Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tubby-like F-box protein 10

Gene

TULP10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • phosphatidylinositol binding Source: GO_Central
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • protein ubiquitination Source: UniProtKB-UniPathway
  • regulation of transcription, DNA-templated Source: TAIR
  • response to fungus Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Tubby-like F-box protein 10
Short name:
AtTLP10
Alternative name(s):
SKP1-interacting partner 26
Gene namesi
Name:TULP10
Synonyms:SKIP26
Ordered Locus Names:At1g25280
ORF Names:F4F7.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G25280.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • nucleus Source: TAIR
  • plasma membrane Source: TAIR
  • plastid Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Tubby-like F-box protein 10PRO_0000272238Add
BLAST

Proteomic databases

PaxDbiQ9FRH7.
PRIDEiQ9FRH7.

PTM databases

iPTMnetiQ9FRH7.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

ExpressionAtlasiQ9FRH7. baseline and differential.
GenevisibleiQ9FRH7. AT.

Interactioni

Subunit structurei

Part of a SCF (ASK-cullin-F-box) protein ligase complex (By similarity). Interacts with SKP1A/ASK1.By similarity1 Publication

Protein-protein interaction databases

BioGridi24349. 3 interactions.
IntActiQ9FRH7. 2 interactions.
MINTiMINT-8059072.
STRINGi3702.AT1G25280.1.

Structurei

3D structure databases

ProteinModelPortaliQ9FRH7.
SMRiQ9FRH7. Positions 122-445.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 11256F-boxAdd
BLAST

Domaini

The F-box is necessary for the interaction with ASK proteins.By similarity

Sequence similaritiesi

Belongs to the TUB family.Curated
Contains 1 F-box domain.Curated

Phylogenomic databases

eggNOGiKOG2502. Eukaryota.
ENOG410XQFT. LUCA.
HOGENOMiHOG000238161.
InParanoidiQ9FRH7.
OMAiSEMGISC.
PhylomeDBiQ9FRH7.

Family and domain databases

Gene3Di3.20.90.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR000007. Tubby_C.
IPR025659. Tubby_C-like.
IPR018066. Tubby_C_CS.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF01167. Tub. 1 hit.
[Graphical view]
PRINTSiPR01573. SUPERTUBBY.
SUPFAMiSSF54518. SSF54518. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEiPS01200. TUB_1. 1 hit.
PS01201. TUB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q9FRH7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFRGIVQDL RDGFGSLSRR SFDFRLSSLH KGKAQGSSFR EYSSSRDLLS
60 70 80 90 100
PVIVQTSRWA NLPPELLFDV IKRLEESESN WPARKHVVAC ASVCRSWRAM
110 120 130 140 150
CQEIVLGPEI CGKLTFPVSL KQPGPRDAMI QCFIKRDKSK LTFHLFLCLS
160 170 180 190 200
PALLVENGKF LLSAKRTRRT TRTEYIISMD ADNISRSSNS YLGKLRSNFL
210 220 230 240 250
GTKFLVYDTQ PPPNTSSSAL ITDRTSRSRF HSRRVSPKVP SGSYNIAQIT
260 270 280 290 300
YELNVLGTRG PRRMHCIMNS IPISSLEPGG SVPNQPEKLV PAPYSLDDSF
310 320 330 340 350
RSNISFSKSS FDHRSLDFSS SRFSEMGISC DDNEEEASFR PLILKNKQPR
360 370 380 390 400
WHEQLQCWCL NFRGRVTVAS VKNFQLVAAR QPQPQGTGAA AAPTSAPAHP
410 420 430 440
EQDKVILQFG KVGKDMFTMD YRYPLSAFQA FAICLSSFDT KLACE
Length:445
Mass (Da):50,010
Last modified:March 1, 2001 - v1
Checksum:iC77BEA9ED18B9D21
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti404 – 4041K → E in BAH19883 (PubMed:19423640).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti114 – 1141L → I in strain: cv. Lisse. 1 Publication
Natural varianti244 – 2441Y → F in strain: cv. Bretagny. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF487271 mRNA. Translation: AAQ06244.1.
AC079374 Genomic DNA. Translation: AAG28805.1.
CP002684 Genomic DNA. Translation: AEE30599.1.
AY140459 Genomic DNA. Translation: AAN46223.1.
AY140460 Genomic DNA. Translation: AAN46224.1.
AY140461 Genomic DNA. Translation: AAN46225.1.
AY140462 Genomic DNA. Translation: AAN46226.1.
AY140463 Genomic DNA. Translation: AAN46227.1.
AY140464 Genomic DNA. Translation: AAN46228.1.
AY140465 Genomic DNA. Translation: AAN46229.1.
AY140466 Genomic DNA. Translation: AAN46230.1.
AY140467 Genomic DNA. Translation: AAN46231.1.
AY140468 Genomic DNA. Translation: AAN46232.1.
AY140469 Genomic DNA. Translation: AAN46233.1.
AK317199 mRNA. Translation: BAH19883.1.
BT001997 mRNA. Translation: AAN72008.1.
BT006290 mRNA. Translation: AAP13398.1.
PIRiE86382.
RefSeqiNP_001117353.1. NM_001123881.1.
NP_173899.1. NM_102338.2. [Q9FRH7-1]
NP_973909.1. NM_202180.1.
UniGeneiAt.23717.

