Q9FWX7 (AB11B_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ABC transporter B family member 11
Short name=ABC transporter ABCB.11
Short name=AtABCB11

Alternative name(s):
Multidrug resistance protein 8
P-glycoprotein 11

Gene names

Name:	ABCB11
Synonyms:	MDR8, PGP11
Ordered Locus Names:	At1g02520
ORF Names:	T14P4.15

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	1278 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay. Source: TAIR plasmodesma Inferred from direct assay. Source: TAIR
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1278	1278	ABC transporter B family member 11		PRO_0000227919
Regions
	Transmembrane	55 – 75	21	Helical; Potential
	Transmembrane	106 – 126	21	Helical; Potential
	Transmembrane	182 – 202	21	Helical; Potential
	Transmembrane	205 – 225	21	Helical; Potential
	Transmembrane	285 – 305	21	Helical; Potential
	Transmembrane	314 – 334	21	Helical; Potential
	Transmembrane	711 – 731	21	Helical; Potential
	Transmembrane	751 – 771	21	Helical; Potential
	Transmembrane	824 – 844	21	Helical; Potential
	Transmembrane	845 – 865	21	Helical; Potential
	Transmembrane	932 – 952	21	Helical; Potential
	Transmembrane	971 – 991	21	Helical; Potential
	Domain	58 – 346	289	ABC transmembrane type-1 1
	Domain	381 – 617	237	ABC transporter 1
	Domain	710 – 997	288	ABC transmembrane type-1 2
	Domain	1032 – 1271	240	ABC transporter 2
	Nucleotide binding	416 – 423	8	ATP 1 Potential
	Nucleotide binding	1067 – 1074	8	ATP 2 Potential
Amino acid modifications
	Glycosylation	483	1	N-linked (GlcNAc...) Potential
	Glycosylation	568	1	N-linked (GlcNAc...) Potential
	Glycosylation	653	1	N-linked (GlcNAc...) Potential
	Glycosylation	806	1	N-linked (GlcNAc...) Potential
	Glycosylation	1121	1	N-linked (GlcNAc...) Potential
	Glycosylation	1222	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9FWX7 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 169B26CCA975D7AD	FASTA	1,278	137,667
	10 20 30 40 50 60 MNGDGAREGD SVSHEPSTSK SPKEGEETKK EEKSEEKANT VPFYKLFAFA DSSDVLLMIC 70 80 90 100 110 120 GSIGAIGNGM SLPFMTLLFG DLIDSFGKNQ NNKDIVDVVS KVCLKFVYLG LGTLGAAFLQ 130 140 150 160 170 180 VACWMITGER QAARIRSTYL KTILRQDIGF FDVETNTGEV VGRMSGDTVL IQDAMGEKVG 190 200 210 220 230 240 KFIQLVSTFV GGFVLAFIKG WLLTLVMLTS IPLLAMAGAA MALIVTRASS RGQAAYAKAA 250 260 270 280 290 300 TVVEQTIGSI RTVASFTGEK QAINSYKKFI TSAYKSSIQQ GFSTGLGLGV MFFVFFSSYA 310 320 330 340 350 360 LAIWFGGKMI LEKGYTGGAV INVIIIVVAG SMSLGQTSPC VTAFAAGQAA AYKMFETIKR 370 380 390 400 410 420 KPLIDAYDVN GKVLEDIRGD IELKDVHFSY PARPDEEIFD GFSLFIPSGA TAALVGESGS 430 440 450 460 470 480 GKSTVISLIE RFYDPKSGAV LIDGVNLKEF QLKWIRSKIG LVSQEPVLFS SSIMENIAYG 490 500 510 520 530 540 KENATVEEIK AATELANAAK FIDKLPQGLD TMVGEHGTQL SGGQKQRIAI ARAILKDPRI 550 560 570 580 590 600 LLLDEATSAL DAESERVVQE ALDRVMVNRT TVIVAHRLST VRNADMIAVI HRGKMVEKGS 610 620 630 640 650 660 HSELLKDSEG AYSQLIRLQE INKDVKTSEL