Reviewed, UniProtKB/Swiss-Prot Q9FWX6 (KCO4_ARATH)

Names and origin

Protein names

Recommended name:
    Putative outward-rectifying potassium channel 4
      Short name=AtKCO4

Gene names

Name:	KCO4
Ordered Locus Names:	At1g02510
ORF Names:	T14P4.16

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Outward rectifying potassium channel. Blocked by barium By similarity.
Subunit structure	Homodimer Potential.
Subcellular location	Membrane; Multi-pass membrane protein.
Domain	Each of the two pore-forming region (also called P-domain or P-loop) is enclosed by two transmembrane segments (2P/4TM) and contains the GYGD signature motif which seems to be involved in potassium selectivity.
Sequence similarities	Belongs to the two pore domain potassium channel (TC 1.A.1.7) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane
Ligand	Potassium
Molecular function	Ionic channel Potassium channel
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	potassium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	potassium channel activity Inferred from electronic annotation. Source: UniProtKB-KW potassium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Putative outward-rectifying potassium channel 4		PRO_0000101778
Regions
	Topological domain	1 – 31	31	Cytoplasmic Potential
	Transmembrane	32 – 52	21	Potential
	Transmembrane	93 – 113	21	Potential
	Topological domain	114 – 156	43	Cytoplasmic Potential
	Transmembrane	157 – 177	21	Potential
	Transmembrane	211 – 231	21	Potential
	Topological domain	232 – 246	15	Cytoplasmic Potential
	Region	70 – 89	20	Pore-forming 1, in membrane Potential
	Region	184 – 203	20	Pore-forming 2, in membrane Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9FWX6-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: FBBBB4AE27877E49	FASTA	246	27,748
	10 20 30 40 50 60 MEEENLLNEN LLHPNESSPE ETQVTTVSKS KWTILVLAMI LLLVYLTFGV CTYSFFRDQF 70 80 90 100 110 120 SGTETNLFVD AFYFSIVTFS TVGYGDIVPS TSTTKILTIV LVSTGVVFLD YLLNRVVSHV 130 140 150 160 170 180 LSLQENAILD RINKTRNRAI RDHIAEDGKI RLKWKLCLAF CAVGLCVGSG ALFLHVFERL 190 200 210 220 230 240 DWLDSVYLSV ISVTTVGYGD KTFKTVEGRG FAVFWLLLST IAMATLFLYL AEMRIDRTTV MKLPPR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Phylogenetic relationships within cation transporter families of Arabidopsis." Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H., Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F., Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L. Plant Physiol. 126:1646-1667(2001) [PubMed: 11500563] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC022521 Genomic DNA. Translation: AAG10638.1.
IPI	IPI00520180.
PIR	D86155.
3D structure databases
ModBase	Search...
Organism-specific databases
GeneFarm	2721. 258.
TAIR	At1g02510.
Gene expression databases
Genevestigator	Q9FWX6.
Family and domain databases
InterPro	IPR013099. Ion_trans_2. IPR003280. K_chnl_2pore. [Graphical view]
Pfam	PF07885. Ion_trans_2. 2 hits. [Graphical view]
PRINTS	PR01333. 2POREKCHANEL.
ProtoNet	Search...

Entry information

Entry name

KCO4_ARATH

Accession

Primary (citable) accession number: Q9FWX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
Last sequence update:	March 1, 2001
Last modified:	November 24, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)