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Protein

Glutathione S-transferase U9

Gene

GSTU9

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to toxic substance Source: UniProtKB-KW
  2. toxin catabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Detoxification

Enzyme and pathway databases

BioCyciARA:AT5G62480-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase U9 (EC:2.5.1.18)
Short name:
AtGSTU9
Alternative name(s):
GST class-tau member 9
Glutathione S-transferase 14
Gene namesi
Name:GSTU9
Synonyms:GST14, GST14B
Ordered Locus Names:At5g62480
ORF Names:K19B1.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G62480.

Subcellular locationi

Cytoplasmcytosol Curated

GO - Cellular componenti

  1. cytoplasm Source: TAIR
  2. cytosol Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Glutathione S-transferase U9PRO_0000413555Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei161 – 1611PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9FUT0.

Expressioni

Gene expression databases

GenevestigatoriQ9FUT0.

Structurei

3D structure databases

ProteinModelPortaliQ9FUT0.
SMRiQ9FUT0. Positions 11-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 8680GST N-terminalAdd
BLAST
Domaini92 – 226135GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 182Glutathione bindingBy similarity
Regioni43 – 442Glutathione bindingBy similarity
Regioni57 – 582Glutathione bindingBy similarity
Regioni70 – 712Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Tau family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

HOGENOMiHOG000125749.
InParanoidiQ9FUT0.
KOiK00799.
OMAiWINAINE.
PhylomeDBiQ9FUT0.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9FUT0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDEEVENKVI LHGSFASPYS KRIELALRLK SIPYQFVQED LQNKSQTLLR
60 70 80 90 100
YNPVHKKIPV LVHNGKPISE SLFIIEYIDE TWSNGPHILP EDPYRRSKVR
110 120 130 140 150
FWANYIQLHL YDLVIKVVKS EGEEQKKALT EVKEKLSVIE KEGLKEIFSD
160 170 180 190 200
TDGEPTVTNE TMSLVDIVMC TLLSPYKAHE EVLGLKIIDP EIVPGVYGWI
210 220 230 240
NAINETSVVK DLSPPYEQIL EILRAFRQMS LSPVLETYQS
Length:240
Mass (Da):27,612
Last modified:March 1, 2001 - v1
Checksum:iD0872464356EA2FB
GO
Isoform 2 (identifier: Q9FUT0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-90: Missing.

Show »
Length:214
Mass (Da):24,673
Checksum:i644A7B5E201D30D3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei65 – 9026Missing in isoform 2. 1 PublicationVSP_041940Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288179 mRNA. Translation: AAG30128.1.
AF288180 mRNA. Translation: AAG30129.1.
AB015469 Genomic DNA. Translation: BAB11498.1.
CP002688 Genomic DNA. Translation: AED97612.1.
CP002688 Genomic DNA. Translation: AED97613.1.
AK176211 mRNA. Translation: BAD43974.1.
RefSeqiNP_568954.2. NM_125642.2. [Q9FUT0-2]
NP_851249.1. NM_180918.2. [Q9FUT0-1]
UniGeneiAt.9304.

Genome annotation databases

EnsemblPlantsiAT5G62480.1; AT5G62480.1; AT5G62480. [Q9FUT0-1]
GeneIDi836368.
KEGGiath:AT5G62480.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288179 mRNA. Translation: AAG30128.1.
AF288180 mRNA. Translation: AAG30129.1.
AB015469 Genomic DNA. Translation: BAB11498.1.
CP002688 Genomic DNA. Translation: AED97612.1.
CP002688 Genomic DNA. Translation: AED97613.1.
AK176211 mRNA. Translation: BAD43974.1.
RefSeqiNP_568954.2. NM_125642.2. [Q9FUT0-2]
NP_851249.1. NM_180918.2. [Q9FUT0-1]
UniGeneiAt.9304.

3D structure databases

ProteinModelPortaliQ9FUT0.
SMRiQ9FUT0. Positions 11-231.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9FUT0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G62480.1; AT5G62480.1; AT5G62480. [Q9FUT0-1]
GeneIDi836368.
KEGGiath:AT5G62480.

Organism-specific databases

TAIRiAT5G62480.

Phylogenomic databases

HOGENOMiHOG000125749.
InParanoidiQ9FUT0.
KOiK00799.
OMAiWINAINE.
PhylomeDBiQ9FUT0.

Enzyme and pathway databases

BioCyciARA:AT5G62480-MONOMER.

Gene expression databases

GenevestigatoriQ9FUT0.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
    Wagner U., Edwards R., Dixon D.P., Mauch F.
    Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), GENE FAMILY, NOMENCLATURE.
    Strain: cv. Columbia.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence features of the regions of 1,013,767 bp covered by sixteen physically assigned P1 and TAC clones."
    Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N., Tabata S.
    DNA Res. 5:297-308(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.

Entry informationi

Entry nameiGSTU9_ARATH
AccessioniPrimary (citable) accession number: Q9FUT0
Secondary accession number(s): Q9FE97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: March 1, 2001
Last modified: March 4, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.