Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase TOR

Gene

TOR

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential cell growth regulator that controls development from early embryo to seed production. Controls plant growth in environmental stress conditions. Acts through the phosphorylation of downstream effectors that are recruited by the binding partner RAPTOR. Acts by activating transcription, protein synthesis and ribosome biogenesis, and inhibiting mRNA degradation and autophagy. Can phosphorylate TAP46, a regulatory subunit of protein phosphatase 2A that modulates cell growth and survival (PubMed:21216945). Involved in modulating the transition from heterotrophic to photoautotrophic growth by regulating the expression of chloroplast- and photosynthesis-associated genes (PubMed:27479935). Essential for auxin signaling transduction, probably acting in polysomes to maintain the active ATPK1/S6K1 (and thus TIF3H1/eIF3h) phosphorylation status that is critical for translation reinitiation (e.g. uORF-mRNAs loading) (PubMed:23524850, PubMed:27014314). Promotes abscisic acid (ABA) biosynthesis (PubMed:26459592). Involved in the regulation of sugar-mediated (e.g. glucose and sucrose) glycolysis- and mitochondrial bioenergetics-dependent root growth promotion (PubMed:23542588). Required for sugar (e.g. glucose) promotion of hypocotyl elongation in the dark, by activating the brassinosteroid pathway and stabilizing BZR1. The regulation of BZR1 degradation is dependent on autophagy (PubMed:27345161).16 Publications
(Microbial infection) Binding to cauliflower mosaic virus (CaMV) Tav protein is critical for both translation reinitiation and viral fitness (PubMed:21343906). When activated by CaMV P6, promotes CaMV translation by inhibiting cellular autophagy and suppressing both silencing and innate immunity, thus confering sensitivity to P.syringae (PubMed:27120694). Required during infection by some potyvirus such as watermelon mosaic virus (WMV) but not for turnip mosaic virus (TuMV) (PubMed:25979731).3 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Enzyme regulationi

Almost insensitive to rapamycin (PubMed:23963679). Strongly repressed by specific active site inhibitors (asTORis) such as AZD-8055, TORIN2 and WYE-132, and, to a lesser extent, by KU63794, WYE-354 and TORIN1, leading to impaired photoautotrophic growth and abnormally early meristematic cells differentiation (PubMed:23963679, PubMed:23524850). Repression by TORIN1 leads to impaired responses to auxin, including gravitropism (PubMed:23524850). Combined treatment with rapamycin and active-site inhibitors (e.g. Torin1 and AZD-8055) results in synergistic inhibition of activity and plant growth (PubMed:27479935). Inhibition by KU63794 leads to reduced auxin content in root tips (PubMed:27014314). AZD-8055 treatment reduces abscisic acid (ABA) levels (PubMed:26459592). In addition, inhibition by AZD-8055 leads to a strong reduction of watermelon mosaic virus (WMV) infection (PubMed:25979731).6 Publications

GO - Molecular functioni

  • 1-phosphatidylinositol-3-kinase activity Source: TAIR
  • ATP binding Source: UniProtKB-KW
  • identical protein binding Source: UniProtKB
  • kinase activity Source: GO_Central
  • macromolecular complex binding Source: InterPro
  • protein kinase activity Source: UniProtKB
  • protein self-association Source: TAIR
  • protein serine/threonine kinase activity Source: UniProtKB-KW
  • regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  • abscisic acid biosynthetic process Source: UniProtKB-KW
  • auxin-activated signaling pathway Source: UniProtKB-KW
  • brassinosteroid mediated signaling pathway Source: UniProtKB-KW
  • defense response Source: UniProtKB-KW
  • DNA repair Source: GO_Central
  • embryo development ending in seed dormancy Source: TAIR
  • gravitropism Source: UniProtKB
  • negative regulation of autophagy Source: UniProtKB
  • negative regulation of defense response to virus Source: UniProtKB
  • positive regulation of abscisic acid biosynthetic process Source: UniProtKB
  • positive regulation of auxin mediated signaling pathway Source: UniProtKB
  • positive regulation of brassinosteroid mediated signaling pathway Source: UniProtKB
  • positive regulation of cell growth Source: UniProtKB
  • positive regulation of embryonic development Source: UniProtKB
  • positive regulation of glucose mediated signaling pathway Source: UniProtKB
  • positive regulation of rRNA processing Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • post-embryonic development Source: TAIR
  • response to auxin Source: UniProtKB
  • response to rapamycin Source: UniProtKB
  • response to virus Source: UniProtKB
  • rRNA transcription Source: TAIR
  • sucrose mediated signaling Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Abscisic acid biosynthesis, Auxin signaling pathway, Brassinosteroid signaling pathway, Growth regulation, Host-virus interaction, Plant defense

