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Protein

Profilin-5

Gene

PRO5

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Has a high affinity for poly-proline.

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-5
Alternative name(s):
Pollen allergen Zea m 12
ZmPRO5
Allergen: Zea m 12
Gene namesi
Name:PRO5
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Chromosome 9

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3533. Zea m 12.0105.
682. Zea m 12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 131130Profilin-5PRO_0000199650Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi13 ↔ 115Curated
Modified residuei111 – 1111PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylated by MAP kinases.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ9FR39.
PRIDEiQ9FR39.

Expressioni

Tissue specificityi

Expressed in vegetative cells.

Gene expression databases

ExpressionAtlasiQ9FR39. baseline and differential.
GenevisibleiQ9FR39. ZM.

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Protein-protein interaction databases

STRINGi4577.GRMZM5G877388_P02.

Structurei

3D structure databases

ProteinModelPortaliQ9FR39.
SMRiQ9FR39. Positions 2-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi81 – 9717Involved in PIP2 interactionAdd
BLAST

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGiKOG1755. Eukaryota.
ENOG41126PD. LUCA.
HOGENOMiHOG000171591.
KOiK05759.
OMAiGKSDNFK.
OrthoDBiEOG09360WEB.

Family and domain databases

InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FR39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWQAYVDDH LLCDIEGQHL SAAAIVGHDG SVWAQSENFP ELKPEEVAGM
60 70 80 90 100
IKDFDEPGTL APTGLFVGGT KYMVIQGEPG VVIRGKKGTG GITIKKTGMS
110 120 130
LIIGIYDEPM TPGQCNMVVE RLGDYLIEQG F
Length:131
Mass (Da):14,114
Last modified:March 1, 2001 - v1
Checksum:i0FCCD16023DA1944
GO

Polymorphismi

Several isoforms of the allergen exist due to polymorphism.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201459 mRNA. Translation: AAG35601.1.
RefSeqiNP_001105622.1. NM_001112152.1.
UniGeneiZm.567.

Genome annotation databases

EnsemblPlantsiGRMZM5G877388_T02; GRMZM5G877388_P02; GRMZM5G877388.
GeneIDi542625.
GrameneiGRMZM5G877388_T02; GRMZM5G877388_P02; GRMZM5G877388.
KEGGizma:542625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201459 mRNA. Translation: AAG35601.1.
RefSeqiNP_001105622.1. NM_001112152.1.
UniGeneiZm.567.

3D structure databases

ProteinModelPortaliQ9FR39.
SMRiQ9FR39. Positions 2-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4577.GRMZM5G877388_P02.

Protein family/group databases

Allergomei3533. Zea m 12.0105.
682. Zea m 12.

Proteomic databases

PaxDbiQ9FR39.
PRIDEiQ9FR39.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiGRMZM5G877388_T02; GRMZM5G877388_P02; GRMZM5G877388.
GeneIDi542625.
GrameneiGRMZM5G877388_T02; GRMZM5G877388_P02; GRMZM5G877388.
KEGGizma:542625.

Phylogenomic databases

eggNOGiKOG1755. Eukaryota.
ENOG41126PD. LUCA.
HOGENOMiHOG000171591.
KOiK05759.
OMAiGKSDNFK.
OrthoDBiEOG09360WEB.

Gene expression databases

ExpressionAtlasiQ9FR39. baseline and differential.
GenevisibleiQ9FR39. ZM.

Family and domain databases

InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPROF5_MAIZE
AccessioniPrimary (citable) accession number: Q9FR39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.