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Protein

ABC transporter B family member 11

Gene

ABCB11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi416 – 4238ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1067 – 10748ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G02520-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter B family member 11
Short name:
ABC transporter ABCB.11
Short name:
AtABCB11
Alternative name(s):
Multidrug resistance protein 8
P-glycoprotein 11
Gene namesi
Name:ABCB11
Synonyms:MDR8, PGP11
Ordered Locus Names:At1g02520
ORF Names:T14P4.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G02520.

Subcellular locationi

  • Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei55 – 7521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei106 – 12621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei182 – 20221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei205 – 22521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei285 – 30521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei314 – 33421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei711 – 73121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei751 – 77121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei824 – 84421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei845 – 86521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei932 – 95221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei971 – 99121HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: TAIR
  • plasmodesma Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12781278ABC transporter B family member 11PRO_0000227919Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi483 – 4831N-linked (GlcNAc...)Sequence analysis
Glycosylationi568 – 5681N-linked (GlcNAc...)Sequence analysis
Glycosylationi653 – 6531N-linked (GlcNAc...)Sequence analysis
Glycosylationi806 – 8061N-linked (GlcNAc...)Sequence analysis
Glycosylationi1121 – 11211N-linked (GlcNAc...)Sequence analysis
Glycosylationi1222 – 12221N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9FWX7.
PRIDEiQ9FWX7.

PTM databases

iPTMnetiQ9FWX7.

Expressioni

Gene expression databases

GenevisibleiQ9FWX7. AT.

Interactioni

Protein-protein interaction databases

BioGridi24588. 1 interaction.
STRINGi3702.AT1G02520.1.

Structurei

3D structure databases

ProteinModelPortaliQ9FWX7.
SMRiQ9FWX7. Positions 41-646, 710-1273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 346289ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini381 – 617237ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini710 – 997288ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1032 – 1271240ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
InParanoidiQ9FWX7.
KOiK05658.
OMAiAFFKPAH.
PhylomeDBiQ9FWX7.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FWX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGDGAREGD SVSHEPSTSK SPKEGEETKK EEKSEEKANT VPFYKLFAFA
60 70 80 90 100
DSSDVLLMIC GSIGAIGNGM SLPFMTLLFG DLIDSFGKNQ NNKDIVDVVS
110 120 130 140 150
KVCLKFVYLG LGTLGAAFLQ VACWMITGER QAARIRSTYL KTILRQDIGF
160 170 180 190 200
FDVETNTGEV VGRMSGDTVL IQDAMGEKVG KFIQLVSTFV GGFVLAFIKG
210 220 230 240 250
WLLTLVMLTS IPLLAMAGAA MALIVTRASS RGQAAYAKAA TVVEQTIGSI
260 270 280 290 300
RTVASFTGEK QAINSYKKFI TSAYKSSIQQ GFSTGLGLGV MFFVFFSSYA
310 320 330 340 350
LAIWFGGKMI LEKGYTGGAV INVIIIVVAG SMSLGQTSPC VTAFAAGQAA
360 370 380 390 400
AYKMFETIKR KPLIDAYDVN GKVLEDIRGD IELKDVHFSY PARPDEEIFD
410 420 430 440 450
GFSLFIPSGA TAALVGESGS GKSTVISLIE RFYDPKSGAV LIDGVNLKEF
460 470 480 490 500
QLKWIRSKIG LVSQEPVLFS SSIMENIAYG KENATVEEIK AATELANAAK
510 520 530 540 550
FIDKLPQGLD TMVGEHGTQL SGGQKQRIAI ARAILKDPRI LLLDEATSAL
560 570 580 590 600
DAESERVVQE ALDRVMVNRT TVIVAHRLST VRNADMIAVI HRGKMVEKGS
610 620 630 640 650
HSELLKDSEG AYSQLIRLQE INKDVKTSEL SSGSSFRNSN LKKSMEGTSS
660 670 680 690 700
VGNSSRHHSL NVLGLTTGLD LGSHSQRAGQ DETGTASQEP LPKVSLTRIA
710 720 730 740 750
ALNKPEIPVL LLGTVAAAIN GAIFPLFGIL ISRVIEAFFK PAHELKRDSR
760 770 780 790 800
FWAIIFVALG VTSLIVSPTQ MYLFAVAGGK LIRRIRSMCF EKAVHMEVAW
810 820 830 840 850
FDEPQNSSGT MGARLSADAT LIRALVGDAL SLAVQNVASA ASGLIIAFTA
860 870 880 890 900
SWELALIILV MLPLIGINGF VQVKFMKGFS ADAKSKYEEA SQVANDAVGS
910 920 930 940 950
IRTVASFCAE EKVMQMYKKQ CEGPIKDGIK QGFISGLGFG FSFFILFCVY
960 970 980 990 1000
ATSFYAGARL VEDGKTTFNN VFQVFFALTM AAIGISQSST FAPDSSKAKV
1010 1020 1030 1040 1050
AAASIFAIID RKSKIDSSDE TGTVLENVKG DIELRHLSFT YPARPDIQIF
1060 1070 1080 1090 1100
RDLCLTIRAG KTVALVGESG SGKSTVISLL QRFYDPDSGH ITLDGVELKK
1110 1120 1130 1140 1150
LQLKWLRQQM GLVGQEPVLF NDTIRANIAY GKGSEEAATE SEIIAAAELA
1160 1170 1180 1190 1200
NAHKFISSIQ QGYDTVVGER GIQLSGGQKQ RVAIARAIVK EPKILLLDEA
1210 1220 1230 1240 1250
TSALDAESER VVQDALDRVM VNRTTIVVAH RLSTIKNADV IAVVKNGVIA
1260 1270
EKGTHETLIK IEGGVYASLV QLHMTASN
Length:1,278
Mass (Da):137,667
Last modified:March 1, 2001 - v1
Checksum:i169B26CCA975D7AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022521 Genomic DNA. Translation: AAG10628.1.
CP002684 Genomic DNA. Translation: AEE27440.1.
PIRiE86155.
RefSeqiNP_171753.1. NM_100133.2.
UniGeneiAt.42596.