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-3371571. HSF1-dependent transactivation.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase TORBy similarity (EC:2.7.11.1By similarity)
Alternative name(s):
Protein TARGET OF RAPAMYCIN1 Publication
Short name:
AtTOR1 Publication
Gene namesi
Name:TOR1 Publication
Ordered Locus Names:At1g50030Imported
ORF Names:F2J10.19Curated
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G50030.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus PROSITE-ProRule annotation1 Publication

  • Note: Associates to polysomes when activated by auxin or cauliflower mosaic virus (CaMV) Tav protein.1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
  • polysome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryo lethality when homozygous. Premature arrest of endosperm and embryo development. RNAi mutant exhibits plant growth arrest and reduced expression of brassinosteroid (BR)-responsive genes, as well as abolished exogenous sugar-mediated promotion of BZR1 accumulation (PubMed:27345161). RNAi plants are impaired in sugar-mediated (e.g. glucose and sucrose) root growth promotion and associated genes expression (PubMed:23542588). In response to auxin, deficient plants have polysomes prebound by inactive ATPK1/S6K1, and loading of uORF-mRNAs and activation TIF3H1/eIF3h are impaired (PubMed:23524850). In RNAi plants, severe alteration of watermelon mosaic virus (WMV) infection, but only slight delay of turnip mosaic virus (TuMV) infection (PubMed:25979731). Deficient plants are resistant to viral infection by cauliflower mosaic virus (CaMV), by failing to support CaMV Tav protein-mediated transactivation of reinitiation (PubMed:21343906).6 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2077 – 2080Missing : Loss of nuclear localization. 1 Publication4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004093301 – 2481Serine/threonine-protein kinase TORAdd BLAST2481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2424Phosphoserine1 Publication1

Post-translational modificationi

Activated by phosphorylation on Ser-2424 triggered by cauliflower mosaic virus P6 and auxin.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9FR53.
PRIDEiQ9FR53.

PTM databases

iPTMnetiQ9FR53.

Expressioni

Tissue specificityi

Highly expressed in root meristems, shoot apical meristem (SAM) and floral buds.4 Publications

Developmental stagei

One day after fertilization, expressed in endosperm, embryo, and the chalazal proliferating tissue. At globular stage, no longer expressed in endosperm, but still in embryo up to the heart and torpedo stages. In mature embryo, expressed in the apical and primary root meristems and dividing vascular tissues. During lateral root formation, expressed in the lateral root primordia and remains during the formation of the emerging secondary root meristem.1 Publication

Inductioni

Activation by auxin triggers recruitment to polysomes which release inactive ATPK1/S6K1.1 Publication

Gene expression databases

ExpressionAtlasiQ9FR53. baseline and differential.
GenevisibleiQ9FR53. AT.

Interactioni

Subunit structurei

Interacts with RAPTOR1 and itself. Interacts with FKBP12 in a rapamycin-dependent manner. Binds to LST8-1 (PubMed:22307851). Hyperactivated upon interaction with cauliflower mosaic virus (CaMV) Tav protein (PubMed:21343906).5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FPR1P200813EBI-1382370,EBI-6961From a different organism.
ORF VIP166666EBI-1382370,EBI-8597718From a different organism.
TIF3C1O491603EBI-1382370,EBI-1635551

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • protein self-association Source: TAIR

Protein-protein interaction databases

BioGridi26652. 2 interactors.
DIPiDIP-39421N.
IntActiQ9FR53. 6 interactors.
MINTiMINT-8177759.
STRINGi3702.AT1G50030.1.

