Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin carboxyl-terminal hydrolase 23

Gene

UBP23

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei116NucleophilePROSITE-ProRule annotation1
Active sitei369Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Protein family/group databases

MEROPSiC19.A12

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 23 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 23
Short name:
AtUBP23
Ubiquitin thioesterase 23
Ubiquitin-specific-processing protease 23
Gene namesi
Name:UBP23
Ordered Locus Names:At5g57990
ORF Names:MTI20.25
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G57990
TAIRilocus:2174403 AT5G57990

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003130491 – 859Ubiquitin carboxyl-terminal hydrolase 23Add BLAST859

Proteomic databases

PaxDbiQ9FPS4
PRIDEiQ9FPS4

Expressioni

Gene expression databases

ExpressionAtlasiQ9FPS4 baseline and differential
GenevisibleiQ9FPS4 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G57990.1

Structurei

3D structure databases

ProteinModelPortaliQ9FPS4
SMRiQ9FPS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 410USPAdd BLAST304

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi814 – 817Poly-Lys4

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

eggNOGiKOG1865 Eukaryota
ENOG410XQ92 LUCA
HOGENOMiHOG000078724
InParanoidiQ9FPS4
KOiK11855
OMAiQVKCEQC
OrthoDBiEOG09360311
PhylomeDBiQ9FPS4

Family and domain databases

InterProiView protein in InterPro
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FPS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVATSSTEI TIQTDRDPSS NNNGSCAVAS STASAVFRKI EFHPARKPFN
60 70 80 90 100
GFSNGRSDFK IETLNPCSSN QRLLSAPSAK KPDSSDLLEH GFEPDLTFSI
110 120 130 140 150
TFRKIGAGLQ NLGNTCFLNS VLQCLTYTEP LAATLQTAAH QKYCHVAGFC
160 170 180 190 200
ALCAIQKHVR TARQANGRIL APKDLVSNLR CISRNFRNCR QEDAHEYMIN
210 220 230 240 250
LLECMHKCSL PSGVPSESSD AYRRSLVHKI FGGSLRSQVK CEQCSHCSNK
260 270 280 290 300
FDPFLDLSLD ISKADSLQRA LSRFTAVELL DNGAKVYQCE RCKQKVKAKK
310 320 330 340 350
QLTVSKAPYV LTVHLKRFEA HRSEKIDRKV DFTSAIDMKP FVSGPHEGNL
360 370 380 390 400
KYTLYGVLVH YGRSSHSGHY ACFVRTSSGM WYSLDDNRVV QVSEKTVFNQ
410 420 430 440 450
KAYMLFYVRD RQNAVPKNSV PVVKKESFAT NRASLIVASN IKDQVNGSTV
460 470 480 490 500
IKECGFGALV ANGLAPLKSC GPSTPAVLTQ KDLNAKETQN NAISNVEAKE
510 520 530 540 550
ILETENGSAP VKTCDLAAPT VLVQKDLNTK EIFQKEVPLP QANGEGSLVK
560 570 580 590 600
EDSKAACLIL PEKVSPHLDG SANAQTLVKL PTLGPKAENS VEEKNSLNNL
610 620 630 640 650
NEPANSLKVI NVSVGNPPVE KAVLIDQTMG HHLEESATSI ESLKLTSERE
660 670 680 690 700
TLTTPKKTRK PKTKTLKVEF KFFKLALGLR KKKVQRRERL STTVAGEIIS
710 720 730 740 750
EELLSKKRVK YQDTSLIAPS KMISSSDGAV TSDQQQPVGS SDLSEASQNA
760 770 780 790 800
KRKRESVLLQ KEAVNILTRG VPETVVAKWD EEISASQKRG SKSEGASSIG
810 820 830 840 850
YVADEWDEEY DRGKKKKIRI KEESYRGPNP FQMLASKRQK ETKKKWTQSI

TDAKTAYRI
Length:859
Mass (Da):94,903
Last modified:January 15, 2008 - v2
Checksum:i046FE8764DBB4609
GO

Sequence cautioni

The sequence BAB08869 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti657K → N in AAG42761 (PubMed:11115897).Curated1
Sequence conflicti660K → E in AAG42761 (PubMed:11115897).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302671 mRNA Translation: AAG42761.1
AB013396 Genomic DNA Translation: BAB08869.1 Sequence problems.
CP002688 Genomic DNA Translation: AED96982.1
RefSeqiNP_568873.1, NM_125184.3
UniGeneiAt.22531

Genome annotation databases

EnsemblPlantsiAT5G57990.1; AT5G57990.1; AT5G57990
GeneIDi835910
GrameneiAT5G57990.1; AT5G57990.1; AT5G57990
KEGGiath:AT5G57990

Similar proteinsi

Entry informationi

Entry nameiUBP23_ARATH
AccessioniPrimary (citable) accession number: Q9FPS4
Secondary accession number(s): Q9FJL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 25, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome