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Protein

Transcription factor TCP21

Gene

TCP21

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor involved in the regulation of the circadian clock. Acts as a repressor of CCA1 by binding to its promoter. No binding to the LHY promoter.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • negative regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  • regulation of circadian rhythm Source: UniProtKB
  • regulation of transcription, DNA-templated Source: TAIR
  • rhythmic process Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor TCP21
Alternative name(s):
Protein CCA1 HIKING EXPEDITION
Protein CHE
Gene namesi
Name:TCP21
Synonyms:CHE
Ordered Locus Names:At5g08330
ORF Names:F8L15.60
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G08330.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

No effect on the period length or phase of the circadian clock.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Transcription factor TCP21PRO_0000330795Add
BLAST

Proteomic databases

PaxDbiQ9FTA2.
PRIDEiQ9FTA2.

Expressioni

Tissue specificityi

Expressed in leaves, roots, and stems.1 Publication

Gene expression databases

GenevisibleiQ9FTA2. AT.

Interactioni

Subunit structurei

Interacts (via N-terminus) with APRR1/TOC1 (PubMed:19286557). Interacts with SPL (PubMed:25527103).2 Publications

Protein-protein interaction databases

BioGridi16008. 37 interactions.
IntActiQ9FTA2. 26 interactions.
STRINGi3702.AT5G08330.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 8555TCPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi118 – 14629Gly-richAdd
BLAST
Compositional biasi174 – 19017Gln-richAdd
BLAST
Compositional biasi191 – 20515Ala-richAdd
BLAST

Sequence similaritiesi

Contains 1 TCP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJ38. Eukaryota.
ENOG410YHVM. LUCA.
HOGENOMiHOG000239283.
InParanoidiQ9FTA2.
KOiK16221.
OMAiAPPEMVF.
OrthoDBiEOG09360PY9.
PhylomeDBiQ9FTA2.

Family and domain databases

InterProiIPR017887. TF_TCP_subgr.
IPR005333. Transcription_factor_TCP.
[Graphical view]
PfamiPF03634. TCP. 1 hit.
[Graphical view]
PROSITEiPS51369. TCP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FTA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADNDGAVSN GIIVEQTSNK GPLNAVKKPP SKDRHSKVDG RGRRIRMPII
60 70 80 90 100
CAARVFQLTR ELGHKSDGQT IEWLLRQAEP SIIAATGTGT TPASFSTASL
110 120 130 140 150
STSSPFTLGK RVVRAEEGES GGGGGGGLTV GHTMGTSLMG GGGSGGFWAV
160 170 180 190 200
PARPDFGQVW SFATGAPPEM VFAQQQQPAT LFVRHQQQQQ ASAAAAAAMG
210 220 230
EASAARVGNY LPGHHLNLLA SLSGGANGSG RREDDHEPR
Length:239
Mass (Da):24,752
Last modified:March 1, 2001 - v1
Checksum:iC0AF9BBF8A841565
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL392174 Genomic DNA. Translation: CAC08333.1.
CP002688 Genomic DNA. Translation: AED91284.1.
AF412074 mRNA. Translation: AAL06527.1.
AY072620 mRNA. Translation: AAL62011.1.
RefSeqiNP_196450.1. NM_120916.2.
UniGeneiAt.22911.

Genome annotation databases

EnsemblPlantsiAT5G08330.1; AT5G08330.1; AT5G08330.
GeneIDi830730.
GrameneiAT5G08330.1; AT5G08330.1; AT5G08330.
KEGGiath:AT5G08330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL392174 Genomic DNA. Translation: CAC08333.1.
CP002688 Genomic DNA. Translation: AED91284.1.
AF412074 mRNA. Translation: AAL06527.1.
AY072620 mRNA. Translation: AAL62011.1.
RefSeqiNP_196450.1. NM_120916.2.
UniGeneiAt.22911.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi16008. 37 interactions.
IntActiQ9FTA2. 26 interactions.
STRINGi3702.AT5G08330.1.

Proteomic databases

PaxDbiQ9FTA2.
PRIDEiQ9FTA2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G08330.1; AT5G08330.1; AT5G08330.
GeneIDi830730.
GrameneiAT5G08330.1; AT5G08330.1; AT5G08330.
KEGGiath:AT5G08330.

Organism-specific databases

TAIRiAT5G08330.

Phylogenomic databases

eggNOGiENOG410IJ38. Eukaryota.
ENOG410YHVM. LUCA.
HOGENOMiHOG000239283.
InParanoidiQ9FTA2.
KOiK16221.
OMAiAPPEMVF.
OrthoDBiEOG09360PY9.
PhylomeDBiQ9FTA2.

Miscellaneous databases

PROiQ9FTA2.

Gene expression databases

GenevisibleiQ9FTA2. AT.

Family and domain databases

InterProiIPR017887. TF_TCP_subgr.
IPR005333. Transcription_factor_TCP.
[Graphical view]
PfamiPF03634. TCP. 1 hit.
[Graphical view]
PROSITEiPS51369. TCP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCP21_ARATH
AccessioniPrimary (citable) accession number: Q9FTA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.