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Protein

Glutathione S-transferase U14

Gene

GSTU14

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione transferase activity Source: TAIR

GO - Biological processi

  1. glutathione metabolic process Source: TAIR
  2. response to toxic substance Source: UniProtKB-KW
  3. toxin catabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Detoxification

Enzyme and pathway databases

BioCyciARA:AT1G27140-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase U14 (EC:2.5.1.18)
Short name:
AtGSTU14
Alternative name(s):
GST class-tau member 14
Glutathione S-transferase 13
Gene namesi
Name:GSTU14
Synonyms:GST13
Ordered Locus Names:At1g27140
ORF Names:T7N9.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G27140.

Subcellular locationi

  1. Cytoplasmcytosol Curated

GO - Cellular componenti

  1. cytoplasm Source: TAIR
  2. cytosol Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Glutathione S-transferase U14PRO_0000413560Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei159 – 1591PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9FUT1.
PRIDEiQ9FUT1.

Expressioni

Gene expression databases

GenevestigatoriQ9FUT1.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G27140.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9FUT1.
SMRiQ9FUT1. Positions 5-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 8783GST N-terminalAdd
BLAST
Domaini93 – 220128GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni15 – 162Glutathione bindingBy similarity
Regioni44 – 452Glutathione bindingBy similarity
Regioni58 – 592Glutathione bindingBy similarity
Regioni71 – 722Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Tau family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000125749.
InParanoidiQ9FUT1.
KOiK00799.
PhylomeDBiQ9FUT1.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FUT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQNDTVKLI GCSDDPFSIR PRVALHLKSI KYEYLEEPDD DLGEKSQLLL
60 70 80 90 100
KSNPIHKKTP VLIHGDLAIC ESLNIVQYLD EAWPSDPSIL PSNAYDRASA
110 120 130 140 150
RFWAQYIDDK CFEAANALTG ANNDEERIAA TGKLTECLAI LEETFQKSSK
160 170 180 190 200
GLGFFGGETI GYLDIACAAL LGPISVIEMF SADKFVREET TPGLIQWAVR
210 220 230 240
FRAHEAVRPY MPTVEEVTEL VKQRIEEGFK RNFKSNVSTS EYE
Length:243
Mass (Da):27,229
Last modified:March 1, 2001 - v1
Checksum:i28D2DA7E3F5EB79A
GO

Sequence cautioni

The sequence AAF79859.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At1g27130 has been split into 2 genes: At1g27130 and At1g27140.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288178 mRNA. Translation: AAG30127.1.
AC000348 Genomic DNA. Translation: AAF79859.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE30786.1.
BT024850 mRNA. Translation: ABD60733.1.
RefSeqiNP_174034.1. NM_102476.3.
UniGeneiAt.26215.

Genome annotation databases

EnsemblPlantsiAT1G27140.1; AT1G27140.1; AT1G27140.
GeneIDi839603.
KEGGiath:AT1G27140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288178 mRNA. Translation: AAG30127.1.
AC000348 Genomic DNA. Translation: AAF79859.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE30786.1.
BT024850 mRNA. Translation: ABD60733.1.
RefSeqiNP_174034.1. NM_102476.3.
UniGeneiAt.26215.

3D structure databases

ProteinModelPortaliQ9FUT1.
SMRiQ9FUT1. Positions 5-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G27140.1-P.

Proteomic databases

PaxDbiQ9FUT1.
PRIDEiQ9FUT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G27140.1; AT1G27140.1; AT1G27140.
GeneIDi839603.
KEGGiath:AT1G27140.

Organism-specific databases

TAIRiAT1G27140.

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000125749.
InParanoidiQ9FUT1.
KOiK00799.
PhylomeDBiQ9FUT1.

Enzyme and pathway databases

BioCyciARA:AT1G27140-MONOMER.

Miscellaneous databases

PROiQ9FUT1.

Gene expression databases

GenevestigatoriQ9FUT1.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
    Wagner U., Edwards R., Dixon D.P., Mauch F.
    Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE.
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Arabidopsis ORF clones."
    Kim C.J., Chen H., Shinn P., Ecker J.R.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiGSTUE_ARATH
AccessioniPrimary (citable) accession number: Q9FUT1
Secondary accession number(s): Q9LFX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: March 1, 2001
Last modified: April 29, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.