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Protein

Glutathione transferase GST 23

Gene
N/A
Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in multiple disease resistance (MDR).1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141GlutathioneBy similarity
Binding sitei41 – 411GlutathioneBy similarity
Binding sitei55 – 551Glutathione; via amide nitrogen and carbonyl oxygenBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. defense response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione transferase GST 23 (EC:2.5.1.18)
Alternative name(s):
Glutathione transferase GST 36
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea
ProteomesiUP000007305 Componenti: Chromosome 7

Organism-specific databases

GrameneiQ9FQA3.
MaizeGDBi452083.
542096.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Glutathione transferase GST 23PRO_0000411116Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiQ9FQA3. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ9FQA3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 8380GST N-terminalAdd
BLAST
Domaini89 – 220132GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni67 – 682Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

HOGENOMiHOG000125749.
KOiK00799.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9FQA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKGVKVLG MWASPMVIRV EWALRLKGVE YEYVDEDLAN KSADLLRHNP
60 70 80 90 100
VTKKVPVLVH DGKPVAESTI IVEYIDEVWK GGYPIMPGDP YERAQARFWA
110 120 130 140 150
RFAEDKCNAA LYPIFTATGE AQRKAVHEAQ QCLKTLETAL EGKKFFGGDA
160 170 180 190 200
VGYLDIVVGW FAHWLPVIEE VTGASVVTHE ELPLMKAWFG RFLALDVVKA
210 220
ALPDRDRLLA ANKARREQLL SA
Length:222
Mass (Da):24,879
Last modified:March 1, 2001 - v1
Checksum:iC56E9A67CC4EE9CC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti141 – 1411E → D.1 Publication
Natural varianti179 – 1791H → D.1 Publication
Natural varianti195 – 1951L → V.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244688 mRNA. Translation: AAG34831.1.
AF244701 mRNA. Translation: AAG34844.1.
BT040471 mRNA. Translation: ACF85476.1.
EU963788 mRNA. Translation: ACG35906.1.
RefSeqiNP_001104994.1. NM_001111524.1.
UniGeneiZm.561.

Genome annotation databases

EnsemblPlantsiGRMZM2G416632_T02; GRMZM2G416632_P02; GRMZM2G416632.
GeneIDi541845.
KEGGizma:541845.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244688 mRNA. Translation: AAG34831.1.
AF244701 mRNA. Translation: AAG34844.1.
BT040471 mRNA. Translation: ACF85476.1.
EU963788 mRNA. Translation: ACG35906.1.
RefSeqiNP_001104994.1. NM_001111524.1.
UniGeneiZm.561.

3D structure databases

ProteinModelPortaliQ9FQA3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiGRMZM2G416632_T02; GRMZM2G416632_P02; GRMZM2G416632.
GeneIDi541845.
KEGGizma:541845.

Organism-specific databases

GrameneiQ9FQA3.
MaizeGDBi452083.
542096.

Phylogenomic databases

HOGENOMiHOG000125749.
KOiK00799.

Gene expression databases

ExpressionAtlasiQ9FQA3. baseline and differential.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A genomics approach to the comprehensive analysis of the glutathione S-transferase gene family in soybean and maize."
    McGonigle B., Keeler S.J., Lau S.M., Koeppe M.K., O'Keefe D.P.
    Plant Physiol. 124:1105-1120(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASP-141; ASP-179 AND VAL-195.
  2. "Maize full-length cDNA project."
    Yu Y., Currie J., Lomeli R., Angelova A., Collura K., Wissotski M., Campos D., Kudrna D., Golser W., Ashely E., Haller K., Descour A., Fernandes J., Zuccolo A., Soderlund C., Walbot V.
    Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. B73.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Multivariate analysis of maize disease resistances suggests a pleiotropic genetic basis and implicates a GST gene."
    Wisser R.J., Kolkman J.M., Patzoldt M.E., Holland J.B., Yu J., Krakowsky M., Nelson R.J., Balint-Kurti P.J.
    Proc. Natl. Acad. Sci. U.S.A. 108:7339-7344(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS, FUNCTION.

Entry informationi

Entry nameiGST23_MAIZE
AccessioniPrimary (citable) accession number: Q9FQA3
Secondary accession number(s): Q9FQB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 1, 2001
Last modified: April 1, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The presence of Asp-179 is significantly associated with a multiple disease resistance.

Caution

PubMed:11080288 describes GST23 and GST36 as two different members of the GST family but they seem to be allelic variants of the same gene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.