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Protein

Serine/threonine-protein kinase TOR

Gene

TOR

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential cell growth regulator that controls development from early embryo to seed production. Controls plant growth in environmental stress conditions. Acts through the phosphorylation of downstream effectors that are recruited by the binding partner RAPTOR. Acts by activating transcription, protein synthesis and ribosome biogenesis, and inhibiting mRNA degradation and autophagy.7 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functioni

  • 1-phosphatidylinositol-3-kinase activity Source: TAIR
  • ATP binding Source: UniProtKB-KW
  • drug binding Source: InterPro
  • identical protein binding Source: UniProtKB
  • kinase activity Source: GO_Central
  • protein self-association Source: TAIR
  • protein serine/threonine kinase activity Source: UniProtKB-KW
  • regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  • DNA repair Source: GO_Central
  • embryo development ending in seed dormancy Source: TAIR
  • negative regulation of autophagy Source: UniProtKB
  • phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
  • positive regulation of cell growth Source: UniProtKB
  • positive regulation of embryonic development Source: UniProtKB
  • positive regulation of rRNA processing Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • post-embryonic development Source: TAIR
  • rRNA transcription Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Growth regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G50030-MONOMER.
ARA:GQT-1674-MONOMER.
ReactomeiR-ATH-3371571. HSF1-dependent transactivation.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase TOR (EC:2.7.11.1)
Alternative name(s):
Protein TARGET OF RAPAMYCIN
Short name:
AtTOR
Gene namesi
Name:TOR
Ordered Locus Names:At1g50030
ORF Names:F2J10.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G50030.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryo lethality when homozygous. Premature arrest of endosperm and embryo development.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2077 – 20804Missing : Loss of nuclear localization. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24812481Serine/threonine-protein kinase TORPRO_0000409330Add
BLAST

Proteomic databases

PaxDbiQ9FR53.
PRIDEiQ9FR53.

PTM databases

iPTMnetiQ9FR53.

Expressioni

Tissue specificityi

Highly expressed in root meristems, shoot apical meristem (SAM) and floral buds.3 Publications

Developmental stagei

One day after fertilization, expressed in endosperm, embryo, and the chalazal proliferating tissue. At globular stage, no longer expressed in endosperm, but still in embryo up to the heart and torpedo stages. In mature embryo, expressed in the apical and primary root meristems and dividing vascular tissues. During lateral root formation, expressed in the lateral root primordia and remains during the formation of the emerging secondary root meristem.1 Publication

Gene expression databases

ExpressionAtlasiQ9FR53. baseline and differential.
GenevisibleiQ9FR53. AT.

Interactioni

Subunit structurei

Interacts with RAPTOR1 and itself. Interacts with FKBP12 in a rapamycin-dependent manner.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FPR1P200813EBI-1382370,EBI-6961From a different organism.
ORF VIP166666EBI-1382370,EBI-8597718From a different organism.
TIF3C1O491603EBI-1382370,EBI-1635551

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • protein self-association Source: TAIR

Protein-protein interaction databases

BioGridi26652. 2 interactions.
DIPiDIP-39421N.
IntActiQ9FR53. 6 interactions.
MINTiMINT-8177759.
STRINGi3702.AT1G50030.1.

Structurei

3D structure databases

ProteinModelPortaliQ9FR53.
SMRiQ9FR53. Positions 297-332, 376-410, 498-681, 742-814, 1611-1638, 1920-2023, 2068-2317, 2451-2481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati205 – 24238HEAT 1Add
BLAST
Repeati292 – 32938HEAT 2Add
BLAST
Repeati373 – 41038HEAT 3Add
BLAST
Repeati569 – 60739HEAT 4Add
BLAST
Repeati608 – 64538HEAT 5Add
BLAST
Repeati737 – 77539HEAT 6Add
BLAST
Repeati781 – 81939HEAT 7Add
BLAST
Repeati908 – 94538HEAT 8Add
BLAST
Repeati996 – 103641HEAT 9Add
BLAST
Repeati1037 – 107539HEAT 10Add
BLAST
Repeati1077 – 111438HEAT 11Add
BLAST
Domaini1309 – 1887579FATPROSITE-ProRule annotationAdd
BLAST
Domaini2091 – 2481391PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST
Domaini2449 – 248133FATCPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi2075 – 20806Nuclear localization signalCurated

