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Protein

ABC transporter B family member 11

Gene

ABCB11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi416 – 423ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1067 – 1074ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G02520-MONOMER.
ReactomeiR-ATH-159418. Recycling of bile acids and salts.
R-ATH-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-ATH-382556. ABC-family proteins mediated transport.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter B family member 11
Short name:
ABC transporter ABCB.11
Short name:
AtABCB11
Alternative name(s):
Multidrug resistance protein 8
P-glycoprotein 11
Gene namesi
Name:ABCB11
Synonyms:MDR8, PGP11
Ordered Locus Names:At1g02520
ORF Names:T14P4.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRilocus:2196145. AT1G02520.

Subcellular locationi

  • Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei55 – 75HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei106 – 126HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei182 – 202HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei205 – 225HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei285 – 305HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei314 – 334HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei711 – 731HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei751 – 771HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei824 – 844HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei845 – 865HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei932 – 952HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei971 – 991HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: TAIR
  • plasmodesma Source: TAIR

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002279191 – 1278ABC transporter B family member 11Add BLAST1278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi483N-linked (GlcNAc...)Sequence analysis1
Glycosylationi568N-linked (GlcNAc...)Sequence analysis1
Glycosylationi653N-linked (GlcNAc...)Sequence analysis1
Glycosylationi806N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1121N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1222N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9FWX7.

PTM databases

iPTMnetiQ9FWX7.

Expressioni

Gene expression databases

ExpressionAtlasiQ9FWX7. baseline and differential.
GenevisibleiQ9FWX7. AT.

Interactioni

Protein-protein interaction databases

BioGridi24588. 1 interactor.
STRINGi3702.AT1G02520.1.

Structurei

3D structure databases

ProteinModelPortaliQ9FWX7.
SMRiQ9FWX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 346ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST289
Domaini381 – 617ABC transporter 1PROSITE-ProRule annotationAdd BLAST237
Domaini710 – 997ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST288
Domaini1032 – 1271ABC transporter 2PROSITE-ProRule annotationAdd BLAST240

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
InParanoidiQ9FWX7.
KOiK05658.
OMAiAFFKPAH.
OrthoDBiEOG093600JM.
PhylomeDBiQ9FWX7.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9FWX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGDGAREGD SVSHEPSTSK SPKEGEETKK EEKSEEKANT VPFYKLFAFA
60 70 80 90 100
DSSDVLLMIC GSIGAIGNGM SLPFMTLLFG DLIDSFGKNQ NNKDIVDVVS
110 120 130 140 150
KVCLKFVYLG LGTLGAAFLQ VACWMITGER QAARIRSTYL KTILRQDIGF
160 170 180 190 200
FDVETNTGEV VGRMSGDTVL IQDAMGEKVG KFIQLVSTFV GGFVLAFIKG
210 220 230 240 250
WLLTLVMLTS IPLLAMAGAA MALIVTRASS RGQAAYAKAA TVVEQTIGSI
260 270 280 290 300
RTVASFTGEK QAINSYKKFI TSAYKSSIQQ GFSTGLGLGV MFFVFFSSYA
310 320 330 340 350
LAIWFGGKMI LEKGYTGGAV INVIIIVVAG SMSLGQTSPC VTAFAAGQAA
360 370 380 390 400
AYKMFETIKR KPLIDAYDVN GKVLEDIRGD IELKDVHFSY PARPDEEIFD
410 420 430 440 450
GFSLFIPSGA TAALVGESGS GKSTVISLIE RFYDPKSGAV LIDGVNLKEF
460 470 480 490 500
QLKWIRSKIG LVSQEPVLFS SSIMENIAYG KENATVEEIK AATELANAAK
510 520 530 540 550
FIDKLPQGLD TMVGEHGTQL SGGQKQRIAI ARAILKDPRI LLLDEATSAL
560 570 580 590 600
DAESERVVQE ALDRVMVNRT TVIVAHRLST VRNADMIAVI HRGKMVEKGS
610 620 630 640 650
HSELLKDSEG AYSQLIRLQE INKDVKTSEL SSGSSFRNSN LKKSMEGTSS
660 670 680 690 700
VGNSSRHHSL NVLGLTTGLD LGSHSQRAGQ DETGTASQEP LPKVSLTRIA
710 720 730 740 750
ALNKPEIPVL LLGTVAAAIN GAIFPLFGIL ISRVIEAFFK PAHELKRDSR
760 770 780 790 800
FWAIIFVALG VTSLIVSPTQ MYLFAVAGGK LIRRIRSMCF EKAVHMEVAW
810 820 830 840 850
FDEPQNSSGT MGARLSADAT LIRALVGDAL SLAVQNVASA ASGLIIAFTA
860 870 880 890 900
SWELALIILV MLPLIGINGF VQVKFMKGFS ADAKSKYEEA SQVANDAVGS
910 920 930 940 950
IRTVASFCAE EKVMQMYKKQ CEGPIKDGIK QGFISGLGFG FSFFILFCVY
960 970 980 990 1000
ATSFYAGARL VEDGKTTFNN VFQVFFALTM AAIGISQSST FAPDSSKAKV
1010 1020 1030 1040 1050
AAASIFAIID RKSKIDSSDE TGTVLENVKG DIELRHLSFT YPARPDIQIF
1060 1070 1080 1090 1100
RDLCLTIRAG KTVALVGESG SGKSTVISLL QRFYDPDSGH ITLDGVELKK
1110 1120 1130 1140 1150
LQLKWLRQQM GLVGQEPVLF NDTIRANIAY GKGSEEAATE SEIIAAAELA
1160 1170 1180 1190 1200
NAHKFISSIQ QGYDTVVGER GIQLSGGQKQ RVAIARAIVK EPKILLLDEA
1210 1220 1230 1240 1250
TSALDAESER VVQDALDRVM VNRTTIVVAH RLSTIKNADV IAVVKNGVIA
1260 1270
EKGTHETLIK IEGGVYASLV QLHMTASN
Length:1,278
Mass (Da):137,667
Last modified:March 1, 2001 - v1
Checksum:i169B26CCA975D7AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022521 Genomic DNA. Translation: AAG10628.1.
CP002684 Genomic DNA. Translation: AEE27440.1.
PIRiE86155.
RefSeqiNP_001322407.1. NM_001331343.1.
NP_001322408.1. NM_001331342.1.
NP_171753.1. NM_100133.3.
UniGeneiAt.42596.

