ID   Q9FRX7_ORYSJ            Unreviewed;       549 AA.
AC   Q9FRX7;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 157.
DE   SubName: Full=Aldehyde dehydrogenase ALDH2b {ECO:0000313|EMBL:BAB19052.1};
DE   SubName: Full=Os06g0270900 protein {ECO:0000313|EMBL:BAS97182.1};
DE   SubName: Full=cDNA clone:J013051L04, full insert sequence {ECO:0000313|EMBL:BAG99957.1};
DE   SubName: Full=cDNA clone:J013116E11, full insert sequence {ECO:0000313|EMBL:BAG94020.1};
DE   SubName: Full=cDNA clone:J033005P04, full insert sequence {ECO:0000313|EMBL:BAG93278.1};
GN   Name=Aldh2b {ECO:0000313|EMBL:BAB19052.1};
GN   OrderedLocusNames=Os06g0270900 {ECO:0000313|EMBL:BAS97182.1};
GN   ORFNames=OSNPB_060270900 {ECO:0000313|EMBL:BAS97182.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947 {ECO:0000313|EMBL:BAB19052.1};
RN   [1] {ECO:0000313|EMBL:BAB19052.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Leaves of seedlings {ECO:0000313|EMBL:BAB19052.1};
RA   Nakazono M., Tsuji H.;
RT   "Rice mitochondrial aldehyde dehydrogenase Aldh2b.";
RL   Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:BAG93278.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Kikuchi S., Satoh K., Nagata T., Kawagashira N., Doi K., Kishimoto N.,
RA   Yazaki J., Ishikawa M., Yamada H., Ooka H., Hotta I., Kojima K., Namiki T.,
RA   Ohneda E., Yahagi W., Suzuki K., Li C., Ohtsuki K., Shishiki T., Otomo Y.,
RA   Murakami K., Iida Y., Sugano S., Fujimura T., Suzuki Y., Tsunoda Y.,
RA   Kurosaki T., Kodama T., Masuda H., Kobayashi M., Xie Q., Lu M.,
RA   Narikawa R., Sugiyama A., Mizuno K., Yokomizo S., Niikura J., Ikeda R.,
RA   Ishibiki J., Kawamata M., Yoshimura A., Miura J., Kusumegi T., Oka M.,
RA   Ryu R., Ueda M., Matsubara K., Kawai J., Carninci P., Adachi J., Aizawa K.,
RA   Arakawa T., Fukuda S., Hara A., Hashidume W., Hayatsu N., Imotani K.,
RA   Ishii Y., Itoh M., Kagawa I., Kondo S., Konno H., Miyazaki A., Osato N.,
RA   Ota Y., Saito R., Sasaki D., Sato K., Shibata K., Shinagawa A., Shiraki T.,
RA   Yoshino M., Hayashizaki Y.;
RT   "Collection, Mapping, and Annotation of Over 28,000 cDNA Clones from
RT   japonica Rice.";
RL   Science 301:376-379(2003).
RN   [3] {ECO:0000313|EMBL:BAG99957.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Adachi J., Aizawa K., Akimura T., Arakawa T., Carninci P., Doi K.,
RA   Fujimura T., Fukuda S., Hanagaki T., Hara A., Hashizume W., Hayashida K.,
RA   Hayashizaki Y., Hayatsu N., Hiramoto K., Hiraoka T., Hori F., Hotta I.,
RA   Iida J., Iida Y., Ikeda R., Imamura K., Imotani K., Ishibiki J., Ishii Y.,
RA   Ishikawa M., Itoh M., Kagawa I., Kanagawa S., Katoh H., Kawagashira N.,
RA   Kawai J., Kawamata M., Kikuchi S., Kishikawa-Hirozane T., Kishimoto N.,
RA   Kobayashi M., Kodama T., Kojima K., Kojima Y., Kondo S., Konno H.,
RA   Kouda M., Koya S., Kurihara C., Kurosaki T., Kusumegi T., Li C., Lu M.,
RA   Masuda H., Matsubara K., Matsuyama T., Miura J., Miyazaki A., Mizuno K.,
RA   Murakami K., Murata M., Nagata T., Nakahama Y., Nakamura M., Namiki T.,
RA   Narikawa R., Niikura J., Nishi K., Nomura K., Numasaki R., Ohneda E.,
RA   Ohno M., Ohtsuki K., Oka M., Ooka H., Osato N., Ota Y., Otomo Y., Ryu R.,
RA   Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Sato K.,
RA   Satoh K., Shibata K., Shinagawa A., Shiraki T., Shishiki T., Sogabe Y.,
RA   Sugano S., Sugiyama A., Suzuki K., Suzuki Y., Tagami M., Tagami-Takeda Y.,
RA   Tagawa A., Takahashi F., Takaku-Akahira S., Tanaka T., Tomaru A., Toya T.,
RA   Tsunoda Y., Ueda M., Waki K., Xie Q., Yahagi W., Yamada H., Yamamoto M.,
RA   Yasunishi A., Yazaki J., Yokomizo S., Yoshimura A.;
RT   "Collection, mapping, and annotation of 28K full-length cDNA clones from
RT   japonica rice.";
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Proteomes:UP000059680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare {ECO:0000313|Proteomes:UP000059680};
