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Protein

Probable protein phosphatase 2C 12

Gene

At1g47380

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi69Manganese 1By similarity1
Metal bindingi69Manganese 2By similarity1
Metal bindingi70Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi245Manganese 2By similarity1
Metal bindingi284Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 12 (EC:3.1.3.16)
Short name:
AtPP2C12
Gene namesi
Ordered Locus Names:At1g47380
ORF Names:T3F24.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G47380
TAIRilocus:2203766 AT1G47380

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003679431 – 428Probable protein phosphatase 2C 12Add BLAST428

Proteomic databases

PaxDbiQ9FX08

PTM databases

iPTMnetiQ9FX08

Expressioni

Gene expression databases

ExpressionAtlasiQ9FX08 baseline and differential
GenevisibleiQ9FX08 AT

Interactioni

Protein-protein interaction databases

BioGridi26366, 1 interactor
STRINGi3702.AT1G47380.1

Structurei

3D structure databases

ProteinModelPortaliQ9FX08
SMRiQ9FX08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 293PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST270

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiKOG0698 Eukaryota
COG0631 LUCA
HOGENOMiHOG000240114
InParanoidiQ9FX08
OMAiQDVGQFI
OrthoDBiEOG09360AH0
PhylomeDBiQ9FX08

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00331 PP2C_SIG, 1 hit
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FX08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKGEHHTV PLSVLLKRES ANEKIDNPEL IHGQHNQSKK GEDFTLVKTE
60 70 80 90 100
CQRVMGDGVT TFSVFGLFDG HNGSAAAIYT KENLLNNVLA AIPSDLNRDE
110 120 130 140 150
WVAALPRALV AGFVKTDKDF QERARTSGTT VTFVIVEGWV VSVASVGDSR
160 170 180 190 200
CILEPAEGGV YYLSADHRLE INEEERDRVT ASGGEVGRLN TGGGTEIGPL
210 220 230 240 250
RCWPGGLCLS RSIGDLDVGE YIVPVPYVKQ VKLSSAGGRL IISSDGVWDA
260 270 280 290 300
ISAEEALDCC RGLPPESSAE HIVKEAVGKK GIRDDTTCIV VDILPLEKPA
310 320 330 340 350
ASVPPPKKQG KGMLKSMFKR KTSDSSSNIE KEYAEPDVVE ELFEEGSAML
360 370 380 390 400
SERLDTKYPL CNMFKLFMCA VCQVEVKPGE GVSIHAGSDN CRKLRPWDGP
410 420
FLCASCQDKK DAMEGKRSSG DRHSSESD
Length:428
Mass (Da):46,422
Last modified:March 1, 2001 - v1
Checksum:i55062CAA157C9CDB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti121Q → R in AAK92805 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015449 Genomic DNA Translation: AAG11427.1
CP002684 Genomic DNA Translation: AEE32161.1
AY050868 mRNA Translation: AAK92805.1
AY150472 mRNA Translation: AAN12997.1
PIRiE96514
RefSeqiNP_564504.1, NM_103632.3
UniGeneiAt.16151

Genome annotation databases

EnsemblPlantsiAT1G47380.1; AT1G47380.1; AT1G47380
GeneIDi841141
GrameneiAT1G47380.1; AT1G47380.1; AT1G47380
KEGGiath:AT1G47380

Similar proteinsi

Entry informationi

Entry nameiP2C12_ARATH
AccessioniPrimary (citable) accession number: Q9FX08
Secondary accession number(s): Q949V4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health