Genome annotation databases

EnsemblPlantsiAT1G02520.1; AT1G02520.1; AT1G02520.
AT1G02520.2; AT1G02520.2; AT1G02520.
AT1G02520.3; AT1G02520.3; AT1G02520.
GeneIDi839353.
GrameneiAT1G02520.1; AT1G02520.1; AT1G02520.
AT1G02520.2; AT1G02520.2; AT1G02520.
AT1G02520.3; AT1G02520.3; AT1G02520.
KEGGiath:AT1G02520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022521 Genomic DNA. Translation: AAG10628.1.
CP002684 Genomic DNA. Translation: AEE27440.1.
PIRiE86155.
RefSeqiNP_001322407.1. NM_001331343.1.
NP_001322408.1. NM_001331342.1.
NP_171753.1. NM_100133.3.
UniGeneiAt.42596.

3D structure databases

ProteinModelPortaliQ9FWX7.
SMRiQ9FWX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi24588. 1 interactor.
STRINGi3702.AT1G02520.1.

PTM databases

iPTMnetiQ9FWX7.

Proteomic databases

PaxDbiQ9FWX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G02520.1; AT1G02520.1; AT1G02520.
AT1G02520.2; AT1G02520.2; AT1G02520.
AT1G02520.3; AT1G02520.3; AT1G02520.
GeneIDi839353.
GrameneiAT1G02520.1; AT1G02520.1; AT1G02520.
AT1G02520.2; AT1G02520.2; AT1G02520.
AT1G02520.3; AT1G02520.3; AT1G02520.
KEGGiath:AT1G02520.

Organism-specific databases

AraportiAT1G02520.
TAIRilocus:2196145. AT1G02520.

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
InParanoidiQ9FWX7.
KOiK05658.
OMAiAFFKPAH.
OrthoDBiEOG093600JM.
PhylomeDBiQ9FWX7.

Enzyme and pathway databases

BioCyciARA:AT1G02520-MONOMER.
ReactomeiR-ATH-159418. Recycling of bile acids and salts.
R-ATH-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-ATH-382556. ABC-family proteins mediated transport.

Miscellaneous databases

PROiQ9FWX7.

Gene expression databases

ExpressionAtlasiQ9FWX7. baseline and differential.
GenevisibleiQ9FWX7. AT.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiAB11B_ARATH
AccessioniPrimary (citable) accession number: Q9FWX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 1, 2001
Last modified: March 15, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.