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RA   Matsumoto T., Wu J., Kanamori H., Katayose Y., Fujisawa M., Namiki N.,
RA   Mizuno H., Yamamoto K., Antonio B.A., Baba T., Sakata K., Nagamura Y.,
RA   Aoki H., Arikawa K., Arita K., Bito T., Chiden Y., Fujitsuka N.,
RA   Fukunaka R., Hamada M., Harada C., Hayashi A., Hijishita S., Honda M.,
RA   Hosokawa S., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M.,
RA   Ito K., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K.,
RA   Karasawa W., Kurita K., Katagiri S., Kikuta A., Kobayashi H., Kobayashi N.,
RA   Machita K., Maehara T., Masukawa M., Mizubayashi T., Mukai Y., Nagasaki H.,
RA   Nagata Y., Naito S., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M.,
RA   Meguro A., Negishi M., Ohta I., Ohta T., Okamoto M., Ono N., Saji S.,
RA   Sakaguchi M., Sakai K., Shibata M., Shimokawa T., Song J., Takazaki Y.,
RA   Terasawa K., Tsugane M., Tsuji K., Ueda S., Waki K., Yamagata H.,
RA   Yamamoto M., Yamamoto S., Yamane H., Yoshiki S., Yoshihara R., Yukawa K.,
RA   Zhong H., Yano M., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K.,
RA   Moffat K., Hill J., Bera J., Fadrosh D., Jin S., Johri S., Kim M.,
RA   Overton L., Reardon M., Tsitrin T., Vuong H., Weaver B., Ciecko A.,
RA   Tallon L., Jackson J., Pai G., Aken S.V., Utterback T., Reidmuller S.,
RA   Feldblyum T., Hsiao J., Zismann V., Iobst S., de Vazeille A.R., Buell C.R.,
RA   Ying K., Li Y., Lu T., Huang Y., Zhao Q., Feng Q., Zhang L., Zhu J.,
RA   Weng Q., Mu J., Lu Y., Fan D., Liu Y., Guan J., Zhang Y., Yu S., Liu X.,
RA   Zhang Y., Hong G., Han B., Choisne N., Demange N., Orjeda G., Samain S.,
RA   Cattolico L., Pelletier E., Couloux A., Segurens B., Wincker P., D'Hont A.,
RA   Scarpelli C., Weissenbach J., Salanoubat M., Quetier F., Yu Y., Kim H.R.,
RA   Rambo T., Currie J., Collura K., Luo M., Yang T., Ammiraju J.S.S.,
RA   Engler F., Soderlund C., Wing R.A., Palmer L.E., de la Bastide M.,
RA   Spiegel L., Nascimento L., Zutavern T., O'Shaughnessy A., Dike S.,
RA   Dedhia N., Preston R., Balija V., McCombie W.R., Chow T., Chen H.,
RA   Chung M., Chen C., Shaw J., Wu H., Hsiao K., Chao Y., Chu M., Cheng C.,
RA   Hour A., Lee P., Lin S., Lin Y., Liou J., Liu S., Hsing Y., Raghuvanshi S.,
RA   Mohanty A., Bharti A.K., Gaur A., Gupta V., Kumar D., Ravi V., Vij S.,
RA   Kapur A., Khurana P., Khurana P., Khurana J.P., Tyagi A.K., Gaikwad K.,
RA   Singh A., Dalal V., Srivastava S., Dixit A., Pal A.K., Ghazi I.A.,
RA   Yadav M., Pandit A., Bhargava A., Sureshbabu K., Batra K., Sharma T.R.,
RA   Mohapatra T., Singh N.K., Messing J., Nelson A.B., Fuks G., Kavchok S.,
RA   Keizer G., Linton E., Llaca V., Song R., Tanyolac B., Young S., Ho-Il K.,
RA   Hahn J.H., Sangsakoo G., Vanavichit A., de Mattos Luiz.A.T., Zimmer P.D.,
RA   Malone G., Dellagostin O., de Oliveira A.C., Bevan M., Bancroft I.,
RA   Minx P., Cordum H., Wilson R., Cheng Z., Jin W., Jiang J., Leong S.A.,
RA   Iwama H., Gojobori T., Itoh T., Niimura Y., Fujii Y., Habara T., Sakai H.,
RA   Sato Y., Wilson G., Kumar K., McCouch S., Juretic N., Hoen D., Wright S.,
RA   Bruskiewich R., Bureau T., Miyao A., Hirochika H., Nishikawa T.,
RA   Kadowaki K., Sugiura M., Burr B., Sasaki T.;
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [5] {ECO:0000313|EMBL:BAS97182.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23299411; DOI=10.1093/pcp/pcs183;
RA   Sakai H., Lee S.S., Tanaka T., Numa H., Kim J., Kawahara Y., Wakimoto H.,
RA   Yang C.C., Iwamoto M., Abe T., Yamada Y., Muto A., Inokuchi H., Ikemura T.,
RA   Matsumoto T., Sasaki T., Itoh T.;
RT   "Rice Annotation Project Database (RAP-DB): an integrative and interactive
RT   database for rice genomics.";
RL   Plant Cell Physiol. 54:E6-E6(2013).