Domaini

The kinase domain is required for its function.1 Publication

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.Curated
Contains 1 FAT domain.PROSITE-ProRule annotation
Contains 1 FATC domain.PROSITE-ProRule annotation
Contains 11 HEAT repeats.Curated
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0891. Eukaryota.
COG5032. LUCA.
HOGENOMiHOG000163215.
InParanoidiQ9FR53.
KOiK07203.
OMAiAYDQLRH.
PhylomeDBiQ9FR53.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
1.25.10.10. 6 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024585. DUF3385_TOR.
IPR003152. FATC_dom.
IPR009076. FRB_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR026683. TOR.
[Graphical view]
PANTHERiPTHR11139:SF9. PTHR11139:SF9. 2 hits.
PfamiPF11865. DUF3385. 1 hit.
PF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF08771. Rapamycin_bind. 1 hit.
[Graphical view]
SMARTiSM01346. DUF3385. 1 hit.
SM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF47212. SSF47212. 1 hit.
SSF48371. SSF48371. 4 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q9FR53-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTSSQSFVA GRPASMASPS QSHRFCGPSA TASGGGSFDT LNRVIADLCS
60 70 80 90 100
RGNPKEGAPL AFRKHVEEAV RDLSGEASSR FMEQLYDRIA NLIESTDVAE
110 120 130 140 150
NMGALRAIDE LTEIGFGENA TKVSRFAGYM RTVFELKRDP EILVLASRVL
160 170 180 190 200
GHLARAGGAM TSDEVEFQMK TAFDWLRVDR VEYRRFAAVL ILKEMAENAS
210 220 230 240 250
TVFNVHVPEF VDAIWVALRD PQLQVRERAV EALRACLRVI EKRETRWRVQ
260 270 280 290 300
WYYRMFEATQ DGLGRNAPVH SIHGSLLAVG ELLRNTGEFM MSRYREVAEI
310 320 330 340 350
VLRYLEHRDR LVRLSITSLL PRIAHFLRDR FVTNYLTICM NHILTVLRIP
360 370 380 390 400
AERASGFIAL GEMAGALDGE LIHYLPTIMS HLRDAIAPRK GRPLLEAVAC
410 420 430 440 450
VGNIAKAMGS TVETHVRDLL DVMFSSSLSS TLVDALDQIT ISIPSLLPTV
460 470 480 490 500
QDRLLDCISL VLSKSHYSQA KPPVTIVRGS TVGMAPQSSD PSCSAQVQLA
510 520 530 540 550
LQTLARFNFK GHDLLEFARE SVVVYLDDED AATRKDAALC CCRLIANSLS
560 570 580 590 600
GITQFGSSRS TRAGGRRRRL VEEIVEKLLR TAVADADVTV RKSIFVALFG
610 620 630 640 650
NQCFDDYLAQ ADSLTAIFAS LNDEDLDVRE YAISVAGRLS EKNPAYVLPA
660 670 680 690 700
LRRHLIQLLT YLELSADNKC REESAKLLGC LVRNCERLIL PYVAPVQKAL
710 720 730 740 750
VARLSEGTGV NANNNIVTGV LVTVGDLARV GGLAMRQYIP ELMPLIVEAL
760 770 780 790 800
MDGAAVAKRE VAVSTLGQVV QSTGYVVTPY KEYPLLLGLL LKLLKGDLVW
810 820 830 840 850
STRREVLKVL GIMGALDPHV HKRNQQSLSG SHGEVPRGTG DSGQPIPSID
860 870 880 890 900
ELPVELRPSF ATSEDYYSTV AINSLMRILR DASLLSYHKR VVRSLMIIFK
910 920 930 940 950
SMGLGCVPYL PKVLPELFHT VRTSDENLKD FITWGLGTLV SIVRQHIRKY
960 970 980 990 1000
