Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tubby-like F-box protein 10

Gene

TULP10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • DNA binding transcription factor activity Source: TAIR
  • phosphatidylinositol binding Source: GO_Central

GO - Biological processi

  • protein ubiquitination Source: UniProtKB-UniPathway
  • regulation of transcription, DNA-templated Source: TAIR
  • response to fungus Source: TAIR

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Tubby-like F-box protein 10
Short name:
AtTLP10
Alternative name(s):
SKP1-interacting partner 26
Gene namesi
Name:TULP10
Synonyms:SKIP26
Ordered Locus Names:At1g25280
ORF Names:F4F7.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G25280
TAIRilocus:2032950 AT1G25280

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002722381 – 445Tubby-like F-box protein 10Add BLAST445

Proteomic databases

PaxDbiQ9FRH7

PTM databases

iPTMnetiQ9FRH7

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

ExpressionAtlasiQ9FRH7 baseline and differential
GenevisibleiQ9FRH7 AT

Interactioni

Subunit structurei

Part of a SCF (ASK-cullin-F-box) protein ligase complex (By similarity). Interacts with SKP1A/ASK1.By similarity1 Publication

Protein-protein interaction databases

BioGridi24349, 3 interactors
IntActiQ9FRH7, 3 interactors
STRINGi3702.AT1G25280.1

Structurei

3D structure databases

ProteinModelPortaliQ9FRH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 112F-boxAdd BLAST56

Domaini

The F-box is necessary for the interaction with ASK proteins.By similarity

Sequence similaritiesi

Belongs to the TUB family.Curated

Phylogenomic databases

eggNOGiKOG2502 Eukaryota
ENOG410XQFT LUCA
HOGENOMiHOG000238161
InParanoidiQ9FRH7
OMAiPAHPEQD
OrthoDBiEOG09360CFC
PhylomeDBiQ9FRH7

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR025659 Tubby-like_C
IPR000007 Tubby_C
IPR018066 Tubby_C_CS
PfamiView protein in Pfam
PF00646 F-box, 1 hit
PF01167 Tub, 1 hit
PRINTSiPR01573 SUPERTUBBY
SUPFAMiSSF54518 SSF54518, 2 hits
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS01200 TUB_1, 1 hit
PS01201 TUB_2, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q9FRH7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFRGIVQDL RDGFGSLSRR SFDFRLSSLH KGKAQGSSFR EYSSSRDLLS
60 70 80 90 100
PVIVQTSRWA NLPPELLFDV IKRLEESESN WPARKHVVAC ASVCRSWRAM
110 120 130 140 150
CQEIVLGPEI CGKLTFPVSL KQPGPRDAMI QCFIKRDKSK LTFHLFLCLS
160 170 180 190 200
PALLVENGKF LLSAKRTRRT TRTEYIISMD ADNISRSSNS YLGKLRSNFL
210 220 230 240 250
GTKFLVYDTQ PPPNTSSSAL ITDRTSRSRF HSRRVSPKVP SGSYNIAQIT
260 270 280 290 300
YELNVLGTRG PRRMHCIMNS IPISSLEPGG SVPNQPEKLV PAPYSLDDSF
310 320 330 340 350
RSNISFSKSS FDHRSLDFSS SRFSEMGISC DDNEEEASFR PLILKNKQPR
360 370 380 390 400
WHEQLQCWCL NFRGRVTVAS VKNFQLVAAR QPQPQGTGAA AAPTSAPAHP
410 420 430 440
EQDKVILQFG KVGKDMFTMD YRYPLSAFQA FAICLSSFDT KLACE
Length:445
Mass (Da):50,010
Last modified:March 1, 2001 - v1
Checksum:iC77BEA9ED18B9D21
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti404K → E in BAH19883 (PubMed:19423640).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti114L → I in strain: cv. Lisse. 1 Publication1
Natural varianti244Y → F in strain: cv. Bretagny. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF487271 mRNA Translation: AAQ06244.1
AC079374 Genomic DNA Translation: AAG28805.1
CP002684 Genomic DNA Translation: AEE30599.1
AY140459 Genomic DNA Translation: AAN46223.1
AY140460 Genomic DNA Translation: AAN46224.1
AY140461 Genomic DNA Translation: AAN46225.1
AY140462 Genomic DNA Translation: AAN46226.1
AY140463 Genomic DNA Translation: AAN46227.1
AY140464 Genomic DNA Translation: AAN46228.1
AY140465 Genomic DNA Translation: AAN46229.1
AY140466 Genomic DNA Translation: AAN46230.1
AY140467 Genomic DNA Translation: AAN46231.1
AY140468 Genomic DNA Translation: AAN46232.1
AY140469 Genomic DNA Translation: AAN46233.1
AK317199 mRNA Translation: BAH19883.1
BT001997 mRNA Translation: AAN72008.1
BT006290 mRNA Translation: AAP13398.1
PIRiE86382
RefSeqiNP_001117353.1, NM_001123881.1
NP_173899.1, NM_102338.3 [Q9FRH7-1]
NP_973909.1, NM_202180.1
UniGeneiAt.23717

Genome annotation databases

EnsemblPlantsiAT1G25280.1; AT1G25280.1; AT1G25280 [Q9FRH7-1]
GeneIDi839112
GrameneiAT1G25280.1; AT1G25280.1; AT1G25280 [Q9FRH7-1]
KEGGiath:AT1G25280

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTLP10_ARATH
AccessioniPrimary (citable) accession number: Q9FRH7
Secondary accession number(s): B9DGL6
, Q84JM8, Q84UG2, Q84UG3, Q8H0W5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health