.9

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in bivalent formation and segregation of homologous chromosomes in meiosis.
Subunit structure	Interacts with MND1 and MIP1. Ref.7 Ref.8
Subcellular location	Nucleus Ref.1.
Tissue specificity	Expressed in vegetative and reproductive tissues. Found in seedlings, leaves and flowers. Ref.1
Disruption phenotype	Sterility due to failure of both male and female gametophyte development. Ref.1
Sequence similarities	Belongs to the HOP2 family.

Ontologies

Keywords
Biological process	DNA recombination Meiosis
Cellular component	Nucleus
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW chiasma assembly Inferred from mutant phenotype PubMed 19763177. Source: TAIR
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 226	226	Homologous-pairing protein 2 homolog		PRO_0000378328
Regions
	Coiled coil	76 – 150	75	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9FX64 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 4F8FB9166ABF294B	FASTA	226	26,245
	10 20 30 40 50 60 MAPKSDNTEA IVLNFVNEQN KPLNTQNAAD ALQKFNLKKT AVQKALDSLA DAGKITFKEY 70 80 90 100 110 120 GKQKIYIARQ DQFEIPNSEE LAQMKEDNAK LQEQLQEKKK TISDVESEIK SLQSNLTLEE 130 140 150 160 170 180 IQEKDAKLRK EVKEMEEKLV KLREGITLVR PEDKKAVEDM YADKINQWRK RKRMFRDIWD 190 200 210 220 TVTENSPKDV KELKEELGIE YDEDVGLSFQ AYADLIQHGK KRPRGQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"AHP2 is required for bivalent formation and for segregation of homologous chromosomes in Arabidopsis meiosis." Schommer C., Beven A., Lawrenson T., Shaw P., Sablowski R. Plant J. 36:1-11(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE. Strain: cv. Landsberg erecta.
[2]	"A study of the Arabidopsis Hop2 gene (AHP2)." Siaud N., Doutriaux M.P. Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Landsberg erecta. Tissue: Flower bud.
[3]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[4]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[5]	"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[6]	"Arabidopsis ORF clones." Shinn P., Chen H., Kim C.J., Ecker J.R. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[7]	"The Arabidopsis thaliana MND1 homologue plays a key role in meiotic homologous pairing, synapsis and recombination." Kerzendorfer C., Vignard J., Pedrosa-Harand A., Siwiec T., Akimcheva S., Jolivet S., Sablowski R., Armstrong S., Schweizer D., Mercier R., Schloegelhofer P. J. Cell Sci. 119:2486-2496(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MND1.
[8]	"A novel ATM dependant X-ray inducible gene is essential for both plant meiosis and gametogenesis." Dean P.J., Siwiec T., Waterworth W.M., Schloegelhofer P., Armstrong S.J., West C.E. Plant J. 58:791-802(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MIP1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY225519 mRNA. Translation: AAO67519.1. AJ627484 mRNA. Translation: CAF28783.1. AC011810 Genomic DNA. Translation: AAG09555.1. CP002684 Genomic DNA. Translation: AEE29001.1. AK176610 mRNA. Translation: BAD44373.1. AK227903 mRNA. Translation: BAE99873.1. BT025172 mRNA. Translation: ABE77410.1.
IPI	IPI00542471.
PIR	A86268.
RefSeq	NP_172791.1. NM_101204.3.
UniGene	At.42036.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9FX64. 2 interactions.
STRING	3702.AT1G13330.1-P.
Proteomic databases
PaxDb	Q9FX64.
PRIDE	Q9FX64.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G13330.1; AT1G13330.1; AT1G13330.
GeneID	837893.
KEGG	ath:AT1G13330.
Organism-specific databases
TAIR	At1g13330.
Phylogenomic databases
eggNOG	NOG274440.
HOGENOM	HOG000005789.
InParanoid	Q9FX64.
OMA	QEQNRPY.
PhylomeDB	Q9FX64.
ProtClustDB	CLSN2682524.
Gene expression databases
Genevestigator	Q9FX64.
Family and domain databases
InterPro	IPR010776. TBPIP. [Graphical view]
PANTHER	PTHR15938. PTHR15938. 1 hit.
Pfam	PF07106. TBPIP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HOP2_ARATH

Accession

Primary (citable) accession number: Q9FX64

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2009
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program