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Q9FX08

- P2C12_ARATH

UniProt

Q9FX08 - P2C12_ARATH

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Protein

Probable protein phosphatase 2C 12

Gene
At1g47380, T3F24.2
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi69 – 691Manganese 1 By similarity
Metal bindingi69 – 691Manganese 2 By similarity
Metal bindingi70 – 701Manganese 1; via carbonyl oxygen By similarity
Metal bindingi245 – 2451Manganese 2 By similarity
Metal bindingi284 – 2841Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT1G47380-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 12 (EC:3.1.3.16)
Short name:
AtPP2C12
Gene namesi
Ordered Locus Names:At1g47380
ORF Names:T3F24.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G47380.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Probable protein phosphatase 2C 12PRO_0000367943Add
BLAST

Proteomic databases

PaxDbiQ9FX08.
PRIDEiQ9FX08.

Expressioni

Gene expression databases

GenevestigatoriQ9FX08.

Interactioni

Protein-protein interaction databases

BioGridi26366. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9FX08.
SMRiQ9FX08. Positions 34-293.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 261231PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.
Contains 1 PP2C-like domain.

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000240114.
InParanoidiQ9FX08.
OMAiICQVELK.
PhylomeDBiQ9FX08.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9FX08-1 [UniParc]FASTAAdd to Basket

« Hide

MSTKGEHHTV PLSVLLKRES ANEKIDNPEL IHGQHNQSKK GEDFTLVKTE    50
CQRVMGDGVT TFSVFGLFDG HNGSAAAIYT KENLLNNVLA AIPSDLNRDE 100
WVAALPRALV AGFVKTDKDF QERARTSGTT VTFVIVEGWV VSVASVGDSR 150
CILEPAEGGV YYLSADHRLE INEEERDRVT ASGGEVGRLN TGGGTEIGPL 200
RCWPGGLCLS RSIGDLDVGE YIVPVPYVKQ VKLSSAGGRL IISSDGVWDA 250
ISAEEALDCC RGLPPESSAE HIVKEAVGKK GIRDDTTCIV VDILPLEKPA 300
ASVPPPKKQG KGMLKSMFKR KTSDSSSNIE KEYAEPDVVE ELFEEGSAML 350
SERLDTKYPL CNMFKLFMCA VCQVEVKPGE GVSIHAGSDN CRKLRPWDGP 400
FLCASCQDKK DAMEGKRSSG DRHSSESD 428
Length:428
Mass (Da):46,422
Last modified:March 1, 2001 - v1
Checksum:i55062CAA157C9CDB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti121 – 1211Q → R in AAK92805. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC015449 Genomic DNA. Translation: AAG11427.1.
CP002684 Genomic DNA. Translation: AEE32161.1.
AY050868 mRNA. Translation: AAK92805.1.
AY150472 mRNA. Translation: AAN12997.1.
PIRiE96514.
RefSeqiNP_564504.1. NM_103632.2.
UniGeneiAt.16151.

Genome annotation databases

EnsemblPlantsiAT1G47380.1; AT1G47380.1; AT1G47380.
GeneIDi841141.
KEGGiath:AT1G47380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC015449 Genomic DNA. Translation: AAG11427.1 .
CP002684 Genomic DNA. Translation: AEE32161.1 .
AY050868 mRNA. Translation: AAK92805.1 .
AY150472 mRNA. Translation: AAN12997.1 .
PIRi E96514.
RefSeqi NP_564504.1. NM_103632.2.
UniGenei At.16151.

3D structure databases

ProteinModelPortali Q9FX08.
SMRi Q9FX08. Positions 34-293.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 26366. 1 interaction.

Proteomic databases

PaxDbi Q9FX08.
PRIDEi Q9FX08.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G47380.1 ; AT1G47380.1 ; AT1G47380 .
GeneIDi 841141.
KEGGi ath:AT1G47380.

Organism-specific databases

TAIRi AT1G47380.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000240114.
InParanoidi Q9FX08.
OMAi ICQVELK.
PhylomeDBi Q9FX08.

Enzyme and pathway databases

BioCyci ARA:AT1G47380-MONOMER.

Gene expression databases

Genevestigatori Q9FX08.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C12_ARATH
AccessioniPrimary (citable) accession number: Q9FX08
Secondary accession number(s): Q949V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 1, 2001
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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