Q9FWQ5 (HAC12_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone acetyltransferase HAC12
EC=2.3.1.48

Gene names

Name:	HAC12
Ordered Locus Names:	At1g16710
ORF Names:	F17F16.8, F17F16_21

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	1706 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation By similarity.
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Subcellular location	Nucleus Probable.
Sequence similarities	Contains 1 PHD-type zinc finger. Contains 2 TAZ-type zinc fingers. Contains 2 ZZ-type zinc fingers.
Sequence caution	The sequence AAG09087.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Activator Acyltransferase Chromatin regulator Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	flower development Inferred from genetic interaction PubMed 17144897. Source: TAIR regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone acetyltransferase activity Inferred from direct assay PubMed 17877703. Source: TAIR transcription cofactor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q9FWQ5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1706	1706	Histone acetyltransferase HAC12		PRO_0000269744
Regions
	Zinc finger	637 – 716	80	TAZ-type 1
	Zinc finger	998 – 1075	78	PHD-type
	Zinc finger	1407 – 1454	48	ZZ-type 1
	Zinc finger	1527 – 1575	49	ZZ-type 2
	Zinc finger	1588 – 1671	84	TAZ-type 2
	Compositional bias	267 – 280	14	Gln-rich
	Compositional bias	407 – 536	130	Gln-rich