LPELLSLVSE LWSSFTLPGP IRPSRGLPVL HLLEHLCLAL NDEFRTYLPV
1010 1020 1030 1040 1050
ILPCFIQVLG DAERFNDYTY VPDILHTLEV FGGTLDEHMH LLLPALIRLF
1060 1070 1080 1090 1100
KVDAPVAIRR DAIKTLTRVI PCVQVTGHIS ALVHHLKLVL DGKNDELRKD
1110 1120 1130 1140 1150
AVDALCCLAH ALGEDFTIFI ESIHKLLLKH RLRHKEFEEI HARWRRREPL
1160 1170 1180 1190 1200
IVATTATQQL SRRLPVEVIR DPVIENEIDP FEEGTDRNHQ VNDGRLRTAG
1210 1220 1230 1240 1250
EASQRSTKED WEEWMRHFSI ELLKESPSPA LRTCAKLAQL QPFVGRELFA
1260 1270 1280 1290 1300
AGFVSCWAQL NESSQKQLVR SLEMAFSSPN IPPEILATLL NLAEFMEHDE
1310 1320 1330 1340 1350
KPLPIDIRLL GALAEKCRVF AKALHYKEME FEGPRSKRMD ANPVAVVEAL
1360 1370 1380 1390 1400
IHINNQLHQH EAAVGILTYA QQHLDVQLKE SWYEKLQRWD DALKAYTLKA
1410 1420 1430 1440 1450
SQTTNPHLVL EATLGQMRCL AALARWEELN NLCKEYWSPA EPSARLEMAP
1460 1470 1480 1490 1500
MAAQAAWNMG EWDQMAEYVS RLDDGDETKL RGLASPVSSG DGSSNGTFFR
1510 1520 1530 1540 1550
AVLLVRRAKY DEAREYVERA RKCLATELAA LVLESYERAY SNMVRVQQLS
1560 1570 1580 1590 1600
ELEEVIEYYT LPVGNTIAEE RRALIRNMWT QRIQGSKRNV EVWQALLAVR
1610 1620 1630 1640 1650
ALVLPPTEDV ETWLKFASLC RKSGRISQAK STLLKLLPFD PEVSPENMQY
1660 1670 1680 1690 1700
HGPPQVMLGY LKYQWSLGEE RKRKEAFTKL QILTRELSSV PHSQSDILAS
1710 1720 1730 1740 1750
MVSSKGANVP LLARVNLKLG TWQWALSSGL NDGSIQEIRD AFDKSTCYAP
1760 1770 1780 1790 1800
KWAKAWHTWA LFNTAVMSHY ISRGQIASQY VVSAVTGYFY SIACAANAKG
1810 1820 1830 1840 1850
VDDSLQDILR LLTLWFNHGA TADVQTALKT GFSHVNINTW LVVLPQIIAR
1860 1870 1880 1890 1900
IHSNNRAVRE LIQSLLIRIG ENHPQALMYP LLVACKSISN LRRAAAQEVV
1910 1920 1930 1940 1950
DKVRQHSGAL VDQAQLVSHE LIRVAILWHE MWHEALEEAS RLYFGEHNIE
1960 1970 1980 1990 2000
GMLKVLEPLH DMLDEGVKKD STTIQERAFI EAYRHELKEA HECCCNYKIT
2010 2020 2030 2040 2050
GKDAELTQAW DLYYHVFKRI DKQLASLTTL DLESVSPELL LCRDLELAVP
2060 2070 2080 2090 2100
GTYRADAPVV TISSFSRQLV VITSKQRPRK LTIHGNDGED YAFLLKGHED
2110 2120 2130 2140 2150
LRQDERVMQL FGLVNTLLEN SRKTAEKDLS IQRYSVIPLS PNSGLIGWVP
2160 2170 2180 2190 2200
NCDTLHHLIR EHRDARKIIL NQENKHMLSF APDYDNLPLI AKVEVFEYAL
2210 2220 2230 2240 2250
ENTEGNDLSR VLWLKSRSSE VWLERRTNYT RSLAVMSMVG YILGLGDRHP
2260 2270 2280 2290 2300
SNLMLHRYSG KILHIDFGDC FEASMNREKF PEKVPFRLTR MLVKAMEVSG
2310 2320 2330 2340 2350
IEGNFRSTCE NVMQVLRTNK DSVMAMMEAF VHDPLINWRL FNFNEVPQLA
2360 2370 2380 2390 2400
LLGNNNPNAP ADVEPDEEDE DPADIDLPQP QRSTREKEIL QAVNMLGDAN
2410 2420 2430 2440 2450
EVLNERAVVV MARMSHKLTG RDFSSSAIPS NPIADHNNLL GGDSHEVEHG
2460 2470 2480
LSVKVQVQKL INQATSHENL CQNYVGWCPF W
Length:2,481
Mass (Da):279,190
Last modified:March 1, 2001 - v1
Checksum:iDA663EA9A9366F93
GO

