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Q9FNX8

- LOX4_ARATH

UniProt

Q9FNX8 - LOX4_ARATH

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Protein

Lipoxygenase 4, chloroplastic

Gene
LOX4, LOX3, At1g72520, F28P22.29, T10D10.1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure By similarity. 13S-lipoxygenase that can use linolenic acid as substrates.1 Publication

Catalytic activityi

Linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate.
Alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate.

Cofactori

Binds 1 iron ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi585 – 5851Iron; catalytic By similarity
Metal bindingi590 – 5901Iron; catalytic By similarity
Metal bindingi777 – 7771Iron; catalytic By similarity
Metal bindingi781 – 7811Iron; catalytic By similarity
Metal bindingi926 – 9261Iron; via carboxylate; catalytic By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. linoleate 13S-lipoxygenase activity Source: UniProtKB

GO - Biological processi

  1. anther dehiscence Source: TAIR
  2. anther development Source: TAIR
  3. lipid oxidation Source: TAIR
  4. oxylipin biosynthetic process Source: UniProtKB-UniPathway
  5. pollen development Source: TAIR
  6. response to bacterium Source: UniProtKB
  7. response to ozone Source: UniProtKB
  8. response to wounding Source: UniProtKB
  9. stamen filament development Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Oxylipin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00382.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoxygenase 4, chloroplastic (EC:1.13.11.12)
Short name:
AtLOX4
Alternative name(s):
LOX3-like protein
Gene namesi
Name:LOX4
Synonyms:LOX3
Ordered Locus Names:At1g72520
ORF Names:F28P22.29, T10D10.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G72520.

Subcellular locationi

Plastidchloroplast Reviewed prediction

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5858Chloroplast Reviewed predictionAdd
BLAST
Chaini59 – 926868Lipoxygenase 4, chloroplasticPRO_0000380593Add
BLAST

Proteomic databases

PaxDbiQ9FNX8.
PRIDEiQ9FNX8.

Expressioni

Tissue specificityi

Expressed in leaves.1 Publication

Developmental stagei

Expression is greatly increased in leaves during leaf senescence.1 Publication

Inductioni

Induced by bacterial pathogens (e.g. Pseudomonas syringae pv. tomato), ozone O3, and wounding.2 Publications

Gene expression databases

GenevestigatoriQ9FNX8.

Structurei

3D structure databases

ProteinModelPortaliQ9FNX8.
SMRiQ9FNX8. Positions 113-926.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini106 – 228123PLATAdd
BLAST
Domaini231 – 926696LipoxygenaseAdd
BLAST

Sequence similaritiesi

Belongs to the lipoxygenase family.
Contains 1 PLAT domain.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG69653.
HOGENOMiHOG000230469.
InParanoidiQ9FNX8.
KOiK00454.
OMAiALANEIM.
PhylomeDBiQ9FNX8.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
4.10.372.10. 1 hit.
InterProiIPR008976. Lipase_LipOase.
IPR000907. LipOase.
IPR013819. LipOase_C.
IPR020834. LipOase_CS.
IPR020833. LipOase_Fe_BS.
IPR001246. LipOase_pln.
IPR027433. Lipoxygenase_domain_3.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PANTHERiPTHR11771. PTHR11771. 1 hit.
PfamiPF00305. Lipoxygenase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PRINTSiPR00087. LIPOXYGENASE.
PR00468. PLTLPOXGNASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF48484. SSF48484. 1 hit.
SSF49723. SSF49723. 1 hit.
PROSITEiPS00711. LIPOXYGENASE_1. 1 hit.
PS00081. LIPOXYGENASE_2. 1 hit.
PS51393. LIPOXYGENASE_3. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FNX8-1 [UniParc]FASTAAdd to Basket

« Hide

MALANEIMGS RLIFERSSSL ASPFHSRFSI KKKTQRTQFS INPFDPRPMR    50
AVNSSGVVAA ISEDLVKTLR ISTVGRKQEK EEEEEKSVKF KVRAVATVRN 100
KNKEDFKETL VKHLDAFTDK IGRNVVLELM STQVDPKTNE PKKSKAAVLK 150
DWSKKSNSKA ERVHYTAEFT VDSAFGSPGA ITVTNKHQKE FFLESITIEG 200
FACGPVHFPC NSWVQSQKDH PSKRILFTNQ PYLPSETPSG LRTLREKELE 250
NLRGNGKGER KLSDRIYDYD VYNDIGNPDI SRELARPTLG GREFPYPRRC 300
RTGRSSTDTD MMSERRVEKP LPMYVPRDEQ FEESKQNTFA ACRLKAVLHN 350
LIPSLKASIL AEDFANFGEI DSLYKEGLLL KLGFQDDMFK KFPLPKIVTT 400
LQKSSEGLLR YDTPKIVSKD KYAWLRDDEF ARQAIAGINP VNIERVTSYP 450
PVSNLDPEIY GPGLHSALTE DHIIGQLDGL TVQQALETNR LFMVDYHDIY 500
LPFLDRINAL DGRKAYATRT ILFLTRLGTL KPIAIELSLP SQSSSNQKSK 550
RVVTPPVDAT SNWMWQLAKA HVGSNDAGVH QLVNHWLRTH ACLEPFILAA 600
HRQLSAMHPI FKLLDPHMRY TLEINAVARQ TLISADGVIE SCFTAGQYGL 650
EISSAAYKNK WRFDMEGLPA DLIRRGMAVP DPTQPHGLKL LVEDYPYAND 700
GLLLWSAIQT WVRTYVERYY ANSNLIQTDT ELQAWYSESI NVGHADHRDA 750
EWWPKLSTVE DLVSVITTII WLASAQHAAL NFGQYPYGGY VPNRPPLMRR 800
LIPDESDPEF TSFIEDPQKY FFSSMPSLLQ TTKFMAVVDT LSTHSPDEEY 850
IGERQQPSIW TGDAEIVDAF YGFSAEIGRI EKEIDKRNRD PSRRNRCGAG 900
VLPYELMAPS SEPGVTCRGV PNSVSI 926
Length:926
Mass (Da):104,814
Last modified:March 1, 2001 - v1
Checksum:i3592FB6ECDCCC4A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ302042 mRNA. Translation: CAC19364.1.
AC010926 Genomic DNA. Translation: AAG51846.1.
AC016529 Genomic DNA. Translation: AAG52571.1.
CP002684 Genomic DNA. Translation: AEE35334.1.
AY056166 mRNA. Translation: AAL07015.1.
AY091193 mRNA. Translation: AAM14132.1.
PIRiE96749.
RefSeqiNP_177396.1. NM_105911.4.
UniGeneiAt.18241.
At.67292.

