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Q9FWQ5 (HAC12_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone acetyltransferase HAC12

EC=2.3.1.48
Gene names
Name:HAC12
Ordered Locus Names:At1g16710
ORF Names:F17F16.8, F17F16_21
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length1706 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 1 PHD-type zinc finger.

Contains 2 TAZ-type zinc fingers.

Contains 2 ZZ-type zinc fingers.

Sequence caution

The sequence AAG09087.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q9FWQ5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 17061706Histone acetyltransferase HAC12
PRO_0000269744

Regions

Zinc finger637 – 71680TAZ-type 1
Zinc finger998 – 107578PHD-type
Zinc finger1407 – 145448ZZ-type 1
Zinc finger1527 – 157549ZZ-type 2
Zinc finger1588 – 167184TAZ-type 2
Compositional bias267 – 28014Gln-rich
Compositional bias407 – 536130Gln-rich

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 9, 2007. Version 2.
Checksum: 71CDA5B8B6184518

FASTA1,706190,272
        10         20         30         40         50         60 
MNVQAHMSGQ RSGQVPNQGT VPQNNGNSQM QNLVGSNGAA TAVTGAGAAT GSGTGVRPSR 

        70         80         90        100        110        120 
NIVGAMDHDI MKLRQYMQTL VFNMLQQRQP SPADAASKAK YMDVARRLEE GLFKMAVTKE 

       130        140        150        160        170        180 
DYMNRSTLES RITSLIKGRQ INNYNQRHAN SSSVGTMIPT PGLSQTAGNP NLMVTSSVDA 

       190        200        210        220        230        240 
TIVGNTNITS TALNTGNPLI AGGMHGGNMS NGYQHSSRNF SLGSGGSMTS MGAQRSTAQM 

       250        260        270        280        290        300 
IPTPGFVNSV TNNNSGGFSA EPTIVPQSQQ QQQRQHTGGQ NSHMLSNHMA AGVRPDMQSK 

       310        320        330        340        350        360 
PSGAANSSVN GDVGANEKIV DSGSSYTNAS KKLQQGNFSL LSFCPDDLIS GQHIESTFHI 

       370        380        390        400        410        420 
SGEGYSTTNP DPFDGAITSA GTGTKAHNIN TASFQPVSRV NSSLSHQQQF QQPPNRFQQQ 

       430        440        450        460        470        480 
PNQIQQQQQQ FLNQRKLKQQ TPQQHRLISN DGLGKTQVDS DMVTKVKCEP GMENKSQAPQ 

       490        500        510        520        530        540 
SQASERFQLS QLQNQYQNSG EDCQADAQLL PVESQSDICT SLPQNSQQIQ QMMHPQNIGS 

       550        560        570        580        590        600 
DSSNSFSNLA VGVKSESSPQ GQWPSKSQEN TLMSNAISSG KHIQEDFRQR ITGMDEAQPN 

       610        620        630        640        650        660 
NLTEGSVIGQ NHTSTISESH NLQNSIGTTC RYGNVSHDPK FKNQQRWLLF LRHARSCKPP 

       670        680        690        700        710        720 
GGRCQDQNCV TVQKLWSHMD NCADPQCLYP RCRHTKALIG HYKNCKDPRC PVCVPVKTYQ 

       730        740        750        760        770        780 
QQANVRALAR LKNESSAVGS VNRSVVSNDS LSANAGAVSG TPRCADTLDN LQPSLKRLKV 

       790        800        810        820        830        840 
EQSFQPVVPK TESCKSSIVS TTEADLSQDA ERKDHRPLKS ETMEVKVEIP DNSVQAGFGI 

       850        860        870        880        890        900 
KETKSEPFEN VPKPKPVSEP GKHGLSGDSP KQENIKMKKE PGWPKKEPGC PKKEELVESP 

       910        920        930        940        950        960 
ELTSKSRKPK IKGVSLTELF TPEQVREHIR GLRQWVGQSK AKAEKNQAME NSMSENSCQL 