Structurei

3D structure databases

ProteinModelPortaliQ9FR53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati205 – 242HEAT 1Sequence analysisAdd BLAST38
Repeati292 – 329HEAT 2Sequence analysisAdd BLAST38
Repeati373 – 410HEAT 3Sequence analysisAdd BLAST38
Repeati434 – 471HEAT 4Sequence analysisAdd BLAST38
Repeati569 – 607HEAT 5Sequence analysisAdd BLAST39
Repeati608 – 645HEAT 6Sequence analysisAdd BLAST38
Repeati737 – 775HEAT 7Sequence analysisAdd BLAST39
Repeati781 – 819HEAT 8Sequence analysisAdd BLAST39
Repeati866 – 904HEAT 9Sequence analysisAdd BLAST39
Repeati908 – 945HEAT 10Sequence analysisAdd BLAST38
Repeati952 – 992HEAT 11Sequence analysisAdd BLAST41
Repeati996 – 1036HEAT 12Sequence analysisAdd BLAST41
Repeati1037 – 1075HEAT 13Sequence analysisAdd BLAST39
Repeati1077 – 1114HEAT 14Sequence analysisAdd BLAST38
Domaini1309 – 1887FATPROSITE-ProRule annotationAdd BLAST579
Domaini2091 – 2481PI3K/PI4KPROSITE-ProRule annotationAdd BLAST391
Domaini2449 – 2481FATCPROSITE-ProRule annotationAdd BLAST33

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1505 – 1512Nuclear localization signalPROSITE-ProRule annotation8
Motifi2075 – 2080Nuclear localization signalCurated6

