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Q9FSB9 (CHS1_RUTGR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase 1

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase 1
Gene names
Name:CHS1
OrganismRuta graveolens (Common rue)
Taxonomic identifier37565 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsSapindalesRutaceaeRuta

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 393393Chalcone synthase 1
PRO_0000216045

Sites

Active site1661 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9FSB9 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: BFC5C37A42DE4A44

FASTA39342,890
        10         20         30         40         50         60 
MAAVTVEAIR KAQRADGPAA VLAIGTATPA NYVTQADYPD YYFRITKSEH MTELKEKFKR 

        70         80         90        100        110        120 
MCDKSMIRKR YMHLTEDILK ENPNMCAYMA PSLDARQDIV VVEVPKLGKE AAVKAIKEWG 

       130        140        150        160        170        180 
QPKSKITHLI FCTTSGVDMP GCDYQLTKLL GLRPSVKRFM MYQQGCFAGG TVLRLAKDLA 

       190        200        210        220        230        240 
ENNRGARVLV VCSEITAVTF RGPADTHLDS LVGQALFGDG AAAVIVGADP DESIERPLYQ 

       250        260        270        280        290        300 
LVSAAQTILP DSDGAIDGHL REVGLTFHLL KDVPGLISKN IEKSLKEAFG PIGISDWNSI 

       310        320        330        340        350        360 
FWIAHPGGPA ILDQVEAKLG LKEEKLRATR QVLSEYGNMS SACVLFILDE MRKNCAEEGR 

       370        380        390 
ATTGEGLDWG VLFGFGPGLT VETVVLRSVP IKA 

« Hide

References

[1]"Specificities of functionally expressed chalcone and acridone synthases from Ruta graveolens."
Springob K., Lukacin R., Ernwein C., Groening I., Matern U.
Eur. J. Biochem. 267:6552-6559(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Immature flower.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ297789 mRNA. Translation: CAC14059.1.

3D structure databases

ProteinModelPortalQ9FSB9.
SMRQ9FSB9. Positions 5-391.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHS1_RUTGR
AccessionPrimary (citable) accession number: Q9FSB9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2001
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways