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Q9FPH3

- THA2_ARATH

UniProt

Q9FPH3 - THA2_ARATH

Protein

Probable low-specificity L-threonine aldolase 2

Gene

THA2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Threonine aldolase involved in threonine degradation to glycine. May play a role in the removal of L-allo-threonine.1 Publication

    Catalytic activityi

    L-threonine = glycine + acetaldehyde.
    L-allo-threonine = glycine + acetaldehyde.

    Cofactori

    Pyridoxal phosphate.By similarity

    Kineticsi

    1. KM=3.8 mM for L-threonine1 Publication

    Pathwayi

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: InterPro
    2. threonine aldolase activity Source: TAIR

    GO - Biological processi

    1. threonine catabolic process Source: TAIR

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciARA:GQT-2165-MONOMER.
    BRENDAi2.1.2.1. 302.
    UniPathwayiUPA00044; UER00429.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable low-specificity L-threonine aldolase 2 (EC:4.1.2.48)
    Alternative name(s):
    Threonine aldolase 2
    Gene namesi
    Name:THA2
    Ordered Locus Names:At3g04520
    ORF Names:T27C4.17
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G04520.

    Pathology & Biotechi

    Disruption phenotypei

    Lethal albino phenotype when homozygous.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 355355Probable low-specificity L-threonine aldolase 2PRO_0000428660Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei211 – 2111N6-(pyridoxal phosphate)lysineBy similarity

    Expressioni

    Tissue specificityi

    Expressed in roots, leaf vasculature and flowers.1 Publication

    Gene expression databases

    GenevestigatoriQ9FPH3.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT3G04520.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9FPH3.
    SMRiQ9FPH3. Positions 10-353.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the threonine aldolase family.Curated

    Phylogenomic databases

    eggNOGiCOG2008.
    InParanoidiQ9FPH3.
    KOiK01620.
    OMAiESESHIY.
    PhylomeDBiQ9FPH3.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR001597. ArAA_b-elim_lyase/Thr_aldolase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR023603. Threonine_aldolase.
    [Graphical view]
    PfamiPF01212. Beta_elim_lyase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017617. Thr_aldolase. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. According to EST sequences.

    Isoform 1 (identifier: Q9FPH3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVTPTTIRTV DLRSDTVTKP TESMRSAMAN AEVDDDVLGN DPTALRLEKE    50
    VAEIAGKEAA MFVPSGTMGN LISVLVHCDE RGSEVILGDD SHIHIYENGG 100
    VSSLGGVHPR TVKNEEDGTM EIGAIEAAVR SPKGDLHHPV TKLICLENTQ 150
    ANCGGRCLPI EYIDKVGELA KKHGLKLHID GARIFNASVA LGVPVKRIVQ 200
    AADSVSICLS KGIGAPVGSV IVGSKKFITK ARWLRKTLGG GMRQIGVLCA 250
    AALVALHENV AKLEDDHKKA RVLAEGLNRI ERLRVNVAAV ETNIIYVDIP 300
    EDPKFGAEEA CKSLEDVGVL VIPQATFRIR IVLHHQISDV DVEYVLSCFE 350
    KIFHS 355
    Length:355
    Mass (Da):38,252
    Last modified:March 1, 2001 - v1
    Checksum:iD7D1EFDBA18B517E
    GO

    Sequence cautioni

    The sequence AAF63783.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC022287 Genomic DNA. Translation: AAF63783.1. Sequence problems.
    CP002686 Genomic DNA. Translation: AEE74091.1.
    AF325033 mRNA. Translation: AAG40385.1.
    AY091093 mRNA. Translation: AAM14044.1.
    AY123033 mRNA. Translation: AAM67566.1.
    AK175345 mRNA. Translation: BAD43108.1.
    AY085456 mRNA. Translation: AAM62682.1.
    RefSeqiNP_566228.1. NM_111323.3. [Q9FPH3-1]
    UniGeneiAt.19145.

    Genome annotation databases

    EnsemblPlantsiAT3G04520.1; AT3G04520.1; AT3G04520. [Q9FPH3-1]
    GeneIDi819608.
    KEGGiath:AT3G04520.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC022287 Genomic DNA. Translation: AAF63783.1 . Sequence problems.
    CP002686 Genomic DNA. Translation: AEE74091.1 .
    AF325033 mRNA. Translation: AAG40385.1 .
    AY091093 mRNA. Translation: AAM14044.1 .
    AY123033 mRNA. Translation: AAM67566.1 .
    AK175345 mRNA. Translation: BAD43108.1 .
    AY085456 mRNA. Translation: AAM62682.1 .
    RefSeqi NP_566228.1. NM_111323.3. [Q9FPH3-1 ]
    UniGenei At.19145.

    3D structure databases

    ProteinModelPortali Q9FPH3.
    SMRi Q9FPH3. Positions 10-353.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT3G04520.1-P.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G04520.1 ; AT3G04520.1 ; AT3G04520 . [Q9FPH3-1 ]
    GeneIDi 819608.
    KEGGi ath:AT3G04520.

    Organism-specific databases

    TAIRi AT3G04520.

    Phylogenomic databases

    eggNOGi COG2008.
    InParanoidi Q9FPH3.
    KOi K01620.
    OMAi ESESHIY.
    PhylomeDBi Q9FPH3.

    Enzyme and pathway databases

    UniPathwayi UPA00044 ; UER00429 .
    BioCyci ARA:GQT-2165-MONOMER.
    BRENDAi 2.1.2.1. 302.

    Gene expression databases

    Genevestigatori Q9FPH3.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR001597. ArAA_b-elim_lyase/Thr_aldolase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR023603. Threonine_aldolase.
    [Graphical view ]
    Pfami PF01212. Beta_elim_lyase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017617. Thr_aldolase. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Two Arabidopsis threonine aldolases are nonredundant and compete with threonine deaminase for a common substrate pool."
      Joshi V., Laubengayer K.M., Schauer N., Fernie A.R., Jander G.
      Plant Cell 18:3564-3575(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiTHA2_ARATH
    AccessioniPrimary (citable) accession number: Q9FPH3
    Secondary accession number(s): Q9M835
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2014
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3