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Protein

Thaumatin-like protein 1a

Gene

TL1

Organism
Malus domestica (Apple) (Pyrus malus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Thaumatin-like protein 1a
Alternative name(s):
Mdtl1
Pathogenesis-related protein 5a
Short name:
PR-5a
Allergen: Mal d 2
Gene namesi
Name:TL1
Synonyms:TL
OrganismiMalus domestica (Apple) (Pyrus malus)Imported
Taxonomic identifieri3750 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesRosaceaeMaloideaeMaleaeMalus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Important allergen of apple fruits that is associated with IgE-mediated symptoms in apple allergic individuals.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3360. Mal d 2.0101.
465. Mal d 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000003404825 – 246Thaumatin-like protein 1aAdd BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 245PROSITE-ProRule annotation
Disulfide bondi81 ↔ 91PROSITE-ProRule annotation
Disulfide bondi96 ↔ 103PROSITE-ProRule annotation
Disulfide bondi151 ↔ 234PROSITE-ProRule annotation
Disulfide bondi156 ↔ 217PROSITE-ProRule annotation
Disulfide bondi164 ↔ 180PROSITE-ProRule annotation
Disulfide bondi184 ↔ 193PROSITE-ProRule annotation
Disulfide bondi194 ↔ 204PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 31Combined sources6
Beta strandi33 – 35Combined sources3
Beta strandi37 – 43Combined sources7
Beta strandi62 – 66Combined sources5
Beta strandi69 – 83Combined sources15
Beta strandi89 – 94Combined sources6
Beta strandi97 – 102Combined sources6
Beta strandi114 – 119Combined sources6
Helixi121 – 123Combined sources3
Beta strandi126 – 131Combined sources6
Beta strandi136 – 138Combined sources3
Beta strandi140 – 146Combined sources7
Beta strandi154 – 156Combined sources3
Helixi160 – 163Combined sources4
Helixi166 – 168Combined sources3
Beta strandi169 – 171Combined sources3
Beta strandi177 – 180Combined sources4
Helixi183 – 187Combined sources5
Helixi190 – 193Combined sources4
Helixi201 – 203Combined sources3
Helixi208 – 216Combined sources9
Beta strandi232 – 236Combined sources5
Beta strandi239 – 244Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZS3X-ray1.80A25-246[»]
ProteinModelPortaliQ9FSG7.
SMRiQ9FSG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thaumatin family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.110.10. 1 hit.
InterProiIPR001938. Thaumatin.
IPR017949. Thaumatin_CS.
[Graphical view]
PANTHERiPTHR31048. PTHR31048. 1 hit.
PfamiPF00314. Thaumatin. 1 hit.
[Graphical view]
PIRSFiPIRSF002703. Thaumatin. 1 hit.
PRINTSiPR00347. THAUMATIN.
SMARTiSM00205. THN. 1 hit.
[Graphical view]
SUPFAMiSSF49870. SSF49870. 1 hit.
PROSITEiPS00316. THAUMATIN_1. 1 hit.
PS51367. THAUMATIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FSG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKSQVASLL GLTLAILFFS GAHAAKITFT NNCPNTVWPG TLTGDQKPQL
60 70 80 90 100
SLTGFELASK ASRSVDAPSP WSGRFWGRTR CSTDAAGKFT CETADCGSGQ
110 120 130 140 150
VACNGAGAVP PATLVEITIA ANGGQDYYDV SLVDGFNLPM SVAPQGGTGE
160 170 180 190 200
CKPSSCPANV NKVCPAPLQV KAADGSVISC KSACLAFGDS KYCCTPPNNT
210 220 230 240
PETCPPTEYS EIFEKQCPQA YSYAYDDKNS TFTCSGGPDY VITFCP
Length:246
Mass (Da):25,700
Last modified:March 1, 2001 - v1
Checksum:i3A34CE175DCB9FE4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8 – 17SLLGLTLAIL → PRPTLAILF in AAC36740 (PubMed:10737193).Curated10
Sequence conflicti127Y → F in AAM12886 (PubMed:12481992).Curated1
Sequence conflicti163V → A in AAM12886 (PubMed:12481992).Curated1
Sequence conflicti167P → Q in AAM12886 (PubMed:12481992).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090143 mRNA. Translation: AAC36740.1.
AJ243427 mRNA. Translation: CAC10270.1.
AF494393 mRNA. Translation: AAM12886.1.
RefSeqiNP_001315714.1. NM_001328785.1.
UniGeneiMdo.203.

Genome annotation databases

GeneIDi103411735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090143 mRNA. Translation: AAC36740.1.
AJ243427 mRNA. Translation: CAC10270.1.
AF494393 mRNA. Translation: AAM12886.1.
RefSeqiNP_001315714.1. NM_001328785.1.
UniGeneiMdo.203.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZS3X-ray1.80A25-246[»]
ProteinModelPortaliQ9FSG7.
SMRiQ9FSG7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3360. Mal d 2.0101.
465. Mal d 2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi103411735.

Family and domain databases

Gene3Di2.60.110.10. 1 hit.
InterProiIPR001938. Thaumatin.
IPR017949. Thaumatin_CS.
[Graphical view]
PANTHERiPTHR31048. PTHR31048. 1 hit.
PfamiPF00314. Thaumatin. 1 hit.
[Graphical view]
PIRSFiPIRSF002703. Thaumatin. 1 hit.
PRINTSiPR00347. THAUMATIN.
SMARTiSM00205. THN. 1 hit.
[Graphical view]
SUPFAMiSSF49870. SSF49870. 1 hit.
PROSITEiPS00316. THAUMATIN_1. 1 hit.
PS51367. THAUMATIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTP1A_MALDO
AccessioniPrimary (citable) accession number: Q9FSG7
Secondary accession number(s): O82546
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.