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Q9FPS3

- UBP24_ARATH

UniProt

Q9FPS3 - UBP24_ARATH

Protein

Ubiquitin carboxyl-terminal hydrolase 24

Gene

UBP24

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei206 – 2061NucleophilePROSITE-ProRule annotation
    Active sitei510 – 5101Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    BioCyciARA:AT4G30890-MONOMER.
    ARA:GQT-738-MONOMER.
    ARA:GQT-739-MONOMER.

    Protein family/group databases

    MEROPSiC19.A14.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 24 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 24
    Short name:
    AtUBP24
    Ubiquitin thioesterase 24
    Ubiquitin-specific-processing protease 24
    Gene namesi
    Name:UBP24
    Ordered Locus Names:At4g30890
    ORF Names:F6I18.200
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 4

    Organism-specific databases

    TAIRiAT4G30890.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: TAIR

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551Ubiquitin carboxyl-terminal hydrolase 24PRO_0000313050Add
    BLAST

    Proteomic databases

    PaxDbiQ9FPS3.
    PRIDEiQ9FPS3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9FPS3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FPS3.
    SMRiQ9FPS3. Positions 198-549.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini197 – 551355USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5533.
    HOGENOMiHOG000084329.
    InParanoidiQ9FPS3.
    KOiK11841.
    OMAiSKIMILH.
    PhylomeDBiQ9FPS3.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9FPS3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEKKVFVFG SFTEHETRSF FEQKPTKDPQ NSKDKCVGSI QFGSLNLAAE    50
    NSSVNTNGEL KKGEADGTVK SAGSQERLDA SRPASSDKNN DSDAKLPRKN 100
    SLRVPEHVVQ NGIIKEISES NKSLNNGVAV KTDPIGLDNL SMSDGESDPV 150
    YKASSSKFQA LDNEDFSSDS SSGSIQRKKN LKVPTESVPP VKDFTPRGLI 200
    NAGNLCFLNA TLQALLSCSP FVQLLQKIQL QDIPKADSPT LAAFSEFISE 250
    LDVPSSSSIR NNVTVVEAGR PFRPAMFEGV LRNFTPDVLN NMSGRPRQED 300
    AQEFLSFIMD QMHDELLKLK EQSPKVTASK SSVISSANDD GDEWETVGPK 350
    NKSAVTRTQS FVPSELSEIF GGQLKSVVKA KGTKASATVQ PYLLLHLDIH 400
    PDGVQGIEDA LHLFSAQEDL EGYRASVTGK TGVVSASKSI KIQKLSKIMI 450
    LHLMRFSYGS QGSTKLRKGV KFPLELNLNR SHLVSLSNES LRYELVATIT 500
    HHGWDPSKGH YTTDARRKNG QWLRFDDASV TPIGTKLVLH DQAYVLFYKQ 550
    V 551
    Length:551
    Mass (Da):60,440
    Last modified:March 1, 2001 - v1
    Checksum:iC4211FEC7E931AD9
    GO

    Sequence cautioni

    The sequence AAM83229.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAA18204.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAB79807.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF302672 mRNA. Translation: AAG42762.1.
    AL022198 Genomic DNA. Translation: CAA18204.1. Sequence problems.
    AL161577 Genomic DNA. Translation: CAB79807.1. Sequence problems.
    CP002687 Genomic DNA. Translation: AEE85824.1.
    CP002687 Genomic DNA. Translation: AEE85825.1.
    CP002687 Genomic DNA. Translation: AEE85826.1.
    AY127002 mRNA. Translation: AAM83229.1. Different initiation.
    BT000568 mRNA. Translation: AAN18137.1.
    PIRiF85361.
    RefSeqiNP_001190875.1. NM_001203946.1.
    NP_567860.1. NM_119236.3.
    NP_974644.1. NM_202915.1.
    UniGeneiAt.22252.

    Genome annotation databases

    EnsemblPlantsiAT4G30890.1; AT4G30890.1; AT4G30890.
    AT4G30890.2; AT4G30890.2; AT4G30890.
    AT4G30890.3; AT4G30890.3; AT4G30890.
    GeneIDi829213.
    KEGGiath:AT4G30890.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF302672 mRNA. Translation: AAG42762.1 .
    AL022198 Genomic DNA. Translation: CAA18204.1 . Sequence problems.
    AL161577 Genomic DNA. Translation: CAB79807.1 . Sequence problems.
    CP002687 Genomic DNA. Translation: AEE85824.1 .
    CP002687 Genomic DNA. Translation: AEE85825.1 .
    CP002687 Genomic DNA. Translation: AEE85826.1 .
    AY127002 mRNA. Translation: AAM83229.1 . Different initiation.
    BT000568 mRNA. Translation: AAN18137.1 .
    PIRi F85361.
    RefSeqi NP_001190875.1. NM_001203946.1.
    NP_567860.1. NM_119236.3.
    NP_974644.1. NM_202915.1.
    UniGenei At.22252.

    3D structure databases

    ProteinModelPortali Q9FPS3.
    SMRi Q9FPS3. Positions 198-549.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C19.A14.

    Proteomic databases

    PaxDbi Q9FPS3.
    PRIDEi Q9FPS3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT4G30890.1 ; AT4G30890.1 ; AT4G30890 .
    AT4G30890.2 ; AT4G30890.2 ; AT4G30890 .
    AT4G30890.3 ; AT4G30890.3 ; AT4G30890 .
    GeneIDi 829213.
    KEGGi ath:AT4G30890.

    Organism-specific databases

    TAIRi AT4G30890.

    Phylogenomic databases

    eggNOGi COG5533.
    HOGENOMi HOG000084329.
    InParanoidi Q9FPS3.
    KOi K11841.
    OMAi SKIMILH.
    PhylomeDBi Q9FPS3.

    Enzyme and pathway databases

    BioCyci ARA:AT4G30890-MONOMER.
    ARA:GQT-738-MONOMER.
    ARA:GQT-739-MONOMER.

    Miscellaneous databases

    PROi Q9FPS3.

    Gene expression databases

    Genevestigatori Q9FPS3.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The ubiquitin-specific protease family from Arabidopsis. AtUBP1 and 2 are required for the resistance to the amino acid analog canavanine."
      Yan N., Doelling J.H., Falbel T.G., Durski A.M., Vierstra R.D.
      Plant Physiol. 124:1828-1843(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY ORGANIZATION, NOMENCLATURE.
      Strain: cv. Columbia.
    2. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
      Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
      , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
      Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 274-551.
      Strain: cv. Columbia.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Root.
    6. "Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis thaliana."
      Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A., Andreasson E., Rathjen J.P., Peck S.C.
      J. Proteomics 72:439-451(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: cv. Columbia.
    7. "Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks."
      Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A., Grossmann J., Gruissem W., Baginsky S.
      Plant Physiol. 150:889-903(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiUBP24_ARATH
    AccessioniPrimary (citable) accession number: Q9FPS3
    Secondary accession number(s): O65560, Q8L7U2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3