Q9FQA3 (GST23_MAIZE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Glutathione transferase GST 23 EC=2.5.1.18 Alternative name(s): Glutathione transferase GST 36
Organism	Zea mays (Maize)
Taxonomic identifier	4577 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Liliopsida › commelinids › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogoneae › Zea

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in multiple disease resistance (MDR). Ref.4
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Miscellaneous	The presence of Asp-179 is significantly associated with a multiple disease resistance.
Sequence similarities	Belongs to the GST superfamily. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.
Caution	Ref.1 describes GST23 and GST36 as two different members of the GST family but they seem to be allelic variants of the same gene.

Ontologies

Keywords
Biological process	Plant defense
Molecular function	Transferase
Gene Ontology (GO)
Biological_process	defense response Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Glutathione transferase GST 23		PRO_0000411116
Regions
	Domain	4 – 83	80	GST N-terminal
	Domain	89 – 220	132	GST C-terminal
	Region	67 – 68	2	Glutathione binding By similarity
Sites
	Binding site	14	1	Glutathione By similarity
	Binding site	41	1	Glutathione By similarity
	Binding site	55	1	Glutathione; via amide nitrogen and carbonyl oxygen By similarity
Natural variations
	Natural variant	141	1	E → D. Ref.1
	Natural variant	179	1	H → D. Ref.1
	Natural variant	195	1	L → V. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9FQA3 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: C56E9A67CC4EE9CC	FASTA	222	24,879
	10 20 30 40 50 60 MAEKGVKVLG MWASPMVIRV EWALRLKGVE YEYVDEDLAN KSADLLRHNP VTKKVPVLVH 70 80 90 100 110 120 DGKPVAESTI IVEYIDEVWK GGYPIMPGDP YERAQARFWA RFAEDKCNAA LYPIFTATGE 130 140 150 160 170 180 AQRKAVHEAQ QCLKTLETAL EGKKFFGGDA VGYLDIVVGW FAHWLPVIEE VTGASVVTHE 190 200 210 220 ELPLMKAWFG RFLALDVVKA ALPDRDRLLA ANKARREQLL SA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A genomics approach to the comprehensive analysis of the glutathione S-transferase gene family in soybean and maize." McGonigle B., Keeler S.J., Lau S.M., Koeppe M.K., O'Keefe D.P. Plant Physiol. 124:1105-1120(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASP-141; ASP-179 AND VAL-195.
[2]	"Maize full-length cDNA project." Yu Y., Currie J., Lomeli R., Angelova A., Collura K., Wissotski M., Campos D., Kudrna D., Golser W., Ashely E., Haller K., Descour A., Fernandes J., Zuccolo A., Soderlund C., Walbot V. Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. B73.
[3]	"Insights into corn genes derived from large-scale cDNA sequencing." Alexandrov N.N., Brover V.V., Freidin S., Troukhan M.E., Tatarinova T.V., Zhang H., Swaller T.J., Lu Y.-P., Bouck J., Flavell R.B., Feldmann K.A. Plant Mol. Biol. 69:179-194(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Multivariate analysis of maize disease resistances suggests a pleiotropic genetic basis and implicates a GST gene." Wisser R.J., Kolkman J.M., Patzoldt M.E., Holland J.B., Yu J., Krakowsky M., Nelson R.J., Balint-Kurti P.J. Proc. Natl. Acad. Sci. U.S.A. 108:7339-7344(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS, FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF244688 mRNA. Translation: AAG34831.1. AF244701 mRNA. Translation: AAG34844.1. BT040471 mRNA. Translation: ACF85476.1. EU963788 mRNA. Translation: ACG35906.1.
RefSeq	NP_001104994.1. NM_001111524.1.
UniGene	Zm.561.
3D structure databases
ProteinModelPortal	Q9FQA3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	541845.
KEGG	zma:541845.
Organism-specific databases
Gramene	Q9FQA3.
MaizeGDB	452083. 542096.
Phylogenomic databases
HOGENOM	HOG000125749.
KO	K00799.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. [Graphical view]
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GST23_MAIZE

Accession

Primary (citable) accession number: Q9FQA3
Secondary accession number(s): Q9FQB6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	March 1, 2001
Last modified:	May 29, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program