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Q9FSB8

- CHS2_RUTGR

UniProt

Q9FSB8 - CHS2_RUTGR

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Protein

Chalcone synthase 2

Gene

CHS2

Organism
Ruta graveolens (Common rue)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei166 – 1661PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 2 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 2
Gene namesi
Name:CHS2
OrganismiRuta graveolens (Common rue)
Taxonomic identifieri37565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsSapindalesRutaceaeRuta

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Chalcone synthase 2PRO_0000216046Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9FSB8.
SMRiQ9FSB8. Positions 5-391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FSB8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAVTVEEIR KAQRADGPAA VLAIGTATPA NYVTQADYPD YYFRITKSEH
60 70 80 90 100
MTELKEKFKR MCDKSMIRKR YMYLTEDILK ENPNMCAYMA PSLDARQDIV
110 120 130 140 150
VVEVPKLGKE AAVKAIKEWG QPKSKITHLI FCTTSGVDMP GCDYQLTKLL
160 170 180 190 200
GLRPSVKRFM MYQQGCFAGG TVLRLAKDLA ENNRGARVLV VCSEITAVTF
210 220 230 240 250
RGPADTHLDS LVGQALFGDG AAAVIVGADP NESIERPLYQ LVSAAQTILP
260 270 280 290 300
DSDGAIDGHL REVGLTFHLL KDVPGLISKN IEKSLKEAFG PIGISDWNSI
310 320 330 340 350
FWIAHPGGPA ILDQVEAKLG LKEEKLRATR QVLSEYGNMS SACVLFILDE
360 370 380 390
MRKKCAEEGR ATTGEGLDWG VLFGFGPGLT VETVVLRSVP INA
Length:393
Mass (Da):42,973
Last modified:March 1, 2001 - v1
Checksum:i18EC732F0FB5D26E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297790 mRNA. Translation: CAC14060.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297790 mRNA. Translation: CAC14060.1 .

3D structure databases

ProteinModelPortali Q9FSB8.
SMRi Q9FSB8. Positions 5-391.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00154 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Specificities of functionally expressed chalcone and acridone synthases from Ruta graveolens."
    Springob K., Lukacin R., Ernwein C., Groening I., Matern U.
    Eur. J. Biochem. 267:6552-6559(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Immature flower.

Entry informationi

Entry nameiCHS2_RUTGR
AccessioniPrimary (citable) accession number: Q9FSB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2001
Last modified: October 1, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3