Domaini

The kinase domain is required for its function.1 Publication

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.Curated
Contains 1 FAT domain.PROSITE-ProRule annotation
Contains 1 FATC domain.PROSITE-ProRule annotation
Contains 14 HEAT repeats.Sequence analysis
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0891. Eukaryota.
COG5032. LUCA.
HOGENOMiHOG000163215.
InParanoidiQ9FR53.
KOiK07203.
OMAiCYDEANS.
OrthoDBiEOG0936000W.
PhylomeDBiQ9FR53.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
1.25.10.10. 6 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024585. DUF3385_TOR.
IPR003152. FATC_dom.
IPR009076. FRB_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR026683. TOR.
[Graphical view]
PANTHERiPTHR11139:SF9. PTHR11139:SF9. 2 hits.
PfamiPF11865. DUF3385. 1 hit.
PF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF08771. FRB_dom. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM01346. DUF3385. 1 hit.
SM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF47212. SSF47212. 1 hit.
SSF48371. SSF48371. 4 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q9FR53-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTSSQSFVA GRPASMASPS QSHRFCGPSA TASGGGSFDT LNRVIADLCS
60 70 80 90 100
RGNPKEGAPL AFRKHVEEAV RDLSGEASSR FMEQLYDRIA NLIESTDVAE
110 120 130 140 150
NMGALRAIDE LTEIGFGENA TKVSRFAGYM RTVFELKRDP EILVLASRVL
160 170 180 190 200
GHLARAGGAM TSDEVEFQMK TAFDWLRVDR VEYRRFAAVL ILKEMAENAS
210 220 230 240 250
TVFNVHVPEF VDAIWVALRD PQLQVRERAV EALRACLRVI EKRETRWRVQ
260 270 280 290 300
WYYRMFEATQ DGLGRNAPVH SIHGSLLAVG ELLRNTGEFM MSRYREVAEI
310 320 330 340 350
VLRYLEHRDR LVRLSITSLL PRIAHFLRDR FVTNYLTICM NHILTVLRIP
360 370 380 390 400
AERASGFIAL GEMAGALDGE LIHYLPTIMS HLRDAIAPRK GRPLLEAVAC
410 420 430 440 450
VGNIAKAMGS TVETHVRDLL DVMFSSSLSS TLVDALDQIT ISIPSLLPTV
460 470 480 490 500
QDRLLDCISL VLSKSHYSQA KPPVTIVRGS TVGMAPQSSD PSCSAQVQLA
510 520 530 540 550
LQTLARFNFK GHDLLEFARE SVVVYLDDED AATRKDAALC CCRLIANSLS
560 570 580 590 600
GITQFGSSRS TRAGGRRRRL VEEIVEKLLR TAVADADVTV RKSIFVALFG
610 620 630 640 650
NQCFDDYLAQ ADSLTAIFAS LNDEDLDVRE YAISVAGRLS EKNPAYVLPA
660 670 680 690 700
LRRHLIQLLT YLELSADNKC REESAKLLGC LVRNCERLIL PYVAPVQKAL
710 720 730 740 750
VARLSEGTGV NANNNIVTGV LVTVGDLARV GGLAMRQYIP ELMPLIVEAL
760 770 780 790 800
MDGAAVAKRE VAVSTLGQVV QSTGYVVTPY KEYPLLLGLL LKLLKGDLVW
810 820 830 840 850
STRREVLKVL GIMGALDPHV HKRNQQSLSG SHGEVPRGTG DSGQPIPSID
860 870 880 890 900
ELPVELRPSF ATSEDYYSTV AINSLMRILR DASLLSYHKR VVRSLMIIFK
910 920 930 940 950
SMGLGCVPYL PKVLPELFHT VRTSDENLKD FITWGLGTLV SIVRQHIRKY
960 970 980 990 1000
LPELLSLVSE LWSSFTLPGP IRPSRGLPVL HLLEHLCLAL NDEFRTYLPV
1010 1020 1030 1040 1050
ILPCFIQVLG DAERFNDYTY VPDILHTLEV FGGTLDEHMH LLLPALIRLF
1060 1070 1080 1090 1100
KVDAPVAIRR DAIKTLTRVI PCVQVTGHIS ALVHHLKLVL DGKNDELRKD
1110 1120 1130 1140 1150
AVDALCCLAH ALGEDFTIFI ESIHKLLLKH RLRHKEFEEI HARWRRREPL
1160 1170 1180 1190 1200
IVATTATQQL SRRLPVEVIR DPVIENEIDP FEEGTDRNHQ VNDGRLRTAG
1210 1220 1230 1240 1250
EASQRSTKED WEEWMRHFSI ELLKESPSPA LRTCAKLAQL QPFVGRELFA
1260 1270 1280 1290 1300
AGFVSCWAQL NESSQKQLVR SLEMAFSSPN IPPEILATLL NLAEFMEHDE
1310 1320 1330 1340 1350
KPLPIDIRLL GALAEKCRVF AKALHYKEME FEGPRSKRMD ANPVAVVEAL
1360 1370 1380 1390 1400
IHINNQLHQH EAAVGILTYA QQHLDVQLKE SWYEKLQRWD DALKAYTLKA
1410 1420 1430 1440 1450
SQTTNPHLVL EATLGQMRCL AALARWEELN NLCKEYWSPA EPSARLEMAP
1460 1470 1480 1490 1500
MAAQAAWNMG EWDQMAEYVS RLDDGDETKL RGLASPVSSG DGSSNGTFFR
1510 1520 1530 1540 1550
AVLLVRRAKY DEAREYVERA RKCLATELAA LVLESYERAY SNMVRVQQLS
1560 1570 1580 1590 1600
ELEEVIEYYT LPVGNTIAEE RRALIRNMWT QRIQGSKRNV EVWQALLAVR
1610 1620 1630 1640 1650
ALVLPPTEDV ETWLKFASLC RKSGRISQAK STLLKLLPFD PEVSPENMQY
1660 1670 1680 1690 1700
HGPPQVMLGY LKYQWSLGEE RKRKEAFTKL QILTRELSSV PHSQSDILAS
1710 1720 1730 1740 1750
MVSSKGANVP LLARVNLKLG TWQWALSSGL NDGSIQEIRD AFDKSTCYAP
1760 1770 1780 1790 1800
KWAKAWHTWA LFNTAVMSHY ISRGQIASQY VVSAVTGYFY SIACAANAKG
1810 1820 1830 1840 1850
VDDSLQDILR LLTLWFNHGA TADVQTALKT GFSHVNINTW LVVLPQIIAR
1860 1870 1880 1890 1900
IHSNNRAVRE LIQSLLIRIG ENHPQALMYP LLVACKSISN LRRAAAQEVV
1910 1920 1930 1940 1950
DKVRQHSGAL VDQAQLVSHE LIRVAILWHE MWHEALEEAS RLYFGEHNIE
1960 1970 1980 1990 2000
GMLKVLEPLH DMLDEGVKKD STTIQERAFI EAYRHELKEA HECCCNYKIT
2010 2020 2030 2040 2050
GKDAELTQAW DLYYHVFKRI DKQLASLTTL DLESVSPELL LCRDLELAVP
2060 2070 2080 2090 2100
GTYRADAPVV TISSFSRQLV VITSKQRPRK LTIHGNDGED YAFLLKGHED
2110 2120 2130 2140 2150
LRQDERVMQL FGLVNTLLEN SRKTAEKDLS IQRYSVIPLS PNSGLIGWVP
2160 2170 2180 2190 2200
NCDTLHHLIR EHRDARKIIL NQENKHMLSF APDYDNLPLI AKVEVFEYAL
2210 2220 2230 2240 2250
ENTEGNDLSR VLWLKSRSSE VWLERRTNYT RSLAVMSMVG YILGLGDRHP
2260 2270 2280 2290 2300
SNLMLHRYSG KILHIDFGDC FEASMNREKF PEKVPFRLTR MLVKAMEVSG
2310 2320 2330 2340 2350
IEGNFRSTCE NVMQVLRTNK DSVMAMMEAF VHDPLINWRL FNFNEVPQLA
2360 2370 2380 2390 2400
LLGNNNPNAP ADVEPDEEDE DPADIDLPQP QRSTREKEIL QAVNMLGDAN
2410 2420 2430 2440 2450
EVLNERAVVV MARMSHKLTG RDFSSSAIPS NPIADHNNLL GGDSHEVEHG
2460 2470 2480
LSVKVQVQKL INQATSHENL CQNYVGWCPF W
Length:2,481
Mass (Da):279,190
Last modified:March 1, 2001 - v1
Checksum:iDA663EA9A9366F93
GO

