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Q9FX08 (P2C12_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable protein phosphatase 2C 12
Short name=AtPP2C12
EC=3.1.3.16
Gene names
Ordered Locus Names:At1g47380
ORF Names:T3F24.2
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

A phosphoprotein + H2O = a protein + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Sequence similarities

Belongs to the PP2C family.

Contains 1 PP2C-like domain.

Ontologies

Keywords
   LigandMagnesium
Manganese
Metal-binding
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmetabolic process

Inferred from electronic annotation. Source: GOC

   Cellular_componentcytosol

Inferred from direct assay PubMed 21166475. Source: TAIR

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 428428Probable protein phosphatase 2C 12
PRO_0000367943

Regions

Domain31 – 261231PP2C-like

Sites

Metal binding691Manganese 1 By similarity
Metal binding691Manganese 2 By similarity
Metal binding701Manganese 1; via carbonyl oxygen By similarity
Metal binding2451Manganese 2 By similarity
Metal binding2841Manganese 2 By similarity

Experimental info

Sequence conflict1211Q → R in AAK92805. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9FX08 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 55062CAA157C9CDB

FASTA42846,422
        10         20         30         40         50         60 
MSTKGEHHTV PLSVLLKRES ANEKIDNPEL IHGQHNQSKK GEDFTLVKTE CQRVMGDGVT 

        70         80         90        100        110        120 
TFSVFGLFDG HNGSAAAIYT KENLLNNVLA AIPSDLNRDE WVAALPRALV AGFVKTDKDF 

       130        140        150        160        170        180 
QERARTSGTT VTFVIVEGWV VSVASVGDSR CILEPAEGGV YYLSADHRLE INEEERDRVT 

       190        200        210        220        230        240 
ASGGEVGRLN TGGGTEIGPL RCWPGGLCLS RSIGDLDVGE YIVPVPYVKQ VKLSSAGGRL 

       250        260        270        280        290        300 
IISSDGVWDA ISAEEALDCC RGLPPESSAE HIVKEAVGKK GIRDDTTCIV VDILPLEKPA 

       310        320        330        340        350        360 
ASVPPPKKQG KGMLKSMFKR KTSDSSSNIE KEYAEPDVVE ELFEEGSAML SERLDTKYPL 

       370        380        390        400        410        420 
CNMFKLFMCA VCQVEVKPGE GVSIHAGSDN CRKLRPWDGP FLCASCQDKK DAMEGKRSSG 


DRHSSESD

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AC015449 Genomic DNA. Translation: AAG11427.1.
CP002684 Genomic DNA. Translation: AEE32161.1.
AY050868 mRNA. Translation: AAK92805.1.
AY150472 mRNA. Translation: AAN12997.1.
IPIIPI00538302.
PIRE96514.
RefSeqNP_564504.1. NM_103632.2.
UniGeneAt.16151.

3D structure databases

ProteinModelPortalQ9FX08.
SMRQ9FX08. Positions 34-293.
ModBaseSearch...

Proteomic databases

PaxDbQ9FX08.
PRIDEQ9FX08.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G47380.1; AT1G47380.1; AT1G47380.
GeneID841141.
KEGGath:AT1G47380.

Organism-specific databases

TAIRAt1g47380.

Phylogenomic databases

eggNOGCOG0631.
HOGENOMHOG000240114.
InParanoidQ9FX08.
OMAKTECQRV.
PhylomeDBQ9FX08.
ProtClustDBCLSN2688508.

Gene expression databases

GenevestigatorQ9FX08.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. PP2C-related. 1 hit.
PROSITEPS01032. PP2C. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameP2C12_ARATH
AccessionPrimary (citable) accession number: Q9FX08
Secondary accession number(s): Q949V4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 1, 2001
Last modified: May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

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