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Protein

Thaumatin-like protein 1a

Gene

TL1

Organism
Malus domestica (Apple) (Pyrus malus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Thaumatin-like protein 1a
Alternative name(s):
Mdtl1
Pathogenesis-related protein 5a
Short name:
PR-5a
Allergen: Mal d 2
Gene namesi
Name:TL1
Synonyms:TL
OrganismiMalus domestica (Apple) (Pyrus malus)Imported
Taxonomic identifieri3750 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesRosaceaeMaloideaeMaleaeMalus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Important allergen of apple fruits that is associated with IgE-mediated symptoms in apple allergic individuals.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3360. Mal d 2.0101.
465. Mal d 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 246222Thaumatin-like protein 1aPRO_0000034048Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 245PROSITE-ProRule annotation
Disulfide bondi81 ↔ 91PROSITE-ProRule annotation
Disulfide bondi96 ↔ 103PROSITE-ProRule annotation
Disulfide bondi151 ↔ 234PROSITE-ProRule annotation
Disulfide bondi156 ↔ 217PROSITE-ProRule annotation
Disulfide bondi164 ↔ 180PROSITE-ProRule annotation
Disulfide bondi184 ↔ 193PROSITE-ProRule annotation
Disulfide bondi194 ↔ 204PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1
246
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 316Combined sources
Beta strandi33 – 353Combined sources
Beta strandi37 – 437Combined sources
Beta strandi62 – 665Combined sources
Beta strandi69 – 8315Combined sources
Beta strandi89 – 946Combined sources
Beta strandi97 – 1026Combined sources
Beta strandi114 – 1196Combined sources
Helixi121 – 1233Combined sources
Beta strandi126 – 1316Combined sources
Beta strandi136 – 1383Combined sources
Beta strandi140 – 1467Combined sources
Beta strandi154 – 1563Combined sources
Helixi160 – 1634Combined sources
Helixi166 – 1683Combined sources
Beta strandi169 – 1713Combined sources
Beta strandi177 – 1804Combined sources
Helixi183 – 1875Combined sources
Helixi190 – 1934Combined sources
Helixi201 – 2033Combined sources
Helixi208 – 2169Combined sources
Beta strandi232 – 2365Combined sources
Beta strandi239 – 2446Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZS3X-ray1.80A25-246[»]
ProteinModelPortaliQ9FSG7.
SMRiQ9FSG7. Positions 25-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thaumatin family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.110.10. 1 hit.
InterProiIPR001938. Thaumatin.
IPR017949. Thaumatin_CS.
[Graphical view]
PANTHERiPTHR31048. PTHR31048. 1 hit.
PfamiPF00314. Thaumatin. 1 hit.
[Graphical view]
PIRSFiPIRSF002703. Thaumatin. 1 hit.
PRINTSiPR00347. THAUMATIN.
SMARTiSM00205. THN. 1 hit.
[Graphical view]
SUPFAMiSSF49870. SSF49870. 1 hit.
PROSITEiPS00316. THAUMATIN_1. 1 hit.
PS51367. THAUMATIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FSG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKSQVASLL GLTLAILFFS GAHAAKITFT NNCPNTVWPG TLTGDQKPQL
60 70 80 90 100
SLTGFELASK ASRSVDAPSP WSGRFWGRTR CSTDAAGKFT CETADCGSGQ
110 120 130 140 150
VACNGAGAVP PATLVEITIA ANGGQDYYDV SLVDGFNLPM SVAPQGGTGE
160 170 180 190 200
CKPSSCPANV NKVCPAPLQV KAADGSVISC KSACLAFGDS KYCCTPPNNT
210 220 230 240
PETCPPTEYS EIFEKQCPQA YSYAYDDKNS TFTCSGGPDY VITFCP
Length:246
Mass (Da):25,700
Last modified:March 1, 2001 - v1
Checksum:i3A34CE175DCB9FE4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 1710SLLGLTLAIL → PRPTLAILF in AAC36740 (PubMed:10737193).Curated
Sequence conflicti127 – 1271Y → F in AAM12886 (PubMed:12481992).Curated
Sequence conflicti163 – 1631V → A in AAM12886 (PubMed:12481992).Curated
Sequence conflicti167 – 1671P → Q in AAM12886 (PubMed:12481992).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090143 mRNA. Translation: AAC36740.1.
AJ243427 mRNA. Translation: CAC10270.1.
AF494393 mRNA. Translation: AAM12886.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090143 mRNA. Translation: AAC36740.1.
AJ243427 mRNA. Translation: CAC10270.1.
AF494393 mRNA. Translation: AAM12886.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZS3X-ray1.80A25-246[»]
ProteinModelPortaliQ9FSG7.
SMRiQ9FSG7. Positions 25-246.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3360. Mal d 2.0101.
465. Mal d 2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.110.10. 1 hit.
InterProiIPR001938. Thaumatin.
IPR017949. Thaumatin_CS.
[Graphical view]
PANTHERiPTHR31048. PTHR31048. 1 hit.
PfamiPF00314. Thaumatin. 1 hit.
[Graphical view]
PIRSFiPIRSF002703. Thaumatin. 1 hit.
PRINTSiPR00347. THAUMATIN.
SMARTiSM00205. THN. 1 hit.
[Graphical view]
SUPFAMiSSF49870. SSF49870. 1 hit.
PROSITEiPS00316. THAUMATIN_1. 1 hit.
PS51367. THAUMATIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTP1A_MALDO
AccessioniPrimary (citable) accession number: Q9FSG7
Secondary accession number(s): O82546
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: March 1, 2001
Last modified: October 14, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.