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Q9FWQ5

- HAC12_ARATH

UniProt

Q9FWQ5 - HAC12_ARATH

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Protein

Histone acetyltransferase HAC12

Gene

HAC12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1288 – 12881Acetyl-CoABy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri637 – 71680TAZ-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri998 – 107578PHD-typeAdd
BLAST
Zinc fingeri1407 – 145448ZZ-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1527 – 157549ZZ-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1588 – 167184TAZ-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. histone acetyltransferase activity Source: TAIR
  2. transcription cofactor activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. flower development Source: TAIR
  2. histone acetylation Source: GOC
  3. protein acetylation Source: TAIR
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G16710-MONOMER.
ARA:GQT-887-MONOMER.
ReactomeiREACT_249954. Attenuation phase.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase HAC12 (EC:2.3.1.48By similarity)
Gene namesi
Name:HAC12
Ordered Locus Names:At1g16710
ORF Names:F17F16.8, F17F16_21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G16710.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17061706Histone acetyltransferase HAC12PRO_0000269744Add
BLAST

Proteomic databases

PaxDbiQ9FWQ5.
PRIDEiQ9FWQ5.

Expressioni

Gene expression databases

ExpressionAtlasiQ9FWQ5. baseline and differential.
GenevestigatoriQ9FWQ5.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G16710.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9FWQ5.
SMRiQ9FWQ5. Positions 961-1359, 1593-1668.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1090 – 1526437CBP/p300-type HATPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1213 – 12153Acetyl-CoA bindingBy similarity
Regioni1232 – 12332Acetyl-CoA bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi267 – 28014Gln-richAdd
BLAST
Compositional biasi407 – 536130Gln-richAdd
BLAST

Sequence similaritiesi

Contains 1 CBP/p300-type HAT (histone acetyltransferase) domain.PROSITE-ProRule annotation
Contains 1 PHD-type zinc finger.Curated
Contains 2 TAZ-type zinc fingers.PROSITE-ProRule annotation
Contains 2 ZZ-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri637 – 71680TAZ-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri998 – 107578PHD-typeAdd
BLAST
Zinc fingeri1407 – 145448ZZ-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1527 – 157549ZZ-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1588 – 167184TAZ-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG326839.
HOGENOMiHOG000242057.
InParanoidiQ9FWQ5.
KOiK04498.
OMAiHTSTISE.
PhylomeDBiQ9FWQ5.

