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Q9FWQ5

- HAC12_ARATH

UniProt

Q9FWQ5 - HAC12_ARATH

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Protein
Histone acetyltransferase HAC12
Gene
HAC12, At1g16710, F17F16.8, F17F16_21
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation By similarity.

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri637 – 71680TAZ-type 1
Add
BLAST
Zinc fingeri998 – 107578PHD-type
Add
BLAST
Zinc fingeri1407 – 145448ZZ-type 1
Add
BLAST
Zinc fingeri1527 – 157549ZZ-type 2
Add
BLAST
Zinc fingeri1588 – 167184TAZ-type 2
Add
BLAST

GO - Molecular functioni

  1. histone acetyltransferase activity Source: TAIR
  2. transcription cofactor activity Source: InterPro
  3. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. flower development Source: TAIR
  2. histone acetylation Source: GOC
  3. protein acetylation Source: TAIR
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G16710-MONOMER.
ARA:GQT-887-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase HAC12 (EC:2.3.1.48)
Gene namesi
Name:HAC12
Ordered Locus Names:At1g16710
ORF Names:F17F16.8, F17F16_21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G16710.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17061706Histone acetyltransferase HAC12
PRO_0000269744Add
BLAST

Proteomic databases

PaxDbiQ9FWQ5.
PRIDEiQ9FWQ5.

Expressioni

Gene expression databases

ArrayExpressiQ9FWQ5.
GenevestigatoriQ9FWQ5.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G16710.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9FWQ5.
SMRiQ9FWQ5. Positions 961-1359, 1593-1668.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi267 – 28014Gln-rich
Add
BLAST
Compositional biasi407 – 536130Gln-rich
Add
BLAST

Sequence similaritiesi

Contains 2 ZZ-type zinc fingers.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG326839.
HOGENOMiHOG000242057.
InParanoidiQ9FWQ5.
KOiK04498.
OMAiHTSTISE.
PhylomeDBiQ9FWQ5.

Family and domain databases

Gene3Di1.20.1020.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF08214. KAT11. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 2 hits.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q9FWQ5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNVQAHMSGQ RSGQVPNQGT VPQNNGNSQM QNLVGSNGAA TAVTGAGAAT     50
GSGTGVRPSR NIVGAMDHDI MKLRQYMQTL VFNMLQQRQP SPADAASKAK 100
YMDVARRLEE GLFKMAVTKE DYMNRSTLES RITSLIKGRQ INNYNQRHAN 150
SSSVGTMIPT PGLSQTAGNP NLMVTSSVDA TIVGNTNITS TALNTGNPLI 200
AGGMHGGNMS NGYQHSSRNF SLGSGGSMTS MGAQRSTAQM IPTPGFVNSV 250
TNNNSGGFSA EPTIVPQSQQ QQQRQHTGGQ NSHMLSNHMA AGVRPDMQSK 300
PSGAANSSVN GDVGANEKIV DSGSSYTNAS KKLQQGNFSL LSFCPDDLIS 350
GQHIESTFHI SGEGYSTTNP DPFDGAITSA GTGTKAHNIN TASFQPVSRV 400
NSSLSHQQQF QQPPNRFQQQ PNQIQQQQQQ FLNQRKLKQQ TPQQHRLISN 450
DGLGKTQVDS DMVTKVKCEP GMENKSQAPQ SQASERFQLS QLQNQYQNSG 500
EDCQADAQLL PVESQSDICT SLPQNSQQIQ QMMHPQNIGS DSSNSFSNLA 550
VGVKSESSPQ GQWPSKSQEN TLMSNAISSG KHIQEDFRQR ITGMDEAQPN 600
NLTEGSVIGQ NHTSTISESH NLQNSIGTTC RYGNVSHDPK FKNQQRWLLF 650
LRHARSCKPP GGRCQDQNCV TVQKLWSHMD NCADPQCLYP RCRHTKALIG 700
HYKNCKDPRC PVCVPVKTYQ QQANVRALAR LKNESSAVGS VNRSVVSNDS 750
LSANAGAVSG TPRCADTLDN LQPSLKRLKV EQSFQPVVPK TESCKSSIVS 800
TTEADLSQDA ERKDHRPLKS ETMEVKVEIP DNSVQAGFGI KETKSEPFEN 850
VPKPKPVSEP GKHGLSGDSP KQENIKMKKE PGWPKKEPGC PKKEELVESP 900
ELTSKSRKPK IKGVSLTELF TPEQVREHIR GLRQWVGQSK AKAEKNQAME 950
NSMSENSCQL CAVEKLTFEP PPIYCTPCGA RIKRNAMYYT VGGGETRHYF 1000
CIPCYNESRG DTILAEGTSM PKAKLEKKKN DEEIEESWVQ CDKCQAWQHQ 1050
ICALFNGRRN DGGQAEYTCP YCYVIDVEQN ERKPLLQSAV LGAKDLPRTI 1100
LSDHIEQRLF KRLKQERTER ARVQGTSYDE IPTVESLVVR VVSSVDKKLE 1150
VKSRFLEIFR EDNFPTEFPY KSKVVLLFQK IEGVEVCLFG MYVQEFGSEC 1200
SNPNQRRVYL SYLDSVKYFR PDIKSANGEA LRTFVYHEIL IGYLEYCKLR 1250
GFTSCYIWAC PPLKGEDYIL YCHPEIQKTP KSDKLREWYL AMLRKAAKEG 1300
IVAETTNLYD HFFLQTGECR AKVTAARLPY FDGDYWPGAA EDIISQMSQE 1350
DDGRKGNKKG ILKKPITKRA LKASGQSDFS GNASKDLLLM HKLGETIHPM 1400
KEDFIMVHLQ HSCTHCCTLM VTGNRWVCSQ CKDFQLCDGC YEAEQKREDR 1450
ERHPVNQKDK HNIFPVEIAD IPTDTKDRDE ILESEFFDTR QAFLSLCQGN 1500
HYQYDTLRRA KHSSMMVLYH LHNPTAPAFV TTCNVCHLDI ESGLGWRCEV 1550
CPDYDVCNAC YKKEGCINHP HKLTTHPSLA DQNAQNKEAR QLRVLQLRKM 1600
LDLLVHASQC RSPVCLYPNC RKVKGLFRHG LRCKVRASGG CVLCKKMWYL 1650
LQLHARACKE SECDVPRCGD LKEHLRRLQQ QSDSRRRAAV MEMMRQRAAE 1700
VAGTSG 1706
Length:1,706
Mass (Da):190,272
Last modified:January 9, 2007 - v2
Checksum:i71CDA5B8B6184518
GO