Sequence cautioni

The sequence AAF76442 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178967 mRNA. Translation: AAG43423.1.
AC015445 Genomic DNA. Translation: AAF76442.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE32509.1.
PIRiG96536.
RefSeqiNP_175425.2. NM_103891.4. [Q9FR53-1]
UniGeneiAt.16944.

Genome annotation databases

EnsemblPlantsiAT1G50030.1; AT1G50030.1; AT1G50030. [Q9FR53-1]
GeneIDi841427.
GrameneiAT1G50030.1; AT1G50030.1; AT1G50030.
KEGGiath:AT1G50030.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178967 mRNA. Translation: AAG43423.1.
AC015445 Genomic DNA. Translation: AAF76442.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE32509.1.
PIRiG96536.
RefSeqiNP_175425.2. NM_103891.4. [Q9FR53-1]
UniGeneiAt.16944.

3D structure databases

ProteinModelPortaliQ9FR53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi26652. 2 interactors.
DIPiDIP-39421N.
IntActiQ9FR53. 6 interactors.
MINTiMINT-8177759.
STRINGi3702.AT1G50030.1.

PTM databases

iPTMnetiQ9FR53.

Proteomic databases

PaxDbiQ9FR53.
PRIDEiQ9FR53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G50030.1; AT1G50030.1; AT1G50030. [Q9FR53-1]
GeneIDi841427.
GrameneiAT1G50030.1; AT1G50030.1; AT1G50030.
KEGGiath:AT1G50030.

Organism-specific databases

TAIRiAT1G50030.

Phylogenomic databases

eggNOGiKOG0891. Eukaryota.
COG5032. LUCA.
HOGENOMiHOG000163215.
InParanoidiQ9FR53.
KOiK07203.
OMAiCYDEANS.
OrthoDBiEOG0936000W.
PhylomeDBiQ9FR53.

Enzyme and pathway databases

ReactomeiR-ATH-3371571. HSF1-dependent transactivation.

Miscellaneous databases

PROiQ9FR53.

Gene expression databases

ExpressionAtlasiQ9FR53. baseline and differential.
GenevisibleiQ9FR53. AT.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
1.25.10.10. 6 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024585. DUF3385_TOR.
IPR003152. FATC_dom.
IPR009076. FRB_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR026683. TOR.
[Graphical view]
PANTHERiPTHR11139:SF9. PTHR11139:SF9. 2 hits.
PfamiPF11865. DUF3385. 1 hit.
PF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF08771. FRB_dom. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM01346. DUF3385. 1 hit.
SM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF47212. SSF47212. 1 hit.
SSF48371. SSF48371. 4 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOR_ARATH
AccessioniPrimary (citable) accession number: Q9FR53
Secondary accession number(s): Q9LPM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Inducible silencing in seedlings or adult plants leads to plant growth arrest. Plants slightly silencing TOR show constitutive autophagy and reduced shoot and root growth, leaf size, seed production and resistance to osmotic stress. Plants overexpressing TOR show increased shoot and root growth, leaf size, seed production and resistance to osmotic stress. Plants expressing FKBP12 (BP12) are sensitive to rapamycin. BP12 plants repressed by rapamycin exhibit slower growth and development leading to poor nutrient uptake and light energy utilization.6 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.