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Protein

6-phosphogluconate dehydrogenase, decarboxylating 3

Gene

At3g02360

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi: pentose phosphate pathway

This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase 3, chloroplastic (At1g24280), Glucose-6-phosphate 1-dehydrogenase 1, chloroplastic (APG1), Glucose-6-phosphate 1-dehydrogenase (At3g27300), Glucose-6-phosphate 1-dehydrogenase (AXX17_At3g29760), Glucose-6-phosphate 1-dehydrogenase (G6PD4), Glucose-6-phosphate 1-dehydrogenase 2, chloroplastic (At5g13110), Glucose-6-phosphate 1-dehydrogenase (AXX17_At1g25530), Glucose-6-phosphate 1-dehydrogenase (At5g35790), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g33080), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g33080), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g12520), Glucose-6-phosphate 1-dehydrogenase (G6PD5), Glucose-6-phosphate 1-dehydrogenase (G6PD5), Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform 2 (ACG12), Glucose-6-phosphate 1-dehydrogenase (At1g09420), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g38480), Glucose-6-phosphate 1-dehydrogenase (AXX17_At1g09330), Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform 1 (ACG9), Glucose-6-phosphate 1-dehydrogenase (At5g40760), Glucose-6-phosphate 1-dehydrogenase 4, chloroplastic (At1g09420)
  2. Probable 6-phosphogluconolactonase 5, chloroplastic (EMB2024), Probable 6-phosphogluconolactonase 3 (At5g24420), Probable 6-phosphogluconolactonase 4 (At5g24410), Probable 6-phosphogluconolactonase 1 (At1g13700), Probable 6-phosphogluconolactonase 2 (At3g49360)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At5g39410), 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At3g01580), 6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic (At5g41670), 6-phosphogluconate dehydrogenase, decarboxylating 3 (At3g02360), 6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic (At1g64190), 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At1g57660)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei107NADPBy similarity1
Binding sitei107SubstrateBy similarity1
Active sitei188Proton acceptorBy similarity1
Active sitei195Proton donorBy similarity1
Binding sitei196SubstrateBy similarity1
Binding sitei266Substrate; via amide nitrogenBy similarity1
Binding sitei293SubstrateBy similarity1
Binding sitei456Substrate; shared with dimeric partnerBy similarity1
Binding sitei462Substrate; shared with dimeric partnerBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 17NADPBy similarity6
Nucleotide bindingi35 – 37NADPBy similarity3
Nucleotide bindingi79 – 81NADPBy similarity3

GO - Molecular functioni

  • phosphogluconate dehydrogenase (decarboxylating) activity Source: TAIR

GO - Biological processi

  • D-gluconate metabolic process Source: UniProtKB-KW
  • male-female gamete recognition during double fertilization forming a zygote and endosperm Source: TAIR
  • pentose-phosphate shunt Source: UniProtKB-UniPathway
  • response to salt stress Source: TAIR

Keywordsi

Molecular functionOxidoreductase
Biological processGluconate utilization, Pentose shunt
LigandNADP

Enzyme and pathway databases

BioCyciARA:GQT-1389-MONOMER
ReactomeiR-ATH-71336 Pentose phosphate pathway (hexose monophosphate shunt)
UniPathwayiUPA00115; UER00410

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating 3 (EC:1.1.1.44)
Gene namesi
Ordered Locus Names:At3g02360
ORF Names:F11A12.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G02360
TAIRilocus:2074577 AT3G02360

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004211001 – 4866-phosphogluconate dehydrogenase, decarboxylating 3Add BLAST486

Proteomic databases

PaxDbiQ9FWA3
PRIDEiQ9FWA3

PTM databases

iPTMnetiQ9FWA3

Expressioni

Gene expression databases

ExpressionAtlasiQ9FWA3 baseline and differential
GenevisibleiQ9FWA3 AT

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi6496, 3 interactors
STRINGi3702.AT3G02360.1

Structurei

3D structure databases

ProteinModelPortaliQ9FWA3
SMRiQ9FWA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni133 – 135Substrate bindingBy similarity3
Regioni191 – 192Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2653 Eukaryota
COG0362 LUCA
HOGENOMiHOG000255147
InParanoidiQ9FWA3
KOiK00033
OMAiQALYMGK
OrthoDBiEOG09360AB8
PhylomeDBiQ9FWA3

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006114 6PGDH_C
IPR006113 6PGDH_Gnd/GntZ
IPR006115 6PGDH_NADP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR006183 Pgluconate_DH
PfamiView protein in Pfam
PF00393 6PGD, 1 hit
PF03446 NAD_binding_2, 1 hit
PIRSFiPIRSF000109 6PGD, 1 hit
PRINTSiPR00076 6PGDHDRGNASE
SMARTiView protein in SMART
SM01350 6PGD, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00873 gnd, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FWA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVQPTRIGL AGLAVMGQNL ALNIAEKGFP ISVYNRTTSK VDETVERAKK
60 70 80 90 100
EGNLPLYGFH DPESFVKSIQ KPRVIIMLVK AGSPVDQTIK TLSAYLEKGD
110 120 130 140 150
CIVDGGNEWY ENTERREKAV AENGFLYLGM GVSGGEEGAR NGPSMMPGGS
160 170 180 190 200
YEAYKNIEDI VLKVAAQVRD SGPCVTYIGK GGSGNFVKMV HNGIEYGDMQ
210 220 230 240 250
LIAEAYDVLK SVGKLSNEEL HSVFSDWNKG ELESFLVEIT ADIFGIKDDK
260 270 280 290 300
GDGHLVDKVL DKTGMKGTGK WTVQQAAELS VPAPTIESSL DARFLSGLKD
310 320 330 340 350
ERVQAAKVFK AGGFGDILTD QKVDKKQLVD DVRKALYASK ICSYAQGMNL
360 370 380 390 400
IRAKSIEKGW GLKLGELARI WKGGCIIRAI FLDRIKQAYD RNAELANLLV
410 420 430 440 450
DPEFAKEIIE RQSAWRRVVC LAINSGISTP GMSASLAYFD SYRRERLPAN
460 470 480
LVQAQRDYFG AHTYERTDVE GSFHTEWFKI ARQSKI
Length:486
Mass (Da):53,577
Last modified:March 1, 2001 - v1
Checksum:i894395559DAEB020
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068900 Genomic DNA Translation: AAG12595.1
CP002686 Genomic DNA Translation: AEE73796.1
CP002686 Genomic DNA Translation: AEE73797.1
AF424591 mRNA Translation: AAL11585.1
BT002299 mRNA Translation: AAN73296.1
AK227160 mRNA Translation: BAE99202.1
AY087341 mRNA Translation: AAM64891.1
RefSeqiNP_186885.1, NM_111103.6
NP_850502.1, NM_180171.2
UniGeneiAt.16821

Genome annotation databases

EnsemblPlantsiAT3G02360.1; AT3G02360.1; AT3G02360
AT3G02360.2; AT3G02360.2; AT3G02360
GeneIDi821163
GrameneiAT3G02360.1; AT3G02360.1; AT3G02360
AT3G02360.2; AT3G02360.2; AT3G02360
KEGGiath:AT3G02360

Similar proteinsi

Entry informationi

Entry namei6GPD3_ARATH
AccessioniPrimary (citable) accession number: Q9FWA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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