SSGSSFRNSN LKKSMEGTSS VGNSSRHHSL 670 680 690 700 710 720 NVLGLTTGLD LGSHSQRAGQ DETGTASQEP LPKVSLTRIA ALNKPEIPVL LLGTVAAAIN 730 740 750 760 770 780 GAIFPLFGIL ISRVIEAFFK PAHELKRDSR FWAIIFVALG VTSLIVSPTQ MYLFAVAGGK 790 800 810 820 830 840 LIRRIRSMCF EKAVHMEVAW FDEPQNSSGT MGARLSADAT LIRALVGDAL SLAVQNVASA 850 860 870 880 890 900 ASGLIIAFTA SWELALIILV MLPLIGINGF VQVKFMKGFS ADAKSKYEEA SQVANDAVGS 910 920 930 940 950 960 IRTVASFCAE EKVMQMYKKQ CEGPIKDGIK QGFISGLGFG FSFFILFCVY ATSFYAGARL 970 980 990 1000 1010 1020 VEDGKTTFNN VFQVFFALTM AAIGISQSST FAPDSSKAKV AAASIFAIID RKSKIDSSDE 1030 1040 1050 1060 1070 1080 TGTVLENVKG DIELRHLSFT YPARPDIQIF RDLCLTIRAG KTVALVGESG SGKSTVISLL 1090 1100 1110 1120 1130 1140 QRFYDPDSGH ITLDGVELKK LQLKWLRQQM GLVGQEPVLF NDTIRANIAY GKGSEEAATE 1150 1160 1170 1180 1190 1200 SEIIAAAELA NAHKFISSIQ QGYDTVVGER GIQLSGGQKQ RVAIARAIVK EPKILLLDEA 1210 1220 1230 1240 1250 1260 TSALDAESER VVQDALDRVM VNRTTIVVAH RLSTIKNADV IAVVKNGVIA EKGTHETLIK 1270 IEGGVYASLV QLHMTASN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"The Arabidopsis thaliana ABC protein superfamily, a complete inventory." Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A. J. Biol. Chem. 276:30231-30244(2001) [PubMed: 11346655] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
[4]	"Plant ABC proteins - a unified nomenclature and updated inventory." Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M., Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A., Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L. Trends Plant Sci. 13:151-159(2008) [PubMed: 18299247] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC022521 Genomic DNA. Translation: AAG10628.1. CP002684 Genomic DNA. Translation: AEE27440.1.
IPI	IPI00521721.
PIR	E86155.
RefSeq	NP_171753.1. NM_100133.2.
UniGene	At.42596.
3D structure databases
ProteinModelPortal	Q9FWX7.
SMR	Q9FWX7. Positions 41-620, 695-1276.
ModBase	Search...
Proteomic databases
PRIDE	Q9FWX7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G02520.1; AT1G02520.1; AT1G02520.
GeneID	839353.
GenomeReviews	Gene locus AT1G02520 in contig CT485782_GR.
KEGG	ath:AT1G02520.
NMPDR	fig|3702.1.peg.373.
Organism-specific databases
TAIR	At1g02520.
Phylogenomic databases
eggNOG	KOG0055.
GeneTree	EPGT00070000028344.
HOGENOM	HBG758042.
InParanoid	Q9FWX7.
OMA	KFITSAY.
PhylomeDB	Q9FWX7.
ProtClustDB	CLSN2679354.
Gene expression databases
Genevestigator	Q9FWX7.
GermOnline	AT1G02520. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR003593. ATPase_AAA+_core. [Graphical view]
KO	K05658.
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 2 hits.
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AB11B_ARATH

Accession

Primary (citable) accession number: Q9FWX7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	March 1, 2001
Last modified:	November 16, 2011
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program