Genome annotation databases

EnsemblPlantsiAT1G02520.1; AT1G02520.1; AT1G02520.
GeneIDi839353.
GrameneiAT1G02520.1; AT1G02520.1; AT1G02520.
KEGGiath:AT1G02520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022521 Genomic DNA. Translation: AAG10628.1.
CP002684 Genomic DNA. Translation: AEE27440.1.
PIRiE86155.
RefSeqiNP_171753.1. NM_100133.2.
UniGeneiAt.42596.

3D structure databases

ProteinModelPortaliQ9FWX7.
SMRiQ9FWX7. Positions 41-646, 710-1273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi24588. 1 interaction.
STRINGi3702.AT1G02520.1.

PTM databases

iPTMnetiQ9FWX7.

Proteomic databases

PaxDbiQ9FWX7.
PRIDEiQ9FWX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G02520.1; AT1G02520.1; AT1G02520.
GeneIDi839353.
GrameneiAT1G02520.1; AT1G02520.1; AT1G02520.
KEGGiath:AT1G02520.

Organism-specific databases

TAIRiAT1G02520.

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
InParanoidiQ9FWX7.
KOiK05658.
OMAiAFFKPAH.
PhylomeDBiQ9FWX7.

Enzyme and pathway databases

BioCyciARA:AT1G02520-MONOMER.

Miscellaneous databases

PROiQ9FWX7.

Gene expression databases

GenevisibleiQ9FWX7. AT.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "The Arabidopsis thaliana ABC protein superfamily, a complete inventory."
    Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.
    J. Biol. Chem. 276:30231-30244(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  4. Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiAB11B_ARATH
AccessioniPrimary (citable) accession number: Q9FWX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.