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 9, 2007. Version 2. Checksum: 71CDA5B8B6184518	FASTA	1,706	190,272
	10 20 30 40 50 60 MNVQAHMSGQ RSGQVPNQGT VPQNNGNSQM QNLVGSNGAA TAVTGAGAAT GSGTGVRPSR 70 80 90 100 110 120 NIVGAMDHDI MKLRQYMQTL VFNMLQQRQP SPADAASKAK YMDVARRLEE GLFKMAVTKE 130 140 150 160 170 180 DYMNRSTLES RITSLIKGRQ INNYNQRHAN SSSVGTMIPT PGLSQTAGNP NLMVTSSVDA 190 200 210 220 230 240 TIVGNTNITS TALNTGNPLI AGGMHGGNMS NGYQHSSRNF SLGSGGSMTS MGAQRSTAQM 250 260 270 280 290 300 IPTPGFVNSV TNNNSGGFSA EPTIVPQSQQ QQQRQHTGGQ NSHMLSNHMA AGVRPDMQSK 310 320 330 340 350 360 PSGAANSSVN GDVGANEKIV DSGSSYTNAS KKLQQGNFSL LSFCPDDLIS GQHIESTFHI 370 380 390 400 410 420 SGEGYSTTNP DPFDGAITSA GTGTKAHNIN TASFQPVSRV NSSLSHQQQF QQPPNRFQQQ 430 440 450 460 470 480 PNQIQQQQQQ FLNQRKLKQQ TPQQHRLISN DGLGKTQVDS DMVTKVKCEP GMENKSQAPQ 490 500 510 520 530 540 SQASERFQLS QLQNQYQNSG EDCQADAQLL PVESQSDICT SLPQNSQQIQ QMMHPQNIGS 550 560 570 580 590 600 DSSNSFSNLA VGVKSESSPQ GQWPSKSQEN TLMSNAISSG KHIQEDFRQR ITGMDEAQPN 610 620 630 640 650 660 NLTEGSVIGQ NHTSTISESH NLQNSIGTTC RYGNVSHDPK FKNQQRWLLF LRHARSCKPP 670 680 690 700 710 720 GGRCQDQNCV TVQKLWSHMD NCADPQCLYP RCRHTKALIG HYKNCKDPRC PVCVPVKTYQ 730 740 750 760 770 780 QQANVRALAR LKNESSAVGS VNRSVVSNDS LSANAGAVSG TPRCADTLDN LQPSLKRLKV 790 800 810 820 830 840 EQSFQPVVPK TESCKSSIVS TTEADLSQDA ERKDHRPLKS ETMEVKVEIP DNSVQAGFGI 850 860 870 880 890 900 KETKSEPFEN VPKPKPVSEP GKHGLSGDSP KQENIKMKKE PGWPKKEPGC PKKEELVESP 910 920 930 940 950 960 ELTSKSRKPK IKGVSLTELF TPEQVREHIR GLRQWVGQSK AKAEKNQAME NSMSENSCQL 970 980 990 1000 1010 1020 CAVEKLTFEP PPIYCTPCGA RIKRNAMYYT VGGGETRHYF CIPCYNESRG DTILAEGTSM 1030 1040 1050 1060 1070 1080 PKAKLEKKKN DEEIEESWVQ CDKCQAWQHQ ICALFNGRRN DGGQAEYTCP YCYVIDVEQN 1090 1100 1110 1120 1130 1140 ERKPLLQSAV LGAKDLPRTI LSDHIEQRLF KRLKQERTER ARVQGTSYDE IPTVESLVVR 1150 1160 1170 1180 1190 1200 VVSSVDKKLE VKSRFLEIFR EDNFPTEFPY KSKVVLLFQK IEGVEVCLFG MYVQEFGSEC 1210 1220 1230 1240 1250 1260 SNPNQRRVYL SYLDSVKYFR PDIKSANGEA LRTFVYHEIL IGYLEYCKLR GFTSCYIWAC 1270 1280 1290 1300 1310 1320 PPLKGEDYIL YCHPEIQKTP KSDKLREWYL AMLRKAAKEG IVAETTNLYD HFFLQTGECR 1330 1340 1350 1360 1370 1380 AKVTAARLPY FDGDYWPGAA EDIISQMSQE DDGRKGNKKG ILKKPITKRA LKASGQSDFS 1390 1400 1410 1420 1430 1440 GNASKDLLLM HKLGETIHPM KEDFIMVHLQ HSCTHCCTLM VTGNRWVCSQ CKDFQLCDGC 1450 1460 1470 1480 1490 1500 YEAEQKREDR ERHPVNQKDK HNIFPVEIAD IPTDTKDRDE ILESEFFDTR QAFLSLCQGN 1510 1520 1530 1540 1550 1560 HYQYDTLRRA KHSSMMVLYH LHNPTAPAFV TTCNVCHLDI ESGLGWRCEV CPDYDVCNAC 1570 1580 1590 1600 1610 1620 YKKEGCINHP HKLTTHPSLA DQNAQNKEAR QLRVLQLRKM LDLLVHASQC RSPVCLYPNC 1630 1640 1650 1660 1670 1680 RKVKGLFRHG LRCKVRASGG CVLCKKMWYL LQLHARACKE SECDVPRCGD LKEHLRRLQQ 1690 1700 QSDSRRRAAV MEMMRQRAAE VAGTSG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes." Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A. Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC026237 Genomic DNA. Translation: AAG09087.1. Sequence problems. CP002684 Genomic DNA. Translation: AEE29487.1.
IPI	IPI00545040.
PIR	E86302.
RefSeq	NP_173115.1. NM_101532.2.
UniGene	At.21902.
3D structure databases
HSSP	HSSP built from PDB template 1TOT based on UniProtKB P45481.
ProteinModelPortal	Q9FWQ5.
SMR	Q9FWQ5. Positions 1091-1346, 1593-1668.
ModBase	Search...
Protein-protein interaction databases
STRING	3702.AT1G16710.1-P.
Proteomic databases
PaxDb	Q9FWQ5.
PRIDE	Q9FWQ5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G16710.1; AT1G16710.1; AT1G16710.
GeneID	838242.
KEGG	ath:AT1G16710.
Organism-specific databases
TAIR	At1g16710.
Phylogenomic databases
eggNOG	NOG326839.
HOGENOM	HOG000242057.
InParanoid	Q9FWQ5.
KO	K04498.
OMA	TISESHN.
PhylomeDB	Q9FWQ5.
ProtClustDB	CLSN2679820.
Gene expression databases
ArrayExpress	Q9FWQ5.
Genevestigator	Q9FWQ5.
Family and domain databases
Gene3D	1.20.1020.10. 2 hits. 3.30.40.10. 1 hit.
InterPro	IPR013178. Histone_H3-K56_AcTrfase_RTT109. IPR019786. Zinc_finger_PHD-type_CS. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR013083. Znf_RING/FYVE/PHD. IPR000197. Znf_TAZ. IPR000433. Znf_ZZ. [Graphical view]
Pfam	PF08214. KAT11. 1 hit. PF02135. zf-TAZ. 2 hits. PF00569. ZZ. 1 hit. [Graphical view]
SMART	SM00249. PHD. 1 hit. SM00551. ZnF_TAZ. 2 hits. SM00291. ZnF_ZZ. 2 hits. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 1 hit. SSF57933. TAZ_finger. 2 hits.
PROSITE	PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. False negative. PS50134. ZF_TAZ. 2 hits. PS01357. ZF_ZZ_1. 2 hits. PS50135. ZF_ZZ_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HAC12_ARATH

Accession

Primary (citable) accession number: Q9FWQ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	May 1, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program