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Q9FSB9

- CHS1_RUTGR

UniProt

Q9FSB9 - CHS1_RUTGR

Protein

Chalcone synthase 1

Gene

CHS1

Organism
Ruta graveolens (Common rue)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    • Comment

    Functioni

    The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

    Catalytic activityi

    3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei166 – 1661PROSITE-ProRule annotation

    GO - Molecular functioni

    1. naringenin-chalcone synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. flavonoid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Flavonoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00154.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chalcone synthase 1 (EC:2.3.1.74)
    Alternative name(s):
    Naringenin-chalcone synthase 1
    Gene namesi
    Name:CHS1
    OrganismiRuta graveolens (Common rue)
    Taxonomic identifieri37565 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsSapindalesRutaceaeRuta

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393Chalcone synthase 1PRO_0000216045Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FSB9.
    SMRiQ9FSB9. Positions 5-391.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the chalcone/stilbene synthases family.Curated

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000451. PKS_III. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9FSB9-1 [UniParc]FASTAAdd to Basket

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    MAAVTVEAIR KAQRADGPAA VLAIGTATPA NYVTQADYPD YYFRITKSEH    50
    MTELKEKFKR MCDKSMIRKR YMHLTEDILK ENPNMCAYMA PSLDARQDIV 100
    VVEVPKLGKE AAVKAIKEWG QPKSKITHLI FCTTSGVDMP GCDYQLTKLL 150
    GLRPSVKRFM MYQQGCFAGG TVLRLAKDLA ENNRGARVLV VCSEITAVTF 200
    RGPADTHLDS LVGQALFGDG AAAVIVGADP DESIERPLYQ LVSAAQTILP 250
    DSDGAIDGHL REVGLTFHLL KDVPGLISKN IEKSLKEAFG PIGISDWNSI 300
    FWIAHPGGPA ILDQVEAKLG LKEEKLRATR QVLSEYGNMS SACVLFILDE 350
    MRKNCAEEGR ATTGEGLDWG VLFGFGPGLT VETVVLRSVP IKA 393
    Length:393
    Mass (Da):42,890
    Last modified:March 1, 2001 - v1
    Checksum:iBFC5C37A42DE4A44
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ297789 mRNA. Translation: CAC14059.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ297789 mRNA. Translation: CAC14059.1 .

    3D structure databases

    ProteinModelPortali Q9FSB9.
    SMRi Q9FSB9. Positions 5-391.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00154 .

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000451. PKS_III. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Specificities of functionally expressed chalcone and acridone synthases from Ruta graveolens."
      Springob K., Lukacin R., Ernwein C., Groening I., Matern U.
      Eur. J. Biochem. 267:6552-6559(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Immature flower.

    Entry informationi

    Entry nameiCHS1_RUTGR
    AccessioniPrimary (citable) accession number: Q9FSB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3