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Q9FUS6

- GSTUD_ARATH

UniProt

Q9FUS6 - GSTUD_ARATH

Protein

Glutathione S-transferase U13

Gene

GSTU13

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    In vitro, possesses glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and benzyl isothiocyanate (BITC). May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.1 Publication

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to cadmium ion Source: TAIR
    2. response to stress Source: UniProtKB-KW
    3. response to toxic substance Source: UniProtKB-KW
    4. toxin catabolic process Source: TAIR

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Detoxification, Stress response

    Enzyme and pathway databases

    BioCyciARA:AT1G27130-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase U13 (EC:2.5.1.18)
    Short name:
    AtGSTU13
    Alternative name(s):
    GST class-tau member 13
    Glutathione S-transferase 12
    Gene namesi
    Name:GSTU13
    Synonyms:GST12
    Ordered Locus Names:At1g27130
    ORF Names:T7N9.190
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G27130.

    Subcellular locationi

    Cytoplasmcytosol Curated

    GO - Cellular componenti

    1. cytoplasm Source: TAIR
    2. cytosol Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 227227Glutathione S-transferase U13PRO_0000413559Add
    BLAST

    Proteomic databases

    PRIDEiQ9FUS6.

    Expressioni

    Inductioni

    By Hyaloperonospora parasitica. Down-regulated by salicylic acid, ethylene and methyl jasmonate.1 Publication

    Gene expression databases

    ArrayExpressiQ9FUS6.
    GenevestigatoriQ9FUS6.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT1G27130.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FUS6.
    SMRiQ9FUS6. Positions 5-223.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 8682GST N-terminalAdd
    BLAST
    Domaini92 – 224133GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni15 – 162Glutathione bindingBy similarity
    Regioni43 – 442Glutathione bindingBy similarity
    Regioni57 – 582Glutathione bindingBy similarity
    Regioni70 – 712Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Tau family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    InParanoidiQ9FUS6.
    KOiK00799.
    OMAiMECLAIL.
    PhylomeDBiQ9FUS6.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9FUS6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQNDTVKLI GSWSSPYSLR ARVALHLKSV KYEYLDEPDV LKEKSELLLK    50
    SNPIHKKVPV LLHGDLSISE SLNVVQYVDE AWPSVPSILP SDAYDRASAR 100
    FWAQYIDDKC FAAVDAVVGA KDDEGKMAAV GKLMECLAIL EETFQKSSKG 150
    LGFFGGETIG YLDIACSALL GPISVIEAFS GVKFLRQETT PGLIKWAERF 200
    RAHEAVKPYM PTVEEVVAFA KQKFNVQ 227
    Length:227
    Mass (Da):25,131
    Last modified:March 1, 2001 - v1
    Checksum:i2D0EB66EF50A690E
    GO

    Sequence cautioni

    The sequence AAF79859.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At1g27130 has been split into 2 genes: At1g27130 and At1g27140.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 41N → K in AAM64510. 1 PublicationCurated
    Sequence conflicti69 – 691S → C in AAM64510. 1 PublicationCurated
    Sequence conflicti130 – 1301V → A in AAM64510. 1 PublicationCurated
    Sequence conflicti142 – 1421E → D in AAM64510. 1 PublicationCurated
    Sequence conflicti147 – 1471S → T in AAM64510. 1 PublicationCurated
    Sequence conflicti187 – 1871Q → L in AAM64510. 1 PublicationCurated
    Sequence conflicti199 – 1991R → S in AAM64510. 1 PublicationCurated
    Sequence conflicti212 – 2121T → S in AAM64510. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF288193 mRNA. Translation: AAG30142.1.
    AC000348 Genomic DNA. Translation: AAF79859.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE30784.1.
    AY044324 mRNA. Translation: AAK73265.1.
    AY050343 mRNA. Translation: AAK91360.1.
    AY094051 mRNA. Translation: AAM16207.1.
    AY086946 mRNA. Translation: AAM64510.1.
    PIRiH86397.
    RefSeqiNP_174033.1. NM_102475.2.
    UniGeneiAt.16269.

    Genome annotation databases

    EnsemblPlantsiAT1G27130.1; AT1G27130.1; AT1G27130.
    GeneIDi839602.
    KEGGiath:AT1G27130.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF288193 mRNA. Translation: AAG30142.1 .
    AC000348 Genomic DNA. Translation: AAF79859.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE30784.1 .
    AY044324 mRNA. Translation: AAK73265.1 .
    AY050343 mRNA. Translation: AAK91360.1 .
    AY094051 mRNA. Translation: AAM16207.1 .
    AY086946 mRNA. Translation: AAM64510.1 .
    PIRi H86397.
    RefSeqi NP_174033.1. NM_102475.2.
    UniGenei At.16269.

    3D structure databases

    ProteinModelPortali Q9FUS6.
    SMRi Q9FUS6. Positions 5-223.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT1G27130.1-P.

    Proteomic databases

    PRIDEi Q9FUS6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G27130.1 ; AT1G27130.1 ; AT1G27130 .
    GeneIDi 839602.
    KEGGi ath:AT1G27130.

    Organism-specific databases

    TAIRi AT1G27130.

    Phylogenomic databases

    InParanoidi Q9FUS6.
    KOi K00799.
    OMAi MECLAIL.
    PhylomeDBi Q9FUS6.

    Enzyme and pathway databases

    BioCyci ARA:AT1G27130-MONOMER.

    Gene expression databases

    ArrayExpressi Q9FUS6.
    Genevestigatori Q9FUS6.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
      Wagner U., Edwards R., Dixon D.P., Mauch F.
      Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, GENE FAMILY, NOMENCLATURE.
      Strain: cv. Columbia.
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiGSTUD_ARATH
    AccessioniPrimary (citable) accession number: Q9FUS6
    Secondary accession number(s): Q8LBX2, Q9LFX4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3