Genome annotation databases

EnsemblPlantsiAT1G25280.1; AT1G25280.1; AT1G25280. [Q9FRH7-1]
GeneIDi839112.
KEGGiath:AT1G25280.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF487271 mRNA. Translation: AAQ06244.1.
AC079374 Genomic DNA. Translation: AAG28805.1.
CP002684 Genomic DNA. Translation: AEE30599.1.
AY140459 Genomic DNA. Translation: AAN46223.1.
AY140460 Genomic DNA. Translation: AAN46224.1.
AY140461 Genomic DNA. Translation: AAN46225.1.
AY140462 Genomic DNA. Translation: AAN46226.1.
AY140463 Genomic DNA. Translation: AAN46227.1.
AY140464 Genomic DNA. Translation: AAN46228.1.
AY140465 Genomic DNA. Translation: AAN46229.1.
AY140466 Genomic DNA. Translation: AAN46230.1.
AY140467 Genomic DNA. Translation: AAN46231.1.
AY140468 Genomic DNA. Translation: AAN46232.1.
AY140469 Genomic DNA. Translation: AAN46233.1.
AK317199 mRNA. Translation: BAH19883.1.
BT001997 mRNA. Translation: AAN72008.1.
BT006290 mRNA. Translation: AAP13398.1.
PIRiE86382.
RefSeqiNP_001117353.1. NM_001123881.1.
NP_173899.1. NM_102338.2. [Q9FRH7-1]
NP_973909.1. NM_202180.1.
UniGeneiAt.23717.

3D structure databases

ProteinModelPortaliQ9FRH7.
SMRiQ9FRH7. Positions 122-445.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi24349. 3 interactions.
IntActiQ9FRH7. 2 interactions.
MINTiMINT-8059072.
STRINGi3702.AT1G25280.1.

PTM databases

iPTMnetiQ9FRH7.

Proteomic databases

PaxDbiQ9FRH7.
PRIDEiQ9FRH7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G25280.1; AT1G25280.1; AT1G25280. [Q9FRH7-1]
GeneIDi839112.
KEGGiath:AT1G25280.

Organism-specific databases

TAIRiAT1G25280.

Phylogenomic databases

eggNOGiKOG2502. Eukaryota.
ENOG410XQFT. LUCA.
HOGENOMiHOG000238161.
InParanoidiQ9FRH7.
OMAiSEMGISC.
PhylomeDBiQ9FRH7.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ9FRH7.

Gene expression databases

ExpressionAtlasiQ9FRH7. baseline and differential.
GenevisibleiQ9FRH7. AT.

Family and domain databases

Gene3Di3.20.90.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR000007. Tubby_C.
IPR025659. Tubby_C-like.
IPR018066. Tubby_C_CS.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF01167. Tub. 1 hit.
[Graphical view]
PRINTSiPR01573. SUPERTUBBY.
SUPFAMiSSF54518. SSF54518. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEiPS01200. TUB_1. 1 hit.
PS01201. TUB_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analyses of the Arabidopsis TUBBY-like protein gene family."
    Lai C.-P., Lee C.-L., Chen P.-H., Wu S.-H., Yang C.-C., Shaw J.-F.
    Plant Physiol. 134:1586-1597(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, NOMENCLATURE.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Selection on rapidly evolving proteins in the Arabidopsis genome."
    Barrier M., Bustamante C.D., Yu J., Purugganan M.D.
    Genetics 163:723-733(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-432, VARIANTS ILE-114 AND PHE-244.
    Strain: cv. Bla-1, cv. Bretagny, cv. Bs-1, cv. Bu-0, cv. Chi-1, cv. Co-1, cv. Hau-0, cv. Jl-1, cv. Kas-1, cv. Kent and cv. Lisse.
  5. "Analysis of multiple occurrences of alternative splicing events in Arabidopsis thaliana using novel sequenced full-length cDNAs."
    Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M., Shinozaki K.
    DNA Res. 16:155-164(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 129-445.
    Strain: cv. Columbia.
  6. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 179-445.
    Strain: cv. Columbia.
  7. "Protein interaction analysis of SCF ubiquitin E3 ligase subunits from Arabidopsis."
    Risseeuw E.P., Daskalchuk T.E., Banks T.W., Liu E., Cotelesage J., Hellmann H., Estelle M., Somers D.E., Crosby W.L.
    Plant J. 34:753-767(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SKP1A/ASK1.

Entry informationi

Entry nameiTLP10_ARATH
AccessioniPrimary (citable) accession number: Q9FRH7
Secondary accession number(s): B9DGL6
, Q84JM8, Q84UG2, Q84UG3, Q8H0W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2001
Last modified: January 20, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.