RN   [6] {ECO:0000313|EMBL:BAS97182.1, ECO:0000313|Proteomes:UP000059680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare {ECO:0000313|Proteomes:UP000059680};
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [7] {ECO:0000313|EMBL:BAS97182.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Sakai H., Kawahara Y., Matsumoto T., Buell C.R., Itoh T.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; AB044537; BAB19052.1; -; mRNA.
DR   EMBL; AK073079; BAG93278.1; -; mRNA.
DR   EMBL; AK099248; BAG94020.1; -; mRNA.
DR   EMBL; AK120296; BAG99957.1; -; mRNA.
DR   EMBL; AP014962; BAS97182.1; -; Genomic_DNA.
DR   RefSeq; XP_015643334.1; XM_015787848.1.
DR   AlphaFoldDB; Q9FRX7; -.
DR   SMR; Q9FRX7; -.
DR   STRING; 39947.Q9FRX7; -.
DR   CarbonylDB; Q9FRX7; -.
DR   PaxDb; 39947-Q9FRX7; -.
DR   EnsemblPlants; Os06t0270900-01; Os06t0270900-01; Os06g0270900.
DR   GeneID; 4340725; -.
DR   Gramene; Os06t0270900-01; Os06t0270900-01; Os06g0270900.
DR   KEGG; osa:4340725; -.
DR   eggNOG; KOG2450; Eukaryota.
DR   HOGENOM; CLU_005391_0_1_1; -.
DR   OMA; HGIGYYP; -.
DR   OrthoDB; 3078548at2759; -.
DR   BRENDA; 1.2.1.5; 4460.
DR   PlantReactome; R-OSA-1119337; Proline degradation.
DR   Proteomes; UP000059680; Chromosome 6.
DR   ExpressionAtlas; Q9FRX7; baseline and differential.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IBA:GO_Central.
DR   CDD; cd07142; ALDH_F2BC; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   1: Evidence at protein level;
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003345};
KW   Proteomics identification {ECO:0007829|ProteomicsDB:Q9FRX7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000059680}.
FT   DOMAIN          77..539
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        316
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   549 AA;  59307 MW;  2B3FC2B841FB6DDD CRC64;
     MAAAAARRGS SLLSRCLLSR PAAAASPAVP SALRRADGTQ GLLPGILQRF STAAVAEEPI
     SPPVQVNYTQ LLIDGKFVDS ASGKTFPTLD PRTGELIAHV AEGDAEDINR AVHAARKAFD
     EGPWPKMTAY ERSRILLRFA DLIEKHNDEI AALETWDNGK PYAQAANIEV PMVARLMRYY
     AGWADKIHGL VVPADGPHHV QVLHEPIGVA GQIIPWNFPL LMFAWKVGPA LACGNTVVLK
     TAEQTPLSAL FASKLLHEAG LPDGVVNVVS GFGPTAGAAL ASHMDVDKIA FTGSTDTGKV
     VLELAARSNL KSVTLELGGK SPFIIMDDAD VDHAVELAHF ALFFNQGQCC CAGSRTFVHE
     RIYDEFVEKA KARALKRVVG DPFKNGVEQG PQIDDEQFNK ILRYIKYGVD SGANLVTGGD
     RLGDKGYYIQ PTIFSDVQDN MRIAQEEIFG PVQSILKFND LNEVIKRANA SQYGLAAGVF
     TNNLNTANTL TRALRVGTVW VNCFDVFDAA IPFGGYKQSG IGREKGIDSL KNYLQVKAVV
     TPIKNAAWL
//