Sequence cautioni

The sequence AAF76442.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178967 mRNA. Translation: AAG43423.1.
AC015445 Genomic DNA. Translation: AAF76442.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE32509.1.
PIRiG96536.
RefSeqiNP_175425.2. NM_103891.3. [Q9FR53-1]
UniGeneiAt.16944.

Genome annotation databases

EnsemblPlantsiAT1G50030.1; AT1G50030.1; AT1G50030. [Q9FR53-1]
GeneIDi841427.
KEGGiath:AT1G50030.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178967 mRNA. Translation: AAG43423.1.
AC015445 Genomic DNA. Translation: AAF76442.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE32509.1.
PIRiG96536.
RefSeqiNP_175425.2. NM_103891.3. [Q9FR53-1]
UniGeneiAt.16944.

3D structure databases

ProteinModelPortaliQ9FR53.
SMRiQ9FR53. Positions 297-332, 376-410, 498-681, 742-814, 1611-1638, 1920-2023, 2068-2317, 2451-2481.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi26652. 2 interactions.
DIPiDIP-39421N.
IntActiQ9FR53. 6 interactions.
MINTiMINT-8177759.
STRINGi3702.AT1G50030.1.

PTM databases

iPTMnetiQ9FR53.

Proteomic databases

PaxDbiQ9FR53.
PRIDEiQ9FR53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G50030.1; AT1G50030.1; AT1G50030. [Q9FR53-1]
GeneIDi841427.
KEGGiath:AT1G50030.

Organism-specific databases

TAIRiAT1G50030.

Phylogenomic databases

eggNOGiKOG0891. Eukaryota.
COG5032. LUCA.
HOGENOMiHOG000163215.
InParanoidiQ9FR53.
KOiK07203.
OMAiAYDQLRH.
PhylomeDBiQ9FR53.

Enzyme and pathway databases

BioCyciARA:AT1G50030-MONOMER.
ARA:GQT-1674-MONOMER.
ReactomeiR-ATH-3371571. HSF1-dependent transactivation.

Miscellaneous databases

PROiQ9FR53.

Gene expression databases

ExpressionAtlasiQ9FR53. baseline and differential.
GenevisibleiQ9FR53. AT.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
1.25.10.10. 6 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024585. DUF3385_TOR.
IPR003152. FATC_dom.
IPR009076. FRB_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR026683. TOR.
[Graphical view]
PANTHERiPTHR11139:SF9. PTHR11139:SF9. 2 hits.
PfamiPF11865. DUF3385. 1 hit.
PF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF08771. Rapamycin_bind. 1 hit.
[Graphical view]
SMARTiSM01346. DUF3385. 1 hit.
SM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF47212. SSF47212. 1 hit.
SSF48371. SSF48371. 4 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression and disruption of the Arabidopsis TOR (target of rapamycin) gene."
    Menand B., Desnos T., Nussaume L., Berger F., Bouchez D., Meyer C., Robaglia C.
    Proc. Natl. Acad. Sci. U.S.A. 99:6422-6427(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. Cited for: TISSUE SPECIFICITY.
  5. "An Arabidopsis homolog of RAPTOR/KOG1 is essential for early embryo development."
    Deprost D., Truong H.N., Robaglia C., Meyer C.
    Biochem. Biophys. Res. Commun. 326:844-850(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Arabidopsis TARGET OF RAPAMYCIN interacts with RAPTOR, which regulates the activity of S6 kinase in response to osmotic stress signals."
    Mahfouz M.M., Kim S., Delauney A.J., Verma D.P.
    Plant Cell 18:477-490(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RAPTOR1.
  7. "Saccharomyces cerevisiae FKBP12 binds Arabidopsis thaliana TOR and its expression in plants leads to rapamycin susceptibility."
    Sormani R., Yao L., Menand B., Ennar N., Lecampion C., Meyer C., Robaglia C.
    BMC Plant Biol. 7:26-26(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "The Arabidopsis TOR kinase links plant growth, yield, stress resistance and mRNA translation."
    Deprost D., Yao L., Sormani R., Moreau M., Leterreux G., Nicolai M., Bedu M., Robaglia C., Meyer C.
    EMBO Rep. 8:864-870(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "TOR is a negative regulator of autophagy in Arabidopsis thaliana."
    Liu Y., Bassham D.C.
    PLoS ONE 5:E11883-E11883(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. Cited for: FUNCTION.
  11. "Target of rapamycin regulates development and ribosomal RNA expression through kinase domain in Arabidopsis."
    Ren M., Qiu S., Venglat P., Xiang D., Feng L., Selvaraj G., Datla R.
    Plant Physiol. 155:1367-1382(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, DOMAIN, MUTAGENESIS OF 2077-ARG--LYS-2080.
  12. "Rapamycin and glucose-target of rapamycin (TOR) protein signaling in plants."
    Xiong Y., Sheen J.
    J. Biol. Chem. 287:2836-2842(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FKBP12.

Entry informationi

Entry nameiTOR_ARATH
AccessioniPrimary (citable) accession number: Q9FR53
Secondary accession number(s): Q9LPM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Inducible silencing in seedlings or adult plants leads to plant growth arrest. Plants slightly silencing TOR show constitutive autophagy and reduced shoot and root growth, leaf size, seed production and resistance to osmotic stress. Plants overexpressing TOR show increased shoot and root growth, leaf size, seed production and resistance to osmotic stress. Plants expressing FKBP12 are sensitive to rapamycin.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.