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Protein

Glutathione S-transferase U18

Gene

GSTU18

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

  • glutathione metabolic process Source: GO_Central
  • toxin catabolic process Source: TAIR

Keywordsi

Molecular functionTransferase
Biological processDetoxification

Enzyme and pathway databases

BioCyciARA:AT1G10360-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase U18 (EC:2.5.1.18)
Short name:
AtGSTU18
Alternative name(s):
GST class-tau member 18
Glutathione S-transferase 29
Gene namesi
Name:GSTU18
Synonyms:GST29
Ordered Locus Names:At1g10360
ORF Names:F14N23.24
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G10360
TAIRilocus:2012758 AT1G10360

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004135641 – 227Glutathione S-transferase U18Add BLAST227

Proteomic databases

PaxDbiQ9FUS9

Expressioni

Gene expression databases

ExpressionAtlasiQ9FUS9 baseline and differential
GenevisibleiQ9FUS9 AT

Interactioni

Protein-protein interaction databases

BioGridi22815, 1 interactor
IntActiQ9FUS9, 1 interactor
STRINGi3702.AT1G10360.1

Structurei

3D structure databases

ProteinModelPortaliQ9FUS9
SMRiQ9FUS9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 83GST N-terminalAdd BLAST80
Domaini90 – 221GST C-terminalAdd BLAST132

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni14 – 15Glutathione bindingBy similarity2
Regioni40 – 41Glutathione bindingBy similarity2
Regioni54 – 55Glutathione bindingBy similarity2
Regioni67 – 68Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Tau family.Curated

Phylogenomic databases

eggNOGiKOG0406 Eukaryota
ENOG410XSIX LUCA
HOGENOMiHOG000125749
InParanoidiQ9FUS9
KOiK00799
OMAiDANHKFL
OrthoDBiEOG09360N01
PhylomeDBiQ9FUS9

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF13417 GST_N_3, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FUS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATEDVKLIG SWASVYVMRA RIALHLKSIS YEFLQETYGS KSELLLKSNP
60 70 80 90 100
VHKKMPVLIH ADKPVCESNI IVHYIDEAWN SSGPSILPSH PYDRAIARFW
110 120 130 140 150
AAYIDDQWFI SVRSILTAQG DEEKKAAIAQ VEERTKLLEK AFNDCSQGKP
160 170 180 190 200
FFNGDHIGYL DIALGSFLGW WRVVELDANH KFLDETKTPS LVKWAERFCD
210 220
DPAVKPIMPE ITKLAEFARK LFPKRQA
Length:227
Mass (Da):25,911
Last modified:March 1, 2001 - v1
Checksum:i2996DA12B9BF590B
GO

Sequence cautioni

The sequence AAD32886 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288190 mRNA Translation: AAG30139.1
AC005489 Genomic DNA Translation: AAD32886.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28570.1
BT000940 mRNA Translation: AAN41340.1
AK317183 mRNA Translation: BAH19868.1
RefSeqiNP_172507.1, NM_100910.5
UniGeneiAt.11288

Genome annotation databases

EnsemblPlantsiAT1G10360.1; AT1G10360.1; AT1G10360
GeneIDi837575
GrameneiAT1G10360.1; AT1G10360.1; AT1G10360
KEGGiath:AT1G10360

Similar proteinsi

Entry informationi

Entry nameiGSTUI_ARATH
AccessioniPrimary (citable) accession number: Q9FUS9
Secondary accession number(s): Q9SY78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health