Q9FUT1 (GSTUE_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione S-transferase U14
Short name=AtGSTU14
EC=2.5.1.18

Alternative name(s):
GST class-tau member 14
Glutathione S-transferase 13

Gene names

Name:	GSTU14
Synonyms:	GST13
Ordered Locus Names:	At1g27140
ORF Names:	T7N9.20

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides By similarity.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subcellular location	Cytoplasm › cytosol Probable.
Sequence similarities	Belongs to the GST superfamily. Tau family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.
Sequence caution	The sequence AAF79859.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At1g27130 has been split into 2 genes: At1g27130 and At1g27140.

Ontologies

Keywords
Biological process	Detoxification
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glutathione metabolic process Inferred from direct assay PubMed 19174456. Source: TAIR response to toxin Inferred from electronic annotation. Source: UniProtKB-KW toxin catabolic process Traceable author statement Ref.1. Source: TAIR
Cellular_component	cytoplasm Non-traceable author statement Ref.1. Source: TAIR cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutathione transferase activity Inferred from direct assay PubMed 19174456. Source: TAIR
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 243	243	Glutathione S-transferase U14		PRO_0000413560
Regions
	Domain	5 – 87	83	GST N-terminal
	Domain	93 – 220	128	GST C-terminal
	Region	15 – 16	2	Glutathione binding By similarity
	Region	44 – 45	2	Glutathione binding By similarity
	Region	58 – 59	2	Glutathione binding By similarity
	Region	71 – 72	2	Glutathione binding By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9FUT1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 28D2DA7E3F5EB79A	FASTA	243	27,229
	10 20 30 40 50 60 MAQNDTVKLI GCSDDPFSIR PRVALHLKSI KYEYLEEPDD DLGEKSQLLL KSNPIHKKTP 70 80 90 100 110 120 VLIHGDLAIC ESLNIVQYLD EAWPSDPSIL PSNAYDRASA RFWAQYIDDK CFEAANALTG 130 140 150 160 170 180 ANNDEERIAA TGKLTECLAI LEETFQKSSK GLGFFGGETI GYLDIACAAL LGPISVIEMF 190 200 210 220 230 240 SADKFVREET TPGLIQWAVR FRAHEAVRPY MPTVEEVTEL VKQRIEEGFK RNFKSNVSTS EYE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Probing the diversity of the Arabidopsis glutathione S-transferase gene family." Wagner U., Edwards R., Dixon D.P., Mauch F. Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE. Strain: cv. Columbia.
[2]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[4]	"Arabidopsis ORF clones." Kim C.J., Chen H., Shinn P., Ecker J.R. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF288178 mRNA. Translation: AAG30127.1. AC000348 Genomic DNA. Translation: AAF79859.1. Sequence problems. CP002684 Genomic DNA. Translation: AEE30786.1. BT024850 mRNA. Translation: ABD60733.1.
IPI	IPI00526046.
RefSeq	NP_174034.1. NM_102476.3.
UniGene	At.26215.
3D structure databases
HSSP	HSSP built from PDB template 1OYJ based on UniProtKB O65032.
ProteinModelPortal	Q9FUT1.
SMR	Q9FUT1. Positions 5-224.
ModBase	Search...
Protein-protein interaction databases
STRING	3702.AT1G27140.1-P.
Proteomic databases
PaxDb	Q9FUT1.
PRIDE	Q9FUT1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G27140.1; AT1G27140.1; AT1G27140.
GeneID	839603.
KEGG	ath:AT1G27140.
Organism-specific databases
TAIR	At1g27140.
Phylogenomic databases
eggNOG	COG0625.
HOGENOM	HOG000125749.
InParanoid	Q9FUT1.
KO	K00799.
OMA	VYYGEAR.
PhylomeDB	Q9FUT1.
ProtClustDB	CLSN2682867.
Gene expression databases
Genevestigator	Q9FUT1.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. [Graphical view]
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSTUE_ARATH

Accession

Primary (citable) accession number: Q9FUT1
Secondary accession number(s): Q9LFX4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2011
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program