Q9FR39 (PROF5_MAIZE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Profilin-5

Alternative name(s):
ZmPRO5

Gene names

Name:

PRO5

Organism

Zea mays (Maize)

Taxonomic identifier

4577 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Liliopsida › commelinids › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogoneae › Zea

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Has a high affinity for poly-proline.
Subunit structure	Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
Subcellular location	Cytoplasm › cytoskeleton.
Tissue specificity	Expressed in vegetative cells.
Sequence similarities	Belongs to the profilin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	Actin-binding
Gene Ontology (GO)
Biological_process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 131	130	Profilin-5		PRO_0000199650

Sequences

	Sequence		Length	Mass (Da)
	Q9FR39 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 0FCCD16023DA1944	FASTA	131	14,114
	10 20 30 40 50 60 MSWQAYVDDH LLCDIEGQHL SAAAIVGHDG SVWAQSENFP ELKPEEVAGM IKDFDEPGTL 70 80 90 100 110 120 APTGLFVGGT KYMVIQGEPG VVIRGKKGTG GITIKKTGMS LIIGIYDEPM TPGQCNMVVE 130 RLGDYLIEQG F

References

[1]	"Maize profilin isoforms are functionally distinct." Kovar D.R., Droebak B.K., Staiger C.J. Plant Cell 12:583-598(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Strain: cv. B73.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF201459 mRNA. Translation: AAG35601.1.
RefSeq	NP_001105622.1. NM_001112152.1.
UniGene	Zm.567.
3D structure databases
ProteinModelPortal	Q9FR39.
SMR	Q9FR39. Positions 2-131.
ModBase	Search...
Protein family/group databases
Allergome	3533. Zea m 12.0105. 682. Zea m 12.
Proteomic databases
PRIDE	Q9FR39.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	542625.
KEGG	zma:542625.
Organism-specific databases
Gramene	Q9FR39.
Phylogenomic databases
HOGENOM	HOG000171591.
KO	K05759.
OMA	QLLASQC.
Family and domain databases
InterPro	IPR027310. Profilin_CS. IPR005455. Profilin_eukaryotes/bac. [Graphical view]
PANTHER	PTHR11604. PTHR11604. 1 hit.
Pfam	PF00235. Profilin. 1 hit. [Graphical view]
PRINTS	PR00392. PROFILIN. PR01640. PROFILINPLNT.
SMART	SM00392. PROF. 1 hit. [Graphical view]
SUPFAM	SSF55770. Profilin. 1 hit.
PROSITE	PS00414. PROFILIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROF5_MAIZE

Accession

Primary (citable) accession number: Q9FR39

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program