Genome annotation databases

EnsemblPlantsiAT1G72520.1; AT1G72520.1; AT1G72520.
GeneIDi843584.
KEGGiath:AT1G72520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ302042 mRNA. Translation: CAC19364.1 .
AC010926 Genomic DNA. Translation: AAG51846.1 .
AC016529 Genomic DNA. Translation: AAG52571.1 .
CP002684 Genomic DNA. Translation: AEE35334.1 .
AY056166 mRNA. Translation: AAL07015.1 .
AY091193 mRNA. Translation: AAM14132.1 .
PIRi E96749.
RefSeqi NP_177396.1. NM_105911.4.
UniGenei At.18241.
At.67292.

3D structure databases

ProteinModelPortali Q9FNX8.
SMRi Q9FNX8. Positions 113-926.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q9FNX8.
PRIDEi Q9FNX8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G72520.1 ; AT1G72520.1 ; AT1G72520 .
GeneIDi 843584.
KEGGi ath:AT1G72520.

Organism-specific databases

TAIRi AT1G72520.

Phylogenomic databases

eggNOGi NOG69653.
HOGENOMi HOG000230469.
InParanoidi Q9FNX8.
KOi K00454.
OMAi ALANEIM.
PhylomeDBi Q9FNX8.

Enzyme and pathway databases

UniPathwayi UPA00382 .

Gene expression databases

Genevestigatori Q9FNX8.

Family and domain databases

Gene3Di 2.60.60.20. 1 hit.
4.10.372.10. 1 hit.
InterProi IPR008976. Lipase_LipOase.
IPR000907. LipOase.
IPR013819. LipOase_C.
IPR020834. LipOase_CS.
IPR020833. LipOase_Fe_BS.
IPR001246. LipOase_pln.
IPR027433. Lipoxygenase_domain_3.
IPR001024. PLAT/LH2_dom.
[Graphical view ]
PANTHERi PTHR11771. PTHR11771. 1 hit.
Pfami PF00305. Lipoxygenase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view ]
PRINTSi PR00087. LIPOXYGENASE.
PR00468. PLTLPOXGNASE.
SMARTi SM00308. LH2. 1 hit.
[Graphical view ]
SUPFAMi SSF48484. SSF48484. 1 hit.
SSF49723. SSF49723. 1 hit.
PROSITEi PS00711. LIPOXYGENASE_1. 1 hit.
PS00081. LIPOXYGENASE_2. 1 hit.
PS51393. LIPOXYGENASE_3. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "AtLOX4, the third chloroplastic jasmonate-inducible 13-LOX from Arabidopsis leaves."
    Kunze S., Fritsche K., Feussner I.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Leaf.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Evidence supporting a role of jasmonic acid in Arabidopsis leaf senescence."
    He Y., Fukushige H., Hildebrand D.F., Gan S.
    Plant Physiol. 128:876-884(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  6. "Expression profiling of the host response to bacterial infection: the transition from basal to induced defence responses in RPM1-mediated resistance."
    de Torres M., Sanchez P., Fernandez-Delmond I., Grant M.
    Plant J. 33:665-676(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY BACTERIAL PATHOGENS AND WOUNDING.
  7. "Oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral root development and defense responses through a specific signaling cascade."
    Vellosillo T., Martinez M., Lopez M.A., Vicente J., Cascon T., Dolan L., Hamberg M., Castresana C.
    Plant Cell 19:831-846(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Nitric oxide modulates ozone-induced cell death, hormone biosynthesis and gene expression in Arabidopsis thaliana."
    Ahlfors R., Brosche M., Kollist H., Kangasjaervi J.
    Plant J. 58:1-12(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY OZONE.
  9. "Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana."
    Bannenberg G., Martinez M., Hamberg M., Castresana C.
    Lipids 44:85-95(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiLOX4_ARATH
AccessioniPrimary (citable) accession number: Q9FNX8
Secondary accession number(s): Q9CAG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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