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Q9FUS6

- GSTUD_ARATH

UniProt

Q9FUS6 - GSTUD_ARATH

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Protein

Glutathione S-transferase U13

Gene

GSTU13

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

In vitro, possesses glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and benzyl isothiocyanate (BITC). May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to cadmium ion Source: TAIR
  2. response to stress Source: UniProtKB-KW
  3. response to toxic substance Source: UniProtKB-KW
  4. toxin catabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Detoxification, Stress response

Enzyme and pathway databases

BioCyciARA:AT1G27130-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase U13 (EC:2.5.1.18)
Short name:
AtGSTU13
Alternative name(s):
GST class-tau member 13
Glutathione S-transferase 12
Gene namesi
Name:GSTU13
Synonyms:GST12
Ordered Locus Names:At1g27130
ORF Names:T7N9.190
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G27130.

Subcellular locationi

Cytoplasmcytosol Curated

GO - Cellular componenti

  1. cytoplasm Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Glutathione S-transferase U13PRO_0000413559Add
BLAST

Proteomic databases

PRIDEiQ9FUS6.

Expressioni

Inductioni

By Hyaloperonospora parasitica. Down-regulated by salicylic acid, ethylene and methyl jasmonate.1 Publication

Gene expression databases

ExpressionAtlasiQ9FUS6. baseline and differential.
GenevestigatoriQ9FUS6.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G27130.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9FUS6.
SMRiQ9FUS6. Positions 5-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 8682GST N-terminalAdd
BLAST
Domaini92 – 224133GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni15 – 162Glutathione bindingBy similarity
Regioni43 – 442Glutathione bindingBy similarity
Regioni57 – 582Glutathione bindingBy similarity
Regioni70 – 712Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Tau family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

InParanoidiQ9FUS6.
KOiK00799.
OMAiMECLAIL.
PhylomeDBiQ9FUS6.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FUS6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQNDTVKLI GSWSSPYSLR ARVALHLKSV KYEYLDEPDV LKEKSELLLK
60 70 80 90 100
SNPIHKKVPV LLHGDLSISE SLNVVQYVDE AWPSVPSILP SDAYDRASAR
110 120 130 140 150
FWAQYIDDKC FAAVDAVVGA KDDEGKMAAV GKLMECLAIL EETFQKSSKG
160 170 180 190 200
LGFFGGETIG YLDIACSALL GPISVIEAFS GVKFLRQETT PGLIKWAERF
210 220
RAHEAVKPYM PTVEEVVAFA KQKFNVQ
Length:227
Mass (Da):25,131
Last modified:March 1, 2001 - v1
Checksum:i2D0EB66EF50A690E
GO

Sequence cautioni

The sequence AAF79859.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At1g27130 has been split into 2 genes: At1g27130 and At1g27140.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41N → K in AAM64510. 1 PublicationCurated
Sequence conflicti69 – 691S → C in AAM64510. 1 PublicationCurated
Sequence conflicti130 – 1301V → A in AAM64510. 1 PublicationCurated
Sequence conflicti142 – 1421E → D in AAM64510. 1 PublicationCurated
Sequence conflicti147 – 1471S → T in AAM64510. 1 PublicationCurated
Sequence conflicti187 – 1871Q → L in AAM64510. 1 PublicationCurated
Sequence conflicti199 – 1991R → S in AAM64510. 1 PublicationCurated
Sequence conflicti212 – 2121T → S in AAM64510. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF288193 mRNA. Translation: AAG30142.1.
AC000348 Genomic DNA. Translation: AAF79859.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE30784.1.
AY044324 mRNA. Translation: AAK73265.1.
AY050343 mRNA. Translation: AAK91360.1.
AY094051 mRNA. Translation: AAM16207.1.
AY086946 mRNA. Translation: AAM64510.1.
PIRiH86397.
RefSeqiNP_174033.1. NM_102475.2.
UniGeneiAt.16269.

Genome annotation databases

EnsemblPlantsiAT1G27130.1; AT1G27130.1; AT1G27130.
GeneIDi839602.
KEGGiath:AT1G27130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF288193 mRNA. Translation: AAG30142.1 .
AC000348 Genomic DNA. Translation: AAF79859.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE30784.1 .
AY044324 mRNA. Translation: AAK73265.1 .
AY050343 mRNA. Translation: AAK91360.1 .
AY094051 mRNA. Translation: AAM16207.1 .
AY086946 mRNA. Translation: AAM64510.1 .
PIRi H86397.
RefSeqi NP_174033.1. NM_102475.2.
UniGenei At.16269.

3D structure databases

ProteinModelPortali Q9FUS6.
SMRi Q9FUS6. Positions 5-223.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT1G27130.1-P.

Proteomic databases

PRIDEi Q9FUS6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G27130.1 ; AT1G27130.1 ; AT1G27130 .
GeneIDi 839602.
KEGGi ath:AT1G27130.

Organism-specific databases

TAIRi AT1G27130.

Phylogenomic databases

InParanoidi Q9FUS6.
KOi K00799.
OMAi MECLAIL.
PhylomeDBi Q9FUS6.

Enzyme and pathway databases

BioCyci ARA:AT1G27130-MONOMER.

Gene expression databases

ExpressionAtlasi Q9FUS6. baseline and differential.
Genevestigatori Q9FUS6.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
    Wagner U., Edwards R., Dixon D.P., Mauch F.
    Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, GENE FAMILY, NOMENCLATURE.
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiGSTUD_ARATH
AccessioniPrimary (citable) accession number: Q9FUS6
Secondary accession number(s): Q8LBX2, Q9LFX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3