Sequence cautioni

The sequence AAG09087.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC026237 Genomic DNA. Translation: AAG09087.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29487.1.
PIRiE86302.
RefSeqiNP_173115.1. NM_101532.2. [Q9FWQ5-1]
UniGeneiAt.21902.

Genome annotation databases

EnsemblPlantsiAT1G16710.1; AT1G16710.1; AT1G16710. [Q9FWQ5-1]
GeneIDi838242.
KEGGiath:AT1G16710.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC026237 Genomic DNA. Translation: AAG09087.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE29487.1 .
PIRi E86302.
RefSeqi NP_173115.1. NM_101532.2. [Q9FWQ5-1 ]
UniGenei At.21902.

3D structure databases

ProteinModelPortali Q9FWQ5.
SMRi Q9FWQ5. Positions 961-1359, 1593-1668.
ModBasei Search...

Protein-protein interaction databases

STRINGi 3702.AT1G16710.1-P.

Proteomic databases

PaxDbi Q9FWQ5.
PRIDEi Q9FWQ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G16710.1 ; AT1G16710.1 ; AT1G16710 . [Q9FWQ5-1 ]
GeneIDi 838242.
KEGGi ath:AT1G16710.

Organism-specific databases

TAIRi AT1G16710.

Phylogenomic databases

eggNOGi NOG326839.
HOGENOMi HOG000242057.
InParanoidi Q9FWQ5.
KOi K04498.
OMAi HTSTISE.
PhylomeDBi Q9FWQ5.

Enzyme and pathway databases

BioCyci ARA:AT1G16710-MONOMER.
ARA:GQT-887-MONOMER.

Miscellaneous databases

PROi Q9FWQ5.

Gene expression databases

ArrayExpressi Q9FWQ5.
Genevestigatori Q9FWQ5.

Family and domain databases

Gene3Di 1.20.1020.10. 2 hits.
3.30.40.10. 1 hit.
InterProi IPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view ]
Pfami PF08214. KAT11. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEi PS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 2 hits.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
    Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
    Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, NOMENCLATURE.

Entry informationi

Entry nameiHAC12_ARATH
AccessioniPrimary (citable) accession number: Q9FWQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: June 11, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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