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Q9FX32

- SUS6_ARATH

UniProt

Q9FX32 - SUS6_ARATH

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Protein

Sucrose synthase 6

Gene

SUS6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways. Functions in callose synthesis at the site of phloem sieve elements.1 Publication

Catalytic activityi

NDP-glucose + D-fructose = NDP + sucrose.

Kineticsi

  1. KM=12.44 mM for D-fructose (synthetic reaction)1 Publication
  2. KM=0.06 mM for UDP-glucose (synthetic reaction)1 Publication
  3. KM=31.06 mM for sucrose (degradative reaction)1 Publication
  4. KM=0.26 mM for UDP (degradative reaction)1 Publication

Vmax=3.27 µmol/min/mg enzyme for synthetic reaction1 Publication

Vmax=1.43 µmol/min/mg enzyme for degradative reaction1 Publication

pH dependencei

Optimum pH is 6.0-7.0 for degradative reaction and 7.0 (PubMed:22184213) or 9.0-9.5 (PubMed:17257168) for synthetic reaction.1 Publication

GO - Molecular functioni

  1. sucrose synthase activity Source: TAIR

GO - Biological processi

  1. biosynthetic process Source: InterPro
  2. callose deposition in phloem sieve plate Source: TAIR
  3. sucrose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciARA:GQT-78-MONOMER.
MetaCyc:AT1G73370-MONOMER.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
Sucrose synthase 6 (EC:2.4.1.13)
Short name:
AtSUS6
Alternative name(s):
Sucrose-UDP glucosyltransferase 6
Gene namesi
Name:SUS6
Ordered Locus Names:At1g73370
ORF Names:T9L24.42
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G73370.

Subcellular locationi

Secretedcell wall 1 Publication

GO - Cellular componenti

  1. cell wall Source: TAIR
  2. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 942942Sucrose synthase 6PRO_0000418805Add
BLAST

Proteomic databases

PaxDbiQ9FX32.
PRIDEiQ9FX32.

Expressioni

Tissue specificityi

Detected in the whole plant but more precisely confined to the vasculature in cotyledons, leaves, petals, anthers and roots.4 Publications

Gene expression databases

ExpressionAtlasiQ9FX32. baseline and differential.
GenevestigatoriQ9FX32.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G73370.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9FX32.
SMRiQ9FX32. Positions 41-812.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni281 – 759479GT-B glycosyltransferaseBy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0438.
HOGENOMiHOG000240125.
InParanoidiQ9FX32.
KOiK00695.
OMAiFFEKCKT.
PhylomeDBiQ9FX32.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
IPR000368. Sucrose_synth.
IPR012820. Sucrose_synthase_pln/cyn.
[Graphical view]
PfamiPF00534. Glycos_transf_1. 1 hit.
PF00862. Sucrose_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02470. sucr_synth. 1 hit.

