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Q9FPS9

- UBP15_ARATH

UniProt

Q9FPS9 - UBP15_ARATH

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Protein
Ubiquitin carboxyl-terminal hydrolase 15
Gene
UBP15, At1g17110, F20D23.20
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei447 – 4471Nucleophile By similarity
Active sitei703 – 7031Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri130 – 16738MYND-type
Add
BLAST

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. ubiquitinyl hydrolase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G17110-MONOMER.
ARA:GQT-1818-MONOMER.

Protein family/group databases

MEROPSiC19.096.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 15 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 15
Short name:
AtUBP15
Ubiquitin thioesterase 15
Ubiquitin-specific-processing protease 15
Gene namesi
Name:UBP15
Ordered Locus Names:At1g17110
ORF Names:F20D23.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G17110.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 924924Ubiquitin carboxyl-terminal hydrolase 15
PRO_0000313041Add
BLAST

Proteomic databases

PaxDbiQ9FPS9.
PRIDEiQ9FPS9.

Expressioni

Gene expression databases

GenevestigatoriQ9FPS9.

Interactioni

Protein-protein interaction databases

BioGridi23521. 3 interactions.
STRINGi3702.AT1G17110.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9FPS9.
SMRiQ9FPS9. Positions 439-741.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini438 – 744307USP
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi172 – 1776Poly-Ser

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiCOG5533.
HOGENOMiHOG000242869.
InParanoidiQ9FPS9.
KOiK11855.
PhylomeDBiQ9FPS9.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS50235. USP_3. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q9FPS9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLEPRGADIP ILFLVLVVLP VVAYILLGKW SNISEKRVRA NLLAQMAAEE    50
ALRAETVVNA DRGVRFESVA TENRAQRTRT KTVSAGGGAV RAEFDAGARE 100
TVAEQRSDSV TATCGVTVVA PVNNNELHVC ARCFGPAKTR CSRCKSVRYC 150
SGKCQIIHWR VAHKDECVPV ESCSSSSERV SFEKDSVLYD HGMDSTMYSN 200
NTTQAAKGKT SKSSVDFASL GISQNDITPQ INTQGRKSVG KQHSSKANRE 250
SCRRDSATVF DSSDEAASAG GDNKTSHIKH KSRGNSYAAE TNPRRHSVDS 300
SAVQMNGQSF VSGMQESHKH ENNLGVRSSF GCPNTQYPSN GTRTATLPRT 350
GINKSGEQSC TETSKKGQVA AVSKTVRSKD TGISEESNGI SSTMGIMKMM 400
GLRNSTKHDD RYKNLKMLFP YEEFLKFFQC EVFDLSPRGL VNCGNSCYAN 450
AVLQSLTCTK PLVAYLLRRS HSRSCSGKDW CLMCELEQHV MMLRESGGPL 500
SASRILSHMR SINCQIGDGS QEDAHEFLRL LVASMQSICL ERLGGETKVD 550
PRLQETTLVQ HMFGGRLRSK VKCLRCDHES ERYENIMDLT LEIYGWVESL 600
QDALTQFTRP EDLDGENMYR CSRCAGYVRA RKELSIHEAP NILTIVLKRF 650
QEGRYGKINK CISFPEMLDM IPFMTRTGDV PPLYMLYAVI VHLDTLNASF 700
SGHYISYVKD LRGNWYRIDD SEIHPVPMTQ VMSEGAYMLF YMRSYPRPQR 750
GEHNGKAPVH HSQPRNEMKE QRKPVNRFKP RADHKNTESS SSEWSLFTSS 800
DEASFTTEST RDSFSTIDYT DVCHVVDSSS PFAIFNNVYH NVEPSPHNTV 850
ACRMFSGTKP ETRYFVEQET NHNNTVVLDA TPSLYPIPAP YPPHDYYDQS 900
MYVNYETNPE FNNGQDQDRT YSYW 924
Length:924
Mass (Da):103,677
Last modified:January 15, 2008 - v2
Checksum:i32BD93822243271C
GO

Sequence cautioni

The sequence AAD50020.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061R → K in AAG42756. 1 Publication
Sequence conflicti390 – 3901I → V in AAG42756. 1 Publication
Sequence conflicti536 – 5361Q → P in AAG42756. 1 Publication
Sequence conflicti568 – 5681R → H in AAG42756. 1 Publication
Sequence conflicti599 – 6002SL → FF in AAG42756. 1 Publication
Sequence conflicti605 – 6051T → I in AAG42756. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF302665 mRNA. Translation: AAG42756.1.
AC007651 Genomic DNA. Translation: AAD50020.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29542.1.
PIRiH86306.
RefSeqiNP_564014.1. NM_101571.2. [Q9FPS9-1]
UniGeneiAt.48199.

Genome annotation databases

EnsemblPlantsiAT1G17110.1; AT1G17110.1; AT1G17110. [Q9FPS9-1]
GeneIDi838281.
KEGGiath:AT1G17110.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF302665 mRNA. Translation: AAG42756.1 .
AC007651 Genomic DNA. Translation: AAD50020.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE29542.1 .
PIRi H86306.
RefSeqi NP_564014.1. NM_101571.2. [Q9FPS9-1 ]
UniGenei At.48199.

3D structure databases

ProteinModelPortali Q9FPS9.
SMRi Q9FPS9. Positions 439-741.
ModBasei Search...

Protein-protein interaction databases

BioGridi 23521. 3 interactions.
STRINGi 3702.AT1G17110.1-P.

Protein family/group databases

MEROPSi C19.096.

Proteomic databases

PaxDbi Q9FPS9.
PRIDEi Q9FPS9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G17110.1 ; AT1G17110.1 ; AT1G17110 . [Q9FPS9-1 ]
GeneIDi 838281.
KEGGi ath:AT1G17110.

Organism-specific databases

TAIRi AT1G17110.

Phylogenomic databases

eggNOGi COG5533.
HOGENOMi HOG000242869.
InParanoidi Q9FPS9.
KOi K11855.
PhylomeDBi Q9FPS9.

Enzyme and pathway databases

BioCyci ARA:AT1G17110-MONOMER.
ARA:GQT-1818-MONOMER.

Gene expression databases

Genevestigatori Q9FPS9.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR002893. Znf_MYND.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS50235. USP_3. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The ubiquitin-specific protease family from Arabidopsis. AtUBP1 and 2 are required for the resistance to the amino acid analog canavanine."
    Yan N., Doelling J.H., Falbel T.G., Durski A.M., Vierstra R.D.
    Plant Physiol. 124:1828-1843(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY ORGANIZATION, NOMENCLATURE.
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.

Entry informationi

Entry nameiUBP15_ARATH
AccessioniPrimary (citable) accession number: Q9FPS9
Secondary accession number(s): Q9SHG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 3, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi