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Protein

Ubiquitin carboxyl-terminal hydrolase 24

Gene

UBP24

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei206NucleophilePROSITE-ProRule annotation1
Active sitei510Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-ATH-5656169 Termination of translesion DNA synthesis
R-ATH-5689880 Ub-specific processing proteases

Protein family/group databases

MEROPSiC19.A14

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 24 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 24
Short name:
AtUBP24
Ubiquitin thioesterase 24
Ubiquitin-specific-processing protease 24
Gene namesi
Name:UBP24
Ordered Locus Names:At4g30890
ORF Names:F6I18.200
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G30890
TAIRilocus:2126649 AT4G30890

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003130501 – 551Ubiquitin carboxyl-terminal hydrolase 24Add BLAST551

Proteomic databases

PaxDbiQ9FPS3

PTM databases

iPTMnetiQ9FPS3

Expressioni

Gene expression databases

ExpressionAtlasiQ9FPS3 baseline and differential
GenevisibleiQ9FPS3 AT

Interactioni

Protein-protein interaction databases

BioGridi14500, 2 interactors
STRINGi3702.AT4G30890.1

Structurei

3D structure databases

ProteinModelPortaliQ9FPS3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini197 – 551USPAdd BLAST355

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

eggNOGiKOG1871 Eukaryota
ENOG410XSIH LUCA
HOGENOMiHOG000084329
InParanoidiQ9FPS3
KOiK11841
OMAiINTSNTC
OrthoDBiEOG093606W6
PhylomeDBiQ9FPS3

Family and domain databases

InterProiView protein in InterPro
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FPS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKKVFVFG SFTEHETRSF FEQKPTKDPQ NSKDKCVGSI QFGSLNLAAE
60 70 80 90 100
NSSVNTNGEL KKGEADGTVK SAGSQERLDA SRPASSDKNN DSDAKLPRKN
110 120 130 140 150
SLRVPEHVVQ NGIIKEISES NKSLNNGVAV KTDPIGLDNL SMSDGESDPV
160 170 180 190 200
YKASSSKFQA LDNEDFSSDS SSGSIQRKKN LKVPTESVPP VKDFTPRGLI
210 220 230 240 250
NAGNLCFLNA TLQALLSCSP FVQLLQKIQL QDIPKADSPT LAAFSEFISE
260 270 280 290 300
LDVPSSSSIR NNVTVVEAGR PFRPAMFEGV LRNFTPDVLN NMSGRPRQED
310 320 330 340 350
AQEFLSFIMD QMHDELLKLK EQSPKVTASK SSVISSANDD GDEWETVGPK
360 370 380 390 400
NKSAVTRTQS FVPSELSEIF GGQLKSVVKA KGTKASATVQ PYLLLHLDIH
410 420 430 440 450
PDGVQGIEDA LHLFSAQEDL EGYRASVTGK TGVVSASKSI KIQKLSKIMI
460 470 480 490 500
LHLMRFSYGS QGSTKLRKGV KFPLELNLNR SHLVSLSNES LRYELVATIT
510 520 530 540 550
HHGWDPSKGH YTTDARRKNG QWLRFDDASV TPIGTKLVLH DQAYVLFYKQ

V
Length:551
Mass (Da):60,440
Last modified:March 1, 2001 - v1
Checksum:iC4211FEC7E931AD9
GO

Sequence cautioni

The sequence AAM83229 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA18204 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB79807 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302672 mRNA Translation: AAG42762.1
AL022198 Genomic DNA Translation: CAA18204.1 Sequence problems.
AL161577 Genomic DNA Translation: CAB79807.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE85824.1
CP002687 Genomic DNA Translation: AEE85825.1
CP002687 Genomic DNA Translation: AEE85826.1
AY127002 mRNA Translation: AAM83229.1 Different initiation.
BT000568 mRNA Translation: AAN18137.1
PIRiF85361
RefSeqiNP_001190875.1, NM_001203946.1
NP_567860.1, NM_119236.4
NP_974644.1, NM_202915.2
UniGeneiAt.22252

Genome annotation databases

EnsemblPlantsiAT4G30890.1; AT4G30890.1; AT4G30890
AT4G30890.2; AT4G30890.2; AT4G30890
AT4G30890.3; AT4G30890.3; AT4G30890
GeneIDi829213
GrameneiAT4G30890.1; AT4G30890.1; AT4G30890
AT4G30890.2; AT4G30890.2; AT4G30890
AT4G30890.3; AT4G30890.3; AT4G30890
KEGGiath:AT4G30890

Similar proteinsi

Entry informationi

Entry nameiUBP24_ARATH
AccessioniPrimary (citable) accession number: Q9FPS3
Secondary accession number(s): O65560, Q8L7U2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health