Q9FUD1 (PROFA_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Profilin-A

Gene names

Ordered Locus Names:	Os10g0323600, LOC_Os10g17660
ORF Names:	OSJNBa0065C16.11
AND
Ordered Locus Names:	Os10g0323900, LOC_Os10g17680
ORF Names:	OSJNBa0065C16.14

Organism

Oryza sativa subsp. japonica (Rice) [Reference proteome]

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Liliopsida › commelinids › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza › Oryza sativa

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity. May serve as a modulator in pollen germination and pollen tube growth.
Subunit structure	Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
Subcellular location	Cytoplasm › cytoskeleton.
Sequence similarities	Belongs to the profilin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	Actin-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: EnsemblPlants/Gramene phragmoplast Inferred from electronic annotation. Source: EnsemblPlants/Gramene
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 131	130	Profilin-A		PRO_0000199659

Sequences

	Sequence		Length	Mass (Da)
	Q9FUD1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: CEB39EB02CA873D4	FASTA	131	14,243
	10 20 30 40 50 60 MSWQTYVDEH LMCEIEGHHL TSAAIVGHDG TVWAQSAAFP QFKPEEMTNI MKDFDEPGFL 70 80 90 100 110 120 APTGLFLGPT KYMVIQGEPG AVIRGKKGSG GITVKKTGQA LVVGIYDEPM TPGQCNMVVE 130 RLGDYLVEQG L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of rice pollen profilin gene." Ye Q., Xu Y., Yan F., Tang L., Chen F. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pollen.
[2]	"In-depth view of structure, activity, and evolution of rice chromosome 10." Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S., Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D., Oates R., Palmer M., Pries G., Gibson J., Anderson H. , Paradkar M., Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F., Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M., Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R., Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F., Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D., Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R., Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K., Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S., Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S., Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R., Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M., Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R., Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E., Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A. Science 300:1566-1569(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[3]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[4]	"The rice annotation project database (RAP-DB): 2008 update." The rice annotation project (RAP) Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF310253 mRNA. Translation: AAG32056.1. AC074354 Genomic DNA. Translation: AAK92577.1. AC074354 Genomic DNA. Translation: AAK92580.1. DP000086 Genomic DNA. Translation: AAP52954.1. DP000086 Genomic DNA. Translation: AAP52957.1. AP008216 Genomic DNA. Translation: BAF26262.1. AP008216 Genomic DNA. Translation: BAF26263.1.
RefSeq	NP_001064348.1. NM_001070883.1. NP_001064349.1. NM_001070884.1.
UniGene	Os.12777. Os.57684.
3D structure databases
ProteinModelPortal	Q9FUD1.
SMR	Q9FUD1. Positions 2-131.
ModBase	Search...
Protein family/group databases
Allergome	3395. Ory s 12.0101. 996. Ory s 12.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	LOC_Os10g17660.1; LOC_Os10g17660.1; LOC_Os10g17660. LOC_Os10g17680.1; LOC_Os10g17680.1; LOC_Os10g17680.
GeneID	4348316. 4348317.
KEGG	osa:4348316. osa:4348317.
Organism-specific databases
Gramene	Q9FUD1.
Phylogenomic databases
eggNOG	NOG277929.
HOGENOM	HOG000171591.
KO	K05759.
OMA	SLYEDPI.
ProtClustDB	CLSN2683194.
Gene expression databases
ArrayExpress	Q9FUD1.
Family and domain databases
InterPro	IPR027310. Profilin_CS. IPR005455. Profilin_eukaryotes/bac. [Graphical view]
PANTHER	PTHR11604. PTHR11604. 1 hit.
Pfam	PF00235. Profilin. 1 hit. [Graphical view]
PRINTS	PR00392. PROFILIN. PR01640. PROFILINPLNT.
SMART	SM00392. PROF. 1 hit. [Graphical view]
SUPFAM	SSF55770. Profilin. 1 hit.
PROSITE	PS00414. PROFILIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROFA_ORYSJ

Accession

Primary (citable) accession number: Q9FUD1
Secondary accession number(s): Q0IYF2, Q7G3W8, Q7G7Y1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program