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Protein

Glutathione S-transferase U18

Gene

GSTU18

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

  • glutathione metabolic process Source: GO_Central
  • response to toxic substance Source: UniProtKB-KW
  • toxin catabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Detoxification

Enzyme and pathway databases

BioCyciARA:AT1G10360-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase U18 (EC:2.5.1.18)
Short name:
AtGSTU18
Alternative name(s):
GST class-tau member 18
Glutathione S-transferase 29
Gene namesi
Name:GSTU18
Synonyms:GST29
Ordered Locus Names:At1g10360
ORF Names:F14N23.24
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G10360.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004135641 – 227Glutathione S-transferase U18Add BLAST227

Proteomic databases

PaxDbiQ9FUS9.

Expressioni

Gene expression databases

GenevisibleiQ9FUS9. AT.

Interactioni

Protein-protein interaction databases

BioGridi22815. 1 interactor.
IntActiQ9FUS9. 1 interactor.
STRINGi3702.AT1G10360.1.

Structurei

3D structure databases

ProteinModelPortaliQ9FUS9.
SMRiQ9FUS9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 83GST N-terminalAdd BLAST80
Domaini90 – 221GST C-terminalAdd BLAST132

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni14 – 15Glutathione bindingBy similarity2
Regioni40 – 41Glutathione bindingBy similarity2
Regioni54 – 55Glutathione bindingBy similarity2
Regioni67 – 68Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Tau family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG0406. Eukaryota.
ENOG410XSIX. LUCA.
HOGENOMiHOG000125749.
InParanoidiQ9FUS9.
KOiK00799.
OMAiFNGDHIG.
OrthoDBiEOG09360N01.
PhylomeDBiQ9FUS9.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FUS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATEDVKLIG SWASVYVMRA RIALHLKSIS YEFLQETYGS KSELLLKSNP
60 70 80 90 100
VHKKMPVLIH ADKPVCESNI IVHYIDEAWN SSGPSILPSH PYDRAIARFW
110 120 130 140 150
AAYIDDQWFI SVRSILTAQG DEEKKAAIAQ VEERTKLLEK AFNDCSQGKP
160 170 180 190 200
FFNGDHIGYL DIALGSFLGW WRVVELDANH KFLDETKTPS LVKWAERFCD
210 220
DPAVKPIMPE ITKLAEFARK LFPKRQA
Length:227
Mass (Da):25,911
Last modified:March 1, 2001 - v1
Checksum:i2996DA12B9BF590B
GO

Sequence cautioni

The sequence AAD32886 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288190 mRNA. Translation: AAG30139.1.
AC005489 Genomic DNA. Translation: AAD32886.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28570.1.
BT000940 mRNA. Translation: AAN41340.1.
AK317183 mRNA. Translation: BAH19868.1.
RefSeqiNP_172507.1. NM_100910.5.
UniGeneiAt.11288.

Genome annotation databases

EnsemblPlantsiAT1G10360.1; AT1G10360.1; AT1G10360.
GeneIDi837575.
GrameneiAT1G10360.1; AT1G10360.1; AT1G10360.
KEGGiath:AT1G10360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288190 mRNA. Translation: AAG30139.1.
AC005489 Genomic DNA. Translation: AAD32886.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28570.1.
BT000940 mRNA. Translation: AAN41340.1.
AK317183 mRNA. Translation: BAH19868.1.
RefSeqiNP_172507.1. NM_100910.5.
UniGeneiAt.11288.

3D structure databases

ProteinModelPortaliQ9FUS9.
SMRiQ9FUS9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi22815. 1 interactor.
IntActiQ9FUS9. 1 interactor.
STRINGi3702.AT1G10360.1.

Proteomic databases

PaxDbiQ9FUS9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G10360.1; AT1G10360.1; AT1G10360.
GeneIDi837575.
GrameneiAT1G10360.1; AT1G10360.1; AT1G10360.
KEGGiath:AT1G10360.

Organism-specific databases

TAIRiAT1G10360.

Phylogenomic databases

eggNOGiKOG0406. Eukaryota.
ENOG410XSIX. LUCA.
HOGENOMiHOG000125749.
InParanoidiQ9FUS9.
KOiK00799.
OMAiFNGDHIG.
OrthoDBiEOG09360N01.
PhylomeDBiQ9FUS9.

Enzyme and pathway databases

BioCyciARA:AT1G10360-MONOMER.

Miscellaneous databases

PROiQ9FUS9.

Gene expression databases

GenevisibleiQ9FUS9. AT.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTUI_ARATH
AccessioniPrimary (citable) accession number: Q9FUS9
Secondary accession number(s): Q9SY78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.