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Protein

BEL1-like homeodomain protein 3

Gene

BLH3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that is responsive of the nuclear import of SHOOT MERISTEMLESS (STM).1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi346 – 40863HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • regulation of timing of transition from vegetative to reproductive phase Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
BEL1-like homeodomain protein 3
Short name:
BEL1-like protein 3
Gene namesi
Name:BLH3
Ordered Locus Names:At1g75410
ORF Names:F1B16.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G75410.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524BEL1-like homeodomain protein 3PRO_0000315459Add
BLAST

Proteomic databases

PaxDbiQ9FWS9.
PRIDEiQ9FWS9.

Expressioni

Gene expression databases

GenevisibleiQ9FWS9. AT.

Interactioni

Subunit structurei

May form heterodimeric complex with the TALE/KNOX protein STM. Interacts with OFP1, OFP2, OFP3, OFP4, OFP5 and OFP15.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
STMQ388744EBI-912915,EBI-530523

Protein-protein interaction databases

BioGridi29096. 24 interactions.
IntActiQ9FWS9. 21 interactions.
STRINGi3702.AT1G75410.1.

Structurei

3D structure databases

ProteinModelPortaliQ9FWS9.
SMRiQ9FWS9. Positions 353-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni171 – 18717SR/KY domainAdd
BLAST
Regioni229 – 30072BELL domainAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi24 – 307Poly-Gln
Compositional biasi455 – 4595Poly-Asn

Domaini

The SR/KY and BELL domains are responsive for the interaction between the TALE/BELL proteins and the TALE/KNOX proteins.

Sequence similaritiesi

Belongs to the TALE/BELL homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
HOGENOMiHOG000239679.
InParanoidiQ9FWS9.
OMAiQESIYLN.
PhylomeDBiQ9FWS9.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR006563. POX_dom.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
PF07526. POX. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00574. POX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FWS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVYYPNSVG MQSLYQESIY LNEQQQQQQQ ASSSSAASFS EIVSGDVRNN
60 70 80 90 100
EMVFIPPTSD VAVNGNVTVS SNDLSFHGGG LSLSLGNQIQ SAVSVSPFQY
110 120 130 140 150
HYQNLSNQLS YNNLNPSTMS DENGKSLSVH QHHSDQILPS SVYNNNGNNG
160 170 180 190 200
VGFYNNYRYE TSGFVSSVLR SRYLKPTQQL LDEVVSVRKD LKLGNKKMKN
210 220 230 240 250
DKGQDFHNGS SDNITEDDKS QSQELSPSER QELQSKKSKL LTMVDEVDKR
260 270 280 290 300
YNQYHHQMEA LASSFEMVTG LGAAKPYTSV ALNRISRHFR CLRDAIKEQI
310 320 330 340 350
QVIRGKLGER ETSDEQGERI PRLRYLDQRL RQQRALHQQL GMVRPAWRPQ
360 370 380 390 400
RGLPENSVSI LRAWLFEHFL HPYPKESEKI MLSKQTGLSK NQVANWFINA
410 420 430 440 450
RVRLWKPMIE EMYKEEFGES AELLSNSNQD TKKMQETSQL KHEDSSSSQQ
460 470 480 490 500
QNQGNNNNNI PYTSDAEQNL VFADPKPDRA TTGDYDSLMN YHGFGIDDYN
510 520
RYVGLGNQQD GRYSNPHQLH DFVV
Length:524
Mass (Da):59,679
Last modified:March 1, 2001 - v1
Checksum:i94A2461E20FB3F39
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611V → L in AAL32623 (PubMed:14593172).Curated
Sequence conflicti61 – 611V → L in AAN15452 (PubMed:14593172).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF353093 mRNA. Translation: AAK43835.1.
AY598452 mRNA. Translation: AAT09418.1.
AC023754 Genomic DNA. Translation: AAG13065.1.
CP002684 Genomic DNA. Translation: AEE35716.1.
CP002684 Genomic DNA. Translation: AEE35717.1.
AY062545 mRNA. Translation: AAL32623.1.
BT000133 mRNA. Translation: AAN15452.1.
AY085278 mRNA. Translation: AAM62510.1.
AK226561 mRNA. Translation: BAE98691.1.
PIRiF96784.
RefSeqiNP_001077827.1. NM_001084358.1.
NP_177674.1. NM_106195.4.
UniGeneiAt.16254.
At.74119.