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q9FX32-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSSSQAMLQ KSDSIAEKMP DALKQSRYHM KRCFASFVGG GKKLMKREHL
60 70 80 90 100
MNEIEKCIED SRERSKILEG LFGYILTCTQ EAAVVPPFVA LAARPNPGFW
110 120 130 140 150
EYVKVNSGDL TVDEITATDY LKLKESVFDE SWSKDENALE IDFGAIDFTS
160 170 180 190 200
PRLSLSSSIG KGADYISKFI SSKLGGKSDK LEPLLNYLLR LNHHGENLMI
210 220 230 240 250
NDDLNTVAKL QKSLMLAVIV VSTYSKHTPY ETFAQRLKEM GFEKGWGDTA
260 270 280 290 300
ERVKETMIIL SEVLEAPDNG KLDLLFSRLP TVFNVVIFSV HGYFGQQDVL
310 320 330 340 350
GLPDTGGQVV YILDQVRALE EELLIRINQQ GLGFKPQILV VTRLIPEARG
360 370 380 390 400
TKCDQELEAI EGTKHSHILR VPFVTNKGVL RQWVSRFDIY PYLERFTQDA
410 420 430 440 450
TSKILQRLDC KPDLIIGNYT DGNLVASLMA TKLGVTQGTI AHALEKTKYE
460 470 480 490 500
DSDAKWKELD PKYHFSCQFT ADLIAMNVTD FIITSTYQEI AGSKDRPGQY
510 520 530 540 550
ESHTAFTMPG LCRVVSGIDV FDPKFNIAAP GADQSVYFPY TEKDKRFTKF
560 570 580 590 600
HPSIQELLYN EKDNAEHMGY LADREKPIIF SMARLDTVKN ITGLVEWYGK
610 620 630 640 650
DKRLREMANL VVVAGFFDMS KSNDREEKAE IKKMHDLIEK YKLKGKFRWI
660 670 680 690 700
AAQTDRYRNS ELYRCIADTK GVFVQPALYE AFGLTVIEAM NCGLPTFATN
710 720 730 740 750
QGGPAEIIVD GVSGFHIDPN NGDESVTKIG DFFSKCRSDG LYWDNISKGG
760 770 780 790 800
LKRIYECYTW KIYAEKLLKM GSLYGFWRQV NEDQKKAKKR YIEMLYNLQF
810 820 830 840 850
KQLTKKVTIP EDKPLPLRLA SLRNLLPKKT TNLGAGSKQK EVTETEKTKQ
860 870 880 890 900
KSKDGQEQHD VKVGEREVRE GLLAADASER VKKVLESSEE KQKLEKMKIA
910 920 930 940
YGQQHSQGAS PVRNLFWSVV VCLYICYILK QRFFGANSAQ EY
Length:942
Mass (Da):106,876
Last modified:March 1, 2001 - v1
Checksum:i0AA4A92EC48815EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012396 Genomic DNA. Translation: AAG30975.1.
CP002684 Genomic DNA. Translation: AEE35450.1.
PIRiC96760.
RefSeqiNP_177480.1. NM_105997.1. [Q9FX32-1]
UniGeneiAt.34995.
At.69495.

Genome annotation databases

EnsemblPlantsiAT1G73370.1; AT1G73370.1; AT1G73370. [Q9FX32-1]
GeneIDi843672.
KEGGiath:AT1G73370.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012396 Genomic DNA. Translation: AAG30975.1 .
CP002684 Genomic DNA. Translation: AEE35450.1 .
PIRi C96760.
RefSeqi NP_177480.1. NM_105997.1. [Q9FX32-1 ]
UniGenei At.34995.
At.69495.

3D structure databases

ProteinModelPortali Q9FX32.
SMRi Q9FX32. Positions 41-812.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT1G73370.1-P.

Protein family/group databases

CAZyi GT4. Glycosyltransferase Family 4.

Proteomic databases

PaxDbi Q9FX32.
PRIDEi Q9FX32.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G73370.1 ; AT1G73370.1 ; AT1G73370 . [Q9FX32-1 ]
GeneIDi 843672.
KEGGi ath:AT1G73370.

Organism-specific databases

TAIRi AT1G73370.

Phylogenomic databases

eggNOGi COG0438.
HOGENOMi HOG000240125.
InParanoidi Q9FX32.
KOi K00695.
OMAi FFEKCKT.
PhylomeDBi Q9FX32.

Enzyme and pathway databases

BioCyci ARA:GQT-78-MONOMER.
MetaCyc:AT1G73370-MONOMER.

Gene expression databases

ExpressionAtlasi Q9FX32. baseline and differential.
Genevestigatori Q9FX32.

Family and domain databases

InterProi IPR001296. Glyco_trans_1.
IPR000368. Sucrose_synth.
IPR012820. Sucrose_synthase_pln/cyn.
[Graphical view ]
Pfami PF00534. Glycos_transf_1. 1 hit.
PF00862. Sucrose_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02470. sucr_synth. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Structure and expression profile of the sucrose synthase multigene family in Arabidopsis."
    Baud S., Vaultier M.N., Rochat C.
    J. Exp. Bot. 55:397-409(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, TISSUE SPECIFICITY.
  4. Cited for: BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  5. "Localization of sucrose synthase in developing seed and siliques of Arabidopsis thaliana reveals diverse roles for SUS during development."
    Fallahi H., Scofield G.N., Badger M.R., Chow W.S., Furbank R.T., Ruan Y.L.
    J. Exp. Bot. 59:3283-3295(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, FUNCTION.

Entry informationi

Entry nameiSUS6_ARATH
AccessioniPrimary (citable) accession number: Q9FX32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3