Family and domain databases

Gene3Di1.20.1020.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF08214. KAT11. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEiPS51727. CBP_P300_HAT. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 2 hits.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q9FWQ5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNVQAHMSGQ RSGQVPNQGT VPQNNGNSQM QNLVGSNGAA TAVTGAGAAT
60 70 80 90 100
GSGTGVRPSR NIVGAMDHDI MKLRQYMQTL VFNMLQQRQP SPADAASKAK
110 120 130 140 150
YMDVARRLEE GLFKMAVTKE DYMNRSTLES RITSLIKGRQ INNYNQRHAN
160 170 180 190 200
SSSVGTMIPT PGLSQTAGNP NLMVTSSVDA TIVGNTNITS TALNTGNPLI
210 220 230 240 250
AGGMHGGNMS NGYQHSSRNF SLGSGGSMTS MGAQRSTAQM IPTPGFVNSV
260 270 280 290 300
TNNNSGGFSA EPTIVPQSQQ QQQRQHTGGQ NSHMLSNHMA AGVRPDMQSK
310 320 330 340 350
PSGAANSSVN GDVGANEKIV DSGSSYTNAS KKLQQGNFSL LSFCPDDLIS
360 370 380 390 400
GQHIESTFHI SGEGYSTTNP DPFDGAITSA GTGTKAHNIN TASFQPVSRV
410 420 430 440 450
NSSLSHQQQF QQPPNRFQQQ PNQIQQQQQQ FLNQRKLKQQ TPQQHRLISN
460 470 480 490 500
DGLGKTQVDS DMVTKVKCEP GMENKSQAPQ SQASERFQLS QLQNQYQNSG
510 520 530 540 550
EDCQADAQLL PVESQSDICT SLPQNSQQIQ QMMHPQNIGS DSSNSFSNLA
560 570 580 590 600
VGVKSESSPQ GQWPSKSQEN TLMSNAISSG KHIQEDFRQR ITGMDEAQPN
610 620 630 640 650
NLTEGSVIGQ NHTSTISESH NLQNSIGTTC RYGNVSHDPK FKNQQRWLLF
660 670 680 690 700
LRHARSCKPP GGRCQDQNCV TVQKLWSHMD NCADPQCLYP RCRHTKALIG
710 720 730 740 750
HYKNCKDPRC PVCVPVKTYQ QQANVRALAR LKNESSAVGS VNRSVVSNDS
760 770 780 790 800
LSANAGAVSG TPRCADTLDN LQPSLKRLKV EQSFQPVVPK TESCKSSIVS
810 820 830 840 850
TTEADLSQDA ERKDHRPLKS ETMEVKVEIP DNSVQAGFGI KETKSEPFEN
860 870 880 890 900
VPKPKPVSEP GKHGLSGDSP KQENIKMKKE PGWPKKEPGC PKKEELVESP
910 920 930 940 950
ELTSKSRKPK IKGVSLTELF TPEQVREHIR GLRQWVGQSK AKAEKNQAME
960 970 980 990 1000
NSMSENSCQL CAVEKLTFEP PPIYCTPCGA RIKRNAMYYT VGGGETRHYF
1010 1020 1030 1040 1050
CIPCYNESRG DTILAEGTSM PKAKLEKKKN DEEIEESWVQ CDKCQAWQHQ
1060 1070 1080 1090 1100
ICALFNGRRN DGGQAEYTCP YCYVIDVEQN ERKPLLQSAV LGAKDLPRTI
1110 1120 1130 1140 1150
LSDHIEQRLF KRLKQERTER ARVQGTSYDE IPTVESLVVR VVSSVDKKLE
1160 1170 1180 1190 1200
VKSRFLEIFR EDNFPTEFPY KSKVVLLFQK IEGVEVCLFG MYVQEFGSEC
1210 1220 1230 1240 1250
SNPNQRRVYL SYLDSVKYFR PDIKSANGEA LRTFVYHEIL IGYLEYCKLR
1260 1270 1280 1290 1300
GFTSCYIWAC PPLKGEDYIL YCHPEIQKTP KSDKLREWYL AMLRKAAKEG
1310 1320 1330 1340 1350
IVAETTNLYD HFFLQTGECR AKVTAARLPY FDGDYWPGAA EDIISQMSQE
1360 1370 1380 1390 1400
DDGRKGNKKG ILKKPITKRA LKASGQSDFS GNASKDLLLM HKLGETIHPM
1410 1420 1430 1440 1450
KEDFIMVHLQ HSCTHCCTLM VTGNRWVCSQ CKDFQLCDGC YEAEQKREDR
1460 1470 1480 1490 1500
ERHPVNQKDK HNIFPVEIAD IPTDTKDRDE ILESEFFDTR QAFLSLCQGN
1510 1520 1530 1540 1550
HYQYDTLRRA KHSSMMVLYH LHNPTAPAFV TTCNVCHLDI ESGLGWRCEV
1560 1570 1580 1590 1600
CPDYDVCNAC YKKEGCINHP HKLTTHPSLA DQNAQNKEAR QLRVLQLRKM
1610 1620 1630 1640 1650
LDLLVHASQC RSPVCLYPNC RKVKGLFRHG LRCKVRASGG CVLCKKMWYL
1660 1670 1680 1690 1700
LQLHARACKE SECDVPRCGD LKEHLRRLQQ QSDSRRRAAV MEMMRQRAAE

VAGTSG
Length:1,706
Mass (Da):190,272
Last modified:January 9, 2007 - v2
Checksum:i71CDA5B8B6184518
GO

Sequence cautioni

The sequence AAG09087.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026237 Genomic DNA. Translation: AAG09087.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29487.1.
PIRiE86302.
RefSeqiNP_173115.1. NM_101532.2. [Q9FWQ5-1]
UniGeneiAt.21902.

Genome annotation databases

EnsemblPlantsiAT1G16710.1; AT1G16710.1; AT1G16710. [Q9FWQ5-1]
GeneIDi838242.
KEGGiath:AT1G16710.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026237 Genomic DNA. Translation: AAG09087.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE29487.1 .
PIRi E86302.
RefSeqi NP_173115.1. NM_101532.2. [Q9FWQ5-1 ]
UniGenei At.21902.

3D structure databases

ProteinModelPortali Q9FWQ5.
SMRi Q9FWQ5. Positions 961-1359, 1593-1668.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT1G16710.1-P.

Proteomic databases

PaxDbi Q9FWQ5.
PRIDEi Q9FWQ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G16710.1 ; AT1G16710.1 ; AT1G16710 . [Q9FWQ5-1 ]
GeneIDi 838242.
KEGGi ath:AT1G16710.

Organism-specific databases

TAIRi AT1G16710.

Phylogenomic databases

eggNOGi NOG326839.
HOGENOMi HOG000242057.
InParanoidi Q9FWQ5.
KOi K04498.
OMAi HTSTISE.
PhylomeDBi Q9FWQ5.

Enzyme and pathway databases

BioCyci ARA:AT1G16710-MONOMER.
ARA:GQT-887-MONOMER.
Reactomei REACT_249954. Attenuation phase.

Miscellaneous databases

PROi Q9FWQ5.

Gene expression databases

ExpressionAtlasi Q9FWQ5. baseline and differential.
Genevestigatori Q9FWQ5.

Family and domain databases

Gene3Di 1.20.1020.10. 2 hits.
3.30.40.10. 1 hit.
InterProi IPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view ]
Pfami PF08214. KAT11. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEi PS51727. CBP_P300_HAT. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 2 hits.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
    Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
    Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, NOMENCLATURE.

Entry informationi

Entry nameiHAC12_ARATH
AccessioniPrimary (citable) accession number: Q9FWQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: November 26, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3