Genome annotation databases

EnsemblPlantsiAT1G75410.1; AT1G75410.1; AT1G75410.
AT1G75410.2; AT1G75410.2; AT1G75410.
GeneIDi843877.
GrameneiAT1G75410.1; AT1G75410.1; AT1G75410.
AT1G75410.2; AT1G75410.2; AT1G75410.
KEGGiath:AT1G75410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF353093 mRNA. Translation: AAK43835.1.
AY598452 mRNA. Translation: AAT09418.1.
AC023754 Genomic DNA. Translation: AAG13065.1.
CP002684 Genomic DNA. Translation: AEE35716.1.
CP002684 Genomic DNA. Translation: AEE35717.1.
AY062545 mRNA. Translation: AAL32623.1.
BT000133 mRNA. Translation: AAN15452.1.
AY085278 mRNA. Translation: AAM62510.1.
AK226561 mRNA. Translation: BAE98691.1.
PIRiF96784.
RefSeqiNP_001077827.1. NM_001084358.1.
NP_177674.1. NM_106195.4.
UniGeneiAt.16254.
At.74119.

3D structure databases

ProteinModelPortaliQ9FWS9.
SMRiQ9FWS9. Positions 353-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi29096. 24 interactions.
IntActiQ9FWS9. 21 interactions.
STRINGi3702.AT1G75410.1.

Proteomic databases

PaxDbiQ9FWS9.
PRIDEiQ9FWS9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G75410.1; AT1G75410.1; AT1G75410.
AT1G75410.2; AT1G75410.2; AT1G75410.
GeneIDi843877.
GrameneiAT1G75410.1; AT1G75410.1; AT1G75410.
AT1G75410.2; AT1G75410.2; AT1G75410.
KEGGiath:AT1G75410.

Organism-specific databases

TAIRiAT1G75410.

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
HOGENOMiHOG000239679.
InParanoidiQ9FWS9.
OMAiQESIYLN.
PhylomeDBiQ9FWS9.

Miscellaneous databases

PROiQ9FWS9.

Gene expression databases

GenevisibleiQ9FWS9. AT.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR006563. POX_dom.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
PF07526. POX. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00574. POX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A family of BEL1-like homeodomain (BLH) proteins in Arabidopsis thaliana."
    Pidkowich M.S., Samach A., Modrusan Z., Haughn G.W.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The BELL family of homeodomain proteins in Arabidopsis."
    Milich R.J., Putterill J.J.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-431.
    Strain: cv. Columbia.
  8. "Competence to respond to floral inductive signals requires the homeobox genes PENNYWISE and POUND-FOOLISH."
    Smith H.M.S., Campbell B.C.C., Hake S.
    Curr. Biol. 14:812-817(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY ORGANIZATION.
  9. "A central role of Arabidopsis thaliana ovate family proteins in networking and subcellular localization of 3-aa loop extension homeodomain proteins."
    Hackbusch J., Richter K., Muller J., Salamini F., Uhrig J.F.
    Proc. Natl. Acad. Sci. U.S.A. 102:4908-4912(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH OFP1; OFP2; OFP3; OFP4; OFP5 AND OFP15.
  10. "Nuclear import of the transcription factor SHOOT MERISTEMLESS depends on heterodimerization with BLH proteins expressed in discrete sub-domains of the shoot apical meristem of Arabidopsis thaliana."
    Cole M., Nolte C., Werr W.
    Nucleic Acids Res. 34:1281-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH STM.

Entry informationi

Entry nameiBLH3_ARATH
AccessioniPrimary (citable) accession number: Q9FWS9
Secondary accession number(s): Q0WW07, Q8W4I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2001
Last modified: February 17, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.