       970        980        990       1000       1010       1020 
CAVEKLTFEP PPIYCTPCGA RIKRNAMYYT VGGGETRHYF CIPCYNESRG DTILAEGTSM 

      1030       1040       1050       1060       1070       1080 
PKAKLEKKKN DEEIEESWVQ CDKCQAWQHQ ICALFNGRRN DGGQAEYTCP YCYVIDVEQN 

      1090       1100       1110       1120       1130       1140 
ERKPLLQSAV LGAKDLPRTI LSDHIEQRLF KRLKQERTER ARVQGTSYDE IPTVESLVVR 

      1150       1160       1170       1180       1190       1200 
VVSSVDKKLE VKSRFLEIFR EDNFPTEFPY KSKVVLLFQK IEGVEVCLFG MYVQEFGSEC 

      1210       1220       1230       1240       1250       1260 
SNPNQRRVYL SYLDSVKYFR PDIKSANGEA LRTFVYHEIL IGYLEYCKLR GFTSCYIWAC 

      1270       1280       1290       1300       1310       1320 
PPLKGEDYIL YCHPEIQKTP KSDKLREWYL AMLRKAAKEG IVAETTNLYD HFFLQTGECR 

      1330       1340       1350       1360       1370       1380 
AKVTAARLPY FDGDYWPGAA EDIISQMSQE DDGRKGNKKG ILKKPITKRA LKASGQSDFS 

      1390       1400       1410       1420       1430       1440 
GNASKDLLLM HKLGETIHPM KEDFIMVHLQ HSCTHCCTLM VTGNRWVCSQ CKDFQLCDGC 

      1450       1460       1470       1480       1490       1500 
YEAEQKREDR ERHPVNQKDK HNIFPVEIAD IPTDTKDRDE ILESEFFDTR QAFLSLCQGN 

      1510       1520       1530       1540       1550       1560 
HYQYDTLRRA KHSSMMVLYH LHNPTAPAFV TTCNVCHLDI ESGLGWRCEV CPDYDVCNAC 

      1570       1580       1590       1600       1610       1620 
YKKEGCINHP HKLTTHPSLA DQNAQNKEAR QLRVLQLRKM LDLLVHASQC RSPVCLYPNC 

      1630       1640       1650       1660       1670       1680 
RKVKGLFRHG LRCKVRASGG CVLCKKMWYL LQLHARACKE SECDVPRCGD LKEHLRRLQQ 

      1690       1700 
QSDSRRRAAV MEMMRQRAAE VAGTSG 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC026237 Genomic DNA. Translation: AAG09087.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29487.1.
PIRE86302.
RefSeqNP_173115.1. NM_101532.2. [Q9FWQ5-1]
UniGeneAt.21902.

3D structure databases

ProteinModelPortalQ9FWQ5.
SMRQ9FWQ5. Positions 961-1359, 1593-1668.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3702.AT1G16710.1-P.

Proteomic databases

PaxDbQ9FWQ5.
PRIDEQ9FWQ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G16710.1; AT1G16710.1; AT1G16710. [Q9FWQ5-1]
GeneID838242.
KEGGath:AT1G16710.

Organism-specific databases

TAIRAT1G16710.

Phylogenomic databases

eggNOGNOG326839.
HOGENOMHOG000242057.
InParanoidQ9FWQ5.
KOK04498.
OMAHTSTISE.
PhylomeDBQ9FWQ5.

Enzyme and pathway databases

BioCycARA:AT1G16710-MONOMER.
ARA:GQT-887-MONOMER.

Gene expression databases

ArrayExpressQ9FWQ5.
GenevestigatorQ9FWQ5.

Family and domain databases

Gene3D1.20.1020.10. 2 hits.
3.30.40.10. 1 hit.
InterProIPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
PfamPF08214. KAT11. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTSM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view]
SUPFAMSSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEPS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 2 hits.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

PROQ9FWQ5.

Entry information

Entry nameHAC12_ARATH
AccessionPrimary (citable) accession number: Q9FWQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: June 11, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names